JOURNAL OF POLYMER RESEARCH
·
2020
·Vol. 27
·期 3
·1-11
·
IF 2.426
Du Chunhui,Zhang Xinyi,Ma Xumin
In order to obtain the tunable and charged surface of the membranes, polymerized ionic liquid(PIL) block copolymers poly (methyl methacrylate) (PMMA)-b-poly(1-[(2-methacryloyloxy)ethyl]-3-butylimidazoliumbromide) (PMEBIm-Br) with different poly(ionic liquid) brush lengths were synthesized by RAFT polymerization method and used in the fabrication of poly(vinylidene fluoride) blend membranes. Chemistry analysis confirmed the successful copolymerization of P(MMA-b-MEBIm-Br) with different chain lengths of PMEBIm-Br blocks, and the PIL groups was also detected on the surface of the blend membranes, which contributes to the hydrophilic and positively charged surface of the membrane. These properties were further enhanced by the chain length of PMEBIm-Br blocks in the copolymer. The surface wettability of the membranes can be regulated from hydrophilicity to hydrophobicity by anion exchange, and the water flux changes also confirmed these phenomena. In addition, the effects of PMEBIm-Br blocks on the separation properties of the membranes were investigated using two dyes, namely, orange G and rhodamine 6G. Results indicated that the blend membranes with long length of PMEBIm-Br blocks had high rejection and good antifouling property to rhodamine 6G. Furthermore, the adsorption experiment of the blend membranes to the two dyes also indicated that blend membranes with long length of PMEBIm-Br blocks would have good dye adsorption-separation property.
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JOURNAL OF BIOMATERIALS APPLICATIONS
·
2024
·
IF 2.3
Dandan Niu,Danyang Zhou,Mengke Zhan,Lijing Lei,Jinhua Zhu,Xiuhua Liu
γ-Cyclodextrin-based metal-organic frameworks (γ-CD-MOF) were successfully synthesized using the solvent diffusion method and applied as carriers for trans-N-p-coumaroyltyramine (N-p-t-CT, NCT) to study the solubability, stability, sustained release and inhibitory activity against α-glucosidase. The solubilization effect of γ-CD-MOF on N-p-t-CT was performed using impregnation (NCT@CD-MOF-1) and co-crystallization (NCT@CD-MOF-2) methods. X-ray diffraction, scanning electron microscope (SEM), fourier transform infrared spectrometer (FTIR), and N2 adsorption/desorption were used to characterize the MOFs before and after loading NCT. The results showed that NCT@CD-MOF-2 had a better solubability for N-p-t-CT, 145.03 μg/mg of drug loading capacity could be achieved, and the solubility of NCT@CD-MOF-2 in water was 366 times higher than free N-p-t-CT. In addition, the stabilities of N-p-t-CT under temperature, UV light and pH conditions were greatly improved after encapsulation in γ-CD-MOF. Furthermore, NCT@CD-MOFs had a sustained release of N-p-t-CT over an extended period in vitro due to the primary encapsulation in pore structures. Notably, γ-CD-MOF loaded with N-p-t-CT showed superior inhibitory activity against α-glucosidase compared to free N-p-t-CT. Cytotoxicity studies demonstrated that NCT@CD-MOF-2 had low toxicity in vitro and perfect biocompatibility with HL-7702 cells, and γ-CD-MOF could reduce the toxicity of free N-p-t-CT at higher concentrations.
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Chinese Physics C
·
2023
·Vol. 47
·期 3
·034001
·
IF 3.6
Long He,Junhua Luo,Li Jiang
Measurement of the cross-sections of the 79Br(n, 2n)78Br, 81Br(n, p)81mSe, 81Br(n, α)78As, and 79Br(n, α)76As reactions was performed at specific neutron energies, precisely, 13.5±0.2, 14.1±0.2, 14.4±0.2, and 14.8±0.2 MeV, relative to the standard 93Nb(n, 2n)92mNb and 27Al(n, α)24Na reference reactions using offline γ-ray spectrometry and neutron activation. Monoenergetic neutrons were generated at the China Academy of Engineering Physics via a 3H(d, n)4He reaction using the K-400 Neutron Generator equipped with a solid 3H-Ti based target. The activity of the reaction produce was obtained using a high-purity germanium detector. The cross-sections of the (n, 2n), (n, p), and (n, α) reactions on the bromine isotopes were measured in the 13–15 MeV neutron energy range. The covariance analysis approach was employed for a thorough inspection of any uncertainties within the measured cross-section data. A discussion and comparison of the observed outcome were carried out with previously published data, especially with the results of the JENDL-4.0, JEFF-3.3, TENDL-2019, and ENDF/B-VIII.0 data libraries, along with the theoretical excitation function curve derived by employing the TALYS-1.95 program. Improved cross-section restrictions for the investigated processes in the 13–15 MeV neutron energy range will be obtained using the current findings, which will help to raise the caliber of associated databases. Furthermore, the parameters of relevant nuclear reaction models can be verified using this data.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xu Yang,Yuandong Zhang,Changpeng Wang,Bingyao Wang,Xiaoxu Liang,Hui Li,Hongyao Ding,Si Yu Zheng
Conductive hydrogels are ideal candidates for flexible electronics owing to their excellent biocompatibility and flexibility. However, achieving excellent mechanical strength and conductivity simultaneously remains a significant challenge. Herein, we report a mechanically robust and ionically conductive hydrogel that can be readily fabricated via a two-step strategy involving polymerization of a hybrid network composed of poly(acrylamide- co ‑sodium acrylate), gelatin and carboxymethyl chitosan followed by immersion in a mixed solution of phytic acid and magnesium sulfate. Phytic acid reinforced hydrogen bonding interactions and acted as dynamic crosslinkers. Sulfate ions promoted the hydrophobic aggregation and triple helices formation via the Hofmeister effect, and magnesium ions coordinated with carboxy groups among the polymer network. These newly formed interactions synergistically strengthened the hydrogel network. The resulting hydrogel exhibited exceptional tensile strength, high stretchability, and remarkable toughness, yet low modulus. Additionally, the incorporation of free ions endowed the hydrogels with high conductivity, making them suitable for flexible strain sensors. These hydrogel-based sensors demonstrated excellent linear responsiveness over a wide strain range with satisfactory sensitivity, thus enabling accurate monitoring of diverse human motions from large joint bending to subtle vocal vibrations. This work presents an effective strategy to design conductive and tough hydrogels for flexible electronics.
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IONICS
·
2021
·Vol. 27
·期 12
·5323-5331
·
IF 2.817
Nai Huimin,Cao Lixin,Sun Shuai,Li Rujin,Liu Haiping,Yan Peisheng
An ultrasensitive label-free electrochemical immunosensor of okadaic acid (OA) was studied based on electrodimerization of p -aminobenzoic acid (p-ABA)-modified gold three-dimensional nanoelectrode ensembles (3DNEEs) which were prepared by electroless gold plating and etching using polycarbonate as template. Staphylococcus protein A (SPA) was introduced to immobilize okadaic acid antibody (anti-OA). The morphology and composition of 3DNEEs were analyzed by scanning electron microscopy (SEM) and energy-dispersive X-ray spectrometer (EDX). The polydimer ( p -aminobenzoic acid) (pPABA) film was measured by Fourier transform infrared spectrometer (FTIR). The concentration of OA was measured by EIS and SWV. The detection limit of EIS is lower than that of SWV (6.47 × 10 −3 ng mL −1 vs. 9.15 × 10 −3 ng mL −1 ), but the linear OA detection range of the latter is wider (0.01–1.0 ng mL −1 vs. 0.01–0.8 ng mL −1 ). The average recovery of OA in oyster samples is 99.81%. The OA recovery test in oyster samples demonstrated potential application value of the electrochemical immunosensor.
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ACTA MATERIALIA
·
2026
·
IF 10.7
Qi-Lin Zheng,Wei-Wei Yuan,Min Wen,Shengqi Chu,Min Lin,Zhensheng Hong,Jiaxin Li,Lituo Zheng,Zhigao Huang,Hu-Rong Yao
P'2-type manganese-rich layered oxides are promising cathodes for sodium-ion batteries. However, their synthesis requires unconventional rapid quenching to prevent O₂ absorption and P'2-P2 phase transformation during cooling, which compromises scalability and safety. Moreover, Jahn-Teller active ion enrichment and irreversible phase transitions during cycling impair structural stability. These synthesis challenges and inadequate electrochemical performance hinder practical applications. Herein, we report for the first time a simple solid-state synthesis of P'2-Na 0.55 Mg 0.05 Mn 0.90 O 2 (Na□MM□) cathode with a 3.78% lattice distortion through a dual-vacancy strategy. The Na□MM□ cathode delivers an ultrahigh energy density of 786 Wh·kg −1 . Na vacancies stabilize P'2 structure and enable a reversible P'2-OP4 transition, delivering 35 mA·h·g⁻¹ extra capacity. TM vacancies further synergize with Na vacancies to stabilize the TM-O framework, suppressing lattice oxygen loss and Mn³⁺ enrichment, which improves 100 cycles capacity retention by 28.7%. This work advances the synthesis and electrochemistry of P'2-type materials, offering a practical path toward application. Download: Download high-res image (286KB) Download: Download full-size image
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Jianbin Deng,Xiaohan Zhang,Qijun Zhang,Pu Wang,Deyun Li,Tian Hu,Kai Yao,Xiaoyuan Chen,Zhihao Wu,Yulong Zhang
Immobilizing reactive Mg phases within macroscopic hydrogel matrices may couple nutrient mineralization with direct retention of the resulting solid product, but such material-integrated systems remain insufficiently explored. Here, a macroscopic Mg(OH) 2 -loaded lignin hydrogel (Mg(OH) 2 @LH) was developed for nitrogen (N) and phosphorus (P) recovery from simulated digestate. The self-supporting hydrogel contained 115.60 ± 20.90 mg Mg·g −1 while retaining its porous block architecture. For powdered Mg(OH) 2 @LH passed through a 100-mesh sieve, Mg(OH) 2 @LH achieved apparent NH 4 + -N and total phosphorus uptake capacities of 73.99 and 30.99 mg·g −1 , respectively. NH 4 + -N removal varied modestly and non-monotonically with MgCl 2 impregnation concentration, whereas TP removal remained statistically unchanged across the tested preparation range. Nutrient recovery was sensitive to solution pH and N/P stoichiometry. XRD, FTIR, and SEM–EDS analyses supported the formation of a struvite-containing phase during nutrient recovery, while the non-stoichiometric N/P removal indicated contributions from processes other than struvite formation to the decrease in aqueous NH 4 + -N. Importantly, the recovered struvite-containing lignin hydrogel (MAP-LH) retained a centimeter-scale, self-supporting block form and could be directly retrieved from the liquid phase without additional fine-solid separation. Although intact blocks showed lower nutrient uptake than powdered material, this revealed a trade-off between mass transfer and macroscopic retrievability. Subsequent acidic-soil column experiments showed that MAP-LH resulted in a 53.3% lower cumulative TN leaching ratio than soluble N–P fertilizer and partially alleviated soil acidity. These results demonstrate a retrievable hydrogel architecture that integrates Mg-phase immobilization, nutrient recovery, macroscopic product retention, and post-recovery soil application. Download: Download high-res image (261KB) Download: Download full-size image
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SENSORS AND ACTUATORS A-PHYSICAL
·
2026
·
IF 5.1
Tongrui Xian,Jiangtao Zhou,Chen Cao,Qiwei Zheng,Yan Peng,Peilun Yin,Xiaohui Tang,Zhongjie Li
Post-poling-free P(VDF-TrFE)/BTO nanofiber sensors prepared by electrospinning. • A β-phase content of 82.86% was achieved through in-situ electric field orientation and interfacial polarization. • Sensor shows 530.6 mV·kPa −1 sensitivity (0.33–3.33 kPa), 21 ms response time, and excellent durability. • A complete "material–device–circuit–virtual feedback" closed-loop interactive system was constructed. With the rapid advancement of the Internet of Things (IoT) and artificial intelligence (AI), the paradigm of human-machine interaction is shifting toward immersive and multidimensional experiences. In this study, a post-poling-free P(VDF-TrFE)/BTO (PVTB) composite nanofiber sensor with high electroactivity was fabricated by leveraging the synergy between charge trapping and interfacial polarization at the BTO/P(VDF-TrFE) interface, combined with in-situ electric-field orientation during electrospinning. The resulting nanofibers exhibit a mean diameter of 469.8 ± 168.2 nm, and the PVTB membrane achieves a high β-phase content of 82.86%. The PVTB sensor exhibits a sensitivity of 530.6 mV·kPa −1 within the low-pressure range of 0.33–3.33 kPa and 18.2 mV·kPa −1 within the pressure range of 3.33–83.33 kPa, with a minimum detectable force of 0.2 N, a response time of 21 ms, and 88.1% voltage retention after 10000 loading cycles. The PVTB sensor enables effective monitoring of ultra-weak muscle tremor signals, while finger tapping produces an output voltage of approximately 0.4 V. A four-channel “material-device-circuit-virtual feedback” closed-loop interactive system was constructed, demonstrating the potential of flexible piezoelectric sensors in immersive human-machine interaction and providing a precise digital approach for movement disorder rehabilitation. Download: Download high-res image (184KB) Download: Download full-size image
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Green Chemical Engineering
·
2026
·
IF 11.9
Kexin Wei,Haoyang Yu,Fan Yang,Yang Sun,Shijia Li,Jiabao Guo,Yongfeng Li
To advance the development of high-performance rechargeable zinc-air batteries (ZABs) with efficient oxygen electrochemistry, significant progress is needed in research on Fe-based nanoparticle/single-atom bifunctional oxygen electrocatalysts. Nevertheless, the structure-activity relationship and synergy mechanism of Fe-based nnoparticle/single-atom hybrid catalysts are not well-known. Herein, Self-supported carbon nanofiber electrocatalysts with in-situ synthesized FeS, Fe 2 P, or Fe 3 C nanoparticles and atomically dispersed Fe-N x sites were prepared in this work by the coaxial electrospinning method. X-ray photoelectron spectroscopy (XPS) and density functional theory (DFT) simulations showed that there was a significant change in charge distribution, an increase in the adsorption of *O intermediates, and a decrease in the *OH desorption energy barrier at the FeS/FeSA interface. It can be concluded that FeS/FeSA has better electronic and adsorption properties than Fe 2 P/FeSA and Fe 3 C/FeSA. Therefore, FeS/FeSA has an oxygen reduction reaction (ORR) half-wave potential of 0.89 V and an oxygen evolution reaction (OER) overpotential of 240 mV at 10 mA/cm 2 , which is relatively high compared with that of Fe 2 P/FeSA (0.79 V, 260 mV) and Fe 3 C/FeSA (0.77 V, 250 mV), and it has a small potential gap (Δ E ) of 0.58 V. FeS/FeSA can be used as the air cathode in liquid ZABs; it has a high peak power density of 116 mW/cm 2 and is stable for more than 150 hours. The above results have laid the foundation for the construction of high-performance air cathode catalysts by means of effective coupling of atomic nanoparticles and shown the direction for developing high-efficiency, long-life rechargeable zinc-air batteries.
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Foods
·
2026
·Vol. 15
·期 8
·1344
·
IF 6
Ningxin Ding,Xiangyu Pang,Yixuan Yan,Mingcong Fan,Haifeng Qian,Li Wang,Yan Li
Hypercholesterolemia is a major modifiable risk factor for cardiovascular disease. Although germinated brown rice (GBR) is rich in bioactive constituents and has shown preliminary lipid-regulating potential, the active compounds and underlying mechanisms remain unclear. Therefore, this study comparatively investigated extracts from four GBR cultivars and evaluated their cholesterol-regulating activity using untargeted metabolomics in combination with a cholesterol-induced HepG2 cell model. After 36 h of germination, the extracts showed significantly increased total phenolic content, total flavonoid content, and antioxidant activities (p< 0.05), with cultivar Q showing the strongest response. In the in vitro cholesterol-induced HepG2 cell model, GBR extract at 150 μg/mL significantly reduced intracellular total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels by approximately 69%, 73%, and 46%, respectively, while increasing high-density lipoprotein cholesterol (HDL-C) levels by approximately 125% (allp< 0.05). Untargeted metabolomics and subsequent validation suggested that p-coumaric acid is a candidate bioactive compound contributing to the cholesterol-lowering effect of GBR. Further analysis indicated that this effect may be associated with modulation of the mRNA expression levels of SREBP2, HMGCR, and LDLR. These findings indicate that germination enhances the bioactivity of brown rice in a cultivar-dependent manner and provides supporting evidence for the potential application of GBR as a functional food ingredient for lipid management.
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Analytical Methods
·
2022
·Vol. 14
·期 32
·3079-3086
·
IF 3.532
Shuang Han,Ruonan Sun,Fu Teng,Yuan Wang,Hongtao Chu,Wei Zong,Yao Chen,Zhonghui Sun
p-Cresol is a harmful phenolic substance that can cause serious effects on human health even at a low concentration in water. Therefore, the detection of p-cresol in a water environment is particularly important. In this paper, a novel zeolite imidazolate framework-67 (ZIF-67) material with regular morphology was prepared on the surface of graphene oxide doped with silver nanoparticles. The composite was modified on the glassy carbon electrode surface to increase the specific surface area, accelerate the electron transfer rate, enhance the current response and improve the performance of electrochemical sensors. Furthermore, a layer of p-cresol-molecularly imprinted polymer was prepared on the surface of the modified electrode by electropolymerization for the selective, rapid and sensitive detection of p-cresol, which greatly improved the specific recognition of p-cresol. Under optimal conditions, the prepared sensor had a good linear range of 1.0 × 10−10 M to 1.0 × 10−5 M with a detection limit as low as 5.4 × 10−11 M, and it presented excellent reproducibility, stability and selectivity. Moreover, the sensor was successfully applied for the detection of trace p-cresol in a real water environment, providing a reliable assay for sensitive, rapid and selective detection of p-cresol in complex samples.
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Frontiers in Cell and Developmental Biology
·
2022
·
IF 6.081
Deng Changping,Hu Fabiao,Zhao Zhangting,Zhou Yiwen,Liu Yuping,Zhang Tong,Li Shihui,Zheng Wenyun,Zhang Wenliang,Wang Tianwen,Ma Xingyuan
Quantitative analysis and regulating gene expression in cancer cells is an innovative method to study key genes in tumors, which conduces to analyze the biological function of the specific gene. In this study, we found the expression levels of Survivin protein (BIRC5) and P-glycoprotein (MDR1) in MCF-7/doxorubicin (DOX) cells (drug-resistant cells) were significantly higher than MCF-7 cells (wild-type cells). In order to explore the specific functions of BIRC5 gene in multi-drug resistance (MDR), a CRISPR/Cas9-mediated knocking-in tetracycline (Tet)-off regulatory system cell line was established, which enabled us to regulate the expression levels of Survivin quantitatively (clone 8 named MCF-7/Survivin was selected for further studies). Subsequently, the determination results of doxycycline-induced DOX efflux in MCF-7/Survivin cells implied that Survivin expression level was opposite to DOX accumulation in the cells. For example, when Survivin expression was down-regulated, DOX accumulation inside the MCF-7/Survivin cells was up-regulated, inducing strong apoptosis of cells (reversal index 118.07) by weakening the release of intracellular drug from MCF-7/Survivin cells. Also, down-regulation of Survivin resulted in reduced phosphorylation of PI3K, Akt, and mTOR in MCF-7/Survivin cells and significantly decreased P-gp expression. Previous studies had shown that PI3K/Akt/mTOR could regulate P-gp expression. Therefore, we speculated that Survivin might affect the expression of P-gp through PI3K/Akt/mTOR pathway. In summary, this quantitative method is not only valuable for studying the gene itself, but also can better analyze the biological phenomena related to it.
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