Frontiers in Bioscience-Landmark
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2026
·Vol. 31
·期 3
·
IF 4.1
Shanshan Zhu,Jiayi Li,Yao Lu,Cheng Sun,Yushan Zou,Yujie Wang,Siqi Wu,Jin Yao,Wen Bai
Background:Dendrobium spp. has traditionally been used to improve visual function, and related formulations, such as Dendrobium Glow in dark pills, are currently used in the management of dry eye disease (DED). This study investigated the positive effects and underlying mechanisms of 3-O-methylgigantol, an active compound from Dendrobium spp., against DED using network pharmacology and in vitro experimental validation.Methods:Active compounds and targets were identified through database screening, and network analysis was used to identify the key compounds and targets. Molecular docking and dynamic simulations were performed to verify the binding of 3-O-methylgigantol to the epidermal growth factor receptor (EGFR). An in vitro DED model was established using hyperosmotic sodium chloride (550 mOsm) in human corneal epithelial cells (HCECs). The effects of 3-O-methylgigantol, with or without the EGFR inhibitor (erlotinib), on cell viability, apoptosis, reactive oxygen species, and inflammatory cytokines were assessed.Results:Network pharmacology predicted 3-O-methylgigantol as a key active compound and EGFR as a core target. Molecular simulations confirmed stable binding. In vitro experiments showed that 3-O-methylgigantol significantly increased HCEC viability and reduced apoptosis, reactive oxygen species accumulation, and inflammatory cytokine release under hyperosmotic conditions. The EGFR inhibitor erlotinib attenuated these protective effects.Conclusions:3-O-methylgigantol, an active compound from Dendrobium spp., alleviates hyperosmolarity-induced corneal epithelial cell damage, oxidative stress, and inflammation by activating the EGFR signaling pathway. This compound may represent a potential therapeutic candidate for DED management, demonstrating its efficacy in restoring tear film homeostasis in in vitro models.
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CERAMICS INTERNATIONAL
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2026
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IF 6
Wenjie Huang,Yuqin Zhang,Wenda Hua,Zengdong Meng,Lilin Luo
This study aimed to develop 45S5 bioglass/hydroxyapatite (BG/HA) composite scaffolds with high porosity, excellent biodegradability, and osteoblast responsiveness for bone defect repair. The scaffolds containing 0, 10, 20, 30, and 40 wt% BG were fabricated using a combination of space-holder, cold pressing and spark plasma sintering techniques. Physicochemical characterization, mechanical properties, and in vitro osteogenic and angiogenic potentials were systematically investigated. The results showed that, compared to HA scaffolds, the composite scaffolds exhibited an increase in porosity from 67% to 75% and macropore (>300 μm) content from 40% to 74%. When the scaffold containing 30 wt.% BG outperformed the others while maintaining adequate mechanical strength. And its 12-week degradation rate was 26.48% versus 5.90% for the HA scaffold. Moreover, the weight gain of the scaffold due to apatite formation increased by approximately 7.89-fold after a 7-day immersion period. In vitro, BG supplementation made cell viability exceed 83% and enhanced the adhesion of MC3T3 cells ( p<0.05 ). Additionally, BG promoted osteogenic differentiation, evidenced by higher expression of osteoblast-specific genes and proteins (Runx2, Col I, OPN and OCN), increased alkaline phosphatase activity and elevated calcium mineralization levels ( p < 0.0001). Furthermore, angiogenesis-related parameters were more desirable in the composite scaffold group. Fundamentally, these effects primarily result from BG altering the physicochemical properties, which modulates the release of bioactive ions, including silicon, calcium and phosphate, thereby driving cellular responses through cascade reactions. These findings suggest that BG/HA composite scaffolds possess consistent high porosity and superior biochemical characteristics, demonstrating significant potential for clinical development and application.
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DESALINATION
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2026
·
IF 9.9
Yubin Zhang,Chen Li,Chenchang Liu,Mengmeng Lou,Shengyang Zheng,Lijun Meng,Manhong Huang
Membrane distillation (MD), a novel membrane separation technology, exhibits advantages in treating high-salinity wastewater. However, membrane wetting caused by surfactants remains a major challenge for the large-scale application of MD. Nanoplastics (NPs) commonly coexist with surfactants such as sodium dodecyl sulfate (SDS) in high-salinity industrial wastewater. Their interactions can lead to the formation of nanoplastic-surfactant complexes, thereby altering membrane wetting behavior during MD operation. Herein, we proposed an air-liquid interfacial deposition strategy to fabricate a Janus membrane with high anti-wetting performance. A dense metal-phenolic network hydrophilic layer was constructed on a hydrophobic PVDF substrate via tannic-Fe 3+ co-deposition, followed by polyethyleneimine (PEI) cross-linking. The as-prepared membrane exhibited superior anti-wetting performance in the treatment of high-salinity water containing SDS@NPs complex with stable normalized flux and ∼ 100% NPs rejection. Notably, the coexistence of NPs significantly mitigated membrane wetting, mainly attributed to the adsorption of SDS on NPs, which reduced the concentration of free SDS in feed solution. The effects of the size and surface charge of NPs were investigated. Moreover, the interactions between the membrane and SDS@NPs were calculated using the XDLVO theory to elucidate the mechanisms underlying the enhanced anti-wetting performance. This study provides a promising approach for the fabrication of high-performance Janus membranes and unveils the anti-wetting mechanism of Janus membranes induced by nanoplastic-surfactant complexes.
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JOURNAL OF POWER SOURCES
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2026
·
IF 8.4
Tianlong Huang,Zhen Mu,Yuanxiang Zhang,Xiaoxiao Wang,Maosheng Cui,Guoqiang Hu,Lingxiu Chen,Yang Zhang,Xiaolan Xue
Magnesium-metal organic batteries (MMOBs) combine high charge-storage capacity with resource abundance and favorable material economics. However, their application is limited by dissolved organic shuttle and separator issues, including thick, costly glass fiber (GF) separators and poor coating adhesion on commercial separators. Herein, we report a rationally designed ZIF-67@polypropylene (PP) separator, fabricated via a robust in situ nucleation strategy that yields a dense, binder-free, and conformal MOF layer on both faces of a commercial substrate. Compared with conventional coating, this in situ modification strategy not only suppresses shuttle and improves wettability, but also strengthens interfacial bonding, enhancing mechanical robustness and durability. Benefiting from well-defined pores, ZIF-67 acts as an ion sieve that effectively suppresses anthraquinone (AQ) dissolution/shuttle while facilitating Mg 2+ transport and accelerating redox kinetics. Consequently, symmetric Mg||Mg cells employing this modified separator deliver an extended lifespan exceeding 1300 h with a mere ∼90 mV overpotential at 0.05 mA cm −2 . More impressively, Mg||AQ full cells demonstrate exceptional durability, retaining a reversible capacity of 94.5 mAh g −1 after 250 cycles at 0.1 A g −1 . This work highlights the critical role of in-situ separator modification in unlocking the full potential of sustainable MMOBs.
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APPLIED CATALYSIS A-GENERAL
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2026
·
IF 4.8
Linlin Wang,Bingjie Liu,Meng Liu,Jikun Li,Jinglei De,Yangchuan Ke
A BiOCl/ZIS heterojunction was constructed by ultrasound-assisted assembly. • Interfacial coupling induced directional redistribution of photocarriers. • 3-BZ efficiently degraded concentrated RhB, CR, and TC under visible light. • 3-BZ achieved efficient photocatalytic H₂O₂ production under visible light. • In situ XPS and DFT supported type-II electron transfer from ZIS to BiOCl. An ultrasound-assisted assembly route was used to construct a BiOCl/Zn₃In₂S₆ (ZIS) heterojunction for visible-light-driven pollutant degradation and H₂O₂ production. After 120 min of irradiation, the optimized composite degraded 99.59% of Rhodamine B (RhB, 600 mg/L), 99.82% of Congo red (CR, 200 mg/L), and 83.50% of Tetracycline (TC, 80 mg/L). In a separate O₂-saturated medium containing 10 vol% isopropanol, the H₂O₂ yield reached 5644 μmol g⁻¹ over the same period. In situ irradiated X-ray photoelectron spectroscopy showed that Bi 4 f, Cl 2p, and O 1 s shifted toward lower binding energies, whereas the ZIS-associated core levels shifted toward higher binding energies. These opposite changes indicate photoelectron enrichment in BiOCl and electron depletion in ZIS. Density functional theory calculations revealed a larger work function for BiOCl (6.72 eV) than for ZIS (5.33 eV), while the differential charge density confirmed interfacial electron redistribution. Together with the density-of-states and experimental band-edge results, these findings support a type-II pathway in which electrons migrate from the ZIS conduction band (CB) to the BiOCl CB, while holes transfer from the BiOCl valence band (VB) to the ZIS VB. The resulting carrier separation favors O₂ reduction toward H₂O₂ formation and promotes oxidative pollutant degradation. Download: Download high-res image (225KB) Download: Download full-size image
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Jiwei Xie,Zhenggang Jia,Mingfang Qian,Xuexi Zhang,Lin Geng
Aqueous zinc-ion batteries (AZIBs) suffer from interfacial instability mainly due to the inherent electrochemical incompatibility between zinc anodes and aqueous electrolytes. Herein, we report aluminum lactate (Al-Lac) as an effective electrolyte additive that stabilizes zinc anodes via comprehensive solvation structure regulation. Al-Lac competitively coordinates with water molecules via Al 3+ and lactate ions, disrupting the original [Zn(H 2 O) 6 ] 2+ solvation sheath, reducing water activity, and suppressing hydrogen evolution. Furthermore, Al 3+ preferentially adsorbs onto the Zn surface under an electric field, establishing a protective electrostatic shield that guides uniform Zn 2+ deposition. As a result, the nucleation overpotential of Zn 2+ is significantly reduced, Zn deposition is oriented preferentially along the (002) plane, and dendrite growth is effectively inhibited. Consequently, the introduction of Al-Lac effectively enhances the interfacial reaction kinetics during Zn deposition and maintains the interfacial impedance. The corresponding Zn||Zn symmetric cells achieve an ultra-long lifespan of 5000 h (2 mA cm −2 , 1 mAh cm −2 ), and full-cells with Na 2 V 6 O 16 ·2.74H 2 O cathodes exhibit negligible capacity decay after 2000 cycles at 10 A g −1 . This work provides a feasible strategy for the development of low-cost and high-stability AZIBs. Aluminum lactate regulates the competitive solvation structure and builds an electrostatic shield, enabling (002)-textured zinc deposition and long lifespan for aqueous zinc-ion batteries. Download: Download high-res image (155KB) Download: Download full-size image
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2026
·Vol. 27
·期 8
·3381
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IF 5.6
Guanyang Chen,Shiting Li,Peng Bai
The safe and precise regulation of therapeutic gene expression remains a major challenge for mammalian synthetic biology and cell-based therapies. Many existing inducible systems rely on non-mammalian regulatory components or ligands with limited clinical compatibility. Designer receptors exclusively activated by designer drugs (DREADDs) offer a human G protein-coupled receptor (GPCR)-based framework for pharmacological control of intracellular signaling, yet their application as clinically relevant gene-regulation platforms remains underexplored. Here, we report a clozapine-responsive gene switch that couples a designer GPCR to signaling-dependent transcriptional control. By linking clozapine-activated receptors to cyclic adenosine monophosphate (cAMP)- or calcium-responsive synthetic promoters, receptor activation is converted into robust transgene expression across a broad dynamic range, with sensitivity to sub-nanomolar to low-nanomolar clozapine concentrations. In vivo, alginate-encapsulated reporter cells implanted in C57BL/6J mice responded to systemic or local clozapine administration with efficient secretion of a reporter protein, achieving robust induction at low daily doses (0.3 mg/kg) following either oral administration or local delivery. Together, these results establish a human GPCR-based clozapine-responsive gene switch that integrates regulation by a clinically used small molecule with modular transcriptional outputs, providing an additional approach for pharmacologically controllable gene expression in mammalian cells and in vivo.
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Chemistry-An Asian Journal
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2026
·Vol. 21
·期 6
·e70700
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IF 3.2
Mingxia Zhang,Ting Wang,Yurong Wang,Yongjian Cui,Huaping Wang,Junze Liu,Hailong Wang
Silicon (Si) anodes are promising candidates for surpassing the energy density limits of current lithium‑ion batteries, owing to the ultra‑high theoretical capacity (4200 mAh g −1 ). However, their practical implementation is hindered by irreversible lithium (Li) loss, which originates from the continuous formation of the solid electrolyte interphase (SEI) and the irreversible trapping of Li + within the silicon matrix due to sluggish Li + diffusion kinetics. To address these issues, a Si/Ge@C heterojunction anode has been designed. In this configuration, a conformal carbon coating effectively mitigates volume expansion and suppresses parasitic reactions on the Si surface, thereby reducing excessive SEI formation. Moreover, the Si/Ge heterojunction establishes a built‑in electric field oriented from Si to Ge, which reduces Li + trapping. This built‑in electric field not only facilitates Li + migration toward Ge during lithiation but also provides an additional driving force to extract trapped Li + from Si during delithiation. Consequently, the optimized Si/Ge@C anode delivers a high initial Coulombic efficiency (ICE) of 92.47% and maintains a high capacity of 539.77 mAh g −1 over 500 cycles at 200 mA g −1 .
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Shuai Wang,Yuqi Chen,Shuyan Zheng,Yanan Yuan,Kexin Du,Min Cui,Yue Wu,Ping Li,Wei Hu,Jingui Wang,Yingshu Guo,Zexing Wu,Yanli Zhao
The incorporation of sp-hybridized nitrogen arisen from graphdiyne (GDY) into the catalyst structure significantly improves the electrocatalytic efficiency of zinc–air batteries by modulating the electronic properties of the active sites, thereby accelerating reaction kinetics and enhancing conductivity. This work highlights the efficacy of the Co–N-GDY catalyst, where sp-N moieties in GDY serving as anchoring centers for cobalt species, which demonstrates exceptional performance in the oxygen reduction reaction, achieving a half-wave potential of 0.85 V, along with high oxygen evolution reaction performance that surpasses that of commercial Pt/C + IrO2-based batteries. The Co–N-GDY catalyst also exhibits commendable cycling stability with minimal fluctuation in voltage difference, indicating its suitability for practical applications in advanced energy storage systems. These findings underscore the importance of developing cost-effective and durable M–N–C catalysts to enhance the commercial viability and sustainability of zinc–air battery technology.
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MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
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2025
·
IF 4.6
Qihu Wu,Wenchang Wang,Zhiyao Ming,Tian Fang,Denghui Tang,Minxian Wu,Pengju Wang,Shuiping Qin,Naotoshi Mitsuzaki,Zhidong Chen
In this study, Se-Sb alloy coatings were successfully fabricated for the first time via constant potential electrodeposition from a choline chloride–ethylene glycol deep eutectic solvent. The correlation between deposition potential and the morphology, composition, crystal phase, optical, and electrical properties of the coatings was systematically investigated. The results showed that as the deposition potential shifted in the negative direction, the fibrous morphology of the coatings initially became denser and subsequently looser. Correspondingly, the Se content first decreased and then increased, while the Sb content exhibited the opposite trend. The crystalline structure was primarily characterized by an amorphous Sb 2 Se 3 phase. Although both the bandgap and photocurrent response initially increased and then decreased with more negative deposition potentials, the coatings consistently exhibited excellent p-type semiconductor characteristics. Chronoamperometry (CA) analysis indicated that the nucleation mechanism of Se-Sb alloys transitioned from diffusion-controlled three-dimensional (3D) progressive nucleation to diffusion-controlled 3D instantaneous nucleation as the deposition potential shifted from −0.45 V to −0.65 V. Furthermore, cyclic voltammetry (CV) analysis revealed an induced co-deposition mechanism: Se was first deposited on the FTO substrate, which subsequently induced the co-deposition of Se and Sb to form the Se-Sb alloy coatings. Finally, a comparison with coatings annealed at 300 °C demonstrated that annealing significantly improved the crystallinity, resulting in the formation of crystalline Sb 2 Se 3 . However, the photocurrent response decreased by a factor of 5.18. These findings suggest that the as-deposited Se-Sb alloy coatings exhibit superior photoelectrical performance compared to their annealed counterparts, highlighting their promising potential for photoelectric applications.
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COMPOSITES PART B-ENGINEERING
·
2025
·
IF 14.2
Chenxiang Gao,Xiangpan Hu,Yun Huang,Xiaoyan Ma
All-solid-state lithium batteries (ASSLBs) are in the spotlight due to their superior safety and enhanced energy density. However, the inferior interface compatibility of electrolyte/electrodes and room temperature ionic conductivity hinder their practical application. Here, we innovatively utilize POSS-crosslinked high-permittivity vinylene carbonate and ionic liquids in multiscale nanocellulose membranes to in-situ solidify polymer electrolytes, achieving ASSLBs with excellent interface compatibility and ionic conductivity. Specifically, multiscale nanocellulose membranes prepared from cellulose nanocrystals and cellulose nanofibers serve as support separators, which can effectively absorb polymer precursors and facilitate lithium-ion transport through abundant hydroxyl groups and nanostructures, realizing high ionic conductivity of 1.10 × 10 −4 S cm −1 at 30 °C. Moreover, the octa-functionalized POSS further enhances the solid-solid interface by forming a highly crosslinked polymer network through in-situ polymerization with active monomers, thereby strengthening the stability of ASSLBs. The above in-situ solidification strategy ultimately achieves robust electrode/electrolyte interfaces and optimizes the long cycle capability of ASSLBs. Li||Li cells can run stably for more than 1200 h at a current density of 0.2 mA cm −2 without noticeable polarization. Furthermore, Li||LFP cells maintain excellent stability after 800 cycles at 1C with a superior capacity retention of 70 % at 55 °C and exhibit excellent rate performance. This work provides an effective strategy to fabricate high-performance ASSLBs and a new solution for the high-value utilization of naturally renewable cellulose resources.
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PLANT PHYSIOLOGY AND BIOCHEMISTRY
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2025
·
IF 5.7
Xingfan Li,Huimei Yu,Yang Guo,Jia Liu,Wei Yu,Xiaorui Guo
Light quality is a critical regulator of plant morphology and physiological metabolism, with spectral optimization emerging as a key strategy for enhancing bioactive compound production in medicinal plants. Catharanthus roseus , valued for its alkaloid content, exhibits significant metabolic plasticity in response to light conditions. This study examined the effects of two red-to-blue light ratios [2:1 (R2B1) and 7:1 (R7B1)] on morphophysiological responses, metabolite profiles, and alkaloid accumulation in C. roseus , using white light as a control. Both R2B1 and R7B1 altered plant morphology and enhanced alkaloid synthesis. R2B1 notably increased antioxidant enzyme activity, while R7B1 boosted non-enzymatic antioxidants and phenolic compounds. The Integrative Biomarker Response version 2 analysis identified R7B1 as the optimal treatment for promoting the accumulation of bioactive compounds. Untargeted metabolomics revealed that R7B1 enhanced sugar levels and induced tissue-specific changes in organic acid metabolism. Correlation analysis suggested that red-to-blue light promotes alkaloid biosynthesis by modulating antioxidant systems and key metabolic pathways. These findings highlight the potential of red-to-blue light optimization to enhance alkaloid production in C. roseus , providing valuable insights into the regulation of secondary metabolism and practical strategies for improving bioactive compound yields in medicinal plants.
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危险品化学品经营许可证（带存储）