Foods
·
2026
·Vol. 15
·期 14
·2420
·
IF 6
Junren Zhao,Yugang Ji,Wenjing Tao,Chun Wang,Zhimei Tang,Yujia Shi,Huiyun Zhang
Chlorogenic acid (CA) exhibits robust lipid antioxidant activity within meat matrices. However, excess CA generates quinones that alter and damage porcine myofibrillar protein (MP). This study investigated the restorative effects of chitosan (CS) on MPs suffering from CA-induced oxidative damage. Three CA concentrations (0, 50, 100 μmol/g protein) and five CS dosages (0.125–1.0 g/g protein) were used to evaluate conformation, turbidity, surface hydrophobicity, solubility, emulsification, rheology, and gel properties. CA-oxidative damage to MP triggered protein unfolding, thiol depletion and aggregation, greatly lowering solubility, emulsifying capacity, viscoelasticity and water retention. CS exerted biphasic effects on turbidity, surface hydrophobicity, tertiary structure, and solubility only under severe CA-induced oxidative modification (100 μmol/g CA): low-to-medium CS aggravated adverse changes, while 1.0 g/g CS partially reversed such damage. For conformational, emulsion and gel parameters, CS consistently alleviated structural disorder caused by CA-induced oxidative damage across all treatments, with 1.0 g/g CS optimally mitigating α-helix loss and uneven emulsion droplets. Significant CA × CS interactions were detected for conformation, turbidity, surface hydrophobicity, solubility, emulsification and rheology (p< 0.001). Gel strength, water-holding capacity and water distribution exhibited non-significant interactions (p> 0.05), revealing independent additive effects of CA and CS on gel networks. Overall, high-dose CS partially ameliorates structural and functional defects of MP caused by CA-induced oxidative damage, which provides theoretical support for the combined application of polyphenols and polysaccharides in meat protein regulation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Lin Huang,Fengxiao He,Tao Wu,Jinghao Fan,Lei Liu,Xiang Zhang,Jiangchen Liu,Shiqian Huang,Decheng Wu,Waruna Lakmal Dissanayaka
This study introduces a new bioactive Janus membrane for guided bone regeneration (GBR) to treat periodontal bone defects. • Unlike conventional barrier membranes that lack long-term stability or biological function, our bilayer membrane, composed of poly(ε-caprolactone) (PCL), chitosan (CS), and the natural polyphenol proanthocyanidin (PA), combines mechanical strength with antioxidant, antibacterial, and anti-inflammatory properties. • Its asymmetric design, with in situ biomineralized hydroxyapatite particles (HAp) on a chitosan layer, supports bone growth on one side while preventing bacterial invasion on the PA-incorporated side. • This innovative approach addresses major challenges in periodontal tissue engineering and offers a promising platform for more effective and biologically intelligent therapies in clinical bone regeneration. The achievement of periodontal bone regeneration using a barrier membrane in guided bone regeneration (GBR) technology is often limited by either its inferior mechanical strength or bioactivity. To address this limitation, we developed a novel Janus bi-layer membrane by sequentially electrospinning poly(ε-caprolactone) (PCL) mixed with proanthocyanidin (PCL-PA) and chitosan (CS) in acetic acid, then biomineralized it in simulated body fluid (BSF) to form hydroxyapatite particles (HAp) in situ on a CS nanofiber layer (CS-HAp): PCL-PA/CS-HAp. This bi-layer membrane exhibited superior mechanical performance compared to single-layer membranes, with a peeling strength of 58 J/m 2 and tensile strength exceeding 5.0 MPa under hydrated conditions. In vitro antioxidant assays demonstrated the strong free-radical-scavenging ability of PCL-PA/CS-HAp. In addition, the PA-incorporated membranes exhibited greater than 95% bacterial inhibition against both Gram-negative E. coli and Gram-positive S. aureus . The bilayer membrane also alleviated oxidative stress induced by hydrogen peroxide (H 2 O 2 ), thereby promoting the proliferation of MC3T3-E1 cells, as monitored by cytoskeletal staining. Flow cytometry analysis showed that the PA-incorporated membrane can stabilize immunomodulatory effects by about 10% in lipopolysaccharides (LPS)-stimulated RAW264.7 cells. When used in a rat periodontal bone defect model, significant bone regeneration was observed in the PCL-PA/CS-HAp group, with a bone volume to total volume ratio of 36.2% and a significant reduction in bone defect size after 8 weeks, outperforming other treatment groups ( p < 0.001). The PCL-PA/CS-HAp bi-layer membrane represents a promising strategy for guided bone regeneration, effectively combining mechanical stability and bioactive properties. A bi-layer barrier membrane, PCL-PA/CS-HAp, prepared via electrospinning, was effective for periodontal bone regeneration in a rat model. Download: Download high-res image (192KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF DRUG TARGETING
·
2026
·
IF 4.7
Juan Du,Xinmei Chen
Acute liver injury (ALI) is a syndrome characterized by rapid deterioration of liver function, rapid progression, and high mortality. In this study, a liver-targeted drug delivery system, galactosylated chitosan modified Coreopsis tinctoria flavonoid liposome (GC-CTF-Lip) was constructed. The targeted ligand was synthesized by the amidation reaction between chitosan and lactobionic acid, and its structure was identified. The modification conditions of GC on liposomes were optimized and characterization of liposomes was studied. The liver-targeting ability of GC-CTF-Lip was evaluated through in vivo and in vitro experiments. A mouse model of ALI induced by CCl4 was established to evaluate the hepatoprotective effect of GC-CTF-Lip. The results confirmed that lactobionic acid was successfully grafted onto chitosan. Finally, GC-CTF-Lip with particle size of 236.32 ± 0.60 nm and encapsulation efficiency of 68.67 ± 0.58% was obtained. GC-CTF-Lip improved the uptake efficiency of CTF in hepatocytes in vitro and exhibited excellent liver enrichment in vivo. Serum ALT/AST levels were significantly decreased, and the histological liver injury was alleviated. It exhibited a trend of liver enrichment and a hepatoprotective effect. This liver-targeted nanodrug delivery system can achieve active accumulation of drugs at the lesion site, providing a potential strategy for the prevention of ALI.
✓ 已验证
产品关联
DOI
高影响因子
Polymer-Plastics Technology and Materials
·
2026
·
IF 3.5
Yanzhuo Lv,Chuan Liu,Yan Xu,Mingao Lei,Ruiyang Sun,Xuan Wen
Ion-responsive hydrogel actuators exhibit tremendous potential for flexible electronics and soft robotics. However, their inherent limitations in mechanical performance and output force hamper their translation into practical applications. In this study, developed chitosan-polyacrylamide (CS-PAAM) dual-network (DN) hydrogel actuators by the integration of in situ polymerization and calcium ion crosslinking, and incorporated Fe3O4 nanoparticles (NPs) for synergistic regulation. The results demonstrate that increasing the CS content strengthens the hydrogen-bonding and ionic crosslinking networks, markedly enhancing the actuators’ mechanical strength while improving its electrochemical performance, resulting in a 79.36% elevation in output force. Concomitantly, an optimal Fe3O4 NP loading concentration further refines the ionic transport channels, yielding an additional 63.27% enhancement in output force. These performance enhancements are poised to facilitate the practical implementation of hydrogel actuators in soft robotics and wearable devices.
✓ 已验证
产品关联
DOI
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
·
2026
·
IF 8.9
Xin Wang,Shuai Yu,Mingkang Wang,Hongru Wang,Wentao Zeng,Huixiang He,Feng Ding,Sizhao Zhang
Bio-based chitosan aerogels for thermal insulators are greatly concerned in green low-carbon buildings field owing to their low thermal conductivity and low environmental load. However, chitosan aerogels are severely restricted by multifunctional integration failure of thermal/acoustic insulation, flame retardancy and superhydrophobicity. Herein we report on bio-based chitosan aerogel composites with multifunctional combination, realized by hybriding fumed silica and introducing glass fiber preform in formation of chitosan networking skeletons. Such bio-based chitosan aerogel composites indicate the first implement of near net forming due to the evidence of almost near-zero shrinkage compared with conventional huge-shrinkage chitosan-nature aerogels. The aerogel composites achieve thermal conductivity of 21 mW m −1 K −1 , noise reduction coefficient of 0.70, limiting oxygen index of 57.5%, and water contact angle of 151° (moisture absorption rate of 0.48% for 160 h at 70 °C and 85% relative humidity). Importantly, we design a series of container building model simulation devices for validating thermal insulation and thermal safety in the condition of chitosan aerogel composites layer embed inside modules case. The resultant evidence shows the superior thermal insulating feature despite experiencing the extreme housing temperatures of −43 or 49 °C, simultaneously retaining the safety situation (smokeless, non-charring appeared at inner wall) even facing the flame attack of ∼1200 °C. Besides, durability for thermal insulation and tensile strength of chitosan aerogel composites both present an outstanding stability at extreme temperatures or physically punctured damage. The combination of thermal/acoustic insulation, flame retardancy and superhydrophobicity makes this aerogel composite very promising for thermal insulators in energy-saving buildings.
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry B
·
2026
·Vol. 14
·期 18
·5707-5723
·
IF 6.2
Nanxiang Zhang,Haoyun Tan,Mingxin Xu,An Liu
Diabetic wounds, characterized by delayed healing and susceptibility to infection, pose a significant clinical challenge. Glabridin (GLD), a natural product, has the potential to promote wound repair, but its application is hindered by poor solubility and low photostability. This study developed a novel adhesive deep eutectic gel (eutectogel) by combining a deep eutectic solvent (DES) formed from sulfobutyl ether-β-cyclodextrin (SBE-β-CD) and levulinic acid (Lev) with chitosan (CS) for the efficient delivery of GLD. This system integrates DES with CS through supramolecular interactions, simultaneously addressing the solubility and photostability issues of GLD. The DES not only acts as a solubilizer but also serves as a dynamic crosslinker within the gel network, imparting favorable mechanical properties. The resulting GLD/CS/DES gel formed a flexible patch, enabling sustained GLD release for over 10 days and effectively protecting GLD from photodegradation. In vitro antibacterial assays demonstrated over 99% efficacy against S. aureus and E. coli, with the mechanism of action linked to disruption of bacterial cell membrane integrity. In an infected diabetic wound model, the GLD/CS/DES gel significantly accelerated wound healing, achieving a wound closure rate of 94.3% by day 21. Mechanistic studies revealed that the GLD/CS/DES gel ameliorated the immune microenvironment, promoted angiogenesis, and tissue regeneration by scavenging reactive oxygen species (ROS), inhibiting the nuclear factor kappa-B (NF-κB) signaling pathway, and facilitating macrophage polarization from the pro-inflammatory M1 phenotype to the reparative M2 phenotype. In summary, the GLD/CS/DES gel developed in this study integrates antibacterial, immunomodulatory, and pro-angiogenic functions, offering a promising therapeutic strategy for the management of infected diabetic wounds.
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Yi Liu,Xingyu Gao,Yongfeng Liu,Rongjun Qu
The design and preparation of adsorbents are crucial in the field of wastewater treatment. The composite adsorbents with chitosan (CTS) and metal organic framework (MOF) were fabricated to enhance the diffusion degree of MOF and acid stability of CTS by heating reflux method and effect of ratio of CTS, Cu 2+ and 2-aminoterephthalic acid of the composite adsorbents on adsorption was investigated. The diffusion degree of MOF on the composite adsorbent (CTS-MOF) was enhanced on the basis of FESEM images. The acid instability of CTS on the CTS-MOF was improved as CTS can partly dissolve in solution with pH lower than 4.0, while the composite was stable. The composite material was used to remove anionic dye methyl orange (MO) from contaminated aquatic environments. The adsorption kinetics showed that the adsorption capacities of CTS-MOF, CTS and MOF for MO with concentration of 200 mg/L were 135.49, 34.84 and 58.95 mg/g, respectively, and the adsorption capacity of CTS-MOF increased to 3.89 and 2.30 times, accordingly, compared to that of CTS and the MOF, due to synergetic effect of CTS and MOF. The adsorption process of CTS-MOF followed pseudo-second-order kinetic model and Langmuir model. In addition, the adsorption was endothermic. For CTS-MOF, the solution pH exhibited slightly small fluctuation on MO adsorption. The presence of NaCl exhibited positive effect for MO adsorption onto the MOF while negative effect for MO onto CTS-MOF, and the influence on the CTS-MOF was much less than that onto the MOF, indicating the salt tolerance of CTS-MOF was better. Adsorption mechanism was analyzed by the FTIR spectra before and after adsorption and quantum chemical calculation by means of independent gradient model based on Hirshfeld partition (IGMH) analysis. And IGMH analysis showed the relative magnitude of coordination effect, hydrogen bonding and π-π stacking involved in the adsorption process. This study provided a valuable method to design and prepare adsorbents with high adsorption efficiencies for organic dyes from aqueous solution.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Chunbao Wang,Pei Tao,Yuzhao Cheng,Pengyu Zhao,Ziyu Zeng,Qingyun Bai,Liang Kong,Yan Dong,Zhongshan Wang
Porcine-derived amelogenins, essential for enamel development and clinically applied in periodontal bone regeneration, faces purification challenges for its specific isoforms, limiting the understanding of their distinct functions and clinical translation. In this study, we purified P148, the most abundant isoform in porcine amelogenins, constructed a chitosan/hyaluronic acid (CS/HA) layer-by-layer coating on polydopamine-modified titanium implants, and preliminarily investigated its osteogenic effects and underlying mechanisms using in vitro and in vivo models. In vitro, the P148-functionalized surfaces exhibited favorable biocompatibility and significantly promoted cell attachment, proliferation, osteogenic gene expression, and extracellular matrix (ECM) production compared to unmodified titanium. Moreover, this modification activated the MAPK-ERK1/2 pathway, a key signaling axis regulating BMSC differentiation. In vivo rat experiments further verified enhanced peri-implant new bone formation, underscoring the translational promise of the P148/CS/HA coating for improving osseointegration. Taken together, these findings suggest that this bioactive surface holds broad application potential for clinical bone regeneration.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2026
·
IF 7.1
Mengna Zhang,Qinchao Zhu,Tingmei Chu,Wei Xia,Hualing Xie,Jianchang Jin,Gongshuai Song,Xichuang Guo,Jinyan Gong
Peimine (P) and curcumin (CM) possess significant bioactivities but suffer from poor water solubility, low bioavailability, and limited stability. To address these challenges, P-CM self-assembled microparticles (SMPs) were prepared via non-covalent interactions and systematically characterized. The results demonstrated that optimal self-assembly reaction conditions occurred at pH 9, 25 °C, and a P:CM molar ratio of 1:1, yielding uniform nanoparticles (284 nm, PDI = 0.202) with a zeta potential of −19.77 mV. P-CM SMPs exhibited superior antioxidant activities, with ABTS, DPPH radical scavenging activity and FRAP values of 62.69%, 34.18%, and 81.02%, respectively, as well as enhanced anti-inflammatory activity compared to their individual components. To further improve stability and control release, the P-CM SMPs were encapsulated in a hollow zein-chitosan (HZ-CH) composite, achieving high encapsulation efficiency (96.0%). HZ-CH-SMPs exhibited storage stability over time and sustained-release behavior under simulated gastrointestinal conditions. This study provides a theoretical basis for designing delivery strategies integrating molecular self-assembly and protein-polysaccharide encapsulation to overcome solubility and bioavailability limitations of bioactive compounds in functional foods.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Bio Materials
·
2026
·
IF 5.6
Yini Liu,Min Guo,Jingyu Lu,Jianxin Zhao,Gang Wang,Ruojie Zhang,Hao Zhang,Zipei Zhang
Lipoteichoic acid (LTA), a component of the Gram-positive bacterial cell wall, exhibits potent immunomodulatory properties. However, it is highly unstable and susceptible to degradation under gastrointestinal conditions, which limits its in vivo functional application. In this study, LTA from theLactobacillus johnsonii was encapsulated into chitosan-tripolyphosphate (CS-TPP) nanoparticles for the first time, establishing a robust delivery system. The resulting LTA@CS-TPP nanoparticles displayed uniform nano size, favorable stability, high encapsulation efficiency, and sustained release behavior. Simulated digestion assays demonstrated that nanoencapsulation effectively protected LTA from gastric degradation and enabled controlled release in the intestinal phase. Cellular experiments showed that LTA@CS-TPP enhanced antioxidative stress defenses, reduced intracellular ROS levels, and alleviated LPS-induced inflammatory injury. Immunofluorescence analysis further revealed that LTA@CS-TPP significantly suppressed NF-κB activation and nuclear translocation, suggesting interference with the TLR4/MyD88/NF-κB signaling cascade. Compared with free LTA, nanoencapsulation not only preserved but also amplified its bioactivity, whereas blank CS-TPP nanoparticles exerted minimal effects. Collectively, these findings provide the first evidence of chitosan-based nanoencapsulation of LTA and highlight its potential as a bioactive delivery platform for inflammation modulation, laying the groundwork for future oral administration studies with promising applications in functional foods and therapeutic strategies.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2026
·
IF 3.9
Weijun Liu,Zhaoqi Zhu,Yunxin Ai,Hanxue Sun,Jiyan Li,Rui Jiao,An Li
Developing multifunctional materials that combine low thermal conductivity with high flame retardancy is key to meeting the demands of modern energy-efficient buildings. Chitosan (CS), with its natural biogenic properties and significant inherent flame retardancy, provides a unique design basis for high-performance thermal insulation and flame-retardant materials. In this work, we use an in situ coprecipitation strategy to load ammonium polyphosphate (APP) and magnesium phosphate compounds (main phase MgNH4PO4·6H2O) onto the three-dimensional framework of CS, successfully constructing a Mg and P codoped chitosan-based composite aerogel (recorded as CS@APP@Mg–P aerogel) that synergistically enhances thermal insulation and flame retardancy. This material exhibits thermal insulation properties, with a thermal conductivity as low as 0.0251 W m–1·K–1, primarily attributed to the three-dimensional network structure and high porosity of the chitosan matrix. Its flame-retardant performance meets the UL-94 V-0 standard, with a peak heat release rate (pHRR) as low as 17.30 kW m–2, significantly outperforming similar composite materials. Additionally, the aerogel exhibits high adsorption capacity for formaldehyde (average adsorption rate >80%). The comprehensive performance mentioned above is attributed to the synergistic interaction among the CS matrix, APP flame retardant, and magnesium phosphate reinforcing phase (MgNH4PO4·6H2O). This provides a strategy for developing biobased aerogels that integrate thermal insulation, flame retardancy, and formaldehyde adsorption, offering broad application prospects in energy-efficient buildings and indoor air purification.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2026
·
IF 12.4
Qiyong Guo,Weihang Cao,Ling Chen
The development of effective oral magnesium supplements is hindered by two major delivery challenges: rapid gastric leakage leading to gastrointestinal side effects, and non-targeted intestinal release resulting in poor absorption and compensatory excretion. To address this, we engineered an intelligent, intestinal-targeted delivery system based on pH-responsive oxidized maize starch (OMS)–chitosan (CS) composite hydrogels, fabricated via hot-extrusion microwave 3D printing (HEM-3DP). The system exhibited a unique gastric-phase structural adaptation: acidic conditions trigger CS dissolution and OMS carboxyl protonation, initiating a dynamic “ionic handoff” where Mg 2+ was recaptured by exposed CS amines via coordination bonds. This mechanism reduced gastric Mg 2+ release by >40% compared to CS-free controls, enabling precise spatiotemporal control with sustained small intestinal release (66.6–74.0%) and enhanced colon-targeted delivery (33.6–56.0% retention). Release kinetics were finely tuned by engineering OMS carboxyl content (0.36–1.57%) and molecular weight (6.84 × 10 5 –2.39 × 10 6 Da), demonstrating programmable design. In magnesium-deficient mice, the optimized OMS2-CS-Mg 2+ gel not only restored serum magnesium to physiological levels (1.35 ± 0.04 mmol/L) but also upregulated key intestinal (claudin1) and colonic (TRPM6/7) absorption transporters—a dual-pathway activation unattained by conventional MgCl 2 supplementation. This work elucidated a clear structure–mechanism–performance relationship governing nutrient release and absorption. It provided a robust, food-grade platform that integrated advanced manufacturing with material intelligence to achieve site-specific, controlled mineral delivery, offering a translatable strategy for oral supplementation and broadening the design principles for smart, responsive hydrogel-based delivery systems.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）