Advanced Healthcare Materials
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2021
·Vol. 11
·期 3
·2102042
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IF 9.933
Zheng Liu,Baofeng Yun,Yaobao Han,Zhilin Jiang,Hongqin Zhu,Feng Ren,Zhen Li
As the primary malignant tumor in the brain, glioblastoma exhibits a high mortality due to the challenges for complete treatment by conventional therapeutic methods. It is of great importance to develop innovative therapeutic agents and methods for treatment of glioblastoma. In this work, the imaging and therapy of glioblastoma are reported by using dye sensitized core-shell NaYF 4 :Yb/Tm@NaYF 4 :Nd nanoparticles with strong up/down-conversion luminescence, of which the ultraviolet up-conversion emissions at 348 and 365 nm are significantly enhanced by nearly 28 times and used to control the release of SO 2 from 5-Amino-1,3-dihydrobenzo[c]thiophene 2,2-dioxide prodrug for gas therapy, and the second near-infrared (NIR-II) down conversion emission at 1340 nm is increased five times and applied for imaging. It is revealed that the released SO 2 molecules not only cause oxidative stress damage of tumor cells, but also induce their pro-death autophagy by down-regulating the expression of p62 and up-regulating the ratio of LC3-II/LC3-I, ultimately inhibiting tumor growth. The work demonstrates the great potential of rare earth nano-platform with functions of NIR-II imaging and photo-controlled gas therapy in the diagnosis and treatment of orthotopic glioblastoma.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2021
·
IF 6.953
Wenkun Zhang,Ting Huang,Yu Ren,Yilei Wang,Ruijin Yu,Jinyi Wang,Qin Tu
Chitosan crosslinked with metal-organic framework (MOF-199)@aminated graphene oxide aerogel (MOF-199@AFGO/CS) were prepared to adsorb formaldehyde and methyl orange. The prepared MOF-199@AFGO/CS aerogel was well characterized via SEM, EDX , FT-IR, XRD and XPS to reveal the microstructure and composition. Besides, the mechanical property and the stability of MOF-199@AFGO/CS aerogel were investigated. The results showed that MOF-199@AFGO/CS aerogel had good stability in water, compression resilience and thermostability . The study on the ability to adsorb formaldehyde gas and methyl orange showed that the adsorption capacity of MOF-199@AFGO/CS aerogel was related to the pore size and the surface functional groups of MOF-199@AFGO/CS aerogel. When the pore size is moderate, as the amino group and MOF-199 on the aerogel increased, the adsorption capacity of formaldehyde gas (197.89 mg/g) and methyl orange (412 mg/g) can reach the maximum. Furthermore, the adsorption process at equilibrium followed the Freundlich isotherm model. The kinetic behavior was well fitted by the pseudo-second-order model, indicating chemisorption as the rate-determining step. This work can provide a reliable basis for the adsorbent to remove pollutants in different forms at the same time, and has potential application in simultaneously adsorbing liquid pollutants and gas pollutants.
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JOURNAL OF CHROMATOGRAPHY A
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2021
·
IF 4.759
Jinqiu Li,Bin Zhao,Liying Guo,Zhuo Wang,Chun Wang,Zhi Wang,Shuaihua Zhang,Qiuhua Wu
Three novel hypercrosslinked polymers (HCPs) were synthesized via Friedel-Crafts reaction employing 1,3,5-tris(bromomethyl)-2,4,6-trimethylbenzene as alkylating agent, and triphenylbenzene, tetraphenylethylene and p -quaterphenyl as the aromatic units, respectively. The prepared HCPs were applied as solid-phase microextraction coatings for direct immersion extraction of polycyclic aromatic hydrocarbons (PAHs) and their oxygenated and nitrated derivatives in environmental water samples. The key factors affecting the extraction efficiency including extraction time, extraction temperature, stirring rate, ionic strength and desorption conditions, were carefully studied. Coupled with gas chromatography mass spectrometry analysis, a new method for determining PAHs and their derivatives was developed. Under the optimized conditions, the limits of detection ( S/N =3) and limits of quantitation (the lowest concentration for quantification) of the method were in the range of 2.5-25.0 and 7.5-75.0 ng L −1 , respectively. The recoveries of spiked samples were in the range of 73.1-118.3% with relative standard deviations less than 13.0%. The developed method was applied for the simultaneous determination of nine PAHs and their derivatives in environmental water samples, showing good accuracy and reliability.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2021
·
IF 5.302
Dehua Liang,Jiguang Huang,Yuntao Zhang,Zheng Zhang,Haiping Chen,Heng Zhang
In this paper, in order to reduce the preparation cost of high-performance ceramic membrane , coal fly ash-based tubular ceramic membrane for flue gas moisture recovery was prepared, and its properties were optimized from two aspects: pore-forming agent (dextrin) content and sintering temperature . The results show that the ceramic membrane with dextrin content of 3 wt.% and sintering temperature of 1150 ℃ has the best performance. Through characterization, the ceramic membrane exhibits an open porosity of 42.0 %, mechanical strength of 26.6 MPa, average pore size of 0.49 μm, pure water flux of 5616 L/(m 2 barh). And, it has excellent corrosion resistance in acid and alkali. In addition, the flue gas moisture recovery performance of coal fly ash-based tubular ceramic membrane was studied experimentally. The highest water recovery ratio and the highest recovered water flux is 87.7 % and 6.01 kg/(m 2 h, respectively.
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RENEWABLE ENERGY
·
2021
·
IF 8.001
Wenchao Wang,Huili Liu,Fashe Li,Hua Wang,Xin Ma,Jingjing Li,Li Zhou,Quan Xiao
To explore the trend of fatty acid methyl esters (FAMEs) during the oxidation process of biodiesel , this study uses gas chromatography - mass spectrometry (GC-MS) combined with information entropy theory to propose a new method to analyze the effect of FAMEs on the stability of biodiesel (especially with different amounts of unsaturated FAMEs). The induction periods of the main FAMEs in biodiesel were determined by the Rancimat method. The results showed that the longest induction period of methyl stearate was 248 h, while the induction of methyl linoleate was only 0.12 h. Accelerated oxidation of biodiesel, using GC-MS analysis showed that the oxidation trends of FAMEs was different. The oxidation rate of methyl linoleate was the fastest. A mathematical equation was proposed to calculate the trend of FAMEs. The results showed that during the 5 h accelerated an oxidation process, the content of methyl linoleate decreased from 28.35% to 2.10%, while the content of methyl oleate decreased by 18.21%. Using information entropy, the weighting coefficients of FAMEs in the oxidation process of biodiesel were calculated. The weighting coefficient of methyl linoleate was as high as 0.6797. Methyl linoleate was the main reason why biodiesel was easily oxidized.
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ACS Sensors
·
2020
·
IF 7.333
Jiaming Chen,Longhua Guo,Lifen Chen,Bin Qiu,Guolin Hong,Zhenyu Lin
Mostly, surface-enhanced Raman scattering (SERS) sensors used the Raman characteristic bands concentrated in the Raman “fingerprint” region (500–1800 cm–1), which may result in spectral overlapping interference. The study of the response in the Raman-silent region (10–500 and 1800–2800 cm–1) can help overcome this problem. Hydrogen sulfide (H2S) gas causes a great threat to human’s health, but its low concentration in the airborne species is a challenge for sensitive and selective detection. Herein, a novel low-wavenumber (10–500 cm–1) SERS sensor for H2S gas detection has been developed based on gold nano-bipyramids (Au NBPs) encapsulated by zeolitic imidazolate framework-8 (ZIF-8) (Au NBPs@ZIF-8). The sensor takes advantage of the high adsorption capacity of ZIF-8 toward H2S gas and the H2S-triggered SERS spectral changes in the low-wavenumber Raman-silent region. A clear SERS peak of Au–Br at ∼175 cm–1 generated from Au NBPs@ZIF-8 showed a decrease in the presence of H2S because of the competition of adsorption sites between Au–S and Au–Br bonds. Furthermore, Au NBPs@ZIF-8 can enrich and monitor the level of H2S gas with high efficiency and low interference. The developed sensor has a detection range of 0.2 nM to 20 mM with a limit of detection (LOD) of 0.17 nM. The developed sensor had been applied to detect the H2S gas released from the spoiled fish meat with high selectivity.
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NANOTECHNOLOGY
·
2020
·Vol. 31
·期 21
·215601
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IF 3.551
Dongming Zhang,Mingpeng Chen,Haiyuan Zou,Yumin Zhang,Jicu Hu,Huapeng Wang,Baoye Zi,Jin Zhang,Zhongqi Zhu,Lele Duan,Qingju Liu
To address the urgent issues of hazardous gas detection and the prevention of environmental pollution, various functional materials for gas sensing and catalytic reduction have been studied. Specifically, the p-type perovskite LaFeO3 has been studied widely because of its promising physicochemical properties. However, there remains several problems to develop a controllable synthesis of LaFeO3-based p-n heterojunctions. In this work, α-Fe2O3 was further compounded with LaFeO3 to form a porous and hollow α-Fe2O3/LaFeO3 heterojunction to improve its gas-sensing performance and photocatalytic efficiency via a microwave-assisted hydrothermal method. While evaluated as sensors of acetone gas, the optimized sample exhibits excellent performance, including a high response (48.3), excellent selectivity, good reversibility, fast response, and recovery ability. Furthermore, it is an efficient catalyst for the degradation of methylene blue. This can be attributed to the enhancement effect of its larger specific surface area, fast diffusion, enhanced surface activities, and p-n heterojunction. Additionally, this work provides a rapid and rational synthesis strategy to produce metal oxides with both enhanced gas-sensing performance and improved photocatalytic properties.
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CERAMICS INTERNATIONAL
·
2020
·
IF 3.83
Yuli Zhou,Jian Wang,Xinkang Li
Flexible chemiresistor-type sensor based on chemically sensitive oxide semiconductors is of great potential for wearable sensing field. It is still challenging in designing sensing materials with high electron mobility for the enhancement of sensitivity and developing flexible chemical sensors with high durability for commercial applications. Herein, we introduce that poly (para-phenylene terephthalamide) fibers, which are currently employed as substrate to support the composite NiO@CuO metal oxide semiconductors. The poly (para-phenylene terephthalamide)-NiO@CuO gas sensor exhibits excellent thermostability, with rarely changing in mass observed up to 450 °C of high temperature testing. Furthermore, a relatively low limit of detection of 46.5 ppb for NH 3 is achieved at room temperature. The gas sensing mechanism of the sensing materials is interpreted via the electron-mobility-dominating gas sensing mode, in which the hole density is directly influenced via the electrons transferring between gas molecules and sensing materials. These results of the chemical gas sensor provide great promising for developing sensing materials with highly sensitivity and unlock the potential for newly-designed flexible chemiresistor-type sensor in the field of wearable sensing applications.
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Food Science and Technology
·
2020
·Vol. 40
·期 4
·786-793
·
IF 1.443
YANG Yi-Ni,LIANG Miao,YANG Yan,ZHENG Fu-Ping,WANG Xing-Ping,YU Ai-Nong
This study optimized using a headspace solid-phase microextraction (HS-SPME) method for extracting volatile aroma compounds, terpenoids in particular, from Litsea mollis Hemsl. immature fruit (LMIF). Gas chromatography-mass spectrometry was used to separate and identify volatile terpenoids in LMIF. The types of SPME fiber coating, salt addition, and desorption time were optimized by single factor-experiments to determine the range of extraction temperature. Built on insights from the single factor-experiments, the response surface methodology was further used to optimize the extraction temperature, extraction time, and equilibrium time of HS-SPME. The results showed that the optimal HS-SPME conditions for extracting volatile terpenoids from LMIF were: 50/30 μm of DVB/CAR/PDMS SPME fiber, 2.0 g of added sodium chloride, desorption at a temperature of 250 °C for 3 min, extraction and equilibrium temperature of 46 °C, extraction time of 36 min, and equilibrium time of 20 min. Under the above conditions, the predicted value of extraction was 66.92, while the experimental value was 65.78. The prediction value matched well with the experimental value with good repeatability. The designed model was proven to be valid, which can be applied for future extraction of aroma compounds from IMIF.
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JOURNAL OF CHROMATOGRAPHY A
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2019
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IF 3.858
Xue Xiong,Meiling Qi
This work presents the investigation of utilizing adenine-functionalized polypropylene glycol (APPG) for capillary gas chromatographic separations. The statically coated APPG column (0.25 mm i.d.) showed moderate polarity and high column efficiencies of 4660 plates/m and 4376 plates/m determined by n -octanol and naphthalene, respectively. Remarkably, the APPG column baseline resolved all the components of the Grob test mixture and displayed good peak shapes for some stringent analytes that are prone to peak tailing or severe adsorption. Also, it achieved complete separation of dimethylaniline isomers, which are difficult to be resolved due to their high resemblance in structures and properties. The above results demonstrate the high selectivity and inertness of the APPG column and its distinct advantages over the polypropylene glycol (PPG) column and commercial polyethylene glycol (PEG) column. In addition, its separation performance has good repeatability with the RSD values on retention times below 0.05% for run-to-run, 0.11–0.12% for day-to-day and 1.7–1.9% for column-to-column, respectively. Further, the APPG column was applied to determination of isomer impurities in commercial dimethylaniline products and to determination of the additives of anilines and phenols in a hair-dye product, proving its great potential for practical GC analysis.
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Royal Society Open Science
·
2019
·Vol. 6
·期 12
·
IF 2.515
Yan Wang,Hui-qiang Li,Li-ming Ren
The electro-Fenton (EF) process was applied to treat mother liquor of gas field wastewater (ML-GFW). The Fe-Fe electrodes were used and H2O2 was added to the EF system. Effect of initial pH on chemical oxygen demand (COD) removal efficiency, specific electrical energy consumption (SEEC), specific electrode plate consumption (SEPC) and organic matter removal mechanism was investigated. The results showed that COD removal efficiency reached the maximum (71.9%) at initial pH of 3 after reaction for 3 h. Besides, considering with the SEEC and SEPC, pH of 3 was also the best choice, at which SEEC was 4.7 kW h kgCOD−1, SEPC was 0.82 kgFe kgCOD−1. Organic matter removal was achieved by two ways: oxidation and flocculation, and oxidation played a major role. With the analysis of GC-MS, the possible degradation pathways of the representative contaminants in the ML-GFW were given.
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JOURNAL OF PHARMACEUTICAL SCIENCES
·
2023
·
IF 3.8
Wanbing Rao,Lijun Li,Yuting Liu,Chenxia Zhang,Xiaofang Wei,Zeyi Wu,Meiyan Qiu,Shuming Wu,Chunhui Qi,Jinfu Zheng,Shaoyu Cai,Zhongqing Wang
During the development of headspace gas chromatography (HSGC) method for assessing residual solvents in rosuvastatin calcium (RSV) drug substance, acetaldehyde (AA) was detected in obtained chromatograms, with a calculated concentration of up to 226 ppm. After a series of experiments, it was established that acetaldehyde originates from matrix interference due to direct degradation of Imp-C, which is accompanied by the formation of impurity at relative retention time (RRT) 2.18, without the involvement of impurity at RRT 2.31. The thermal instability of Imp-C also results in the formation of impurity at RRT 2.31 through dehydration and decarboxylation. In addition, cyclization reaction of degradant at RRT 2.18 further resulted in the generation of impurity at RRT 2.22. The structure of these three degradants, were confirmed by liquid chromatography-mass spectrometry (LC-MS), 1D and 2D nuclear magnetic resonance (NMR) measurement. In order to minimize the said matrix interference, a simple precipitation procedure was proposed as a pretreatment to mitigate the impact of Imp-C. Subsequently, an HSGC method was developed for the simultaneous determination of the degradant AA and the other five residual solvents used in RSV synthetic process. The final method was validated concerning precision, limit of detection (LOD) and limit of quantitation (LOQ), linearity, and accuracy.
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