JOURNAL OF MATERIALS RESEARCH
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2026
·
IF 2.9
Jia Changlong,Fu Jieni,Zhao Jin,Yuan Xubo
Bacterial infection of biomedical devices presents a significant challenge in modern clinical medicine. Therefore, manufacturing surfaces with antibacterial and anti-adhesion properties is crucial to reduce the risk of infection. In this study, we created a copper-zinc antibacterial coating on stainless steel by electrochemical deposition. A superhydrophobic coating made of Cu 5 Zn 8 with a micro-nano structure was formed on the steel surface. The coating exhibits a water contact angle of 154°, effectively reducing bacterial adhesion by over 99%. The ions and reactive oxygen species released from the coating can kill more than 99% of bacteria and provide a static antibacterial effect lasting over 24 h. Additionally, the coating exhibits notable antibacterial and photothermal properties under near-infrared light irradiation, reaching temperatures of 60 °C within 2 min. This work successfully constructs a copper-zinc antibacterial coating with anti-adhesion, antibacterial, and NIR-responsive photothermal antibacterial properties, providing a dynamic and static combined antibacterial strategy for medical device surfaces. Graphical abstract
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
·
IF 4.1
Chen Hongze,Wan Yuebing,Li Kangcong,Li Xiuqin,Li Xiaomin,Chu Hongtao,Zhang Qinghe
Organophosphorus flame retardants (OPFRs) are widespread environmental contaminants with bioaccumulative potential and associated human health risks. The lack of commercial reference standards for many OPFRs limits the accuracy of their quantification. In this study, a compound-independent calibration (CIC) method using gas chromatography-inductively coupled plasma mass spectrometry (GC-ICP-MS) was developed for the simultaneous quantification of seven alkyl OPFRs, with tripropyl phosphate (TnPP) as a single universal calibrant. Key parameters were optimized: a DB-5MS column (15 m × 0.25 mm × 0.10 μm) with pulsed splitless injection (70 psi, 280 °C), and ICP-MS settings including an RF power of 1600 W, sampling depth of 7.5 mm, dilution gas flow rate of 0.5 mL/min, and octopole voltage of − 5 V. The method exhibited excellent linearity ( R 2 = 0.9994 to 0.9999) over the range of 0.01–1.0 μg/mL. Limits of detection and quantification were 0.22 to 0.91 ng/mL and 0.75 to 3.02 ng/mL, respectively. For six of the seven OPFRs (excluding TEHP), the relative P response ratios compared to TnPP ranged from 0.91 to 1.01, confirming effective structure-independent calibration. The matrix effect in rice was moderate (enhancement factors 1.13–1.35). Quantitative results obtained by the CIC method agreed well with those from an external standard approach, with relative deviations within −8.54% to +7.78%. This work demonstrates that CIC-GC-ICP-MS using a single, readily available calibrant provides a reliable, practical solution for quantifying alkyl OPFRs in complex food matrices, effectively overcoming the challenge posed by the scarcity of compound-specific reference standards. Graphical
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Cell Death & Disease
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2026
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IF 12.2
Qiu Quanpeng,Ding Yi,Han Jing,Guo Xiaolong,Zhang Jiaqi,Chen Yue,Xue Xinzhu,Hu Xiake,Yu Tianyu,Liu Gaixia,Zhang Haowei,Li Qixin,Li Xiang,She Junjun,Chen Yinnan
The malignant transition of colorectal cancer (CRC) is caused by the combined action of epigenetic dysregulation and genomic instability. It is well known that EZH2-directed H3K27me3 modification is one of the main contributors to tumorigenesis; however, how it affects the DNA mismatch repair (MMR) system and the genesis of extrachromosomal circular DNA (eccDNA) remains unknown. Here, we demonstrate that EZH2 epigenetically represses critical MMR genes, which results in genomic instability and abnormal eccDNA accumulation, ultimately accelerating CRC progression. On the molecular level, the H3K27me3 mark catalyzed by EZH2 is the main cause of the downregulation of MMR genes, which affects the stability of the genome and leads to an increase in eccDNA that makes the tumor more aggressive. Our study reveals an unprecedented role of EZH2 in controlling chromosomal instability and eccDNA production through the MMR pathway and offers a conceptual framework for the development of CRC-targeted epigenetic therapies.
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Stem Cell Research & Therapy
·
2026
·Vol. 17
·期 1
·200
·
IF 7.8
Chen Qi,Chen Xiaolong,Yang Qu,Miao Xinxin,Yuan Jinghong,Ding Shuihua,Ding Rui,Cai Shenghao,Li Bin,Cheng Xigao
Background Intervertebral disc degeneration (IVDD) is characterized by progressive nucleus pulposus cell loss and extracellular matrix degradation, in which persistent oxidative stress plays a critical pathogenic role. Transplantation of nucleus pulposus–derived stem cells (NPSCs) is a promising therapeutic strategy, yet the hostile oxidative microenvironment severely compromises cell survival. Although cellular quiescence has been suggested to enhance stress tolerance, its regulatory mechanisms and relevance in NPSCs remain largely unexplored. Methods Oxidative stress was evaluated in human degenerated disc tissues, a rat needle-puncture degeneration model, and tert-butyl hydroperoxide–treated NPSCs in vitro. Proliferating and quiescent NPSCs were compared for reactive oxygen species (ROS) levels, apoptosis, viability, and transcriptomic profiles. Pathway enrichment analyses were performed to identify critical signaling mechanisms. Recombinant transforming growth factor-beta 3 (rhTGF-β3) was used to activate the pathway, while small interfering RNA targeting the transforming growth factor-beta receptor type 2 ( Tgfbr2 ) and the pharmacological inhibitor SB431542 were applied for pathway suppression. Functional assays, organ culture, and in vivo transplantation were conducted to assess cell survival and regenerative effects. Results Elevated oxidative stress was consistently observed across clinical, animal, and cellular models of disc degeneration. Quiescent NPSCs demonstrated enhanced resistance to oxidative injury, with reduced ROS accumulation, decreased apoptosis, and improved survival. Transcriptomic analyses revealed suppression of metabolic and P53-mediated apoptotic pathways, alongside marked activation of TGF-β/SMAD signaling. Activation of this pathway induced quiescence, reduced ROS levels, inhibited mitochondrial apoptotic signaling, and protected NPSCs from oxidative injury, whereas pathway inhibition abolished these protective effects. In both organ culture and in vivo transplantation models, quiescent and TGF-β–activated NPSCs exhibited superior survival and significantly improved disc structural preservation compared with proliferating or pathway-blocked cells. Conclusion Activation of the TGF-β/SMAD pathway induces NPSC quiescence and enhances oxidative stress tolerance by suppressing P53-dependent mitochondrial apoptosis. Pharmacological induction of quiescence represents a potential strategy to improve stem cell–based therapies for intervertebral disc degeneration.
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APOPTOSIS
·
2026
·Vol. 31
·期 6
·158
·
IF 9
Zhen Shuman,Gao Yifan,Wang Jiaqi,Ren Jingyi,Pei Huanting,Yin Danjing,Deng Yandong
Acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) remains a major clinical challenge in non-small cell lung cancer. Emerging evidence indicates that metabolic reprogramming and epigenetic alterations contribute to drug resistance, particularly through the evasion of ferroptosis, a regulated form of cell death characterised by lipid peroxidation. This study investigated the role of lactate-associated histone modifications in driving EGFR-TKI resistance. Resistant lung adenocarcinoma tissues and cell lines were analysed using transcriptomics, Cleavage Under Targets and Tagmentation (CUT&Tag) profiling, and biochemical assays. Glycolytic activity, lactate accumulation, and ferroptosis-related lipid peroxidation were assessed, followed by genetic and pharmacological interventions and in vivo xenograft validation. Resistant cells exhibited enhanced glycolysis and lactate accumulation, with pathway analyses highlighting ferroptosis evasion as a key resistance-associated process. Consequently, histone H4 lysine 8 lactylation (H4K8la) was significantly elevated in resistant tissues and cells. Mechanistically, H4K8la was enriched at transcription start sites, particularly at the promoter of aldo-keto reductase family 1 member C1 (AKR1C1). This epigenetic modification profoundly suppressed ferroptosis and promoted drug resistance. Disrupting this H4K8la-AKR1C1 defence axis restored lipid peroxidation, increased ferroptotic sensitivity, and resensitised resistant cells to EGFR-TKIs, as confirmed in vivo. These findings reveal a novel lactate-driven epigenetic mechanism that orchestrates ferroptosis escape and EGFR-TKI resistance, offering a promising therapeutic strategy to overcome treatment failure.
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ARCHIVES OF TOXICOLOGY
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2026
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IF 10.9
Huang Fang-Fang,Luo Ying,Chen Hao,Meng Yu-Huan,Li Wei,Liang Hong,Ai Chun-Zhi
Pregnane X receptor (PXR), a nuclear receptor superfamily member, maintains bile acid homeostasis by regulating metabolic enzymes [e.g., cytochrome P450 3A4 (CYP3A4), uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1)] and multidrug resistance protein 1 transporter, and alleviates liver/intestinal inflammation via inhibiting the nuclear factor kappa-B pathway, serving as a critical therapeutic target for cholestatic liver diseases and inflammatory bowel disease. In this study, we established a novel structure-based machine learning strategy to identify PXR agonists from a natural product database. With generated bioactive conformations binding with PXR, we integrated ligand-based and structure-based features to construct a comprehensive machine learning model using light gradient boosting machine. This model illustrated an R 2 of 0.874 for the internal validation set and an R 2 of 0.845 for the external test set, superior to the performance of other machine learning models, e.g. random forest regression, support vector regression, gradient boosting regression, K-nearest neighbors, and extreme gradient boosting. The model was used to predict the PXR agonistic activity of the candidate molecules screened out by the pharmacophore model. Promising candidates were selected out for further assay with HepG2 cell culture combined with a dual-luciferase reporter. Ultimately, natural products like schisantherin A, rhynchophylline, and irigenin were identified as potent PXR agonists, with half-maximal effective concentrations (EC 50 ) of 1.58 μM, 2.57 μM, and 20.67 μM, respectively. These PXR agonists act as potential candidates for targeted therapies against PXR-related diseases. We anticipate that this work will provide support for the design and discovery of PXR modulators.
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Nature Communications
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2026
·
IF 18.1
Deng Canbin,Xie Yizhan,Tang Jiayue,Lu Xibin,Li Yiqing,Weng Lu-Tao,Li Biao,Li Kaikai,Huang Jiaqiang
Electrochemical reactions are generally accompanied by mechanical evolutions, which, in turn, play a critical role in the performance of the electrochemical system. In aqueous Zn||MnO 2 batteries, the intrinsically structural instability of MnO 2 and rampant side reactions create considerable strain/stress changes in operation. However, the electrochemistry-mechanics-performance relationship of the Zn||MnO 2 cell is still missing. Herein, we decode the electrochemomechanical interplay of Zn||β-MnO 2 pouch cells with different electrolytes via optical fiber sensors. The operando stress monitoring provides proof of the prevailing proton intercalation and Mn dissolution/deposition mechanisms in the system, where the basic zinc salts play a dominant role in stress evolution. Additionally, the non-monotonic stress variation during discharge implies Zn-compensated reaction. For cycling ageing, a negative correlation is found between early stress amplitudes and capacity retention in long cycles. For calendar ageing, greater stress variation during open-circuit ageing is linked with more severe self-discharge. Altogether, this work provides a deep understanding of the electrochemistry-mechanics-performance correlation in aqueous Zn||MnO 2 batteries, offering additional tools for electrolyte screening and battery design.
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Journal of Earth Science
·
2026
·Vol. 37
·期 4
·1584-1593
·
IF 4.8
Zhang Jingyi,Huang Shengxuan,Qin Shan,Chariton Stella,Prakapenka Vitali B.,Chen Bin
Most nitrogen is predicted to reside in the Earth’s interior and could be in the form of nitrides. In this study, the chemical reaction of Si 3 N 4 with SiO 2 was explored up to 50 GPa and 2 600 K using laser-heated diamond anvil cells combined with synchrotron radiation X-ray diffraction. The experimental results demonstrate that Si 3 N 4 does not react with SiO 2 and cubic γ-Si 3 N 4 remains stable at extreme pressure and temperature. First-principles calculations were performed to investigate the chemical stability of Si 3 N 4 with the SiO 2 -MgO assemblage, showing that Si 3 N 4 can coexist with Mg 2 SiO 4 and MgSiO 3 polymorphs. Based on our thermal equation of state of cubic γ-Si 3 N 4 , we suggest that cubic γ-Si 3 N 4 is denser than the upper mantle but less dense than the lower mantle. The formation of Si 3 N 4 in the early Earth may contribute to the nitrogen preservation in the deep mantle soon after crystallization of the mantle and Si 3 N 4 is likely a precursor of nitrogen hosts in the modern deep Earth.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 9
·649
·
IF 5.4
Cai Chuangui,Lin Zhen,Yao Wensong,Lian Shan,Huang Kaiyuan,Deng Haohua,Lin Xinhua,Chen Wei
Arginine surface-engineered 6-aza-2-thiothymine gold nanoclusters (Arg/ATT-AuNCs) via host-guest assembly were synthesized which exhibit exceptional catalytic activity and intense photoluminescence. Arg/ATT-AuNCs enhanced the CL intensity from NaIO 4 -H 2 O 2 system by 1200-fold. The CL mechanistic studies revealed that Arg/ATT-AuNCs not only accelerated decay of H 2 O 2 to form reactive oxygen species, but also acted as efficient energy acceptors of singlet oxygen ( 1 O 2 ) via a CL resonance energy transfer (CRET) pathway. It was observed that doxorubicin (DOX) quenches the CL signal through an inner filter effect that disrupts the CRET process. Based on this, a straightforward, rapid, and highly sensitive biosensor has been developed for the detection of DOX in human serum samples, achieving a low detection limit of 0.029 µM. The biosensor was applied to DOX determination in human serum samples with recoveries ranging from 91.1 to 106.2%. This study not only provides a new method for the detection of DOX, but also broadens the application scope of AuNCs in the field of CL. Graphical
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WOOD SCIENCE AND TECHNOLOGY
·
2026
·Vol. 60
·期 5
·81
·
IF 3.2
Huang Changzhu,Zhu Yaqin,Luo Yilong,He Bin,Wu Yunfei,Zhang Chunmei,Duan Gaigai,Han Xiaoshuai,Zhou Rongfei,He Shuijian,Jiang Shaohua
Efficient CO 2 capture remains challenging due to limited adsorption capacity and slow kinetics of conventional materials. Herein, we report a strong–weak acid modulation strategy for the in situ growth mesoporous UiO-66-F 4 within the aligned carbonized wood channels, yielding a hierarchical MOF–carbon composite denoted as meso-UiO-66-F 4 @CP. Dual-acid regulation enables highly uniform and controlled MOF growth under environmentally friendly aqueous conditions, avoiding the use of toxic organic solvents and ensuring a sustainable synthesis route. This composite effectively combines the macroporous framework of carbonized wood with the intrinsic micropores and mesopores of UiO-66-F 4 , establishing a hierarchical pore network that significantly enhances CO 2 diffusion, mass transport, and overall adsorption efficiency. Furthermore, the introduction of fluorinated linkers strengthens dipole–quadrupole interactions, generating abundant high-affinity adsorption sites specifically tailored for CO 2 molecules. Under the present experimental conditions, meso-UiO-66-F 4 @CP exhibits a CO 2 uptake of 38 cm 3 g⁻ 1 (approximately 1.70 mmol g⁻ 1 ) at 298 K and 1 bar, together with a measured adsorption rate of 0.085 mmol g⁻ 1 min⁻ 1 . This work provides a sustainable strategy for constructing hierarchical MOF–carbon composites with tailored pore structures and surface chemistry for CO 2 capture applications.
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WATER AIR AND SOIL POLLUTION
·
2026
·Vol. 237
·期 21
·1212
·
IF 3.5
Liu Ruxue,Bian Ye,Wang Yong
Airborne microplastics (MPs) have emerged as a growing concern in indoor air quality, whereas quantitative evidence on inhalation exposure remains limited. This study investigated the abundance, physicochemical characteristics, and inhalation exposure of airborne microplastics across functionally representative campus locations with an outdoor site as reference. Microplastics were universally present, with indoor concentrations (679 ± 229 MPs·m −3 ) substantially exceeding outdoor levels (149 ± 27 MPs·m −3 ). Fragments and fibers dominated across all environments, with more than 69% of microplastics were below 50 μm, indicating the predominance of fine microplastics capable of remaining airborne for extended periods. Polyamide (PA) was the most frequently detected microplastics indoors, while garages displayed greater microplastic diversity associated with traffic-related sources. By integrating zone-specific concentration data with time activity patterns, the highest estimated daily inhalation exposure within commonly occupied indoor environments reached 100.9 ± 35.2 MPs·kg BW −1 ·day −1 , highlighting zone-dependent exposure risks that challenge the conventional use of uniform indoor averages. Overall, this study provides an exposure relevant characterization of indoor airborne microplastics, emphasizing the importance of partitioning indoor spaces for precise risk assessment and management, and highlights the importance of integrating environmental measurements with human activity patterns when evaluating potential health implications.
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Nature Photonics
·
2026
·
IF 38.1
Chen Changshun,Yao Qing,Ding Youjian,Zhao Yanxiang,Chu Anshi,Ran Chenxin,Xia Yingdong,Chen Yonghua,Huang Wei
Fully screen-printed perovskite solar cells represent a promising solution for scalable manufacturing of perovskite photovoltaics. However, their development is hindered by inefficient vertical phase transformation within thick, multi-layered films, which results in incomplete infiltration, premature surface nucleation and residual stress. Here we report a fluid motion crystallization strategy employing a co-solvent system of ionic liquid methylammonium propionate and butyronitrile. The butyronitrile reduces the fluid motion resistance and disperses PbI 2 aggregates with optimized solvation structure, enabling rapid and deep infiltration of the perovskite precursor. This promotes a bottom-up, ordered phase transition before surface nucleation, effectively suppressing defect formation. The subsequent growth of a dense, interconnected perovskite nanocrystal network featuring an island-like surface morphology strengthens the interfacial contact with the carbon electrode. This intimate contact enhances the carrier transport and minimizes the recombination losses. Finally, air-processed, fully screen-printed perovskite solar cells yield a power conversion efficiency of 22.41% (certified 21.86%). Devices retain over 90.5% of their initial power conversion efficiency after 2,000 h under International Summit on Organic Photovoltaic Stability light-soaking-1 (ISOS-L-1) accelerated ageing conditions and show no degradation after 900 h of operation at 85 °C with 50% ± 10% relative humidity (ISOS-L-3 protocol).
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危险品化学品经营许可证（带存储）