Advanced Composites and Hybrid Materials
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2026
·Vol. 9
·期 4
·307
·
IF 15.5
Wei Min,Fan Haobo,Yu Fanjun,Qiu Zhe,Xiao Zefang,Zhang Tianpeng,Xie Yanjun
The rapid growth of electronic devices has intensified electromagnetic wave (EMW) pollution, creating an urgent demand for sustainable and multifunctional shielding materials. Here, we present a novel “three birds with one stone” strategy involving Ni 3 Fe-induced three-in-one modification for carbonized wood/epoxy composite electromagnetic interference shielding material. Specifically, by encapsulating Ni 3 Fe nanoparticles in carbonized wood/epoxy composite materials through a facile impregnation-carbonization approach, the composite material (Ni 3 Fe-EP-carbonized wood composite) achieves enhanced conductive and reflective losses through catalytic graphitization, promotes interfacial polarization via abundant heterojunctions, and incorporates intrinsic magnetic dissipation capabilities. Meanwhile, leveraging the natural microstructure advantages of wood, the well-tailored Ni 3 Fe-EP-carbonized wood composite achieves a shielding effectiveness of 59.88 dB (2.6 times higher than pristine CW), in the X-band at a density of merely 0.193 g cm -3 . Furthermore, owing to the elevated electrical conductivity and unique layered porous structure of carbonized wood that absorbs sunlight strongly, Ni 3 Fe-EP-carbonized wood composite exhibits a suite of multifunctional properties, including stable heat conduction and effective photothermal conversion up to 55 °C under low solar irradiance (100 mW cm -2 ). This work offers a novel perspective on an environmentally friendly wood-based electromagnetic interference shielding material design.
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Nature Communications
·
2026
·
IF 18.1
Ju Na,Wang Yao,Liu Zilong,Wang Yiming,Wang Zhenyu,Niu Suyan,Chen Xin,Jia Mingjie,Shao Die,Ai Yongjian,Xu Guangwen,Sun Hong-bin
Aqueous organic batteries attract attention owing to their intrinsic safety, low cost, and low polarization. However, while most studies focus on molecular design, the influence of supramolecular assembly and crystal structure beyond the molecular scale remains somehow largely overlooked. In this work, a single crystal electrode of aqueous proton batteries, 2,3-Dichloro-1,4-naphthoquinone is investigated by the means of combined characterization techniques including nuclear magnetic resonance, single crystal X ray diffraction, operando X ray diffraction, and cryogenic transmission electron microscopy combined with theoretical calculations. The roles of molecular structure, supramolecular assembly and crystal structure in proton storage performance are elucidated. Notably, the π-donor-acceptor stacked bimolecular pairs form a reinforced 100 facet with the lowest proton adsorption energy, enabling 96.82% capacity utilization. The full cell using this material as negative electrode and lead dioxide as positive electrode delivers stable cycling performance at 5 A g −1 over a wide-temperature from −20 o C to 40 o C with a capacity retention of 95% after 300 cycles. This work provides insights into the structure property relationships in aqueous organic battery materials across molecular, supramolecular and crystalline levels.
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Nature Communications
·
2026
·
IF 18.1
Yidan Chen,Shu Wang,Xilu Ye,Chenghui Lv,Jialin Wei,Yingxin Zhang,Jianfeng Ping,Yibin Ying,Lingyi Lan
The human fingertip skin, with its interlocked epidermal-dermal architecture and dense tactile receptors, enables unique perception and inspires the design of innovative electronic skin (e-skin). However, most e-skin materials fail to replicate the hierarchical integration of composition, structure, and function found in natural skin. Drawing direct inspiration from the dermal extracellular matrix–a composite hydrogel reinforced by a collagen-hyaluronic acid, here we report an e-skin that mimics key composition and architectural features of human skin. By incorporating sodium lactate and montmorillonite nanosheets into a gelatin matrix, we engineer a biomimic gel with mechanical and hydration properties similar to those of natural skin through dynamic ionic crosslinking and hydrogen bond networks. The microstructure resembling the dermal papillae is designed using a sandpaper-templating strategy. The resulting iontronic sensor achieves high sensitivity (466.3 kPa −1 ), rapid response (47 ms), and a wide pressure detection range (20 Pa–2000 kPa). We further develop a stretchable, ultrathin, hand-shaped iontronic sensor array that integrates seamlessly with a dexterous robotic hand, achieving precise, nondestructive grasping and high-fidelity, multichannel pressure mapping. Hydrogels are promising materials for electronic skins and devices, though it is challenging to mimic the composition and architectural features of human skin. Here the authors use a sandpaper templating strategy for a gelatin based hydrogel electronic skin.
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Nature Communications
·
2026
·
IF 18.1
Shi Si,Wang Changhong,Feng Qiliner,Li Hailin,Shi Aike,Liu Jie,Ma Yongzheng,Gong Xiangjun,Li Zifu,Chen Baizhu
Engineered living materials have recently expanded into the field of bioelectronics when incorporating the rationally rewired microbes inside. Integrating living materials with force sensing provides an alternative route to overcome limitations of traditional sensors, such as fragility and stretching-sensitivity. Here, we present a programmable living force sensor fabricated by surface engineered microbial network with a bottom-up design for human-machine interfaces. Bacterial cells are genetically rewired to display surface-anchored affinity pairs that mediate the assembly of bacteria to macroscale. Functioning as the conductive and sensing layer, the microbial network is encapsulated in elastic tubes to fabricate the macroscopic force sensor. The resulting living sensor features a tunable measuring range, rapid self-recovery capacity within tens of milliseconds, and remarkably, excellent stretching-insensitivity with only ~30% increase in resistance under 800% of elongation. This bio-integrated approach enables microbes to prepare robust and reconfigurable force sensor suitable for tensile, dynamic and extreme mechanical conditions.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 8
·568
·
IF 5.4
Chen Jinhu,Huang He,Zeng Yi,Wang Xiaopeng,Chen Shu,Jiang Jianping,Xiao Youping,Zheng Miao,Lin Xiandong,Ye Zaisheng
Exosome analysis in gastric cancer (GC) serum requires sensitive readout with reduced matrix interference. Circulating GC-related CD63-positive exosomes can indicate vesicle burden and stress-induced secretion. Herein, we developed a dual-mode photothermal/colorimetric aptasensor using CD63 aptamer-functionalized core-shell AuPt nanozymes for detecting GC-related CD63-positive exosomes in serum samples. The innovation of this platform lies in integrating aptamer recognition, Pt-shell peroxidase-like catalysis, and Au-core near-infrared (NIR) photothermal conversion within one nanoprobe. The porous Pt shell showed high TMB affinity ( K m = 0.18 mM), and the Au core enabled 808 nm-responsive photothermal enhancement. Arrhenius analysis showed that 808 nm NIR irradiation decreased the apparent activation energy by 45.9%, while NIR-XPS, photocurrent, impedance, and wavelength-dependent analyses supported localized photothermal heating and plasmon-assisted interfacial charge transfer in the catalytic enhancement. The colorimetric mode achieved a limit of detection of 5.0 × 10² particles/mL and a linear range of 1.0 × 10³ to 1.0 × 10⁶ particles/mL. The photothermal mode covered 1.0 × 10⁵ to 1.0 × 10⁸ particles/mL and reduced hemolysis-induced optical interference. In a preliminary double-blind cohort with 60 serum samples, the assay showed a significant difference between GC patients and healthy donors ( P < 0.0001). Biologically, the assay tracked increased particle-level exosome release from SGC-7901 cells under hypoxia and 5-FU stress over 48 h, supporting dynamic monitoring of stress-related vesicle abundance. A portable format combining smartphone RGB analysis and pocket-sized thermal imaging also showed good linearity under fixed imaging conditions. This strategy provides a dual-mode tool for quantitative GC-related exosome analysis and preliminary extracellular vesicle monitoring. Graphical abstract
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Jiahao Wang,Tianao Xie,Heng Jiang,Yukai Shan,Sarun Juengpanich,Shijie Li,Win Topatana,Yeling Liu,Hong Wan,Yeben Qian,Peng Chen,Bo Chen
Background: Navitoclax (ABT-263) exhibits strong cytotoxic effects against hepatocellular carcinoma cells in vitro; however, its therapeutic efficacy in vivo is limited by insufficient local drug accumulation and compensatory upregulation of the anti-apoptotic protein myeloid cell leukemia-1 during long-term treatment. In addition, effective immune activation in hepatocellular carcinoma remains challenging due to the immune-privileged hepatic microenvironment. This study aimed to overcome these limitations through a tumor-targeted nanotherapeutic strategy. Results: Dual pH-responsive copolymeric nanoparticles modified with folic acid and co-loaded with navitoclax and indocyanine green (FPN AI ) were developed. FPN AI preferentially accumulated at hepatocellular carcinoma sites through folate receptor-mediated targeting and released navitoclax in response to the acidic tumor microenvironment, thereby inducing mitochondria-mediated apoptosis. Upon near-infrared irradiation, indocyanine green generated excessive reactive oxygen species, leading to downregulation of myeloid cell leukemia-1 and further enhancement of apoptotic signaling. The combined effects of navitoclax and reactive oxygen species synergistically promoted tumor cell apoptosis. Moreover, apoptosis induced by FPN AI triggered immunogenic cell death, characterized by dendritic cell maturation and activation of cytotoxic CD8⁺ T cells. In vivo studies demonstrated that FPN AI with near-infrared irradiation achieved significantly improved antitumor efficacy compared with navitoclax monotherapy, while maintaining favorable tumor-targeting capability and biosafety. Conclusions: This study demonstrates that FPN AI enhances the antitumor activity of navitoclax by integrating targeted drug delivery, reactive oxygen species-mediated mitochondrial apoptosis, and immunogenic cell death induction. The proposed nanotherapeutic platform represents a promising approach for improving hepatocellular carcinoma treatment outcomes.
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MOLECULAR AND CELLULAR BIOCHEMISTRY
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2026
·
IF 4.7
Gao Jie,Lv Xiaoyu,Zhao Pingping,Pan Bingjing,Liu Jingfang
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes. The glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide exerts renoprotective effects beyond glucose control; however, the underlying mechanisms remain incompletely understood. The protective effects and mechanisms of liraglutide were investigated using in vitro (HK-2 cells under glucolipotoxic conditions) and in vivo (DKD rat) models. Key molecular and functional assessments included the evaluation of oxidative stress, apoptosis, mitochondrial function (dynamics (MFN1, MFN2, FIS1, and DRP1), mitophagy (PINK1, PARKIN, LC3II/I, and P62), and ultrastructure), and histone acetylation (H3K9/14/18/27ac). The critical role of the NQO1/SIRT3 pathway was validated using pharmacological inhibition and genetic silencing (shRNA/AAV). Both in vitro and in vivo, a multifaceted injury phenotype, including oxidative stress, apoptosis, mitochondrial dysfunction, and histone hyperacetylation, was induced, accompanied by downregulation of the NQO1/SIRT3 pathway. Disruption of this pathway further exacerbated these injuries. Conversely, liraglutide treatment effectively counteracted this phenotype, improving metabolic parameters (blood glucose, blood insulin, and blood lipids), renal function (blood urea nitrogen, serum creatinine, and urine albumin-to-creatinine ratio) and histopathology. Liraglutide attenuated oxidative stress and apoptosis, restored mitochondrial function and mitophagy, and reduced histone hyperacetylation. These protective effects were consistently associated with the restoration of NQO1/SIRT3 expression. Genetic or pharmacological disruption of the NQO1/SIRT3 axis significantly attenuated the efficacy of liraglutide, and combined inhibition completely abolished its effects. Our findings demonstrate that liraglutide attenuates DKD by activating the NQO1/SIRT3 pathway, which coordinates the enhancement of mitochondrial function and the restoration of epigenetic homeostasis. This study revealed that the NQO1/SIRT3 pathway is a critical mechanistic mediator of the renoprotective effect of liraglutide.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Zhang Qian,Chen Tiange,Chen Jianwei,Ai Ying,Chen Ziyang,Liu Ganzhi,Zhang Yi,Liu Boxun,Liu Jiacheng,Tang Zexuan,Lin Lin,Chen Xin,Xia Yuguo,Xu Tao,Liu Jinfang
Traumatic brain injury (TBI)-induced neuroinflammation, driven by inflammatory microglial polarization, continues to pose a significant regenerative and clinical challenge. Small extracellular vesicles (sEVs) have demonstrated great potential in mitigating post-TBI inflammation. Nevertheless, the limited yield and efficacy of sEVs produced via conventional two-dimensional (2D) culture systems (2D-sEVs) substantially hinder their clinical applicability. Moreover, effective strategies for the therapeutic application of sEVs in TBI treatment, along with an understanding of their underlying mechanisms, remain largely unexplored. In this study, we employed a 3D coaxial bioprinting method to encapsulate adipose-derived stem cells (ADSCs) within a hydrogel microfiber, facilitating 3D culturing and large-scale production of 3D-sEVs. Additionally, we utilized GelMA hydrogel for the sustained release of 3D-sEVs and evaluated their effects in LPS-activated microglia as well as in a TBI mouse model. Our results demonstrated that 3D culture significantly enhanced sEV production. GelMA improved sEV stability and prolonged sEV release up to 30 days in vivo. Compared to 2D-sEVs, 3D-sEVs offered superior therapeutic benefits. Specifically, 3D-sEVs substantially reduced neuroinflammation and brain tissue loss while accelerating motor function recovery in TBI mice. Furthermore, 3D-sEVs shifted pro-inflammatory microglia toward an anti-inflammatory polarization state, as evidenced by elevated expression levels of IL-4, IL-10, TGF-β, Arg1, and CD206, alongside reduced expression of IL-6, IL-1β, TNF-α, iNOS, and CD86, both in vitro and in vivo. Additionally, 3D-sEVs attenuated chemotaxis and migration in LPS-activated microglia. Further mechanistic exploration through RNA-seq, proteomic profiling, and GAS6 knockdown in 3D-sEVs, revealed that 3D-sEVs deliver growth arrest-specific protein 6 (GAS6) to modulate the transition of microglia from a pro-inflammatory to an anti-inflammatory state, thereby mitigating neuroinflammation following TBI. Our findings underscore the therapeutic promise of sEVs derived from 3D-cultured ADSCs in treating TBI via modulating microglia polarization. Graphical abstract
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2015
·Vol. 407
·期 20
·6071-6079
·
IF 3.436
Du Fuyou,Sun Lin,Zhen Xian,Nie Honggang,Zheng Yanjie,Ruan Guihua,Li Jianping
High-internal-phase-emulsion polymers (polyHIPEs) show great promise as solid-phase-extraction (SPE) materials because of the tremendous porosity and highly interconnected framework afforded by the high-internal-phase-emulsion (HIPE) technique. In this work, polyHIPE monolithic columns as novel SPE materials were prepared and applied to trace enrichment of cytokinins (CKs) from complex plant samples. The polyHIPE monoliths were synthesized via the in-situ polymerization of the continuous phase of a HIPE containing styrene (STY) and divinylbenzene (DVB) in a stainless column, and revealed highly efficient and selective enrichment ability for aromatic compounds. Under the optimized experimental conditions, a method using a monolithic polyHIPE column combined with liquid chromatography–electrospray tandem mass spectrometry (LC–MS–MS) was developed for the simultaneous extraction and sensitive determination of trans -zeatin ( t Z), meta -topolin ( m T), kinetin (K), and kinetin riboside (KR). The proposed method had good linearity, with correlation coefficients ( R
2 ) from 0.9957 to 0.9984, and low detection limits (LODs, S/N = 3) in the range 2.4–47 pg mL −1 for the four CKs. The method was successfully applied to the determination of CKs in real plant samples, and obtained good recoveries ranging from 68.8 % to 103.0 % and relative standard deviations (RSDs) lower than 16 %.
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Journal of Food Measurement and Characterization
·
2025
·
IF 3.3
Hu Lu,Li Yuanbin,Li Shanshan,Wu Chengyu,Wang Zhenyuan,Zhang Jichuan,Huang Chujie,Zhang Jiaheng
Chronic oxidative stress and inflammation accelerate skin aging by inducing structural compromise in intracellular components and extracellular matrix (ECM) degradation. Plant-derived bioactive peptides have attracted great attention for their outstanding biological activities. However, before protein hydrolysis, the traditional extraction strategy of protein was unsustainable for its polluting solvents and reagents. Tricholoma matsutake ( T. matsutake ) is rich in proteins, vitamins, poly-peptides and double-chain polysaccharides. Several natural deep eutectic solvents (NaDESs) were synthesized for the efficient extraction of protein from T. matsutake . The highest yield of protein (52.5 ± 0.66%) was obtained from extraction at 35 of matrine/1,2-Propanediol (MaPd) concentration for 2 h, a solid-liquid ratio of 40 mL/mg. Furthermore, the optimal peptides were prepared by protein hydrolysis with 20% alkaline protease at 55 °C for 90 min. Notably, T. matsutake peptides were good in scavenging radicals and in decreased levels of IL-1α, IL-6. Meanwhile, T. matsutake peptides exhibited anti-skin aging ability by preventing the secretion of MMP-1 and MMP-3, degradation of collagen I and elastin. The study demonstrates that NaDES combined with enzymolysis extraction is a suitable, green technique with high potential of peptides from T. matsutake . Therefore, T. matsutake peptides can be considered for developing crude drug formulations and functional food or cosmetics materials with anti-inflammatory and Anti-aging properties.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-18
·
IF 15.7
Wang Weili,Ye Binglin,Liu Yao,Li Zhi,Huang Qianying,Zhou Jialin,Hu Min,Jiang Jun,Wang Weilin,Mao Zhengwei,Ding Yuan
Metronomic photodynamic therapy is a long-term, low-dose treatment strategy that employs optical devices with continuous photosensitizer administration and requires stable device attachment with a consistent power source. These factors significantly limit patient mobility. Currently, no metronomic photodynamic therapy modality can operate independent of external devices, underscoring the critical need for in vivo light sources that function without external energy inputs. In this study, we integrate self-luminous bacteria with a photosensitizer in alginate microcapsules to create a self-driven metronomic photodynamic therapy that can be securely implanted within a tumour, thereby enabling continuous light emission without requiring an external energy source or ongoing replenishment of photosensitive reactants. By harnessing nutrients from the tumour microenvironment, this system sustains the generation of reactive oxygen species. A single injection effectively eliminates larger tumours (>300 mm 3 ) in an opaque melanoma mouse model and transplanted hepatocarcinoma rabbit model. Self-driven metronomic photodynamic therapy demonstrates advantages over traditional photodynamic therapy, indicating its potential as a versatile therapeutic approach for cancer treatment with deeply situated lesions.
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Cell Communication and Signaling
·
2025
·Vol. 23
·期 1
·1-18
·
IF 8.9
Zhang Jiaqi,Li Jinjin,Cheng Mengting,Zhou Haiyang,Zhang Xiaochen,Yan Hao,Xu Zhifei,Yang Bo,He Qiaojun,Gao Zizheng,Chen Xueqin,Luo Peihua
Sotorasib, the first FDA-approved KRAS G12C inhibitor, has demonstrated remarkable clinical efficacy in non-small cell lung cancer (NSCLC). However, its clinical utility is hampered by life-threatening interstitial lung disease (ILD), whose molecular basis remains unknown. Through the integration of transcriptomic and metabolomic analyses, we revealed that sotorasib activates PPAR-γ signaling, upregulating fatty acid oxidation (FAO) via its downstream effector CPT1B. This metabolic shift triggered mitochondrial ROS overproduction, which drives alveolar epithelial apoptosis and fibrosis in vivo and in vitro . Mechanistically, sotorasib directly binds to PPAR-γ via Thr325, facilitated by FABP4-mediated nuclear translocation, amplifying its transcriptional activity via a feedforward loop. Pharmacological inhibition of FABP4 attenuated PPAR-γ activation, mitigated ROS-driven apoptosis, and rescued pulmonary fibrosis in mice. Taken together, these findings identify the FABP4-PPARγ-CPT1b axis as a novel off-target mechanism of sotorasib-induced lung toxicity and propose FABP4 inhibition as a promising therapeutic target to enhance its clinical safety.
Section
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