Nano Research
·
2019
·Vol. 12
·期 4
·931-938
·
IF 8.515
Zheng Judun,Wu Yunxia,Xing Da,Zhang Tao
Cellular redox status presents broad implications with diverse physiological and pathological processes. Simultaneous detection of both the oxidative and reductive species of redox couples, especially the most representative pair glutathione/hydrogen peroxide (GSH/H 2 O 2 ), is crucial to accurately map the cellular redox status. However, it still remains challenging to synchronously detect GSH/H 2 O 2 in vivo due to lack of a reliable measuring tool. Herein, a ratiometric nanoprobe (UCNP-TB) possessing simultaneous delectability of GSH/H 2 O 2 is established based on a multi-spectral upconverting nanophosphor (UCNP-OA) as the luminescence resonance energy transfer (LRET) donor and two dye molecules as the acceptors, including a GSH-sensitive dye (TCG) and a H 2 O 2 -sensitive dye (BCH). With the as-prepared UCNP-TB, real-time and synchronous monitoring the variation of GSH and H 2 O 2 in vitro and in living mice can be achieved using the ratio of the upconversion luminescence (UCL) at 540 and 650 nm to that at 800 nm as the detection signal, respectively, providing highly inherent reliability of the sensing results by self-calibration. Moreover, the nanoprobe is capable of mapping the redox status within the drug-resistant tumor and the drug-induced hepatotoxic liver via ratiometric UCL imaging. Thus, this nanoprobe would provide a reliable tool to elucidate the redox state in vivo .
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MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 8
·1-8
·
IF 5.705
Song Xinjian,Fu Ju,Wang Juan,Li Chunya,Liu Zhihong
Graphene nanosheets (GSs) were prepared via liquid-phase non-covalent exfoliation of graphite powder in N , N -dimethylformamide under the assistance of copper(II) meso-tetra(4-carboxyphenyl)porphyrin tetrasodium salt Na 4 (CuTCPP). A glassy carbon electrode (GCE) was modified with a film of such GSs which, due to the good electrical conductivity of graphene and the electrocatalytic properties of Na 4 (CuTCPP), is capable of simultaneous determination of acetaminophen (AC) and dopamine (DA). The peak currents, best measured at voltage of 0.2 V (for DA) and 0.4 V (for AC; both vs. SCE), increase linearly in the 0.0024–3.6 μM and 0.004–7.6 μM concentration ranges, respectively. The detection limits are 0.8 nM for DA and 0.7 nM for AC. The sensor was successfully applied to the simultaneous determination of AC and DA in pharmaceutical preparations and spiked human serum. The results were in good agreement with those obtained for the same samples by HPLC.
Graphene nanosheets were prepared via a facile liquid-phase exfoliation of graphite with the assistance of copper(II) meso-tetra(4-carboxyphenyl)porphyrin tetrasodium salt. A graphene nanosheet-film modified glassy carbon electrode was fabricated to determine acetaminophen and dopamine through a simple and effective strategy.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2021
·Vol. 413
·期 7
·1917-1927
·
IF 4.157
Zhang Liyang,Yi Xinyao,Wang Saisai,Liang Peida,Zhou Huaxin,Fu Jia,Jia Qianqian,Gao Jiapan,Lv Yanni,Han Shengli
A novel stability-enhanced graphene quantum dot (GQD)-decorated epidermal growth factor receptor (EGFR) cell membrane chromatography was constructed to study the potential application of GQDs in bioaffinity chromatography, and to screen active components acting on EGFR from traditional Chinese medicine (TCM). The carboxyl groups on the surface of GQDs reacted with the amino groups of the amino-silica gel ( SiO 2 -NH 2 ) to form a covalent bond, thereby preparing the GQD-decorated silica gel ( SiO 2 -GQDs ). The EGFR cell membrane was further immobilized on the SiO 2 -GQDs through the same covalent binding method to obtain the GQD-decorated cell membrane stationary phase ( SiO 2 -GQDs-CMSP ). In this way, the cell membrane was firmly immobilized on the decorated silica carrier. The life span and stability of the GQD-decorated cell membrane chromatographic ( SiO 2 -GQDs-CMC ) column were both enhanced, and the optimal immobilization conditions of the EGFR cell membrane were also determined. This model was then verified by establishing a SiO 2 -GQDs-CMC online liquid chromatography-ion trap-time-of-flight (LC-IT-TOF) system to screen possible active components in Peucedanum praeruptorum Dunn . As a result, praeruptorin B (Pra-B) was screened out, and its inhibitory effect against EGFR cell growth was evaluated by the cell counting kit-8 (CCK-8) assay. Molecular docking assay was also conducted to further estimate the interaction between Pra-B and EGFR. Overall, this research indicated that GQDs may be a promising nanomaterial to be used in prolonging the life span of the CMC column, and Pra-B could be a potential EGFR inhibitor so as to treat cancer. Graphical abstract
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Scientific Reports
·
2019
·Vol. 9
·期 1
·1-10
·
IF 4.011
Wang Jiaying,He Yang,Wu Quan,Zhang Yunfeng,Li Zhiyuan,Liu Zhihong,Huo Shikang,Dong Jiaming,Zeng Danli,Cheng Hansong
The drawbacks of low porosity, inferior electrolyte wettability, low thermal dimensional stability and permissive lithium dendrite growth of the conventional microporous polyolefin-based separators hinder their widely application in the high power density and safe Lithium ion batteries. Herein, highly porous polybenzimidazole-based separator is prepared by a facile non-solvent induced phase separation process (NIPS) using water, ethanol, chloroform and ethyl acetate as the coagulation bath solvent, respectively. It was found that the ethanol is suitable to fabricate uniform morphology macroporous separator with the porosity of 92%, electrolyte uptake of 594 wt.%, and strong mechanical strength of 15.9 MPa. In addition, the experimental tests (electrochemical analysis and XPS test) and density functional theory calculation suggest that the electron-rich imidazole ring of polybenzimidazle can enhance Li + mobility electrostatic attraction interaction while the block the PF 6 − mobility via electrostatic repulsion interaction. Therefore, high Li + transference number of 0.76 was obtained for the neat polybenzimidazole-based polymer electrolyte. As a proof of concept, the Li/LiFePO 4 cell with the polybenzimidazole-based polymer electrolyte/1.0 M LiPF 6 − ethylene carbonate/dimethyl carbonate (v:v = 1:1) electrolyte exhibits excellent rate capability of >100 mAh g −1 at 6 C (1 C = 170 mA g −1 ) and superior cycle stability of 1000 cycles.
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npj Flexible Electronics
·
2022
·Vol. 6
·期 1
·1-8
·
IF 12.019
Lin Baojun,Wang Meng,Zhao Chao,Wang Shijie,Chen Kai,Li Xiao,Long Zaishang,Zhao Chenxu,Song Xinyue,Yan Sen,Wang Laili,Ma Wei
Smart contact lens has drawn extensive research interests due to the noninvasive real-time detection of the human body to provide biomedical information for health management. However, it has been difficult to accurately measure the physiological signals in tears, and the use of external power source has also hindered the future applications. Here, we demonstrated an organic electrochemical transistor based multiplexed sensors self-powered by the organic solar cells (OSCs). The integrated device was fabricated via simple process including solution blade-coating and thermal evaporation. OSCs were optimized to provide optimal operation voltage for the sensors that exhibit semilog-linear response to the glucose and calcium ions in tear fluids without any peripheral circuits. The sensing signals can be transmitted to the laptop wirelessly through a near filed communication unit. This integrated self-powered multiplexed sensing device will provide real-time monitoring of the biomarkers in tears, prospected to be installed on the smart contact lens for the early detection and diagnosis of diabetes.
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RESEARCH ON CHEMICAL INTERMEDIATES
·
2013
·Vol. 41
·期 4
·2345-2352
·
IF 0.88
Liu Bin,Li Xiao Fang,Zhang Jie,Wang Meng Ting,Zeng Rong Jin
The conjugate addition of bromoform with 2-aryliene-2,3-dihydro-1 H -pyrrolizin-1-ones in the presence of magnesium afforded novel 2,2-dibromo-3-arylspiro[cyclopropane-1,2′-pyrrolizin]-1′(3′ H )-ones in moderate yield. The structures of all the products were characterized thoroughly by 1 H NMR, 13 C NMR, infrared spectroscopy, and mass spectrum.
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Frontiers of Chemical Science and Engineering
·
2021
·Vol. 16
·期 4
·498-510
·
IF 4.204
Bo Jinxiao,Li Mei,Zhu Xinli,Ge Qingfeng,Han Jinyu,Wang Hua
The electrochemical conversion of CO 2 -H 2 O into CO-H 2 using renewable energy is a promising technique for clean syngas production. Low-cost electrocatalysts to produce tunable syngas with a potential-independent CO/H 2 ratio are highly desired. Herein, a series of N -doped carbon nanotubes encapsulating binary alloy nanoparticles (M x Ni-NCNT, M= Fe, Co) were successfully fabricated through the co-pyrolysis of mela-mine and metal precursors. The M x Ni-NCNT samples exhibited bamboo-like nanotubular structures with a large specific surface area and high degree of graphitization. Their electrocatalytic performance for syngas production can be tuned by changing the alloy compositions and modifying the electronic structure of the carbon nanotube through the encapsulated metal nanoparticles. Consequently, syngas with a wide range of CO/H 2 ratios, from 0.5:1 to 3.4:1, can be produced on M x Ni-NCNT. More importantly, stable CO/H 2 ratios of 2:1 and 1.5:1, corresponding to the ratio to produce biofuels by syngas fermentation, could be realized on Co 1 Ni-NCNT and Co 2 Ni-NCNT, respectively, over a potential window of −0.8 to −1.2 V versus the reversible hydrogen electrode. Our work provides an approach to develop low-cost and potential-independent electrocatalysts to effectively produce syngas with an adjustable CO/H 2 ratio from electrochemical CO 2 reduction.
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JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
·
2019
·Vol. 93
·期 3
·289-299
·
IF 1.429
Li Zhendong,Liu Huijun,Qi Caixia,Yang Aohui,Deng Shanxia
Using ethylenediamine-β-cyclodextrin and α-naphthylacetic acid as raw material, a novel inclusion complex (en-β-CD@NAA) was synthesized. The inclusion complex structures and properties were analyzed by reliable spectroscopic and physicochemical techniques. The stoichiometry of the inclusion complex was 1:1 and the stability constant ( K S ) value was found to be 2511 M −1 at 293 K. Molecular thermodynamic parameters indicated that the spontaneous and exothermic nature of the process. The inclusion form was foreseen by Chem 3D program combined with 1 H-NMR experimental data. The solubilization curves ( K 1 = 2.05) and in-vitro dissolution data demonstrated that the en-β-CD@NAA inclusion complex has satisfactory water solubility.
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Nanoscale Research Letters
·
2019
·Vol. 14
·期 1
·1-11
·
IF 3.159
Zhou Shiqiang,Chen Mingpeng,Lu Qingjie,Zhang Yumin,Zhang Jin,Li Bo,Wei Haitang,Hu Jicu,Wang Huapeng,Liu Qingju
Formaldehyde (HCHO) is the main source of indoor air pollutant. HCHO sensors are therefore of paramount importance for timely detection in daily life. However, existing sensors do not meet the stringent performance targets, while deactivation due to sensing detection at room temperature, for example, at extremely low concentration of formaldehyde (especially lower than 0.08 ppm), is a widely unsolved problem. Herein, we present the Ag nanoparticles (Ag NPs) sensitized dispersed In 2 O 3 nanograin via a low-fabrication-cost hydrothermal strategy, where the Ag NPs reduces the apparent activation energy for HCHO transporting into and out of the In 2 O 3 nanoparticles, while low concentrations detection at low working temperature is realized. The pristine In 2 O 3 exhibits a sluggish response (R a /R g = 4.14 to 10 ppm) with incomplete recovery to HCHO gas. After Ag functionalization, the 5%Ag-In 2 O 3 sensor shows a dramatically enhanced response (135) with a short response time (102 s) and recovery time (157 s) to 1 ppm HCHO gas at 30 °C, which benefits from the Ag NPs that electronically and chemically sensitize the crystal In 2 O 3 nanograin, greatly enhancing the selectivity and sensitivity.
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Microsystems & Nanoengineering
·
2020
·Vol. 6
·期 1
·1-13
·
IF 5.048
Zhu Li-Yuan,Yuan Kai-Ping,Yang Jia-He,Hang Cheng-Zhou,Ma Hong-Ping,Ji Xin-Ming,Devi Anjana,Lu Hong-Liang,Zhang David Wei
Highly sensitive and selective hydrogen sulfide (H 2 S) sensors based on hierarchical highly ordered SnO 2 nanobowl branched ZnO nanowires (NWs) were synthesized via a sequential process combining hard template processing, atomic-layer deposition, and hydrothermal processing. The hierarchical sensing materials were prepared in situ on microelectromechanical systems, which are expected to achieve high-performance gas sensors with superior sensitivity, long-term stability and repeatability, as well as low power consumption. Specifically, the hierarchical nanobowl SnO 2 @ZnO NW sensor displayed a high sensitivity of 6.24, a fast response and recovery speed (i.e., 14 s and 39 s, respectively), and an excellent selectivity when detecting 1 ppm H 2 S at 250 °C, whose rate of resistance change (i.e., 5.24) is 2.6 times higher than that of the pristine SnO 2 nanobowl sensor. The improved sensing performance could be attributed to the increased specific surface area, the formation of heterojunctions and homojunctions, as well as the additional reaction between ZnO and H 2 S, which were confirmed by electrochemical characterization and band alignment analysis. Moreover, the well-structured hierarchical sensors maintained stable performance after a month, suggesting excellent stability and repeatability. In summary, such well-designed hierarchical highly ordered nanobowl SnO 2 @ZnO NW gas sensors demonstrate favorable potential for enhanced sensitive and selective H 2 S detection with long-term stability and repeatability.
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MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 2
·1-9
·
IF 6.232
Zhu Yanyan,Wang Yalin,Kang Kai,Lin Yulong,Guo Wei,Wang Jing
The authors describe Ni–Co bimetal phosphide (NiCoP) nanocages that exhibit enhanced electrocatalytic performance toward glucose oxidation. The nanocages offer an appealing architecture, large specific area, and good accessibility for the analyte glucose. When placed on a glassy carbon electrode, the sensor exhibits attractive figures of merit for sensing glucose in 0.1 M NaOH solution including (a) a wide linear range (0.005–7 mM), (b) a low determination limit (0.36 μM), (c) high sensitivity (6115 μA•μM −1 •cm −2 ), (d) a relatively low working potential (0.50 V vs. Ag/AgCl), and (e) good selectivity, reproducibility, and stability. The sensor is successfully applied to the determination of glucose in human serum samples.
Schematic representation of a glassy carbon electrode modified with Ni–Co bimetal phosphide (NiCoP) nanocage. NiCoP nanocage exhibits excellent electrocatalytic activity toward glucose oxidation. NiCoP nanocage is applied in a sensitive non-enzymatic glucose sensor.
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Environmental Chemistry Letters
·
2018
·Vol. 16
·期 3
·1083-1088
·
IF 3.125
Yi Yayi,Zhou Xuehua,Xue Likun,Wang Wenxing
Air pollution by industry and humans activities is a major health issue, notably in major cities. Secondary organic aerosols are formed by oxidation of volatile organic compounds, accounting for 20–80% of organic aerosols in the atmosphere. Secondary organic aerosols are contributing to photochemical smog in urban areas. However, the mechanisms of formation of secondary organic aerosols are still poorly understood. Here, we synthesized secondary organic aerosols by aqueous reaction of hydroxyacetone and methylamine in the dark. Products were analyzed by UV–Vis spectrophotometry and liquid chromatography–mass spectrometry-ion trap-time of flight. Results showed that all reactions fit first-order kinetics, and reactions were accelerated with reactants’ concentrations and pH. The main reaction mechanisms were aldolization of hydroxyacetone, and nucleophilic attack of methylamine to hydroxyacetone, followed by dehydration. The main products were imines, transforming the solution from colorless to deep brown, which is responsible for about 1% of light absorption by atmospheric brown carbon.
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