RESEARCH ON CHEMICAL INTERMEDIATES
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2026
·
IF 3.3
Peng Qiao,Xu Chang,Zhang Shengwei,Zhang Jinlong,Lei Juying,Ye Ziwei,Wang Lingzhi
The low solubility of methane in water and the resulting gas–liquid–solid mass-transfer limitation severely restrict the efficiency of photocatalytic selective methane oxidation. Herein, Pt-In 2 O 3 catalysts were constructed and further modified with triethoxy-n-octylsilane (OTES) to achieve the synergistic enhancement of charge transfer and triphase mass transport. Pt loading and OTES grafting preserved the bulk crystal phase of In 2 O 3 , while establishing a Pt/In 2 O 3 heterointerface and a hydrophobic surface layer. Pt mainly promoted photogenerated charge separation and interfacial electron transfer, whereas OTES had only a minor effect on the electronic process. Among the catalysts examined, the optimized catalyst showed the best performance, giving a total productivity of 4659.1 μmol g −1 h −1 , a liquid-phase productivity of 4116.7 μmol g −1 h −1 , and a liquid-product selectivity of 88.4%, with the liquid-phase productivity being 1.44 times that of the corresponding catalyst without OTES modification. The activity showed a volcano-type dependence on OTES dosage, indicating an optimal hydrophobic range. Trapping experiments, electron paramagnetic resonance (EPR), and chemical-probe analyses identified ·OH and ·O 2 − /·OOH as the key reactive species involved in the reaction. This work demonstrates that tuning interfacial wettability is an effective strategy for enhancing photocatalytic methane oxidation in water.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Xu Zhang,Qian Zhu,Hao Rong,Siyao Zhu,Pan Feng,Jing Li,Yusong Wang,Hong Cheng,Wenbo Liu,Jie Sun,Zhisen Shen,Jilai Li,Yangnan Hu,Renjie Chai
Peripheral nerve injury remains a major clinical challenge due to limited regenerative capacity and insufficient therapeutic strategies. In this study, we developed biomimetic nerve guidance conduits composed of high-concentration gelatin methacryloyl (GelMA) hydrogel (GMH), providing mechanical support and structural integrity. The conduits lumen was filled with a softer, low-concentration GelMA hydrogel (GML) incorporating zeolitic imidazolate framework-8 (ZIF-8) nanoparticles encapsulating nerve growth factor (NGF), enabling sustained neurotrophic delivery. This bilayer design combines mechanical reinforcement with localized biochemical stimulation. In vitro experiments demonstrate that the system can continuously release NGF, exhibits good cellular compatibility, promotes neurite outgrowth in PC-12 cells, and can facilitate the conversion of RAW264.7 cells to an anti-inflammatory phenotype. Rat sciatic nerve injury model experiments have demonstrated that these nerve guidance conduits have a beneficial effect on the regeneration and functional recovery of nerve axons. Together, these findings highlight a versatile platform for nerve guidance conduits with the potential to improve functional recovery in peripheral nerve regeneration.
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PubMed
高影响因子
Chinese Medicine
·
2026
·Vol. 21
·期 1
·154
·
IF 7.4
Ding Wei,Zhang Ni,Xiao Lei,Yu Le,Wu Tian-Shi,Feng Yuan-Jie,Chen Wei
Background Hypertrophic cardiomyopathy (HCM) is often complicated by coronary microvascular dysfunction (CMD), which precipitates localized myocardial ischemia and metabolic disturbance, triggering compensatory cardiomyocyte hypertrophy. This hypertrophy, in turn, exacerbates microvascular insufficiency, forming a pathological feedback loop and culminating in persistent cellular stress, inflammatory infiltration, and myocardial fibrosis. This “ischemia–hypertrophy–inflammation–fibrosis” interrelationship not only drives pathological remodeling but also significantly elevates the risk of heart failure, arrhythmias, and adverse prognosis. The traditional formula Huayu Qutan Formula (HYQT), used clinically for years, has been shown to significantly enhance cardiac function in HCM patients. However, its underlying mechanisms remain poorly elucidated. This study aims to explore HYQT’s therapeutic effects on HCM and to reveal its intrinsic mechanisms. Methods Blood-absorbed constituents of HYQT were identified using UHPLC-MS, followed by network pharmacology analysis and molecular docking to predict potential targets and key signaling pathways. An isoproterenol (ISO)-induced HCM mouse model, along with parallel in vitro injury models using H9C2 cardiomyocytes and human cardiac microvascular endothelial cells (HCMECs), was established to systematically assess the in vivo and in vitro effects of HYQT. To comprehensively evaluate HYQT’s modulation of myocardial hypertrophy, fibrosis, and angiogenesis, echocardiography, laser speckle perfusion imaging, immunohistochemistry, western blotting, reactive oxygen species (ROS) assays, and wound-healing assays were performed. Results UHPLC-MS analysis identified 31 blood-absorbed bioactive components of HYQT. Integrated network pharmacology and molecular docking analyses identified the MAPK and HIF-1α-signaling pathways as key therapeutic targets. In ISO-induced HCM mice, HYQT significantly improved cardiac morphology and function, reduced hypertrophic markers (ANP and BNP), inhibited myocardial collagen deposition, attenuated fibrosis, restored microvascular perfusion and density, and suppressed oxidative stress (MDA and ROS) and pro-inflammatory cytokine expression (TNF-α and IL-6). Mechanistically, in vitro experiments supported a cell-type–resolved, parallel regulatory effect: in HCMECs, HYQT-containing serum enhanced migration and viability, reduced ROS accumulation, and activated HIF-1α/VEGF-mediated angiogenic signaling, thereby alleviating microvascular dysfunction; concurrently, in H9C2 cardiomyocytes, HYQT inhibited phosphorylation of ERK, p38, and JNK, restored mitochondrial membrane potential, and reduced cell death, thereby mitigating hypertrophic remodeling and its downstream fibrotic progression. Conclusion HYQT effectively ameliorates key pathological features of HCM, including myocardial hypertrophy, fibrosis, and microvascular dysfunction. As a clinically used herbal formulation, this study provides mechanistic insight into its therapeutic effects by revealing a cell-type–resolved, myocardium–microvasculature regulatory framework. Specifically, HYQT suppresses MAPK signaling to attenuate cardiomyocyte hypertrophy while enhancing HIF-1α–mediated angiogenesis to improve the microvascular environment. These simultaneous effects are associated with mitigation of pathological cardiac remodeling, suggesting that HYQT may serve as a promising multi-target therapeutic strategy for HCM.
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PubMed
高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 6
·417
·
IF 5.4
Xue Huiling,Cheng Guorong,Zhang Bing,Zhan Ying,Zhao Zhihuan,Lin Jianying,Cheng Yan
Carbohydrate antigen 19 − 9 (CA19-9) is a critical biomarker in clinical oncology, as its serum concentration is closely associated with tumor detection and therapeutic monitoring. In this study, a novel colorimetric immunoassay was developed for the sensitive detection of CA19-9, utilizing g-C₃N₄/Ag₂S nanocomposites as a photoactive signal probe. The nanocomposites, synthesized via a hydrothermal method, demonstrated strong absorption in the visible region and high photocatalytic activity. In the immunoassay, antibody-functionalized magnetic beads were used to capture the target antigen, followed by labeling with detection probes based on the g-C₃N₄/Ag₂S nanocomposites. Under visible light irradiation, the nanocomposites catalyzed the oxidation of 3,3’,5,5’-tetramethylbenzidine (TMB), producing a distinct color change that was quantitatively analyzed via UV–vis spectroscopy. The method exhibited a wide linear detection range from 4.0 to 400 U/mL, with a detection limit of 1.86 U/mL, and demonstrated excellent specificity, stability, and reproducibility. Successful application to human serum samples further validated the reliability and practical utility of the assay, highlighting its promising potential for clinical cancer diagnosis and screening. Graphical abstract The alternative text for this image may have been generated using AI.
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Science China-Materials
·
2026
·
IF 7.7
Miao Senlin,Meng Zhipeng,Liu Chenchen,Ma Yujie,Li Yalin,Huang Haofei
Mechanochromic photonic crystals are promising for smart optical materials due to their tunable photonic stop band. Here, we report interface-engineered transparent and mechanochromic non-close-packed photonic crystals (NPCs) by incorporating polystyrene@vinyl-modified SiO 2 (PS@V-SiO 2 ) nanospheres ( n PS = 1.59, \(n_{\mathrm{V}-\text{SiO}_{2}}=1.46\) ) into a photocurable phenoxypolyethylene glycol acrylate (PEGPEA) matrix ( n PEGPEA = 1.52). The nanospheres formed solvation-mediated liquid NPCs in the precursor. Ultraviolet (UV) curing promoted copolymerization between surface C=C bonds of nanospheres and the matrix, which reduced interfacial scattering and enabled highly transparent NPC films. Meanwhile, non-uniform polymer shrinkage led to variations in the ordering of nanospheres, especially in structures with a low volume fraction ( φ ⩽ 0.23). Under external strain ( ε : 0–64%), the film exhibited a dynamic color response. Initially, stretching enhanced the ordering of the nanospheres and the reflection intensity of NPCs, thereby activating the structural color. Further deformation, however, introduced defects and reduced the reflectivity. A blue shift of ∼213 nm was achieved in an NPC ( φ = 0.23) fabricated by 170 nm of PS@V-SiO 2 nanospheres, accompanied by a color gradient from red to blue. Comparisons across SiO 2 -poly(ethylene glycol) diacrylate (PEGDA, n PEGDA = 1.45), SiO 2 -PEGPEA, and PS@V-SiO 2 -PEGDA NPC systems highlighted the key role of interfacial scattering, which is affected by the synergistic effects of interfacial covalent polymerization, refractive index matching between the elastomer matrix and nanospheres, and the crosslinking density. This work demonstrates spectrally tunable mechanochromism via size control and patterned anti-counterfeiting labels, thereby providing insights for designing advanced anti-counterfeiting materials applicable in flexible electronics and displays.
The alternative text for this image may have been generated using AI.
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Nature Catalysis
·
2026
·
IF 48.3
Gao Pengyu,Li Xuyao,Zhang De,Li Junjian,Zhong Li,Liu Min,Franke Carlo,Gao Zongyan,Zhou Lina,Wei Guangfeng,Li Tong,Liu Hao,Cheng Yongxin,Zhang Lihan,Yan Pengfei,Shi Zhan,Liu Tao
Incorporating light non-metallic elements into compositionally complex alloy (CCA) electrocatalysts can potentially overcome the activity–stability trade-off challenge. However, practical realization of this potential is limited by the lack of a generic method to incorporate multiple types of non-metal into single-phase CCAs. Here we present a facile solvothermal strategy enabling the incorporation of fluorine, boron and nitrogen into the interstitial sites of Pt-based CCAs. Mechanistic investigations unravel three decisive factors for the synthesis: prior formation of Pt clusters catalysing 3d-transition-metal reduction, coordination and activation of non-metal precursors by 3d-transition-metal ions, and rational selection of non-metal-containing functional groups. This methodology yields a library of non-metal-hybridized interstitial CCAs with tuneable compositions. Notably, selected Pt-based CCAs demonstrate exceptional performance as oxygen reduction electrocatalysts for fuel cells, with outstanding activity and durability surpassing state-of-the-art benchmarks. These non-metal-hybridized interstitial CCAs offer a promising platform for tackling demanding electrocatalytic processes involving complex tandem reaction steps. The alternative text for this image may have been generated using AI.
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Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·375
·
IF 38.5
Liu Quanxi,Wang Yousheng,Ma Qiaoyan,Zheng Jianzha,Peng Yinghui,Wang Liwei,Chen Zeyu,Du Tianhao,Xiao Daxin,Fan Jiandong,Hahn Yoon-Bong,Mai Yaohua
Perovskite indoor photovoltaics (PIPVs) present great potential for powering Internet-of-Things (IoT)-integrated portable and low-power-consumption wireless electronics, owing to their theoretically high indoor power conversion efficiency (PCE(i)) under natural/artificial lighting conditions. Under low-light irradiance, suppressing shunting paths in PIPVs are of paramount importance to minimize interface defects induced losses in open-circuit voltage ( V oc ) and fill factor (FF). In this work, we propose a dual insulator contact (DIC) strategy that synergistically mitigates nonradiative recombination and shunting losses: (i) a grain boundary insulator contact (GIC) using insulating polymer poly(methyl methacrylate) (PMMA) to passivate grain boundary defects and (ii) a buried interface insulator contact (BIC) employing a hybrid PMMA/mesoporous alumina ultrathin composite interlayer to reduce heterointerface defects at the perovskite/hole transport layer junction. Leveraging this DIC approach, wide-band gap (WBG)-PIPVs achieve a PCE(i) of 44.36% (a power output of 127.94 µW cm −2 ) with a high V oc of 1.091 V and FF of 83.97% under a light-emitting diode (LED) (1000 lx, 288.4 µW cm −2 , and 2950 K). Remarkably, the devices under LED illumination remain high indoor performance with small V oc and FF deficits even under lower irradiance, delivering PCEs(i) of 43.08% ( V oc of 1.064 V and FF of 84.52%) at 600 lx, 40.24% ( V oc of 1.050 V and FF of 82.97%) at 400 lx, and 40.94% ( V oc of 1.020 V and FF of 82.83%) at 200 lx. The unencapsulated WBG-PIPVs also exhibit robust operational stability under continuous maximum power point tracking in under ambient LED lighting conditions, underscoring their practicality for IoT applications. The alternative text for this image may have been generated using AI.
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高影响因子
CHEMICAL PAPERS
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2026
·
IF 2.7
Hu Zhijun,Zhang Juntao,Wei Benmei,Li Sheng,Long Yangke
Porous carbon derived from waste biomass exhibits significant potential for removing environmental contaminants due to its adsorptive properties. However, a structural trade-off exists between achieving the high porosity necessary for optimal adsorption capacity and the high energy consumption with equipment corrosion resulting from the pore-forming process. In this study, a novel strategy based on a free-radical-assisted hydrothermal process was presented for synthesizing porous biochar. Peroxymonosulfate (PMS) serves as the free radical source, enabling controlled oxidation of corn stalk pith during a straightforward hydrothermal pretreatment at 120 °C, followed by carbonization at 700 °C to form internal pores. This innovative approach enhanced the sulfamethoxazole (SMX) adsorption capacity by approximately threefold, from 43.37 mg/g to 130.22 mg/g. Although the PMS-pretreated porous biochar surface displayed superhydrophilic properties due to carboxyl group modification, results analyses indicate that SMX adsorption is primarily driven by π–π conjugation, hydrophobic interactions, and hydrogen bonding, relying on specific surface area rather than electrostatic interactions. This study presents a beneficial attempt at a free-radical-based pretreatment for the straightforward and robust synthesis of porous biochar. Graphical abstract The alternative text for this image may have been generated using AI.
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高影响因子
npj Science of Food
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2026
·
IF 9.7
Zhang Yuyu,Wang Da,Wang Chuhan,Li Yiju,Pang Jingxi,Liu Xuebo,Liu Zhigang,Yuan Tian
Diabetic kidney disease (DKD) is a major diabetes complication lacking effective dietary therapies. While amino-acid-targeted diets modulate metabolic health, their impact on renal outcomes via gut microbiota-derived metabolites remains unclear. Here, we investigated whether a 13-week methionine-restricted (MR) diet improves renal outcomes in db/db mice and alters gut-derived short-chain fatty acids (SCFAs) and their receptors. MR improved renal function and histopathology, restored colonic barrier markers (Claudin-1, ZO-1, MUC2), and reduced circulating endotoxin (LPS). 16S rRNA profiling revealed MR-induced gut microbiota remodeling, enriching SCFA-producing taxa like Clostridium spp. This coincided with increased fecal propionate and restored colonic propionate receptor GPR41 expression. Furthermore, fecal propionate and its associated taxa correlated positively with barrier integrity and negatively with systemic LPS, renal TLR4/JNK activation, inflammation, and oxidative stress. Collectively, MR confers renoprotection in db/db mice by modulating the gut–kidney axis via microbiota remodeling and enhanced propionate-GPR41 signaling, highlighting MR as a promising nutritional strategy for DKD management. The alternative text for this image may have been generated using AI.
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PubMed
高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 6
·401
·
IF 5.4
Zhang Xiaohui,Yang Shuai,Pan Lifei,Zhong Jiapeng,Chen Pengsheng,Zhai Haiyun
A dual-emission, ratiometric fluorescence sensor is reported based on a europium(III)-doped metal-organic framework (Eu/DUT-52) that exhibits blue emission from DUT-52 and red emission from Eu³⁺. Notably, we fond that aflatoxin B1 (AFB1) enhances the fluorescence intensity of DUT-52, whereas the Eu³⁺ emission remains essentially unchanged, enabling ratiometric detection with a concentration-dependent color change from pink to purple. We further investigated the origin of this fluorescence enhancement. The ratiometric response provides a detection limit of 3.9 ng mL⁻¹. For field deployment, Eu/DUT-52 was embedded in a hydrogel to form a simple assay kit, and AFB1 was quantified by smartphone-based RGB analysis of fluorescence images, enabling instrument-free readout with a detection limit of 0.04 µg mL⁻¹. The hydrogel sensor shows good selectivity against other mycotoxins and common metal ions with recoveries of 80.59–111.7% in real samples. This work provides a low-cost, recognition-element-free platform for rapid, on-site screening of AFB1. Graphical abstract The alternative text for this image may have been generated using AI.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·Vol. 24
·期 1
·382
·
IF 15
Jiang Zhou,Li Yuning
Lung cancer (LC) remains a leading cause of cancer-related mortality worldwide, and the limited efficacy of immunotherapy due to treatment resistance underscores the urgent need for new therapeutic strategies. In the present study, CD93-targeted poly(lactic-co-glycolic acid) (PLGA) nanoparticles encapsulating resveratrol (CD93-NPs@RSV) were developed to remodel the metabolic fitness of CD8 + tumor-infiltrating lymphocytes. The nanoparticles were precisely engineered and characterized using dynamic light scattering, transmission electron microscopy, and in vivo imaging, which confirmed their stability and tumor-targeting capability. Mechanistic studies revealed that CD93-NPs@RSV suppressed CD93 expression, facilitated apoptosis-inducing factor (AIF) mitochondrial translocation, and activated oxidative phosphorylation (OXPHOS), thereby enhancing T cell function in the tumor microenvironment. Transcriptomic and proteomic analyses further confirmed regulation of the CD93-AKT-PAK5-AIF signaling axis. In a Lewis LC model, CD93-NPs@RSV significantly inhibited tumor progression and displayed strong synergy with anti-PD-1 therapy, resulting in improved survival outcomes. Collectively, our study demonstrates that CD93-NPs@RSV provide a powerful nanotechnology-driven approach to reverse immunotherapy resistance by reprogramming T cell metabolism. These findings establish a promising paradigm for precision cancer immunotherapy and underscore the translational potential of targeted nanomedicine in overcoming therapeutic bottlenecks in LC. Graphical abstract The alternative text for this image may have been generated using AI.
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Journal of Central South University
·
2026
·Vol. 32
·期 11
·4248-4259
·
IF 4.4
Wang Jia-yi,Liu Xin-li,Wu Zhuang-zhi,Wang De-zhi
Eco-friendly electrocatalytic nitrogen reduction reaction (NRR) is aimed to replace the traditional polluting industrial process, but NRR needs electrocatalysts with high selectivity and activity to boost desired NH 3 yield rate and Faradic efficiency (FE). In this work, high-entropy sulfides (HES) (FeCoNiMoM)S x (M=Cr, Cu, Mn) were synthesized via a two-step solvothermal method. The optimized composition for HES is (FeCoNiMoCr)S x , with promising NRR performance that NH 3 yield rate reached 47.97 µg/(h·mg cat ) at −0.7 V vs RHE and FE was 26.1% at −0.4 V vs RHE. Comprehensive characterization and electrochemical testing were performed to investigate the effects of the metal component on NRR performance. It reveals that (FeCoNiMoCr)S x shows more intense charge transport, more electrocatalytic active sites, higher selectivity, etc, resulting from the electron transport and element synergy of HES. Also, it is proved to have targeted NRR selectivity and limiting competitive hydrogen evolution reaction. The results offer promising guidance for further improving the NRR electrocatalysts based on transition elements.
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