Food Bioscience
·
2024
·
IF 4.8
Haoyue Ning,Lixin Lu,Yuemei Zhang
To achieve long-term effective protection of food by continuously controlling the release of active substances in an active film, IRMOF-3 was post-synthetic modified with benzoic acid (BA) to obtain BA-IRMOF-3. This modification enhanced the loading capacity of carvacrol (CA) and slowed down its release rate. Research on IRMOF-3 synthesis has found that increasing the proportion of metal nodes can improve its crystallinity. The post-synthesis modification of IRMOF-3 through amide reaction successfully enhanced the binding energy with CA from −5.1 kcal/mol to −6 kcal/mol, resulting in an improved CA loading rate of 28.62% ± 0.15% and delayed release. Furthermore, the BA-IRMOF-3/CA assembly was added to the sodium alginate matrix to prepare the active film BMC@SA, which improved the mechanical and physical properties of the film. The release and antibacterial/antioxidant properties were investigated. The results demonstrated that the active film BMC@SA exhibited significant sustained-release properties and antibacterial/antioxidant activities, reducing the growth of E. coli and S. aureus by 61.95% and 49.33% respectively. In refrigerated pork experiments, the film BMC@SA slowed down the color, weight, pH changes and inhibited microbial growth of fresh pork effectively, and extended the shelf life of pork from 6 d to 12 d, which demonstrated the potential application of active film BMC@SA in food preservation.
研究领域:
食品科学
·
材料科学
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产品关联
DOI
高影响因子
Food Bioscience
·
2024
·
IF 4.8
Danyang Liu,Yiming Song,Xinyi Chen,Jianhua Xie,Yi Chen,Xiaobo Hu,Jiayan Xie,Qiang Yu
Previous studies have shown that bound polyphenols from tea residue dietary fiber (TBP) were novel natural food ingredient with hypoglycemic activity, but the protective effects against aging have not been fully explored. This study investigated the potential of TBP to alleviate aging in Caenorhabditis elegans induced by 3-monochloropropane-1,2-diol (3-MCPD) and elucidated the underlying mechanisms through transcriptomic and metabolomic analyses. The results demonstrated that TBP markedly prolonged the lifespan of the nematodes, improved body morphology and locomotion, and effectively reduced reactive oxygen species and lipofuscin accumulation, while enhancing antioxidant defenses. Transcriptomic and metabolomic analyses further highlighted the critical role of the Insulin/Insulin-like Growth Factor 1 (insulin/IGF-1) signaling pathway in lifespan extension, with validation provided through gene expression and fluorescent mutants. These findings underscored the significant potential of TBP to counteract the adverse effects of 3-MCPD and extend lifespan, thereby providing a solid theoretical foundation for developing health products and exploring novel applications.
研究领域:
生物化学
·
分子生物学
·
营养学
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产品关联
DOI
高影响因子
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
·
2018
·Vol. 61
·期 14
·1043-1047
·
IF 1.423
Wulian Chen,Chaomin Zhao,Xiaojun Deng
An efficient and simple synthetic route of deuterium-labeled 2-quinoxalinecarboxylic acid- d 4 (QCA- d 4 ) and 3-methylquinoxaline-2-carboxylic acid- d 4 (MQCA- d 4 ) is presented with 99.9% and 99.6% isotopic enrichment using aniline- d 5 as labeled starting material. Their chemical structures were confirmed by 1 H NMR, and their isotopic abundance was determined by mass spectrometry analysis.
研究领域:
有机化学
·
药物化学
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DOI
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2011
·
IF 0.901
Dongshun DENG,Rufa WANG,Lianzhong ZHANG,Yun GE,Jianbing JI
Vapor-liquid equilibrium (VLE) data were measured for ternary system water + ethanol + 1-butyl-3-methylimidazolium acetate ([bmim][OAc]), in a relatively wide range of ionic liquid (IL) mass fractions up to 0.8. Six sets of complete T - x - y data were obtained, in which the mole fraction of ethanol on IL-free basis was fixed separately at 0.1, 0.2, 0.4, 0.6, 0.8, and approximate 0.98. The non-random-two-liquid (NRTL) and electrolyte non-random-two-liquid (eNRTL) equations were used for correlation, showing similar deviations. The ternary VLE was also modeled with the correlation from two data sets, with the mole fractions of ethanol on IL-free basis being 0.1 and approximate 0.98. The VLE data were also reproduced satisfactorily. With the eNRTL model, the root-mean-square deviation for temperature is 0.79 K and that for vapor-phase mole fraction is 0.0094. The calculations are in good agreement with experimental data. The effect of the IL on the VLE behavior of the volatile components is also illustrated.
研究领域:
化学工程
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物理化学
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DOI
高影响因子
MATERIALS RESEARCH BULLETIN
·
2014
·
IF 1.968
Shu-Mei Zhou,De-Kun Ma,Ping Cai,Wei Chen,Shao-Ming Huang
Photocatalysts with excellent photocatalytic reaction activity and ideal selectivity are highly desirable for pollutants clearance and purification of targeted organics from a mixture. Continued efforts toward the goal, we here present a facile hydrothermal route to synthesize TiO 2 /Bi-benzenedicarboxylate/BiOCl nanoparticles decorated ultrathin nanosheets with a thickness less than 5 nm on a large scale. The as-synthesized products showed excellent photocatalytic activities for the degradation of various dyes such as rhodamine B, eosin Y and methylene blue in aqueous solution under visible light irradiation. The photocatalytic activities of TiO 2 /Bi-benzenedicarboxylate/BiOCl nanocomposites for the degradation of rhodamine B and eosin Y could be adjusted through tuning the content of TiO 2 . With increasing the amount of TiO 2 , the composites showed declining photocatalytic activities in decomposing of rhodamine B while on the contrary they displayed enhanced photocatalytic activities in decomposing of eosin Y. Interestingly, TiO 2 /Bi-benzenedicarboxylate/BiOCl composite nanosheets showed obvious photocatalytic selectivity in a mixed dyes system. The photocatalytic reaction and selectivity mechanisms of the nanocomposites for the degradation of the dyes were discussed on the basis of experimental results. The current study not only develops a new methodology to synthesize ultrathin nanosheets but also provides a novel strategy to design composite photocatalysts with high reaction activity and good selectivity.
研究领域:
材料科学
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环境科学
·
化学
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产品关联
DOI
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2016
·Vol. 97
·期 5
·1475-1481
·
IF 2.076
Jianxia Sun,Xinghua Li,Xinyu Lin,Zhouxiong Mei,Yitao Li,Lijun Ding,Weibin Bai
BACKGROUND As an alternative preservation method for thermal treatment, ultrasound comprises a novel non-thermal processing technology that can significantly avoid undesirable nutritional changes. However, the recent literature indicates that anthocyanin degradation occurs when ultrasound is applied in juice at high amplitude parameters. Such work has mainly focussed on the effect of ultrasound on stability, the antioxidant capacity of cyanidin-3-glucosylrutinoside (Cy-3-glc-rut) and the correlation between anthocyanin degradation and ·OH generation in a simulated system. RESULTS The spectral intensities of Cy-3-glc-rut at 518 and 282 nm decreased with increasing ultrasound power and treatment time. The degradation of Cy-3-glc-rut was consistent with first-order reaction kinetics ( r 2 > 0.9000) and there was a good linear correlation between anthocyanin degradation and hydroxyl radical formation induced by ultrasound ( r 2 = 0.9258). Moreover, a decrease in the antioxidant activity of Cy-3-glc-rut after ultrasound evaluated by the 1,1-diphenyl-2-picrylhydrazyl and ferric reducing antioxidant power methods was observed. CONCLUSION Overall, the results of the present study show that ultrasound will accelerate the degradation of Cy-3-glc-rut with the growth of power over time. © 2016 Society of Chemical Industry
研究领域:
食品科学
·
化学工程
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产品关联
DOI
PubMed
高影响因子
BIOCHEMISTRY-MOSCOW
·
2015
·Vol. 80
·期 3
·379-389
·
IF 1.303
Zhao Shancheng,Deng Chao,Wang Zhen,Teng Liping,Chen Jinghua
The roles of sugar chains such as heparan sulfate (HS) in stem cell self-renewal and differentiation are poorly understood. HS is a sugar chain with linear sulfated polyanionic disaccharide repeating structures that interact with many proteins, including structural proteins in the extracellular matrix and growth factors and their receptors. Thus, unraveling the role of HS in stem cell self-renewal and differentiation could provide new insights and technical routes in clinical stem cell applications. Here, we purified rat bone marrow mesenchymal stromal cells (BMMSCs) by density gradient centrifugation, analyzed mesenchymal stromal cell surface stemness marker expression by flow cytometry, and identified the sulfotransferases responsible for sulfation ester modification of HS. An osteogenic differentiation model was established by chemical induction reagents and confirmed via alkaline phosphatase (ALP) activity detection and the expression of the osteogenic differentiation markers Runx2 and Ocn. The expression profiles of HS sulfotransferases in rat BMMSCs before and after osteogenic induction were detected by RT-PCR and Western blot. Cell spheroids were formed in both control and osteogenic culture systems when BMMSCs were grown to high confluence. We determined that this type of cell spheroid was a highly calcified nodule by histochemical staining. Among all the sulfotransferases examined, heparan sulfate 6-O-sulfotransferase 3 (HS6ST3) mRNA and protein were upregulated in these calcified cell spheroids. HS6ST3 knockdown BMMSCs were established with RNA interference, and they had significantly lower ALP activity and decreased expression of the osteogenic differentiation markers Runx2 and Ocn. These findings suggest that HS6ST3 is involved in BMMSC differentiation, and new glycotherapeutic-based technologies could be developed in the future.
研究领域:
细胞生物学
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分子生物学
·
再生医学
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DOI
PubMed
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 6.8
Wei Zhu,Pei Zhao,Tingting Liu,Feng Gao,Qi Li,Xin Cai,Man Zhang,Alex Aliper,Feng Ren,Alex Zhavoronkov,Xiao Ding
The dual inhibition of SIK2/3 has been considered as a potential treatment approach for MEF2C-high acute myeloid leukemia (AML). Although diverse scaffolds of pan-SIK or SIK2/3 inhibitors have been reported, few of them showed sufficient in vitro or in vivo antitumor activity. Based on the proposed binding mode of the hit molecule (7), chemical space in the solvent/P-loop region was explored via fragment growing/replacement, supported by the generative chemistry platform. Further SAR exploration and ADME optimization led to the discovery of 7s, which exhibited excellent potency and strong selectivity in MEF2C high-expression cell lines over MEF2C-low cell lines. Moreover, oral administration of 7s was found to demonstrate significant tumor growth inhibition in a MV4-11 AML mice CDX model without any body weight loss. This work highlights the potential of targeting MEF2C-dependent AML by selective oral SIK2/3 inhibitors, which was supported by the generative models.
研究领域:
药理学
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肿瘤学
·
药物化学
·
血液学
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产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2019
·Vol. 11
·期 47
·22890-22898
·
IF 6.97
Zihua Wu,Yuling Liang,Linqi Cao,Qing Guo,Suju Jiang,Fangfang Mao,Jiarong Sheng,Qi Xiao
Facile synthesis of high quality gold nanorods (AuNRs) with a tunable size is of great value for applications of AuNRs in various fields and for the study of the growth mechanism of such anisotropic nanostructures. However, limitations usually exist in a specific synthetic protocol. In this work, using 3-aminophenol as the reducing agent, we present a AuNR synthetic strategy with an excellent comprehensive performance, which includes an exceptional monodispersity, a AuNR shape purity of around 99%, a conversion ratio of the gold precursor of about 91%, and an easily tuned longitudinal surface plasmon resonance wavelength ranging from 580 to ∼1050 nm. Studies on the impacts of the experimental parameters including silver ions, gold seeds, reducing agent, and cetyltrimethylammonium bromide (CTAB) revealed a profound recognition of the significant effect of the reductive atmosphere, in synergy with other parameters, in directing the growth and structural evolution of the gold seeds, thus deeply affecting the size, shape yield, monodispersity, and morphology of the final structure. These results could be immensely useful for the application and revelation of the growth mechanism of AuNRs.
研究领域:
纳米材料
·
化学合成
·
光学材料
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产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2020
·
IF 3.83
Bingjing Tao,Weifeng Wang,Huanyu Liu,Tianxiu Du,Haitao Wu,Chunfang Xing,Dongzhi Wang,Yuping Zhang
Li 4 Mg 3 [Ti 0 · 6 (Mg 1/3 Nb 2/3 ) 0.4 ] 2 O 9 (LMT 0.6 (MN) 0.4 O) ceramics doped with 1–5 wt% lithium fluoride (LiF) were prepared through a conventional solid-state reaction at a relatively low sintering temperature . The influences of the LiF additive on the micromorphology, crystal phase composition, and sintering behavior, as well as the microwave dielectric properties of the LMT 0.6 (MN) 0.4 O ceramics were explored in depth. The addition of the LiF sintering additive reduced the densification temperature of the LMT 0.6 (MN) 0.4 O ceramics from 1450 °C–950 °C. X-ray powder diffractometer patterns indicated that a single phase formed for all experimental samples. Scanning electron microscopy photographs revealed that dense and homogeneous microstructures were obtained at 950 °C for the LMT 0.6 (MN) 0.4 O ceramics with 3–5 wt% LiF. Additionally, the optimized microwave dielectric properties, including ε r = 16.24, Q·f = 107,828 GHz (at 8.13 GHz), and τ f = −6.25 ppm/°C were achieved in the prepared LMT 0.6 (MN) 0.4 O ceramics with 4 wt% LiF at the sintering temperature of 950 °C. Furthermore, the excellent chemical compatibility between this component and silver were confirmed based on the results of XRD and EDS analyses, suggesting that the LMT 0.6 (MN) 0.4 O ceramics with 4 wt% LiF could be a suitable material for the application of low temperature co-fired ceramics.
研究领域:
材料科学
·
陶瓷
·
微波工程
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DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Zhang Shirong,Tan Yuxin,Liu Yilei,Li Yafei,Li Jishun,Zhang Shenglan,Pan Hongcheng
Quantum dots (QDs) have emerged as highly sensitive fluorescent markers for lateral flow immunoassays (LFIAs) due to their excellent fluorescence brightness and photostability. The incorporation of multiple QDs onto a carrier can further enhance detection sensitivity. However, traditional carriers such as polystyrene, while commercially successful, involve complex preparation processes and rely on organic solvents, which can lead to fluorescence quenching and adversely affect detection performance. In this study, we selected isoreticular metal–organic framework-3 (IRMOF-3), characterized by its porous structure, high surface area, and abundant amine functional groups, as the carrier. We synthesized IRMOF-3@CdSe/ZnS composite nanoparticles with an average diameter of 378 ± 46 nm by coupling carboxyl-modified CdSe/ZnS QDs to the IRMOF-3 surface through an aqueous synthesis method. These nanocomposites efficiently loaded a high density of QDs without aggregation, thereby maintaining strong fluorescence intensity. Moreover, the abundant amino and carboxyl groups on their surfaces facilitate efficient antibody conjugation, and the nanoparticles retain excellent water dispersibility after labeling. Utilizing IRMOF-3@CdSe/ZnS composite nanoparticles as immunomarkers, we developed a novel fluorescent LFIA for the detection of interleukin-6 (IL-6), a biomarker associated with various inflammatory and autoimmune diseases. The method achieved a limit of detection for IL-6 as low as 8.6 pg/mL, with relative standard deviations ranging from 2.73% to 6.14% and spiking recoveries between 96.4% and 110.8%. Passing-Bablok regression analysis demonstrated good consistency between our method and commercially available immunochromatography assays. The IRMOF-3@CdSe/ZnS composite nanoparticles, as a novel fluorescent label, exhibit considerable potential for applications in biomedical detection. Graphical abstract
研究领域:
分析化学
·
生物化学
·
纳米技术
·
免疫学
·
生物医学工程
·
材料科学
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产品关联
DOI
PubMed
高影响因子
Chemistry of Heterocyclic Compounds
·
2014
·Vol. 50
·期 1
·12-18
·
IF 0.698
Ge H. Y.,Fang Z. J.,Qian B. H.
3-Arylcoumarins were conveniently synthesized in excellent yields by an iron(III) chloride-promoted tandem reaction using methoxy-substituted ( E )-2,3-diphenylpropenoic acids or their methyl esters. The structure of 3-(4-methoxyphenyl)coumarin was established from X-ray crystallographic data.
研究领域:
有机化学
·
药物化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）