ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Ding Zhengyuan,Zhu Linlian,Zhou Yaqiu,Li Mengwei,Yao Yi,Su Mengjie,Wu Zengqiang,Wang Li,Yu Chunmei
In this study, we presented the design and development of a flexible and non-enzymatic electrochemical sensor based on in situ growth of Au nanowires (AuNWs) on carbon cloth (CC) for the dynamic monitoring of uric acid levels in human sweat. The electrode was fabricated through a controllable process, resulting in a three-dimensional conductive network with high surface area and abundant electroactive sites on the electrode surface. Electrochemical analyses demonstrated that the electrode exhibits excellent sensitivity toward uric acid with a wide linear response range from 10 to 700 μM and a low detection limit of 1.4 μM. The electrode was further integrated into a wearable sensing platform and applied for real-time, non-invasive sweat sampling and monitoring during exercise. The results indicated that the sensor exhibited a high correlation between sweat and blood uric acid levels measured by a commercial device, validating its potential applicability for the daily monitoring of uric acid. This work provides a promising strategy for the development of facile and reliable wearable sensors, with significant potential in non-invasive healthcare monitoring. Graphical abstract
A flexible and wearable sensor by in situ growth of Au nanowires on carbon cloth was developed for the real-time and non-invasive monitoring of uric acid metabolite in sweat.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Hang Li,Muhammad Mubeen,Jingbao Wang,Salman Khalid,Jingmao Zhao,Baomin Fan,Yiqian Lv,Mohammad Tabish,Haiqing Liu
Zn-Al-Mg coated steel (ZM-steel) has emerged as a preferred material in automotive and infrastructure applications, yet its long-term durability remains challenged by localized corrosion in chloride-rich environments. Herein, a sustainable and scalable corrosion protection strategy based on the in-situ formation of layered double hydroxide (LDH) films intercalated with benzothiazole (BTZ) was reported. By exploiting the controlled corrosion of ZM-steel surface in BTZ-containing NaCl solution, compact LDH architectures spontaneously formed, incorporating BTZ molecules within their interlayers. The resulting hybrid coating integrated the physical barrier effect of LDH with the release of BTZ anions, enabling interfacial passivation and sustained corrosion inhibition. Comparative electrochemical tests revealed that BTZ-containing NaCl solution yielded markedly enhanced corrosion-resistance as compared to NaCl solution or bare BTZ solution, with charge transfer resistance increasing from 9.44 × 10 2 to 9.13 × 10 4 Ω·cm 2 . Moreover, epoxy-overcoating effectively suppressed filiform corrosion (FFC) of ZM-steel substrate for over 35 days. Unlike conventional hydrothermal or carbonate-assisted routes for LDH fabrication, this precursor-free strategy proceeds under ambient conditions without additional reagents, underscoring its simplicity, efficiency, and scalability. These findings demonstrate that the moderate corrosion is beneficial to the formation of LDH on ZM-steel surface.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Baobao Bai,Liangmu Pei,Ziqun Yang,Juan Lei,Caiyun Han,Shuang Wang,Jiancheng Wang
Precisely controlling active-site architecture is key for non-noble metal oxide catalysts in volatile organic compounds elimination. Herein, we demonstrate that lattice-doped Cu, rather than surface-loaded Cu, plays a decisive role in regulating the coordination environment and defect chemistry of MnO 2 , thereby fundamentally enhancing its toluene oxidation performance. Combined theoretical and experimental studies reveal that lattice-doped Cu creates a favorable coordination environment by significantly reducing oxygen vacancy formation energy and increasing electron density near the Fermi level. As a result, the Cu-Mn catalyst achieves 90 % toluene conversion at 218 °C, outperforming surface-loaded Cu/Mn (229 °C) and pristine MnO 2 (250 °C). The enhanced activity originates from the coupled increase of Mn 3 + species and oxygen vacancies, which synergistically improves reducibility and oxygen activation. In-situ DRIFTS further demonstrates that lattice-doped Cu facilitates aromatic ring opening and accelerates deep oxidation pathways. In addition, the Cu-Mn catalyst exhibits excellent hydrothermal stability under humid conditions, underscoring its practical potential. This work establishes a clear structure-activity-mechanism relationship and highlights lattice Cu doping as a general strategy for designing efficient non-noble metal oxide catalysts for VOC abatement.
✓ 已验证
DOI
高影响因子
Foods
·
2026
·Vol. 15
·期 4
·744
·
IF 6
Xiqian Tan,Shuaibo Gao,Xiaoxiao Cheng,Lijun You,Xuepeng Li,Jianrong Li
Hyperuricemia (HUA) is a metabolic disorder that can easily lead to gout or kidney disease, and it is believed that it can be treated effectively using probiotics. This study evaluated the safety, probiotic, and functional properties ofWickerhamomyces anomalusYFJ252, isolated from pickled vegetables, including its in vitro inhibitory activity against xanthine oxidase (XO) and in vivo uric acid-lowering activity in mice, using virulence factor screening, plate counting, and colorimetric assays. Meanwhile, the potential anti-HUA mechanism was also investigated using untargeted metabolomics and whole-genome analysis. The results show that YFJ252 is non-hemolytic and does not produce DNase, gelatinase, or biogenic amine. It has potential probiotic properties: 85.83% DPPH radical scavenging, 39.94% α-amylase inhibition, 35.32% α-glucosidase inhibition, 20.73% anti-inflammatory ability, and 84.15% XO inhibition capacity. Animal experiments indicated that early intake of YFJ252 could maintain serum uric acid levels at 165.08 μmol/L (p< 0.05), lower than the HUA group (212.19 μmol/L), and significantly decrease creatinine and urea nitrogen levels (p< 0.05). The hypothetical anti-HUA potential of YFJ252 might be due to the production of antioxidant, hypoglycemic, and XO-inhibitory metabolites during growth, as well as a purine-degrading pathway that the strain inherited. This study provides a theoretical basis for usingW. anomalusYFJ252 as a food ingredient with preventive effects against HUA.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2026
·Vol. 27
·期 8
·3381
·
IF 5.6
Guanyang Chen,Shiting Li,Peng Bai
The safe and precise regulation of therapeutic gene expression remains a major challenge for mammalian synthetic biology and cell-based therapies. Many existing inducible systems rely on non-mammalian regulatory components or ligands with limited clinical compatibility. Designer receptors exclusively activated by designer drugs (DREADDs) offer a human G protein-coupled receptor (GPCR)-based framework for pharmacological control of intracellular signaling, yet their application as clinically relevant gene-regulation platforms remains underexplored. Here, we report a clozapine-responsive gene switch that couples a designer GPCR to signaling-dependent transcriptional control. By linking clozapine-activated receptors to cyclic adenosine monophosphate (cAMP)- or calcium-responsive synthetic promoters, receptor activation is converted into robust transgene expression across a broad dynamic range, with sensitivity to sub-nanomolar to low-nanomolar clozapine concentrations. In vivo, alginate-encapsulated reporter cells implanted in C57BL/6J mice responded to systemic or local clozapine administration with efficient secretion of a reporter protein, achieving robust induction at low daily doses (0.3 mg/kg) following either oral administration or local delivery. Together, these results establish a human GPCR-based clozapine-responsive gene switch that integrates regulation by a clinically used small molecule with modular transcriptional outputs, providing an additional approach for pharmacologically controllable gene expression in mammalian cells and in vivo.
✓ 已验证
DOI
PubMed
高影响因子
Chemistry-An Asian Journal
·
2026
·Vol. 21
·期 6
·e70700
·
IF 3.2
Mingxia Zhang,Ting Wang,Yurong Wang,Yongjian Cui,Huaping Wang,Junze Liu,Hailong Wang
Silicon (Si) anodes are promising candidates for surpassing the energy density limits of current lithium‑ion batteries, owing to the ultra‑high theoretical capacity (4200 mAh g −1 ). However, their practical implementation is hindered by irreversible lithium (Li) loss, which originates from the continuous formation of the solid electrolyte interphase (SEI) and the irreversible trapping of Li + within the silicon matrix due to sluggish Li + diffusion kinetics. To address these issues, a Si/Ge@C heterojunction anode has been designed. In this configuration, a conformal carbon coating effectively mitigates volume expansion and suppresses parasitic reactions on the Si surface, thereby reducing excessive SEI formation. Moreover, the Si/Ge heterojunction establishes a built‑in electric field oriented from Si to Ge, which reduces Li + trapping. This built‑in electric field not only facilitates Li + migration toward Ge during lithiation but also provides an additional driving force to extract trapped Li + from Si during delithiation. Consequently, the optimized Si/Ge@C anode delivers a high initial Coulombic efficiency (ICE) of 92.47% and maintains a high capacity of 539.77 mAh g −1 over 500 cycles at 200 mA g −1 .
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2026
·
IF 6.3
Changxiang Xie,Bingzhu Wang,Yonghui Yu,Wenhao Dou,Jing Guo,Haiwang Wang,Jianjun Sha
UHTCs are expected to be widely used in the aerospace industry due to their excellent ablation resistance. Currently, the low-temperature densification technology for 3D carbon fibre reinforced UHTCs is relatively scarce, meanwhile the long-term and high-temperature ablation-resistant materials still require further development. Herein, combining with reactive hot pressing at 1800 ℃, the highly dense 3D C f /ZrC-SiC composites were innovatively prepared through cyclic infiltration of slurry into 3D carbon fibre preform. The 3D C f /ZrC-SiC exhibited an excellent ablation resistance under a heat flux of 8.9 MW/m². By regulating the ratio of in situ phases ZrC and SiC, 3D C f /ZrC-SiC had an optimal mass ablation rate of only 0.75 mg/s and an optimal linear ablation rate of only -0.20 μm/s during the ablation process. The excellent ablation resistance was attributed to the formation of a dense ablation layer, which effectively inhibited the matrix from further ablation.
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2026
·
IF 6.7
He-Wei Ma,Cai-Dan Zhang,Jian-Xun Luo,Yu-Dan Yi
Alkylphenol ethoxylates (APEOs) in waterborne coatings (WBCs) pose substantial health and environmental risks due to their estrogenic degradation metabolites, necessitating robust analytical methods to meet stringent regulations. Conventional liquid chromatography-mass spectrometry (LC-MS) methods often suffer from congener separation difficulties and severe matrix interference. To overcome these limitations, we developed an analytical procedure based on facile one-pot cleavage technique using aluminum iodine (AlI 3 ) generated in-situ for the reliable quantification of APEOs in WBCs. The method integrates three core innovations: (1) rapid dehydration with MgCl 2 (1.5 × the mass of sample water) to prevent moisture-induced AlI 3 decomposition; (2) efficient, one-pot AlI 3 -mediated cleavage under ultrasonic irradiation (85 °C, 20 min) for quantitative APEOs-to-alkylphenol (AP) conversion; and (3) simple, quantitative AP isolation via tert -butyl methyl ether (BME) extraction. Validated using gas chromatography-mass spectrometry (GC-MS), the method exhibited excellent linearity (R 2 > 0.999), low limits of quantification (3.0 mg/kg for OPEO 10 , 9.0 mg/kg for NPEO 10 ), satisfactory recoveries (92.9–107.4%) and relative standard deviations (RSDs) ≤ 11.8%. Compared to routine LC-MS methods, this approach effectively mitigates matrix effects, reduces analytical cost, and offers a greener alternative suitable for batch analysis. Application to 20 real WBC samples confirmed its reliability in quantifying APEOs across concentration ranges, from low-level contaminants to high-load formulations. Overall, this integrated strategy enables sensitive, rapid and accurate APEO analysis, presenting a promising new avenue for screening these contaminants in complex sample matrices such as WBCs.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Insects
·
2026
·Vol. 17
·期 9
·967
·
IF 3
Jinjia Liu,Bailu Xie,Shiyan Jia,Yu Gong,Miaomiao Liu,Huiting Zhao
Simple SummaryThe keen olfactory capacity ofApis cerana ceranaprovides substantial plasticity in pollination and resource selection, with odorant receptors (ORs) playing indispensable roles in detecting and transducing environmental chemical signals. In this study, we systematically characterized the structural properties, evolutionary conservation, and spatiotemporal expression patterns ofAcerOR120, and evaluated alterations in olfactory sensitivity following gene knockdown. The protein exhibits a classical seven-transmembrane architecture, shares high sequence conservation with orthologs across the genusApis, and peaks in expression during the early foraging stage (15- and 20-day-old workers), predominantly localized in antennae, heads, thoraces, and legs. SilencingAcerOR120via RNA interference significantly weakened antennal sensitivity to key odorants, including geraniol, isoamyl acetate, decanal, (E)-2-octenal, ocimene, linalool, and (+)-dihydrocarvone. These results demonstrate thatAcerOR120is involved in foraging behavior by modulating the perception of floral scents and colonial pheromones, offering a functional molecular target for deciphering and manipulating olfactory recognition inA. c. cerana.This study aims to characterize the structural features and spatiotemporal expression patterns of the protein encoded by odorant receptor geneAcerOR120, and to explore its biological functions in olfactory recognition inApis cerana cerana. Bioinformatic software was used to predict the transmembrane topology, secondary/tertiary structures and conserved domains of the AcerOR120 protein. A neighbor-joining phylogenetic tree was constructed based on homologous sequences within the genus Apis. qRT-PCR was performed to detect the gene expression profiles in antennae of worker bees at 1, 5, 10, 15, 20 and 25 days old, as well as different tissues of foragers. EAG recording was applied to compare the electrophysiological responses of worker antennae to 11 volatile odorants before and after gene silencing via RNA interference. The open reading frame ofAcerOR120is 1203 bp, encoding a 401-amino-acid protein containing seven transmembrane domains with an intracellular N-terminus. Its secondary structure is dominated by α-helices accounting for 82.79%, which matches the typical structural signature of insect odorant receptors. Phylogenetic analysis revealed that AcerOR120 shares high conservation acrossApisspecies. Spatiotemporal expression assays showed that transcript abundance in antennae increased first and then decreased with worker age, reaching the minimum at day 1 and the maximum at day 20. Among tissues of foragers, the highest expression was detected in antennae and thoraxes, followed by heads and legs, while abdomens and wings possessed low expression levels. RNAi silencing significantly reduced overall EAG responses of antennae to all 11 tested odorants, with the most dramatic decreases observed for Geraniol, Decanal, Ocimene and (+)-Dihydrocarvone.AcerOR120encodes a canonical insect odorant receptor and is highly expressed in forager antennae. It mediates the recognition of multiple floral volatiles and pheromones and is speculated to participate in olfactory-related physiological processes, including nectar source localization and social behavior regulation inA. cerana cerana.
✓ 已验证
DOI
高影响因子
PHARMACEUTICAL RESEARCH
·
2026
·
IF 4.1
Xiang Yucheng,Song Haoyuan,Li Dongjun,Li Jingxian,Ruan Jiuheng
Purpose As a key excipient in drug-in-adhesive patches, the diffusion behavior of chemical penetration enhancers (CPE) directly affects the diffusion behavior of drugs and thus determines whether the drug can achieve effective skin penetration. Therefore, the study of the release kinetics (RK) of CPE is pivotal. Methods RK of five CPEs (Span 80 (Span), Isopropyl palmitate (IPP); Dipropylene Glycol (DPG); Menthol (MEN) and N-methyl-2-pyrrolidone (NMP)) and its effect on drug diffusion were researched by in vitro release study, in vitro skin penetration study, molecular dynamic simulation and Raman imaging. And the molecular mechanisms were characterized using modulated-temperature differential scanning calorimetry, rheology study, Fourier transform infrared spectroscopy and 13 C nuclear magnetic resonance spectroscopy. Results The various RK behaviors of CPE enhanced the dynamic change in release rate ( k ) of drug at different degrees, and their RK parameters ( k a-CPEs and T lag-CPEs ) had a multilinear correlation (R 2 = 0.96) with the increment in k (Δ k ) over the whole diffusion process. Moreover, the physicochemical properties of CPE determined their k a-CPEs and T lag-CPEs , k a-CPEs were related to polarizability ( P ) and dielectric constant (ε’) and T lag-CPEs had linear relationship (R 2 = 0.98) with Log P o/w . Conclusions The miscibility between CPE and the matrix (assessed by Log P o/w and ε’) as well as the interaction strength between CPE and the matrix or drug (assessed by P ) determined the RK behaviors, thereby enhancing their overall effect on drug diffusion. The proposed mathematical model enabled prediction of CPE's regulatory effect on drug diffusion based on CPE’s inherent properties.
✓ 已验证
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2026
·
IF 4
Xinyang Zhang,Long Cai,Mengqing Cui,Xinke Huang,Huilan Piao,Xiangzi Jin,Xiaotong Shi,Donghao Li,Yilin Zou
This method (0.1 mL solvent, 60 s) is eco-friendly and highly sensitive. • CNFs/CFs are reusable, anti-interference, for trace pollutant detection in complex samples. • Needle-tip device was prepared via CNFs/CFs confined methanol for the in-situ detection of PFCs in cerebrospinal fluid. Perfluorinated compounds (PFCs) are emerging pollutants with strong bioaccumulation and stability, and potential risks to human health. Biological samples are usually limited in volume and content trace levels of target analytes, thus requiring in-situ and minimally invasive detection techniques (such as solid-phase microextraction (SPME), microfluidic chip analysis, and in vivo sampling). However, conventional detection methods are difficult to achieve accurate qualitative and quantitative analysis of trace PFCs. In this study, a rapid, in-situ and green analytical method was developed by combining nanoconfined liquid phase nanoextraction (NLPNE) with liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the determination of 9 PFCs in cerebrospinal fluid. The interlaced carbon nanofibers (CNFs) form multi-dimensional network nanopores, which provide favorable structural basis for the construction of NLPNE systems. The carbon nanofibers/carbon fibers (CNFs/CFs) was used to confined methanol, which was packed into the needle tip to fabricate a portable needle-tip extraction device. The confined methanol enhanced the extraction efficiency of 9 PFCs. Key parameters affecting extraction performance were optimized (including confined fluid type and volume, extraction time, desorption solvent type and desorption time). Under optimal conditions, the method exhibited excellent linearity (r ≥ 0.9955) in the range of 0.1–500 μg L −1 , with method limits of detection (MDLs) and limits of quantification (MQLs) ranging from 0.15 to 7.5 μg L −1 and 0.50 to 24.98 μg L −1 , respectively. The intra-day and inter-day relative standard deviations (RSDs) were ≤12.99%, and the recovery of PFCs in cerebrospinal fluid samples was 70.56%–119.12% with RSD ≤11.63%. Compared with traditional methods, this method has the advantages of short time, small organic solvent, and simple operation ability, providing a novel and reliable approach for the real-time rapid analysis of trace PFCs in small-volume complex biological samples. Nanoconfined liquid phase nanoextraction (NLPNE) for the in-situ determination of perfluorinated compounds (PFCs) in cerebrospinal fluid. Download: Download high-res image (227KB) Download: Download full-size image
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2026
·
IF 2.8
Hou Dusong,Gao Danhong,Liu Hongwei,Deng Hanling,Lu Qianyao,Xiong Fan,Shao Hengwei,Lu Yuanyuan,Wang Mengxin,He Xinjian,Huang Sheng
The advancements in flexible display technology impose stringent demands on the optical properties and environmental stability of perovskite luminescent materials. Addressing the core challenges of poor environmental stability and optical performance degradation in methylammonium lead bromide (MAPbBr 3 ) quantum dots, this study proposes a dual-stability strategy combining “internal crystallization regulation” with “external physical protection.” A ZnO/MAPbBr 3 /PVDF composite film was prepared through synergistic modification with zinc oxide (ZnO) and polyvinylidene fluoride (PVDF), with the optimal ZnO content identified as 40 μL. Under these conditions, the composite film exhibited a green light emission full width at half maximum (FWHM) as low as 19.88 nm and a photoluminescence quantum yield (PLQY) of 76.06%, demonstrating high color purity. After heating at 100°C for 60 min, the PL intensity decayed by only 30%, and after 168 h of immersion in water, it retained 65% of its initial PL intensity, indicating significantly enhanced environmental tolerance. When this film served as the green conversion layer integrated with red CsPbI 3 quantum dot films and GaN blue LEDs to form a white light-emitting diode (WLED), the device achieved a color gamut coverage of 126% of the NTSC standard and 94% of the Rec. 2020 specification. Research indicates that ZnO enhances crystalline integrity by regulating MAPbBr 3 nucleation and growth, while PVDF forms a compact hydrophobic barrier. Their combined effect enhances both the film’s optical performance and environmental stability, enabling WLEDs with ultrawide color gamut that meet the requirements of high-performance flexible display and lighting applications.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）