Catalysis Science & Technology
·
2022
·Vol. 12
·期 9
·2903-2911
·
IF 6.177
Zhenzhen Yang,Yuhan He,Pengfei Tang,Bangchong Zhu,Genlei Zhang,Jianbo He
Direct conversion of biomass-based fructose to 2,5-diformylfuran (DFF) has attracted much attention in recent years. In this study, molybdenum carbide anchored on glucose-derived carbon (β-Mo2C@C) was synthesized by a simple, green and economical method and was found to be highly active for production of DFF from 5-hydromethylfurfural (HMF) and fructose. DFF was obtained with high yields of 94.5% and 76.0% from aerobic oxidation of HMF and “one-pot” conversion of fructose under optimal reaction conditions, respectively. A probable mechanism involving Mo6+/Mo2+ redox cycles was proposed for β-Mo2C@C-catalyzed oxidation of HMF to DFF according to the experimental and characterization results. Furthermore, the β-Mo2C@C catalyst can be reused without much loss of catalytic activity, suggesting that β-Mo2C@C is highly stable.
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GREEN CHEMISTRY
·
2019
·Vol. 21
·期 19
·5336-5344
·
IF 9.405
Da Yang,Huan Liu,Lei Liu,Wen-Di Guo,Yong Lu,Ye Liu
An amphiphilic tri-functional ligand (L1) containing a Lewis acidic phosphonium cation, a phosphino-fragment and a hydrophilic sulfonate anion (–SO3−) enabled Pd(OAc)2 to efficiently co-catalyze the hydroxycarbonylation of terminal alkynes towards α,β-unsaturated carboxylic acids. These incorporated functional groups synergistically promoted the reaction, which proved more effective than the ligands lacking –SO3− and/or phosphonium and the mechanical mixtures of the individual functional groups independently. The molecular structure of Pd-L1 indicated that –SO3− in L1 served as a secondary O-donor ligand with reversible coordinating ability, cooperating with the phosphino-fragment to stabilize the Pd-catalyst. The in situ FT-IR analysis verified that the formation and stability of Pd–H active species in charge of hydroxycarbonylation were dramatically facilitated by the presence of L1. It was believed that, over the L1-based Pd-catalyst, H2O was cooperatively activated by the Lewis acidic phosphonium via “acid–base pair” interaction (H2O → P(V)+) and by the hydrophilic SO3−via hydrogen bonding (SO3−⋯H2O), giving rise to the formation of dimeric and mono-nuclear Pd–H species driven by reversible SO3−-coordination. In addition, the L1-based Pd-catalyst could be immobilized in the ionic liquid [Bmim]NTf2 for six-run recycling uses without obvious activity loss and detectable metal leaching.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2018
·
IF 3.412
Qianqian Geng,Jingchan Xie,Xin Wang,Mengling Cai,Hui Ma,Hanwen Ni
A water-soluble inclusion complex for butachlor was prepared by complexation with (2-hydroxypropyl)-β-cyclodextrin (HP-β-CD). Phase solubility results indicated a 1:1 stoichiometric ratio with an apparent stability constant of 864.3 M–1 in the obtained solid complex. The formation of the complex was confirmed by 1H nuclear magnetic resonance, Fourier transform infrared, and differential scanning calorimetry spectra. Coupled with the molecular docking results, butachlor was considered to be completely included in HP-β-CD cavity. Butachlor complexation with HP-β-CD decreased its adsorption capacity and enhanced its mobility in soil. The inclusion complex displayed better herbicidal activities than free butachlor. The 96 h median lethal concentration values of the inclusion complex and free butachlor was 2.30 and 0.65 mg L–1, respectively, for zebrafish, indicating that the complexation could significantly reduce toxicity to fishes. The present study provides an approach to develop environment-friendly formulations using CDs for herbicides.
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FOOD CHEMISTRY
·
2019
·
IF 5.399
Xiaodong Xu,Rui Xu,Qian Jia,Tao Feng,Qingrong Huang,Chi-Tang Ho,Shiqing Song
The volatile compounds of Volvariella volvacea mushroom were investigated by solvent assisted flavor evaporation (SAFE)/gas chromatography-mass spectrometry (GC–MS), gas chromatography-olfactometry (GC-O), odor activity value (OAV), combined with aroma reconstitution and omission. The results showed that a total of 63 compounds were detected after SAFE extraction. A total of 26 compounds were determined after GC-O and 17 compounds whose OAV greater than 1 were subjected to reconstitution and omission experiments. The results showed that dihydro-β-ionone, 1-octen-3-one, 1-octen-3-ol, γ-undecalactone, 3-octanol, 2-octanone, hexanal, 2-methylbutanal, camphene, carvone, 2-nonanone, and phenylacetaldehyde have been successfully identified as the key aroma compounds. More significantly, dihydro-β-ionone as a key aroma compound was first found in Volvariella volvacea mushroom.
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高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2020
·
IF 4.049
Yazhou Shuang,Yuqin Liao,Tianci Zhang,Laisheng Li
An ethylenediamine dicarboxyethyl diacetamido-bridged bis (β-cyclodextrin) was firstly synthesized through the reaction of 6-deoxy-6-amino-β-cyclodextrin (NH 2 -CD) with ethylenediaminetetraacetic dianhydride. Then it was bonded onto the surface of silica gel SBA-15 to obtain an ethylenediamine dicarboxyethyl diacetamido-bridged bis (β-CD)-bonded chiral stationary phase (EBCDP). The structures of the bridged bis (β-CD) and EBCDP were characterized by infrared spectroscopy, mass spectrometry, elemental analysis and thermogravimetric analysis, accordingly. The chiral chromatographic performances of EBCDP were systematically evaluated by separating 28 racemic analytes in the reversed-phase or polar organic mode, including eight flavanones, eight bolckers, five dansyl-amino acids, three DL-amino acids and four other common drugs. As a result, the relatively high enantioselectivity of EBCDP was observed in comparison with a native β-CD-CSP (CDSP). All selected analytes were separated on EBCDP, of which 20 analytes had resolutions up to baseline, 2′-hydroxyflavanone and arotinolol had resolutions up to 4.35 and 2.05 in about 30 min, respectively, whereas CDSP only separated 11 analytes with low resolutions (0.55~1.69). Moreover, EBCDP was able to utilize the complexation of the bridging linker (ethylenediamine dicarboxyethyl diamide group, EDTA-based) to realize direct separations of DL-amino acids with a mobile phase containing copper ion (Cu 2+ ), which was similar to the chiral ligand exchange chromatography. Unlike the native cyclodextrin with small cavity (~242 Å 3 ), the bridged bis (β-CD) combined two β-CD units with a bridging linker, having a well-organized “pseudo-cavity” as an organic whole to encapsulate more analytes, which made EBCDP have broad-spectrum applications in chiral separations.
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FOOD CHEMISTRY
·
2018
·
IF 4.946
Ling Chen,Ming Li,Youhong Ai,Xueping Dang,Jianlin Huang,Huaixia Chen
This work describes, for the first time, an acryloyled β -cyclodextrin hybrid monolith column was synthesized, under aqueous-phase conditions, and used for solid-phase microextraction of carbendazim and carbaryl . The monolithic column was characterized using scanning electron microscopy, nitrogen adsorption–desorption, thermogravimetric analysis and Fourier transform infrared spectroscopy, and used as the adsorbent for solid phase microextraction (SPME) of carbendazim and carbaryl. After optimization of the SPME conditions, a simple and sensitive SPME-HPLC method was developed for the determination of carbendazim and carbaryl in leafy vegetables. The method exhibited a good liner response in the range 5–400 μg/kg (R 2 = 0.9994) for carbendazim and 10–400 μg/kg (R 2 = 0.9996) for carbaryl, respectively. The limits of detection were 1.0 and 1.5 μg/kg for carbendazim and carbaryl, respectively, in leafy vegetables. Recoveries ranged from 92.6% to 110.1%, and the relative standard deviations were less than 6.1%.
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INTERNATIONAL DAIRY JOURNAL
·
2025
·
IF 3.4
Qianqian Ding,Jiuxiu Shi,Mengjiao Lv,Ling Li,Danli Wang,Tinglan Yuan,Gongshuai Song,Jinyan Gong
Protein-based complexes are critical for enhancing food functionality, particularly owing to the synergistic effects of ternary covalent complexes containing proteins, polysaccharides, and polyphenols. This study investigated the formation mechanism, structural characteristics, and functional properties of ternary covalent complexes composed of β-lactoglobulin (β-Lg), hyaluronic acid (HA), and three dicaffeoylquinic acid (DCQA) isomers (3,5-DCQA, 3,4-DCQA, and 4,5-DCQA); the complexes were prepared using different addition sequences. These complexes exhibited reduced surface hydrophobicity, altered secondary structures, and enhanced thermal stability. They showed significantly better antioxidant activities and emulsifying properties in comparison with native β-Lg. The protein-polysaccharide-polyphenol sequence yielded more stable and compact structures with higher polyphenol binding capacity. Subsequently, the protein-polysaccharide-polyphenol complexes were used to encapsulate curcumin (Cur), and it yielded encapsulation efficiencies up to 76.14 % (β-Lg-HA-3,4-DCQA-Cur), which was significantly higher than the encapsulation efficiency of native β-Lg-Cur (36.35 %). These complexes also improved the physical stability and antioxidant activity of Cur under adverse conditions. These findings highlight the critical roles of the addition sequence and polyphenol structure in modulating the functionality of protein-based complexes, and offer promising strategies for enhancing the delivery of bioactive compounds in food applications.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Jialin Hu,Lingling Guo,Xinxin Xu,Hua Kuang,Liguang Xu,Liqiang Liu,Chuanlai Xu,Hongyu Zhang,Maozhong Sun
Food fraud practices, such as milk adulteration, exacerbate allergy risks by introducing undeclared allergens, primarily β-lactoglobulin (β-Lg). Therefore, the effective detection of β-Lg in food is crucial for ensuring consumer safety. In this study, we screened hybridoma cell lines 11F10 and 4G1, which recognized β-Lg variants A (β-Lg A) and B (β-Lg B). Genes of these hybridoma cell lines were extracted, amplified, and cloned into expression vectors to produce recombinant antibodies (rAbs). Using rAbs 11F10 and 4G1, colloidal gold-based immunochromatographic strips were developed for detecting β-Lg A and B in dairy products. The strips exhibited a visual limit of detection of 200 μg/kg in cheese and amino acid formulas, and 200 ng/mL in raw milk. The results of molecular docking indicated that the critical amino acid residues for 11F10 were Asp57, Tyr32, and Arg49, whereas those for 4G1 included Tyr101, Tyr106, and Tyr49.
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ACS Chemical Neuroscience
·
2025
·
IF 3.9
Wenjing Li,Xiaochuan Zha,Xiaoyu Zhang,Haixin Dai,Suyun Pu,Xinya Yao,Wenxue Hui,Rui Xu,Junyu Bao,Jiahao Yu,Yan Wei,Jiawen Huang,Na Guo,Ming Xu,Jian Zhao,Bingbing Cheng,Zonghua Luo
Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is an innovative approach for enhancing the delivery of central nervous system drugs. 68Ga radiotracers are advantageous for imaging due to their ideal half-life and imaging properties; however, their limited ability to traverse the BBB constrains their application in brain imaging. This study investigates the application of FUS to selectively deliver the 68Ga radiotracer, [68Ga]STZL4110, into the hippocampus for β-amyloid positron emission tomography (PET) imaging in an Alzheimer’s disease (AD) mouse model. The synthesis and radiolabeling of [68Ga]STZL4110 were accomplished, demonstrating robust binding to β-amyloid, as validated by Thioflavin T assays and in vitro autoradiography with both wild-type (WT) and APP/PS1 AD mouse brain sections. Cavitation activity measurements confirmed effective and consistent BBB opening post-FUS treatment, ensuring targeted delivery without vascular damage, as supported by histological analysis. Quantitative PET imaging revealed the successful detection of β-amyloid deposition following FUS treatment. Initially, [68Ga]STZL4110 showed a low volume of distribution in the right hippocampus of AD mice. FUS application significantly enhanced BBB permeability, leading to a 74% increase in [68Ga]STZL4110 uptake in the targeted right hippocampus of APP/PS1 mice compared with the left hippocampus, whereas no significant change was observed in WT mice. These findings suggest that combining FUS with [68Ga]STZL4110 could significantly enhance the sensitivity and specificity of 68Ga PET imaging for β-amyloid. FUS-mediated PET imaging may potentially address the challenge of effective brain imaging with radiotracers that traditionally exhibit a low penetration of the BBB.
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Food Chemistry-X
·
2025
·
IF 8.2
Weijun Chen,Hui Hou,Jiaxin Han,Xinhui Wang,Yuncheng Li,Fanbing Meng,Donghong Liu,Xiaoying Guo
A ternary covalent complex was prepared by conjugating whey protein isolate (WPI)-(−)-epigallocatechin-3-gallate (EGCG) covalent complex with gum acacia (GA). A blue shift in the amide A band and decreased intensity of amide bands in the Fourier transform infrared spectroscopy spectra, and an increase in molecular size confirmed the covalent linkage. It was utilized to stabilize β-carotene emulsion. The freeze–thaw, ionic strength, thermal and pH stability of emulsions were enhanced by conjugation with GA. Compared with WPI, the WPI-EGCG covalent complex and its mixture with GA, the ternary covalent complex used as an emulsifier more effectively inhibited the degradation of encapsulated β-carotene under ultraviolet light irradiation and thermal treatment. The stability of the emulsion during simulated gastrointestinal digestion and the in vitro bioaccessibility of BC also significantly ( p < 0.05) increased after conjugation with GA. These findings could provide insights into the design of promising and effective food-grade emulsion delivery systems.
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Catalysis Science & Technology
·
2025
·
IF 4.2
Haoxi Jiang,Qian Ran,Yingying Zhao,Guochao Yang,Lingtao Wang
In response to the challenges of equipment corrosion and environmental pollution associated with the homogeneous catalytic production of crotonaldehyde via acetaldehyde aldol condensation, this work focused on the synthesis of Zr-β zeolites with Lewis acidity. The crotonaldehyde selectivity was significantly improved by tailoring the acidic properties of the zeolites. A comparative study of three distinct Lewis acid sites identified isolated framework tetra-coordinated Zr sites as the most efficient catalytic centers, which were successfully constructed using hydrothermal synthesis and liquid-phase incorporation methods. Zr-β zeolites synthesized via liquid-phase incorporation demonstrated higher conversion and selectivity owing to larger pore size, greater total Lewis acidity and a higher proportion of weak and medium Lewis acid sites. These properties were further optimized by adjusting the precursor and solvent during the synthesis process. In situ DRIFTS analysis revealed that the Lewis acid sites activated the α-H of acetaldehyde, forming carbanion intermediates essential for the enolization and subsequent aldol condensation. The main by-product, methyl cyclopentenone, was found to originate from the Prins reaction of sorbaldehyde formed through excessive aldol condensation, which was mediated by Brønsted acid sites. To suppress this side reaction, the zeolites were modified with alkali cations (Na+, K+) to selectively passivate the Brønsted acid sites while enhancing the Lewis acidity significantly. This strategy effectively reduced by-product formation and ultimately achieved a crotonaldehyde selectivity of 94.7%.
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Food Bioscience
·
2025
·
IF 5.9
Chen Yang,Tianlai Guo,Zizhen Zhang,Aitong Li,Yaqian Han,Yening Qiao,Guoqiang Xia,Lina Wang,Jianming Wang
Oleogels have been extensively employed for the encapsulation and protection of lipophilic nutrient. This study was investigated the effect of low ionic strength (0-100 mM) on the delivery system properties of oleogels prepared by emulsion template method using Soy protein isolate - Xanthan gum nanoparticles (SXNPs) as stabilizers. With the increase of ionic strength (0-100 mM), the particle size of SXNPs showed a trend of decreasing and then increasing. At ionic strength of 50 mM, SXNPs had the best interfacial adsorption properties (82.71 ± 0.19%), which was attributed to the salt ions improved the surface hydrophobicity of SXNPs. Under this condition, the emulsion stabilized by SXNPs exhibited the smallest particle size (2.23 μm) and the best rheological properties. Microscopic images showed that the oleogel had the densest network structure at ionic strength of 50 mM , which enhanced the retention of β-carotene in storage environments at 4, 25 and 55 °C and oil binding capacity of oleogel (10.20%). In vitro digestion showed up to 55.17% free fatty acid release from the oleogels compared to bulk oil, highlighting their potential for controlled nutrient delivery.
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