CHINESE JOURNAL OF CHEMICAL PHYSICS
·
2020
·Vol. 33
·期 6
·749-756
·
IF 1.067
Zhou Xue-zheng,Yan Xiang-yang,Zhu Ling,Ma Ming,Dai Ya,Wang Chang-guo,Zhu Li-jun,Yu Ke-jie,Liu Shao-min
A new kind of phenyl-functionalized magnetic fibrous mesoporous silica (Fe 3 O 4 @SiO 2 @KCC-1-phenyl) was prepared by copolymerization as an efficient adsorbent for the magnetic extraction of phthalate esters from environmental water samples. The obtained Fe 3 O 4 @SiO 2 @KCC-1-phenyl showed monodisperse fibrous spherical morphology, fairly strong magnetic response (29 emu/g), and an abundant π -electron system, which allowed rapid isolation of the Fe 3 O 4 @SiO 2 @KCC-1-phenyl from solutions upon applying an appropriate magnetic field. Several variables that affect the extraction efficiency of the analytes, including the type of the elution solvent, amount of adsorbent, extraction time and reusability, were investigated and optimized. Under optimum conditions, the Fe 3 O 4 @SiO 2 @KCC-1-phenyl was used for the extraction of four phthalate esters from environmental water samples followed by high-performance liquid chromatographic analysis. Validation experiments indicated that the developed method presented good linearity (0.1–20 ng/mL), low limit of detection (7.5–29 µg/L, S / N =3). The proposed method was applied to the determination of phthalate esters in different real water samples, with relative recoveries of 93%−103.4% and relative standard deviation of 0.8%–8.3%.
研究领域:
环境科学
·
分析化学
✓ 已验证
DOI
高影响因子
npj Biofilms and Microbiomes
·
2025
·Vol. 11
·期 1
·1-17
·
IF 9.2
Yang Ruili,Xu Yi,Xu Jinchun,Huang Chengqing,Zhu Feng,Wang Tian,Kong Rui,Xiao Jie,He Biao,Gu Xiaozhen,Wang Hui-Li
As a prevalent neurodevelopmental disease, whether ASD (autism spectrum disorder) can be ameliorated by the early use of a single microbe remains unknown. Here we used a lactobacillus strain, Lacticaseibacillus rhamnosus GR-1 (LGR-1), for prenatal intervention in autism-like mice with either environmental or idiopathic origins by exclusively administering to the pregnant dams at a dose of 10 9 /mouse/day, followed by offspring behavioral assessment with 3-chamber trial and marble burying test. The results revealed that LGR-1 prevented the occurrence of autism-like symptoms, as evidenced by the improved behaviors and restored E/I (excitatory-inhibitory) balance in the prefrontal cortex of male pups. In parallel, the offspring microbiome was reshaped by LGR-1 treatment, probably mediated by the vertical transmission of maternal microbiome, with its roles further unraveled by fecal microbiota transplant and cross-fostering experiments. In addition to gut commensals, the LGR-1-shaping vaginal microbiota also contributed to the establishment of “beneficial” microbiome. Regarding key taxa in offspring, Akkermansia muciniphila was influenced by LGR-1 and exerted impact on behaviors via pathways related to IL-17-producing lymphocytes. Our findings demonstrate that prenatal microbial administration protects offspring against autism-like behavioral phenotypes through microbiome transmission, highlighting a potential microbe-based therapeutic avenue to mitigate ASD risk.
研究领域:
微生物学
·
神经发育学
·
围产期医学
·
免疫学
·
转化医学
·
分子生物学
·
菌群-宿主互作
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6.8
Tao Xie,Gao-Yao Cao,Shize Zhang,Meng-Ke Li,Xin Jin,Liu Liu,Guangji Wang,Le Zhen
Inflammatory bowel disease (IBD) is a clinically heterogeneous disease demanding more therapeutic targets and intervention strategies. Vanin-1, an oxidative stress-regulating protein, has emerged as a promising target for alleviating inflammation and oxidative stress. In this study, a series of thiazole carboxamide derivatives as vanin-1 inhibitors were designed and synthesized. The preferred compound, X17, demonstrated potent inhibition against vanin-1 at the protein, HT-29 cell, and tissue levels, whose binding mode with the target was confirmed via the cocrystal structure. X17 achieved a high bioavailability of 81% in rats, accompanied by concentration-dependent inhibition of serum vanin-1. In a DSS-induced mouse colitis model, X17 exhibited potent anti-inflammatory and antioxidant activities, repressing the inflammatory factor expressions and myeloperoxidase activity, elevating the colonic glutathione reserve, and restoring the intestinal barrier. Collectively, these findings depict the discovery of a potent vanin-1 inhibitor, providing an opportunity for further drug candidate development for treating IBD.
研究领域:
药理学
·
药物化学
·
炎症
·
胃肠病学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
·
2022
·
IF 6.437
Ping Ye,Heng Zhai,Yueqi Li,Wenkun Zhu,Guangcheng Yang,Changping Guo
Breaking the inherent contradiction between high energy and insensitivity and pursuing enviro-friendly, high safety and excellent thermal decomposition properties are urgently desired for the development of modern composite solid propellants . 2,6-Diamino-3,5-dinitropyrazine-1-oxide (LLM-105) nanoparticles were uniformly deposited on the surface of ammonium perchlorate (AP) by ultrasonic shock with Estane as modifier. In the current work, it was concluded that the crystal phase and morphology of AP remained unchanged, and that complete and dense AP@LLM-105 core-shell composites were obtained at 15% LLM-105. In addition, the high temperature decomposition peak of AP@LLM-105 is advanced to 296.5 ℃ and the heat release is increased to 1271 J/g. More importantly, AP@LLM-105 also showed excellent performance in sensitivity test, with impact sensitivity H 50 and friction sensitivity as low as 39 cm and 18%. Obviously, low-pollution AP@LLM-105 with high safety performance and excellent thermal decomposition performance provides a good candidate for composite solid propellants.
研究领域:
推进剂材料科学
·
能源材料工程
✓ 已验证
DOI
高影响因子
Frontiers of Chemical Science and Engineering
·
2022
·Vol. 16
·期 8
·1237-1246
·
IF 4.803
Sun Xiaofei,Feng Shijie,Zhang Zhe,Zhang Pengyu,Zhao Jiefeng,Gao Yunling,Yun Junxian
A Ag particle-coated and 1-dodecanethiol-modified melamine sponge (Ag-DDT-MS) was prepared through surface roughness by coating silver particles and subsequent grafting of a hydrophobic long hydrocarbon chain. Superhydrophobic and 3D porous Ag-DDT-MS was characterized by Fourier transform infrared spectroscopy, scanning electron microscope, energy-dispersive X-ray spectroscopy, and X-ray diffraction. The water contact angle of Ag-DDT-MS reached 159.2°. Ag-DDT-MS exhibited excellent absorption capacity for high viscous oils and organic solvents, ranging from 42.8 to 105.2 g·g −1 . The absorbed oils can be easily collected by the mechanical pressing process, and the oil recovery rate was satisfactory, more than 90% after 20 recycles. Ag-DDT-MS material also demonstrated good stability and excellent compression-recovery ability, keeping 88.6% of the initial height after ten compression-release cycles.
研究领域:
材料科学
·
环境工程
·
化学工程
✓ 已验证
DOI
高影响因子
CELL BIOLOGY INTERNATIONAL
·
2024
·
IF 3.3
Guang Yang,Xin Shi,Meixia Zhang,Kaiwen Wang,Xin Tian,Xiaofeng Wang
Oral squamous cell carcinoma (OSCC) is the most common oral malignancy. DEAD/H-box helicase 11 (DDX11), a DNA helicase, has been implicated in the progression of several cancers. Yet, the precise function of DDX11 in OSCC is poorly understood. The DDX11 expression in OSCC cells and normal oral keratinocytes was evaluated in the Gene Expression Omnibus database (GSE146483 and GSE31853). SCC-4 and CAL-27 cells expressing doxycycline-inducible DDX11 or DDX11 shRNA were generated by lentiviral infection. The role of DDX11 in OSCC cells was determined by 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay, colony formation assay, flow cytometry assay, TUNEL staining, and western blot. The effects of DDX11 on tumor growth were explored in a xenograft nude mouse model. The relationship between DDX11 and transcription factor Yin Yang-1 (YY1) was researched using the dual luciferase report assay and chromatin immunoprecipitation assay. DDX11 expression was significantly upregulated in OSCC cells. Knockdown of DDX11 inhibited cell proliferation, induced cell cycle arrest, and suppressed PI3K-AKT pathway, while DDX11 overexpression showed opposite effects. The number of apoptotic cells was increased in DDX11 silenced cells. DDX11 upregulation or knockdown accelerated or suppressed tumor growth in vivo, respectively. Moreover, the YY1 bound and activated the DDX11 promoter, resulting in increasing DDX11 expression. Forced expression DDX11 reversed the anticancer effects of YY1 silencing on OSCC cells. DDX11 has tumor-promoting function in OSCC and is transcriptionally regulated by YY1, indicating that DDX11 may serve as a potential target for the OSCC treatment.
研究领域:
肿瘤学
·
分子生物学
·
细胞生物学
·
转化医学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF HETEROCYCLIC CHEMISTRY
·
2024
·
IF 2
Guofang Jiang,Can Zhang,Xiaohong Xing,Jinbo Ouyang,Hong Yang,Zongbo Xie,Zhanggao Le
A novel and highly efficient method for the synthesis of 1-(4-hydroxybutyl)-2-benzoyl indoles from 2-pyrrolidine benzaldehyde and α -bromoacetophenone in a choline chloride (ChCl)/ZnCl 2 eutectic mixture was developed. This method, which does not require any catalyst, additive, or alkali, is useful for realizing tandem cyclization reactions. Several indoles were produced after cyclization and ring opening processes. Not all the compounds obtained are reported in the literature. This synthetic strategy proves that deep eutectic solvents can replace catalysts and organic solvents. Consequently, this is an environmentally friendly strategy that has significant potential in the development of green and sustainable chemistry.
研究领域:
有机化学
·
绿色化学
✓ 已验证
DOI
高影响因子
ChemistrySelect
·
2023
·Vol. 8
·期 9
·e202203332
·
IF 2.1
Cunwei Qian,Ying Wang,Xian Li,Changsheng Yao
Graphical A convenient, rapid and electrochemical one-pot protocol is designed for the synthesis of pyrazolo[3,4- b ]quinolines derivatives. The reaction is carried out in an undivided cell equipped with an iron cathode and a graphite anode in the presence of sodium bromide as a supporting electrolyte. Fourteen pyrazolo[3,4- b ]quinoline derivatives are obtained under a constant current of 30 mA after 0.14 F/mol of electricity passed. A convenient, rapid and electrochemical one-pot protocol was developed successfully for the preparation of pyrazolo[3,4- b ]-quinoline derivatives. The reaction is carried out in a 25 mL three neck flask equipped with graphite electrode as anode and iron electrode as cathode (electrode area of 1 cm 2 ) with sodium bromide as supporting electrolyte at room temperature in ethanol. Fourteen pyrazolo-[3,4- b ]-quinoline derivatives were synthesized by use of various aldehyde (including aryl aldehydes and aliphatic aldehydes), dimedone and 5-amino-3-methyl-1-phenylpyrazole as substrates in good yields (76–86 %) with a constant current of 30 mA after 0.14 F/mol of electricity passed. All aimed products were characterized by IR, 1 H NMR and HRMS. Notably, the presented method features ecologically sound, simple experimental procedure and good yields.
研究领域:
有机化学
·
电化学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2023
·
IF 7.2
Ran Li,Hao Shi,Jinlin Song,Zihong Dong,Tao Wan,Hua Dong
The introduction of magnetism into a catalyst can greatly optimize its separation performance. In the present work, a kind of magnetically separable catalysts for promoting NaBH 4 hydrolysis have been fabricated by anchoring cobalt nanoparticles on magnetic dendritic KCC-1 nanospheres composed of magnetic Fe 3 O 4 core and fibrous shell. The fabricated catalysts were characterized with various characterization methods, including absorption spectroscopy (AAS), scanning electron microscopy (SEM), high-resolution transmission electronic microscopy (HRTEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometry (VSM), and Fourier transform infrared (FT-IR), etc. This kind of catalysts exhibit high catalytic activity for promoting the hydrolysis of NaBH 4 under alkaline conditions, giving a hydrogen generation rate and activation energy of 3.83 L min −1 g Co −1 (30 °C) and 53.63 kJ mol −1 , respectively. After used for 5 cycles, the catalyst showed 36.5% catalytic activity reserved. Most importantly, the magnetism of the catalyst made it easily separated and recycled from the solution after the reaction completed. The development of this kind of catalysts could provide a promising option for catalyzing NaBH 4 hydrolysis for portable hydrogen production from.
研究领域:
催化
·
纳米技术
·
氢能
·
材料科学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2025
·Vol. 26
·期 9
·4095
·
IF 4.9
Ekaterina A. Litus,Marina P. Shevelyova,Alisa A. Vologzhannikova,Evgenia I. Deryusheva,Alina V. Chaplygina,Victoria A. Rastrygina,Andrey V. Machulin,Valeria D. Alikova,Aliya A. Nazipova,Maria E. Permyakova,Victor V. Dotsenko,Sergei E. Permyakov,Ekaterina L. Nemashkalova
Clinical data as well as animal and cell studies indicate that certain antidiabetic drugs, including glucagon-like peptide 1 receptor agonists (GLP-1RAs), exert therapeutic effects in Alzheimer’s disease (AD) by modulating amyloid-β peptide (Aβ) metabolism. Meanwhile, the direct interactions between GLP-1RAs and Aβ and their functional consequences remain unexplored. In this study, the interactions between monomeric Aβ40/Aβ42 of GLP-1(7-37) and its several analogs (semaglutide (Sema), liraglutide (Lira), exenatide (Exen)) were studied using biolayer interferometry and surface plasmon resonance spectroscopy. The quaternary structure of GLP-1RAs was investigated using dynamic light scattering. The effects of GLP-1RAs on Aβ fibrillation were assessed using the thioflavin T assay and electron microscopy. The impact of GLP-1RAs on Aβ cytotoxicity was evaluated via the MTT assay. Monomeric Aβ40 and Aβ42 directly bind to GLP-1(7-37), Sema, Lira, and Exen, with the highest affinity for Lira (the lowest estimates of equilibrium dissociation constants were 42–60 nM). GLP-1RAs are prone to oligomerization, which may affect their binding to Aβ. GLP-1(7-37) and Exen inhibit Aβ40 fibrillation, whereas Sema promotes it. GLP-1 analogs decrease Aβ cytotoxicity toward SH-SY5Y cells, while GLP-1(7-37) enhances Aβ40 cytotoxicity without affecting the cytotoxic effect of Aβ42. Overall, GLP-1RAs interact with Aβ and differentially modulate its fibrillation and cytotoxicity, suggesting the need for further studies of our observed effects in vivo.
研究领域:
神经生物学
·
分子药理学
·
蛋白质科学
·
神经退行性疾病
·
转化医学
·
代谢疾病
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Gels
·
2025
·Vol. 11
·期 8
·568
·
IF 5.3
Yi Wang,Enkai Lin,Ze Wang,Tong Feng,An Xie
Electrochromic (EC) devices are gaining increasing attention for next-generation smart windows and low-power displays due to their reversible color modulation, low operating voltage, and flexible form factors. Recently, electrochromic energy storage devices (EESDs) have emerged as a promising class of multifunctional systems, enabling simultaneous energy storage and real-time visual monitoring. In this study, we report a flexible dual-functional EESD constructed using polyaniline (PANI) films doped with anthraquinone-1-sulfonic acid sodium salt (AQS), coupled with a redox-active PVA-based gel electrolyte also incorporating AQS. The incorporation of AQS into both the polymer matrix and the gel electrolyte introduces synergistic redox activity, facilitating bidirectional Faradaic reactions at the film–electrolyte interface and within the bulk gel phase. The resulting vertically aligned PANI-AQS nanoneedle films provide high surface area and efficient ion pathways, while the AQS-doped gel electrolyte contributes to enhanced ionic conductivity and electrochemical stability. The device exhibits rapid and reversible color switching from light green to deep black (within 2 s), along with a high areal capacitance of 194.2 mF·cm−2at 1 mA·cm−2and 72.1% capacitance retention over 5000 cycles—representing a 31.5% improvement over undoped systems. These results highlight the critical role of redox-functionalized gel electrolytes in enhancing both the energy storage and optical performance of EESDs, offering a scalable strategy for multifunctional, gel-based electrochemical systems in wearable and smart electronics.
研究领域:
材料科学
·
电化学
·
能量存储
·
智能材料
·
柔性电子学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2021
·
IF 4.43
Lu Shi,Wei Liu,Yanhu Xue,Mei Hong,Xiangling Ji
Temperature Rising Elution Fractionation (TREF) is effective for separating polyolefin resins according to crystallizability. A relatively low isothermal crystallization temperature is necessary to fractionate poly(1-butene) (PB-1) resin because of its slow crystallization kinetics . This study aims to investigate the influence of isothermal crystallization temperature of TREF on the fractionation and chain microstructure of eluted fractions for one poly(1-butene-co-ethylene) with 5.8 mol% ethylene. The resin is fractionated using P-TREF under four different isothermal crystallization temperatures, i.e. 0 °C, −5 °C, −10 °C, and −30 °C, and then the fractions are characterized by high-temperature gel permeation chromatography (HT-GPC), 13 C nuclear magnetic resonance spectroscopy ( 13 C NMR), and differential scanning calorimetry (DSC) to acquire their chain microstructure information. The isothermal crystallization temperature significantly affects the nucleation and growth of the crystals, which consequently results in differences in the relative content of eluted fractions. With the decrease of isothermal crystallization temperature from 0 °C to −30 °C, the copolymer is fractionated more effectively since fractions are more evenly distributed among elution temperatures rather than concentrated at lower elution temperatures. Furthermore, the isothermal crystallization temperature influences the chain microstructure of fractions obtained at the same elution temperature, which are different in ethylene content, isotacticity, and average sequence length. The distribution of ethylene content and isotacticity becomes broader with the decrease in isothermal crystallization temperature. Lower isothermal crystallization temperature is conducive to effective separation of the fractions with weak crystallizability. These results are of great significance for the selection of fractionation conditions and chain microstructure analysis of poly(1-butene-co-ethylene) resins.
研究领域:
高分子化学
·
材料科学
·
聚合物表征
·
热分析
·
核磁共振波谱学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）