Materials Today Bio
·
2023
·
IF 8.2
Tianhua Xiao,Jiamin Liu,Yuanxin Li,Yu Cai,Xudan Xing,Ming Shao,Chi Zhang,Dongming Duan,Song Liu,Guoxin Tan,Le Wang,Zenghui Wu,Zunlei Gong,Lei Zhou
Methicillin-resistant Staphylococcus aureus (MRSA) infection is a pressing clinical issue that impedes wound healing. Pro-inflammatory M1 macrophages is required to clear bacteria and recruit various cell types during the initial phase of wound healing, but timing of this process is crucial. Herein, a microenvironment-responsive nanofibrous dressing capable of timely macrophage phenotype transition in vivo is constructed by coating copper ions (Cu 2+ )-polydopamine (PDA) networks on poly (ε-caprolactone) fiber (PCL-fiber) membrane. During the initial post-implantation period, the nanofibrous dressing show pH-sensitive Cu 2+ release in the acidic infection microenvironment. The release Cu 2+ have a direct killing effect on MRSA, and promote the proinflammatory M1 phenotype of macrophages to enhance the antibacterial macrophage response. Later, PDA to become a reactive oxygen species (ROS) scavenger when in microenvironments with elevated ROS levels, which conferred the dressing with an immunomodulatory activity that convert M1 macrophages into M2 macrophages. In vivo examination in an MRSA infected full-thickness skin wounds of rat model demonstrates that this dressing significantly facilitated infection eradication and wound healing through modulating local inflammatory phenotype. Overall, this study offers a simple and effective approach for timely manipulation of inflammation progression to promote infected wound healing.
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ACS Omega
·
2023
·
IF 4.1
Zhuohuan Wu,Wei Liu,Jiayun Feng,Zhicheng Wen,Xinyue Zhang,Xinming Wang,Chunqing Wang,Yanhong Tian
Due to the harsh working environments up to 600 °C, the exploration of high-temperature interconnection materials is significantly important for high-power devices. In this study, a hybrid paste including Cu@Ag core–shell microparticles (MPs) and Ag nanoparticles (NPs) was designed to achieve Cu–Cu bonding. The Cu@Ag MPs exhibited excellent oxidation stability in an air atmosphere with the Ag layer coating on the Cu core. Ag NPs fill the pores among the Cu@Ag MPs and reduce the sintering temperature of the hybrid paste. The Cu–hybrid paste–Cu joints were formed via electromagnetic induction heating within approximately 15 s. When sintered at 26 kW, the shear strength of the joint reached 48 MPa, the porosity decreased to 0.73%, and the resistivity was down to 13.25 μΩ·cm. Furthermore, a possible interconnection mechanism at the contact interface between the Cu substrate and the sintered hybrid paste was proposed, which is related to the melting point of metal particles and the effect of magnetic eddy currents. This fast bonding technology inspires a new approach to interconnection for high-power devices under high operation temperatures.
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JOURNAL OF CONTROLLED RELEASE
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2023
·
IF 10.8
Yifu Feng,Qian Chen,Chong Jin,Yanyun Ruan,Qi Chen,Weidong Lin,Chumeng Zhu,Tinglin Zhang,Yang Zhang,Jie Gao,Jinggang Mo
Percutaneous microwave ablation (PMA) is a thermoablative method used as a minimally invasive treatment for liver cancer. However, the application of PMA is limited by its insufficient ROS generation efficiency and thermal effects. Herein, a new microwave-activated Cu-doped zirconium metal-organic framework (MOF) (Cu Zr MOF) used for enhanced PMA has a significantly improved microwave sensitizing effect. Owing to the strong inelastic collisions between ions confined in numerous micropores, Cu Zr MOF has strong microwave sensitivity and high thermal conversion efficiency, which can significantly improve microwave thermal therapy (MTT). Moreover, because of the existence of Cu 2+ ions, a further benefit of Cu Zr MOF is their Fenton-like activity, in particular, microwaves used as an excitation source for microwave dynamic therapy (MDT) can improve the Fenton-like reaction to maximize the synergistic effectiveness of cancer therapy. Importantly, Cu Zr MOF can inhibit the production of heat shock proteins (HSPs) by producing abundant ROS to enhance tumor destruction. Mechanistically, we found that Cu Zr MOF + MW treatment modulates ferroptosis-mediated tumor cell death by targeting the HMOX1/GPX4 axis. In summary, this study develops a novel Cu Zr MOF microwave sensitizer with great potential for synergistic treatment of liver cancer by MTT and MDT.
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FUEL
·
2023
·
IF 7.4
Changdi Wang,Hao Wang,Lu Li,Ruiyang Zhao,Jishu Han,Lei Wang
Photocatalytic hydrogen production technology is an efficient method to solve the environmental pollution problem and obtain renewable energy. To improve the hydrogen production efficiency, it is still a great challenge to develop novel photocatalysts with high activity and high stability. In this work, a hollow rod-shaped Cu-In-Zn-S@ZnCo 2 O 4 @In 2 O 3 tandem heterojunction photocatalyst was designed and synthesized. Under visible light irradiation, the photocatalytic hydrogen production amount was up to 21404.54 μmol·g −1 in 5 h. The hollow tandem heterojunction would improve the light absorption, facilitate the electron transfer, inhibit the recombination of photogenerated electrons and holes, and provide more active sites for hydrogen production reaction. The design of Cu-In-Zn-S@ZnCo 2 O 4 @In 2 O 3 photocatalyst provided an effective method to enhance the photocatalytic hydrogen production performance.
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CHEMOSPHERE
·
2023
·
IF 8.8
Jieli Ou,Jiewen Deng,Zhenran Wang,Yongsheng Fu,Yiqing Liu
A Cu(II)/heat coactivated peracetic acid (PAA) system for enhancing diclofenac (DCF) degradation was proposed in this work. The superiority of this synergetic activation strategy for PAA, working reactive species, catalytic mechanism and effects of reaction parameters on DCF elimination in this system were simultaneously investigated. Based on our results, the DCF loss rate in Cu(II)-heat/PAA process at pH 8.0 was about 49.3 and 4.2 times of that in Cu(II)/PAA and heat/PAA processes, respectively. Increasing the reaction temperature to 60 о C not only motivated the conversion of Cu(II) to Cu(I) but also facilitated the one-electron transfer between Cu(I) and PAA, boosting the generation of radicals. Organic radicals (mainly CH 3 C(O)O• and CH 3 C(O)OO•) were evidenced to be the core oxidizing substances dominating in the destruction of DCF while hydroxyl radical (•OH) made a minor contribution in this system by electron paramagnetic resonance (EPR) method together with scavenging experiments. This study broads the eyes into enhanced PAA activation initiated by homogenous Cu(II), providing a simple but efficient tool to degrade micropollutants .
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2023
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IF 9.8
Peng Yi,Yani Yan,Ying Kong,Quan Chen,Min Wu,Ni Liang,Lijuan Zhang,Bo Pan
Wetting-drying cycles in the environment could change the inner- or outer-sphere complexation of heavy metal cations on natural organic matter (NOM) and then influence ternary interactions with organic contaminants - a rarely-discussed essential geochemical process. In this work, the sorption of sulfamethoxazole (SMX) on humic acids (HAs) mediated by cations (Cu 2+ and Cd 2+ ) was investigated. Considering that outer-sphere complexation could be transformed into inner-sphere complexation during vacuum freeze-drying, the role of inner- or outer-sphere complexation on SMX sorption was explored. The experimental sorption results and density functional theory (DFT) calculations suggested that Cu 2+ and Cd 2+ sorption on HAs was mainly outer- and inner-sphere complexation, respectively. Cd 2+ consistently promoted SMX sorption on HAs, while Cu 2+ promoted and inhibited SMX sorption before and after freeze-drying. The structure of HA-Cu complexes with inner-sphere complexation was more compact than those with outer-sphere complexation, which reduced the accessibility of sorption sites for SMX on HA-Cu and inhibited SMX sorption. However, the greater number of coordination sites of Cd 2+ may provide more sorption sites and the structure of HA-Cd was looser. These findings provide a groundbreaking understanding of the sorption of organics on natural adsorbents in the presence of cations.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2023
·Vol. 34
·期 21
·1-14
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IF 2.8
Sun Quan,Liu Yang,Zhang Jing,Li Ke,Lu Jicun
Copper paste sintering has great potential for WBG (wide bandgap) semiconductor packaging, but the problems of copper susceptibility to oxidation and high sintering temperatures have hindered its development. A micron copper paste suitable for low-temperature sintering was successfully formulated using the synergistic effect of metal organic decomposition (MOD) ink and ascorbic acid (AA) to achieve high shear strength sintered joints. During the sintering process, AA acted as a reducing agent to effectively remove oxide on the surface of the Cu microparticles (MPs), while the decomposition process of MOD was facilitated by the reduction products. The diffusion channels formed by the decomposed nanoparticles connect the Cu-MPs, forming dense sintered joints. At a sintering temperature of 250 °C, the combination of MOD and AA in the paste resulted in a significant improvement in the shear strength of the sintering joints, reaching 102.2 MPa. This is in contrast to the addition of only MOD or AA, which resulted in a shear strength of less than 5 MPa. Furthermore, the strength of the sintered joints was increased to 128.1 MPa after storage at 250 °C for 1000 h. At a sintering temperature of 210 °C, the strength could still reach 47.6 MPa, which was approximately double the strength of traditional Sn-based solder joints. This has greater practical significance for the fabrication of high-strength bonded joints and the expansion of the sintering process window.
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Journal of Water Process Engineering
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2023
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IF 7
Lilan Huang,Haimei Chen,Jin Han,Haojie Chen,Jian Pan,Zihan Zhao,Zhichao Dong,Hailin Cong
Printing and dying wastewater has a pervasive problem afflicting people worldwide due to negative impacts on ecosystems and humans. Herein, Fe/Cu bimetallic catalyst/polyethersulfone (4A-Fe@Cu/PES) mixed matrix membrane (APMMM) with macropore and high porosity were developed as catalytic membrane reactor for reduction of congo red (CR) in flow-through reaction. The forced flow of the reactants through the membrane improved the mass transfer and intensified the contact between reactants and immobilized catalysts, allowing for efficient adsorption and catalysis. Furthermore, the CR adsorption by 4A-Fe@Cu would form catalytic microzones in the membrane, which was conducive to further improving the catalytic efficiency. As a result, the apparent activation energy of dynamic catalysis (21.1 kJ/mol) was significantly decreased compared with that of static catalysis (93.7 kJ/mol). Therefore, the dynamic processes exhibited more excellent adsorption and catalytic efficiency. In cross-flow circulation mode, the maximum CR adsorption capacity of APMMM-18 (doping amount of 4A-Fe@Cu is 18.0 wt%) was 199.5 mg/g 4A-Fe@Cu with a catalyst/CR mass ratio of 1/1.5 and initial CR concentration of 50 mg/L. For catalysis, the APMMM-18 could remove 99.8 % CR after 5 h with a catalyst/CR mass ratio of 1/1.5 and 1.9 mM of H 2 O 2 at pH 8. The catalytic membranes showed much higher performances than 4A-Fe@Cu particles even under lower H 2 O 2 conditions. The intrinsic CR adsorption and degradation ratio of one layer of APMMM-18 under dead-end filtration was also investigated. The combination of the Fenton catalyst with the membrane process accomplished the effective removal of CR.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Xian-Xian Ji,Yu-Long Liu,Xin-Yue Chang,Rui-Long Li,Fei Ye,Liu Yang,Ying Fu
Diflubenzuron is widely used as a benzoylurea insecticide, and its impact on human health should not be underestimated. Therefore, the detection of its residues in food and the environment is crucial. In this paper, octahedral Cu-BTB was fabricated using a simple hydrothermal method. It served as a precursor for synthesizing Cu/Cu 2 O/CuO@C with a core–shell structure through annealing, creating an electrochemical sensor for the detection of diflubenzuron. The response of Cu/Cu 2 O/CuO@C/GCE , expressed as Δ I / I 0 exhibited a linear correlation with the logarithm of the diflubenzuron concentration ranging from 1.0 × 10 −4 to 1.0 × 10 −12 mol·L −1 . The limit of detection (LOD) was determined to be 130 fM using differential pulse voltammetry (DPV). The electrochemical sensor demonstrated excellent stability, reproducibility, and anti-interference properties. Moreover, Cu/Cu 2 O/CuO@C/GCE was successfully employed to quantitatively determine diflubenzuron in actual food samples (tomato and cucumber) and environmental samples (Songhua River water, tap water, and local soil) with good recoveries. Finally, the possible mechanism of Cu/Cu 2 O/CuO@C/GCE for monitoring diflubenzuron was thoroughly investigated.
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JOURNAL OF MOLECULAR LIQUIDS
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2023
·
IF 6
Shihao Zhang,Yazhen Wang,Baimei Tan,Fangyuan Wang,Xiaolong Wang,Haoyu Du
Post-chemical mechanical polishing (CMP) cleaning is an indispensable process to remove organic residues and particles on the wafer surface after CMP. Benzotriazole (BTA), a dominant corrosion inhibitor in Cu-CMP slurry, can easily remain on the copper surface after CMP, affecting the performance and yield of devices, and its removal has attracted more attention. This paper revealed the effect and mechanism of three amino acids, lysine, serine, and proline, on BTA removal in tetraethyl ammonium hydroxide-based alkaline solutions during post-Cu-CMP cleaning. Experimental results showed a diminishing enhancement in the cleaning efficiency of BTA after adding lysine (97.1%), serine (96.7%), and proline (94.1%) with almost the same concentration. Ultraviolet–visible absorption spectrum proved the lysine’s complexing ability was slightly better than the other. Besides, quantum chemical parameters of amino acid molecules calculated by density functional theory further suggested that lysine has more reactive sites and mainly bonds with copper through N2 and N8. The adsorption structures of three amino acids were simulated through the molecular dynamics method, and lysine turned out to be parallel absorbed on the Cu (1 1 1) surface with the lowest adsorption energy of −30.24 eV. Finally, the cleaning process simulation revealed the dynamic behaviors of BTA and lysine.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
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IF 6.2
Huangqing Ye,Jiahui Chen,Songrui Wei,Yougen Hu,Yu Wang,Xian-Zhu Fu,Rong Sun
Copper/carbon (Cu/C) hybrids with two-dimensional (2D) dendritic-like structure were successfully synthesized by a one-pot biological hydrothermal method with biomass as the reducing agent, capping agent, and template. By hydrothermal carbonization, the graphitic carbon is in-situ coated on the surface of nano copper to obtain a new type of 2D Cu/C materials. This method was facile, green, tunable and scalable. The influential factors on the morphology and carbon content of as-prepared hybrids were investigated, and possible growth mechanism was proposed. The as-prepared Cu/C hybrid materials exhibited a smallest thickness of 2.5 nm, with a radius-to-thickness ratio as high as 10 3 . Benefiting from the typical 2D structure and graphitic carbon coating layer, Cu/C hybrids exhibited excellent oxidation resistance and electrical conductivity , thus having great potential as a conductive adhesive filler used in the field of flexible electronics.
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Journal of Energy Chemistry
·
2023
·
IF 13.1
Mengxia Li,Tianxi Zheng,Dongfei Lu,Shiwei Dai,Xin Chen,Xinchen Pan,Dibo Dong,Rengui Weng,Gang Xu,Fanan Wang
The electrochemical hydrogenation of HMF to BHMF is an elegant alternative to the conventional thermocatalytic route for the production of high-value-added chemicals from biomass resources. In virtue of the wide potential window with promising Faradic efficiency (FE) towards BHMF, Cu-based electrode has been in the center of investigation. However, its structure–activity relationship remains ambiguous and its intrinsic catalytic activity is still unsatisfactory. In this work, we develop a two-step oxidation–reduction strategy to reconstruct the surface atom arrangement of the Cu foam (CF). By combination of multiple quasi-situ/in-situ techniques and density functional theory (DFT) calculation, the critical factor that governs the reaction is demonstrated to be facet effect of the metallic Cu crystal: Cu(110) facet accounts for the most favorable surface with enhanced chemisorption with reactants and selective production of BHMF, while Cu(100) facet might trigger the accumulation of the by-product 5,5′-bis(hydroxymethy)hydrofurion (BHH). With the optimized composition of the facets on the reconstructed Cu(OH) 2 -ER/CF, the performance could be noticeably enhanced with a BHMF FE of 92.3% and HMF conversion of 98.5% at a potential of −0.15 V versus reversible hydrogen electrode (vs. RHE) in 0.1 M KOH solution. This work sheds light on the incomplete mechanistic puzzle for Cu-catalyzed electrochemical hydrogenation of HMF to BHMF, and provides a theoretical foundation for further precise design of highly efficient catalytic electrodes.
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