JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2025
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IF 4.9
Wentao Ma,Shiwen Gong,Xianbiao He,Die Hu,Bo Cheng,Jing Yang,Binbin Li,Xinyu Wang
Thrombosis is a critical marker of cardiovascular diseases such as stroke and myocardial infarction. Timely diagnosis and dissolution of thrombi can significantly reduce patient mortality risk. Theranostic nanoparticles with targeting capabilities offer a promising solution to this issue. We developed fucoidan-modified PLGA nanoparticles loaded with indocyanine green (ICG) and lumbrokinase (LK) (FCP-ICG@LK NPs) to achieve integrated diagnosis and treatment of thrombotic diseases while minimizing hemorrhagic risks. Targeting experiments demonstrated the affinity of fucoidan for P-selectin. In a mouse model of carotid thrombosis, FCP-ICG@LK NPs demonstrated excellent diagnostic and monitoring capabilities while effectively dissolving thrombi under near-infrared light. Compared with free LK, FCP-ICG@LK NPs showed better thrombolysis effects at the same dose. Furthermore, bleeding risk assessment experiments indicated that FCP-ICG@LK NPs do not induce hemorrhagic risks. FCP-ICG@LK NPs showed no significant cytotoxicity or hemolysis. These results indicate that fucoidan-modified PLGA drug-loaded nanoparticles are a promising thrombus-targeted theranostic agent.
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JOURNAL OF MATERIALS SCIENCE
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2025
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IF 3.9
Lai Jinyin,Guo Zhengqiang,Liu Wangyu
Interface solar evaporators generate fresh water through solar evaporation, presenting significant potential to address global water scarcity. However, current evaporators struggle to balance sustainability, high evaporation rates, and robust mechanical properties, resulting in limited applications. In this study, agar/sodium alginate hydrogels were synthesized using a dual-network strategy, with the internal water state adjusted to optimize their properties. Additionally, the incorporation of nanocellulose significantly enhanced the mechanical properties of the evaporator (improved 65% compressive strength), thereby extending its service life in harsh environments. Moreover, nanocellulose acted as an efficient green dispersant for carbon nanotubes (CNTs), facilitating photothermal conversion and improving solar energy absorption. Notably, we employed a freeze–thaw process to induce lateral aggregation of sodium alginate, resulting in layered water channels that optimized water transport and evaporator performance. This unique design resulted in the development of evaporators that exhibited a high evaporation rate of 3.286 kg·m −2 ·h −1 in a 3.5 wt% NaCl solution, achieving a photothermal conversion efficiency of 98.65% under 1 kW·m −2 light intensity. Moreover, even in a 20 wt% NaCl solution, the evaporation rate remained at 3.02 kg·m⁻ 2 ·h⁻ 1 . This work combined highly hydrophilic natural materials with a specialized water delivery channel design to develop hydrogel-based solar evaporators with high evaporation rates and excellent mechanical properties, offering strong potential for long-term interfacial evaporation applications.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Xuehua Shen,Ruirui Zhang,Ruiheng Zhang,Feng Xie,Han Hua,Pengju Wang,Feng Yan,Zewei Quan,Zuotai Zhang
CaO-based sorbents represent a highly viable solution for post-combustion CO 2 capture, with granulation commonly employed to mitigate elutriation in fluidized-bed reactors. Nonetheless, granulation markedly increases the density of these sorbents, thereby impairing their CO 2 uptakes and cyclic stability. In this study, a cost-effective strategy was developed by incorporating various pore-forming agents (agar, urea, straw, and biochar) into CaO-based particles (denoted as CaO+C+A, CaO+C+U, CaO+C+S, and CaO+C+B) to enhance their adsorption performance and durability. The findings revealed that the mechanical strength of uncalcined CaO-based particles remained unaltered by the incorporation of additives, whereas only the CaO+C+S particle maintained acceptable compressive strength (17.1 N) and a low attrition rate (6.6 %) after calcination. Compared with the CaO+C+A particle, the compressive strength of CaO+C+S particle was increased by 87.5 % and the attrition rate was decreased by 22.8 %. Meanwhile, the CaO+C+S particle exhibited the highest CO 2 adsorption performance, achieving 541 mg/g within 10 min, alongside outstanding cyclic stability, maintaining 217 mg/g after 20 cycles. This represents a 17.4 % increase in initial adsorption and a 25.3 % improvement in long-term stability compared to the control particle. These advancements are attributed to straw’s role in facilitating pore formation, refining CaO crystal size, and increasing the proportion of high-melting-phase (CaAl 4 Si 2 O 11 ). The first two factors markedly enhance the diffusion kinetics conditions and thus improving the CO 2 adsorption performance of CaO-based particles. Combined, these three factors enhance resistance to sintering by creating spatial physical barriers and increasing the melting point. This study offers a straightforward and cost-efficient modification approach to improve the CO 2 adsorption performance and durability of CaO-based particles.
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APPLIED ENERGY
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2025
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IF 11
Yimeng Du,Shengfan Qin,Pengcheng Lin,Ying Chen
Efficient conversion of salinity energy into green power is an innovative renewable energy technology towards offshore electricity supply and utilization. Improving the conversion efficiency through sustainable strategies, low-cost materials, and facile processes still remains a challenge. In this work, a strategy of constructing a three-dimensional nano-hybrid hydrogel membrane with gradient charge density is proposed. The charged nanoparticles fabricated by post modification of commercial ZnO is dispersed in the hydrogel to ensure high selectivity for ion transport. The asymmetric pore structure in the hydrogel membrane provides high transport capacity for ion transport. The cost of nano-hybrid hydrogel membrane is as low as 0.0122 $ g −1 . After optimizing the effect of different environmental conditions on the membrane performance, a power density of 4.33 W·m −2 and an energy conversion efficiency of 33.6 % are obtained. To overcome the volatility of the power production, a capacitor is utilized to collect and store the electrical energy converted from salinity energy. The charged capacitor is coupled with offshore self-powered electronics and successfully communication and positioning. This work proposes offshore application scenarios for efficient conversion of renewable salinity energy into green power through sustainable technology.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Tunga Kuhana Arsene,Miaomiao Tian,Yatao Zhang
The increasing demands of modern industrialization underscore the need for efficient separation and purification technologies. Multifunctional nanofiltration (NF) membranes are gaining prominence as a means to lower energy consumption, enhance efficiency, and increase process flexibility. This study explores the development of thermally stable NF membranes through interfacial polymerization (IP), employing organophosphorus bis(4-aminophenyl) phenylphosphonate (BAPP) and trimesoyl chloride (TMC) as monomers in the aqueous and organic phase, respectively. The optimized BAPP-4 membrane (containing 0.1550 w/v% BAPP), which presented a nodular buried structure, exhibited exceptional water permeability (9.23 L m −2 h −1 bar −1 ) and high Na 2 SO 4 rejection (98.52 %). Furthermore, the membrane exhibited enhanced antibacterial properties, achieving 98.00 % Escherichia coli removal, attributed to hydrogen bonding and electrostatic interactions involving amide and phosphorus groups. The BAPP-4 membrane also showed rapid flux recovery in antifouling tests, primarily due to its surface hydrophilicity. Notably, the utilization of BAPP increased the rigidity of the cross-linked polyamide network, leading to improved thermal stability. This research presents a facile and effective approach for developing high-performance and multifunctional NF membranes.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2025
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IF 5.2
Tiancheng Xiong,Yang Han,Zhiyun Qi,Sha Guo,Xueyan Hu,Cui Wang,Lingkun Li,Tianyu Ma,Jingyi Chen,Jinghui Li,Jing Han,Hao Wu
The COVID-19 pandemic has underscored the significant challenges of vaccine distribution, particularly to low- and middle-income countries. Even when vaccines are made available through purchases or donations, issues such as insufficient trained medical personnel and inadequate infrastructure impede their widespread use. To address these challenges, we propose the Microneedle & Film-Forming Gel Transdermal Delivery Strategy (MFT strategy), which combines the minimally invasive nature of microneedles with the stability of film-forming gels that can be stored at room temperature. This strategy aimed to simplify vaccine production, reduce logistical burdens, and improve the efficiency of transdermal vaccine delivery while generating strong immune responses. In this study, we used ovalbumin as a model antigen and developed microneedles from methacrylic acid-modified hyaluronic acid, polyvinylpyrrolidone, and polyvinyl alcohol, in conjunction with a polyvinyl alcohol-borax (PVA-B) film-forming gel. In vitro experiments demonstrated that the MFT strategy has achieved an efficiency improvement of 202.75 % compared to previously reported strategies. Besides, PVA-B film forming gel displayed strong antimicrobial properties and effectively stabilized proteins over 30 days at 25 °C, preserving the antigenic structure essential for vaccine efficacy. In vivo tests revealed that the MFT strategy induced humoral immune responses comparable to those achieved by intramuscular injection, with histological analysis confirming good skin tolerance and safety. Overall, the MFT strategy represents a promising vaccine delivery method with substantial clinical potential.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Yuan Yuan,Mengqin Zhang,Guoyang Xie,Jianxiu Wang,Fan Wu,Xinyao Yi
The fabrication of DNA-based nanomaterials with specific functionalities is crucial for advancing tumor therapy. Herein, a novel and facile approach was presented to construct a corona-shaped DNA hybrid nanoplatform, which involved the anchoring of rolling circle amplification (RCA) products on near-infrared (NIR) light-responsive gold nanoflowers (AuNFs). The incorporation of AS1411 aptamer into the RCA product endowed the nanoplatform with the capability of multivalent targeted binding to cancer cells. The nanoplatform exhibited good biocompatibility, notable NIR absorption and robust photothermal conversion, thereby enabling controlled drug release in response to dual NIR/pH stimulation. The developed nanoplatform holds great promise for targeted and responsive cancer treatments.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2025
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IF 6.6
Honglin Jiang,Xinwen Wang,Junzhe Shang,Yiwen Bao,Jiaxin Li,Yifan Guo,Dongnan Li,Bin Li,Xu Si,Jinyan Zhu
This study investigated the effect of trehalose coating on the quality and shelf life of Atlantic salmon ( Salmo Salar ) treated by ultra-high pressure (UHP). Key parameters, including microbial safety, texture properties, protein oxidation, and volatile compounds, were analyzed. Results showed that UHP at 200-300 MPa achieved approximately 0.3–2.9 log reductions in microbial counts, while also inducing texture loss and protein oxidation. At 300 MPa, the carbonyl content exceeded 50%. Trehalose coating effectively mitigated texture degradation by restoring hardness to 98% of fresh samples and inhibiting oxidative damage in terms of 13% increased total sulfhydryl groups. Aroma analysis showed that UHP treatment promoted the accumulation of aldehydes derived from lipid oxidation and the beneficial flavor of hexanal and nonanal, while also inhibiting spoilage odor. Trehalose coating further inhibited 2-ethylhexanol and acetic acid, while retaining key flavor ketones of 3-hydroxy-2-butanone. A shelf-life prediction model integrating first-order kinetics and the Arrhenius equation achieved high accuracy (R 2 >0.97), indicating the extended refrigerated shelf life from 3 d to 25 d. This study provides a novel strategy by combining non-thermal treatment and bioprotectants for aquatic product preservation.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Tangjun Ren,Junyu Meng,Mengke Sun,Qi Zhang,Chenyang Yao,Haonan Wu,Xinting Wang,John Osilama Thomas,Liuliu yang,Enpeng Gu,Xi Wang,Jian Yang
As a physiological process maintaining skin integrity, wound healing is often disrupted by complex microenvironments, infection, and abnormal pH levels, leading to delayed healing. Additionally, irregularly shaped wounds are complex enough to cover adequately with traditional dressings. To address these issues, we developed a functional hydrogel via the Schiff base reaction between chitosan (CS) and difunctional telechelic-polyethylene glycol (DT-PEGn) of varying molecular weights, which was subsequently loaded with ciprofloxacin (CIP) to form a CS@DT-PEGn@CIP composite system. The results demonstrate that DT-PEGn of different molecular weights effectively modulate the hydrogel's swelling ratio, mechanical properties, injectability, self-healing capacity, and drug release characteristics, thereby conferring tunable functional advantages in wound repair. In vitro antibacterial assays and a rat full-thickness wound model further confirmed the outstanding efficacy of CS@DT-PEGn@CIP in significantly inhibiting bacterial growth and accelerating wound healing. Notably, the CS@DT-PEG6000 hydrogel containing only one-third of the free CIP dose exhibited superior therapeutic outcomes compared to free CIP alone, highlighting the high efficiency and safety of the composite system. In summary, this study systematically demonstrates the unique advantages of CS@DT-PEGn hydrogel in promoting wound healing, including its responsiveness to microenvironmental pH, antibacterial properties, and excellent conformability to wound surfaces. These findings provide novel strategies and potential applications for clinical wound management.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Shuyang Gan,Tianran Zheng,Jiayu Miao,Yunhua Bai,Xiong-Fei Zhang,Jianfeng Yao
Escalating environmental concerns over plastic packaging have prompted extensive researches into renewable bio-based alternatives. In this study, bacterial cellulose (BC) films modified with natural Sapindus saponin (SS) and gelatin were developed as multifunctional active packaging materials for fruit preservation. SS and gelatin gave the composite a denser and more stable structure via the formation of covalent crosslinking, thereby strengthening the mechanical properties of the bio-based films (BFs). The tensile stress of the designed film (BF3) was 28.21 MPa, which was 89.93% greater than that of the BC film. Compared with the control, the BFs had better thermal stability and greater barrier properties, coupled with good natural affinity. Additionally, owing to the presence of SS, the BF3 showed remarkable ultraviolet-blocking capacity (92.24% UVA and 99.71% UVB shielding rates), antioxidant activity (68.47% DPPH and 74.38% ABTS scavenging activities), and anti-bacterial property ( Escherichia coli , 6.4 mm; Staphylococcus aureus , 22.8 mm), which corresponded to the excellent freshness preservation ability. The fresh blueberries packaged with BF3 had less weight loss, reduced postharvest decay, and delayed softening, thus achieving a longer shelf life. In summary, BFs have a promising application prospect as a sustainable and effective packaging material for fruit preservation.
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ACS Nano
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2025
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IF 16
Xianyou Sun,Zihan Jin,Shaoxiang Zhang,Peng Lin,Xueming Zhang,Jiaying Sun,Yanchi Zhang,Yong Zhou,Yanjie Hu,Zhuoru Huang,Jiahao Hu,Shichao Tian,Guangqing Ren,Ping Wang,Liubing Kong,Hao Wan
Urine, abundant in disease-related biomarkers, offers advantages such as easy collection and noninvasiveness. Portable biochemical sensors are ideal for efficient on-site applications due to their flexibility and accessibility. However, existing sensors face challenges in complex sample operations and limited sensor renewal, hindering large-scale and convenient urine analysis. This study presents the “lab on pipette” (LOP) concept to address these issues, enabling efficient on-site urine analysis. The LOP system integrates a multifunctional pipette tip and a miniaturized system, facilitating the detection of multiple biomarkers in urine. Laser-induced graphene (LIG) technology fabricates an electrochemical electrode array on flexible polyimide, and custom-designed electrical interfaces ensure quick plug-and-play connections. Gold nano dendrites, Prussian blue (PB), and nickel hexacyanoferrate (NiHCF) form a multilayer functional interface, enabling highly sensitive detection of pH, hydrogen peroxide, glucose, and ascorbic acid with pH compensation. NiHCF doping enhances PB stability, while nanoalumina-doped porous enzyme membranes improve sensor repeatability and reliability. Gold nano dendrites anchor the enzyme membrane on curved surfaces, ensuring robust performance. The LOP achieves detection limits of 7.19 and 8.57 μM for glucose and ascorbic acid, respectively. Its low cost, disposability, portability, and reliability highlight its potential for on-site biochemical detection and personalized health monitoring.
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BIOMACROMOLECULES
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2025
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IF 5.4
Shunlan Chen,Jing Liu,Dapeng Li,Ying Wen,Yiwan Huang,Shijun Long,Xuefeng Li
Bioadhesive hydrogels of favorable tribological attributes have attracted intensive attention for their potential usage due to the large benefits they can bring to surgical critical care. We report an all-natural polymer-based and bilayer-integrated asymmetrical Janus hydrogel bioadhesive patch for efficient myocardial infarction (MI) repair. We developed a low-friction polyelectrolyte composite biohydrogel (Bio-PEC hydrogel), CA, using naturally occurring cationic chitosan quaternary ammonium salt (HACC) and anionic sodium hyaluronate (HA). We further developed a high-adhesion Bio-PEC hydrogel, TA@CA, by incorporating tannic acid (TA). Ultimately, we integrated them into a bilayer asymmetrical Janus hydrogel bioadhesive, CA|TA@CA, which exhibited excellent bulk mechanical properties and favorable one-sided adequate adhesion to myocardial tissue (fracture strength 0.98 MPa, fracture strain 330%, and interfacial toughness 50.87 J/m2). Additionally, the in vivo myocardial repair surgery using the CA|TA@CA Janus hydrogel has been shown to inhibit ventricular remodeling more effectively. Such CA|TA@CA Janus hydrogel bioadhesives may have high potential as medical patches for MI repair.
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