INDUSTRIAL CROPS AND PRODUCTS
·
2025
·
IF 6.2
Xu Dong,Liping Chen,Danjie Xu,Jian Zhang,Fang Hu,Qingwei Ping
Considering the non-renewable and non-biodegradable characteristics of conventional petroleum-based plastic films, their widespread use contributes significantly to environmental degradation. This study utilizes a green synthesis citrate-based chemical cross-linking strategy to improve the dispersion of ethanol lignin within the film, thereby promoting the development of a natural, safe, renewable, biodegradable, and environmentally friendly biomass-based functional food packaging material. A novel, multifunctional green food preservation film (ELA x C) was synthesized by employing CMC film as the substrate, ethanol lignin (EL) as the functional agent, and citric acid (CA) as the cross-linking agent. The influence of CA addition on the properties of the film was systematically examined. The results indicated that the ELA 0.2 C film exhibited an optimal elongation at a break of 8.0 %, a tensile strength of 28.49 MPa, and outstanding UV-blocking performance, effectively blocking 100 % of UVB and 99.2 % of UVA radiation. Furthermore, the ELA 0.2 C film exhibits antioxidant properties, gas barrier performance, and biodegradability. This film demonstrates significant potential as a multifunctional cling film for apple slices. Moreover, EL can be directly applied as a functional agent without the need for re-dissolution, thereby offering an innovative pathway for the efficient and environmentally sustainable utilization of lignin.
研究领域:
食品科学与技术
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高分子材料
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绿色化学
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可持续包装
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木质素利用
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Xin Jiang,Siyu Yuan,Jie Yang,Hui Liao,Hansong Wu,Baolin Jiang,Kun Qian
Drug cocrystal can not only improve the physicochemical properties of drugs but also exert a synergistic effect without altering the original structure of drugs. Herein, we successfully synthesized a norfloxacin-kaempferol cocrystal hydrate (cocrystal 1 ) from an antibacterial drug and a flavonoid active ingredient. Compared with norfloxacin or kaempferol alone, cocrystal 1 enhanced antibacterial activity against Gram-positive bacteria ( S. aureus ), Gram-negative bacteria ( K. pneumoniae and P. aeruginosa ), and fungus ( C. albicans ). Meanwhile, cocrystal 1 enhanced the antioxidant activity of kaempferol and also improved the solubility of norfloxacin and kaempferol. Moreover, cocrystal 1 enhanced the anticancer activity against human breast cancer cells MDA-MB-231, colon cancer cells SW480 and lung cancer cells H1299.
研究领域:
药学
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药物化学
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晶体工程
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抗菌研究
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癌症药理学
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产品关联
DOI
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Jing Zhang,Yuxiao Wang,Na Li,Lin Gao,Dongxu Zhang,Hongxun Tao,Rentang Zhang
Previous studies demonstrated that the blackening process could enhance the bioactivity of jujubes while it could also lead to uncontrolled Maillard reactions, potentially compromising product quality. To address this, we investigated how exogenous anthocyanin regulated the Maillard pathway and promoted desirable aroma formation during the fermentation of blackened jujube wine. Results showed that exogenous anthocyanin reduced the 5-hydroxymethylfurfural content in blackened jujube wine from 1.18 mg/L to 0.82 mg/L, suggesting a potential interaction with Maillard intermediates or 5-hydroxymethylfurfural. Moreover, the contents of bioactive compounds increased during the fermentation. HS-SPME-GC-MS analysis identified that a crucial phase for flavor development occurred on day 6 of fermentation, with ester compounds peaking at 7658.19 μg/L. Among these, ethyl caprylate and ethyl caprate were the predominant flavor compounds. The addition of exogenous anthocyanin increased the concentration of total volatile compounds in blackened jujube wine, resulting in a rich fruity and floral aroma at the end of fermentation. These results elucidate the mechanistic role of exogenous anthocyanin in modulating the Maillard pathway and aroma formation, providing a theoretical foundation for optimizing blackened jujube wine quality.
研究领域:
食品科学与技术
·
酿酒与发酵技术
·
风味化学
·
植物化学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xiaoyi Zheng,Yijie Xie,Linlin Zhao,Xiaojuan Huang,Shige Wang,Yongkang Lai,Peng Fan,Yanbo Zeng,Jiulong Zhao,Zhaoshen Li
This study developed a chitosan (CS)‑sodium tripolyphosphate (TPP)‑zinc (Zn) nanogel for treating Helicobacter pylori ( H. pylori ) through synergistic antibacterial, anti-inflammatory, and mucosal repair mechanisms. The nanogel was synthesized via an emulsion method, leveraging electrostatic interactions between CS amino groups and TPP phosphate ions, followed by Zn incorporation. Characterization revealed uniform spherical nanoparticles (~200 nm) with high Zn content (20.18 %) and controlled hydrogen (H 2 ) and Zn 2+ release (15 h) in acidic environments. In vitro assays demonstrated potent antibacterial activity against H. pylori (95.83 % inhibition at pH = 2; 28.54 % inhibition at pH = 7) attributed to Zn 2+ -mediated enzyme disruption. The nanogel exhibited significant antioxidant capacity, scavenging 82.3 % of PTIO and 65.48 % of DPPH radicals. Biocompatibility testing confirmed minimal haemolysis (<5 %) and high cell viability (>95 %). In vivo studies in H. pylori -infected mice demonstrated a bacterial inhibition rate of 97.54 % through upregulation of β-catenin and tight junction proteins. Concurrently, mucosal repair was enhanced, achieving migration rates of 44.2 ± 5.6 % and 72.34 ± 2.1 % at 12 and 24 h respectively. The nanogel also preserved gut microbiota diversity post-treatment, unlike conventional antibiotics. This multifunctional nanogel platform combines biocompatibility, ease of manufacture and dual therapeutic effects. In summary, this study proposes a multifunctional therapeutic strategy capable of simultaneously addressing H. pylori infection, gastric inflammation and mucosal damage. It offers a paradigm shift from traditional antibiotic-centred therapies, providing a promising strategy for eradicating Helicobacter pylori and restoring gastric injury.
研究领域:
纳米医学
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胃肠病学
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抗菌治疗
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药物递送
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生物材料
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Baojin Tan,Weilin Yang,Guanglin Zhang,Rong Zeng
Acute lung injury (ALI), a life-threatening inflammatory syndrome driven by macrophage polarization imbalance, triggers uncontrolled cytokine storms and alveolar-capillary barrier collapse. While macrophage-targeted immunomodulation holds therapeutic promise, current strategies suffer from imprecise cellular targeting and inadequate functional reprogramming. To address this, we developed an inhaled biomimetic apoptotic body-mimicking nanoplatform (CeCPT@PSL). Its phosphatidylserine-containing liposomal (PSL) shell replicates the “eat-me” signaling of apoptotic bodies to enable macrophage targeting and immunomodulation. Inspired by the organelle-regulating capacity of apoptotic cargo, the encapsulated synthetic mitochondrial-targeting nanozyme complexes (CeCPT) execute precision mitochondrial restitution through redox homeostasis restoration. This dual-pathway strategy achieves synergistic therapy by concurrently modulating macrophage function and repairing damaged mitochondria, thereby enhancing macrophage repolarization. In murine ALI models, inhaled CeCPT@PSL concurrently attenuated inflammatory cascades and resolved mitochondrial impairment via targeting lung-macrophage-mitochondrial axis, and restored pulmonary function. This bio-inspired multi-function platform establishes a heuristic strategy wherein artificial nanovesicles recapitulate cellular functions to resolve dysregulated pathological cascades, offering a promising therapeutic avenue for intractable inflammatory diseases.
研究领域:
纳米医学
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免疫治疗
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炎症性疾病
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呼吸医学
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线粒体生物学
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产品关联
DOI
PubMed
高影响因子
PHYTOCHEMICAL ANALYSIS
·
2025
·
IF 2.6
Yan Jiang,Hui Ni,Wen-Jing Zhao,Long Wang,Cai Zhang,Ping Li,Hui-Jun Li
Introduction Multiorigin phenomenon is quite common in Chinese herbal medicine, whereas quality consistency evaluation among the involved plant species is seldom considered. Objectives The present study, taking Taraxaci herba as a typical case, aimed to develop a strategy based on a combination of chemical similarity and in vitro bioequivalence to evaluate the quality consistency of three Taraxacum species. Materials and Methods The chromatographic fingerprints were established through two approaches, namely, high-performance liquid chromatography coupled with photodiode array detector and quadrupole time-of-flight mass spectrometry (HPLC-PDA/QTOF-MS) and gas chromatography coupled with quadrupole time-of-flight mass spectrometry (GC-QTOF-MS). The common characteristic peaks from chromatographic fingerprints were quantified. The bioactivities were tested by antioxidant and anti-inflammatory activity assays. Quality consistency of the three Taraxacum species was globally evaluated by using a combination of chemical similarity and in vitro bioequivalence through univariate and multivariate statistical analysis. Results The statistical results showed no classification of the three species based on contents of quantified analytes and in vitro bioactivities, respectively. Conclusion This study not only demonstrated the medicinal interchangeability of three species of Taraxaci herba but also proposed a comprehensive strategy to evaluate quality consistency of multiorigin Chinese herbal medicines by integrating chemical similarity and in vitro bioequivalence.
研究领域:
生药学
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天然产物化学
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中医药学
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分析化学
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药物评价
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Shuyang Gan,Tianran Zheng,Jiayu Miao,Yunhua Bai,Xiong-Fei Zhang,Jianfeng Yao
Escalating environmental concerns over plastic packaging have prompted extensive researches into renewable bio-based alternatives. In this study, bacterial cellulose (BC) films modified with natural Sapindus saponin (SS) and gelatin were developed as multifunctional active packaging materials for fruit preservation. SS and gelatin gave the composite a denser and more stable structure via the formation of covalent crosslinking, thereby strengthening the mechanical properties of the bio-based films (BFs). The tensile stress of the designed film (BF3) was 28.21 MPa, which was 89.93% greater than that of the BC film. Compared with the control, the BFs had better thermal stability and greater barrier properties, coupled with good natural affinity. Additionally, owing to the presence of SS, the BF3 showed remarkable ultraviolet-blocking capacity (92.24% UVA and 99.71% UVB shielding rates), antioxidant activity (68.47% DPPH and 74.38% ABTS scavenging activities), and anti-bacterial property ( Escherichia coli , 6.4 mm; Staphylococcus aureus , 22.8 mm), which corresponded to the excellent freshness preservation ability. The fresh blueberries packaged with BF3 had less weight loss, reduced postharvest decay, and delayed softening, thus achieving a longer shelf life. In summary, BFs have a promising application prospect as a sustainable and effective packaging material for fruit preservation.
研究领域:
食品科学与技术
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材料科学
·
可持续包装
·
高分子化学
·
采后生物学
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产品关联
DOI
PubMed
高影响因子
Biochar
·
2025
·Vol. 7
·期 1
·1-18
·
IF 13.5
Gao Yajie,Gao Yuan,Li Aimin
Persistent free radicals (PFRs) in biochar have attracted wide attention due to their multifaceted roles in the environment. The regulation of PFRs in biochar is not only beneficial to broaden its application potential, but also eliminates its environmental risks. However, as a common biochar modification reagent, phosphoric acid (H 3 PO 4 ) has not been studied in the field of PFRs regulation. Herein, this study systematically investigated the effect of H 3 PO 4 on PFRs in biochar under various conditions. The results indicated that H 3 PO 4 promoted the formation of PFRs in biochar at low pyrolysis temperature (< 500 °C), owing to the positive effect of catalytic cross-linking on the degradation of biomass precursor. Yet, H 3 PO 4 reduced PFRs in biochar at high pyrolysis temperature (≥ 500 °C), since the capture of H∙ or HO∙ by PO∙ and the steric hindrance changed by H 3 PO 4 , which caused the rearrangement and polycondensation of carbon structure. H 3 PO 4 also favored carbon-centered PFRs as the dominant type. The ingredients of biomass precursor, including cellulose, Fe, Ti, protein, etc., contributed to different effects on PFRs under H 3 PO 4 modification. This study provided new insights into the roles of H 3 PO 4 on the formation and transformation of PFRs in biochar, coupled with regulation strategies in the practical application. Graphical
研究领域:
环境科学
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材料化学
·
污染控制
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热解技术
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产品关联
DOI
高影响因子
Cosmetics
·
2025
·Vol. 12
·期 6
·281
·
IF 3.2
Chuanjun Ye,Kangfu Zhou,Zhicheng Ye,Yazhuo Shang,Feifei Wang
The valorization of agricultural byproducts into functional cosmetic ingredients is a promising strategy for sustainable formulation development. In this work, rawPrinsepia utilisRoyle seed residue powder (RPURSRP) which was discarded after oil pressing was upcycled and micronizedPrinsepia utilisRoyle seed powder (MPURSRP) was obtained by micronization as an eco-friendly Pickering stabilizer. The physicochemical properties of MPURSRP have been studied comprehensively. The results have shown that the MPURSRP (20.28 ± 0.00 μm) exhibited a spherical shape, which is significantly smaller than the RPURSRP (61.49 ± 2.28 μm). The MPURSRP particles tend to reside at the interface between oil and water, allowing them to function as emulsifiers that promote the formation of Pickering emulsions. The emulsifying properties of MPURSRP were investigated systematically. The results revealed that the MPURSRP displayed a better emulsifying performance for non-polar oils. Meanwhile, the existence of polyphenols—an endogenous substance of thePrinsepia utilisRoyle seed, endows the prepared Pickering emulsion with good antioxidant activity. As the MPURSRP concentration increased from 0% to 3.0 wt%, more MPURSRP adsorbed at the oil–water interface, and the DPPH radical scavenging rate of the emulsion increased from 9.99 ± 0.63% to 91.71 ± 4.22% (p< 0.001). By upcycling agricultural waste into amphiphilic particles with interfacial properties, we establish a green strategy for stabilizing Pickering emulsions with endogenous antioxidant functionality, offering meaningful guidance toward sustainable colloid systems. This work aligns with the growing demand for natural, bioactive ingredients in green cosmetic formulations.
研究领域:
绿色化学
·
胶体科学
·
化妆品科学
·
可持续材料
·
食品与农业副产物利用
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产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Leshou Zhang,Lili Yu,Shengchun Yang,Xiaofang Yang,Shaodui Ye,Haiwei Ma,Jiayi Hu,Yong Liu,Zhenjuan Duan,Xiaodong Wen
Natural deep eutectic solvents (NADESs), as a newly developed class of environmentally benign solvents, offer a promising alternative to conventional toxic organic solvents for the extraction of valuable bioactive compounds from medicinal plants. This study developed an innovative green approach for the simultaneous extraction of active ingredients from Erigeron breviscapus (E. breviscapus) by utilizing ultrasound-assisted natural deep eutectic solvent extraction (UAE-NADES). Response surface methodology was employed to systematically optimize the extraction parameters. Under the optimized extraction conditions, the total extraction yield of phenolic acids and flavonoids obtained using UAE-NADES was 68.66 mg/g, demonstrating superior performance compared to that of traditional organic solvents. Additionally, the extraction mechanism of the representative bioactive constituent, scutellarin, established by the proposed method was investigated by using density functional theory (DFT), revealing that hydrogen-bonding and van der Waals forces exerted a significant influence on the extraction process. More importantly, NADES exhibits the capacity for multiple recycling and reuse cycles. Finally, the UAE-NADES strategy was applied to achieve the simultaneous extraction of target bioactive constituents from E. breviscapus under varying light qualities following supplementary lighting. This study provides a novel strategy for the green, sustainable, and simultaneous extraction of multiple bioactive constituents from medicinal plants via recyclable NADES.
研究领域:
绿色化学
·
植物化学
·
提取技术
·
天然产物
·
计算化学
·
可持续工程
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产品关联
DOI
高影响因子
ACS Applied Bio Materials
·
2025
·
IF 4.7
Qi Meng,Chenyu Li,Jiayi Jiang,Fengzhen Guo,Yang Fu,Shuchen Gu,Tianyi Jiang,Jialu Pan,Yichun Zeng,Lei Sun,Shaohua Wu
Constructing fibrous dressings integrating innovative physical cues with appropriate biological cues is crucial for enhancing wound healing and reducing patient’s discomfort. In this study, a series of nanomicro conjugated fibrous dressings (NCFDs) were constructed via conjugated electrospinning, comprising poly(caprolactone) (PCL) microfibers (diameter >2 μm) with/without zinc oxide (ZnO) nanoparticles and PCL nanofibers (diameter <100 nm) with/without resveratrol (Res). ZnO-loaded NCFDs exhibited dramatically high antibacterial rates exceeding 99% against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Additionally, all NCFDs, regardless of ZnO and Res loading, demonstrated excellent biocompatibility for human dermal fibroblasts (HDFs) and superior hemostatic performance in a mouse liver bleeding model. The in vivo experiments revealed that the incorporation of ZnO and Res significantly promoted the wound healing process. Specifically, the wound closure rate of mPCL + 0.5%ZnO/nPCL + 8%Res NCFD reached 93.7 ± 0.6% after 10 days of treatment. The regenerated skin tissues displayed enhanced collagen deposition, improved epithelial regeneration, and neovascularization. The mPCL + 0.5%ZnO/nPCL + 8%Res NCFD was also found to significantly stimulate macrophage polarization toward the M2 phenotype, thereby reducing inflammation levels at the injury site. This study provides a novel routine to develop mPCL + ZnO/nPCL + Res NCFDs with innovative structure and appropriate biofunctions, demonstrating potential in wound treatment and skin tissue engineering.
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Junxian Xie,Jiahui Xie,Junjun Chen,Shiyun Zhu,Jun Xu,Haitao Yang
Light-colored lignin nanoparticles (LNPs) have shown great potential in their conversion and high value-added applications. However, the direct extraction of light-colored LNPs from lignocellulosic materials remains a significant challenge in the field. In this study, we developed a very effective strategy for rapid extraction (1 h) of light-colored LNPs from radiata pine using a new ternary deep eutectic solvent (TDES) composed of benzyltrimethyl-ammonium chloride (BTMAC), formic acid (FA) and maleic acid (MA). The results indicated the obtained average particle size of LNPs ranged from 127 nm to 171 nm. The extraction process was optimized to achieve high yields (84.7 %), purity (94.1 %) and low polydispersity index (PDI = 1.96) while maintaining the light-colored LNPs (brightness ISO 24.15 %), which was 9.7, 10.5 and 2.5 folds higher than Kraft lignin, alkali lignin and lignosulfonate, respectively. Further evaluation revealed that the IC50 of the three LNPs samples were less than 60 μg·mL −1 , exhibiting significant antioxidant activity. In addition, the introduction of MA could protect the β-O-4 linkage from excessive cleavage and recondensation as well as avoid the deepening of LNPs color. This work not only presents an effective method for extracting light-colored LNPs but also highlights their advantageous properties, paving the way for sustainable product development utilizing lignocellulosic biomass.
研究领域:
材料科学
·
纳米技术
·
绿色化学
·
木质素化学
·
生物质利用
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）