JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 15
·1125
·
IF 3.2
Tang Hui,Wang Ren-Zhi,Luo Qing-Wei,Lu Yuan-Fang,Ma Jiu-Ming
Lead-free BiFeO 3 –BaTiO 3 (BFO–BTO) ceramics possess large spontaneous polarization and high Curie temperature, while their practical energy storage applications are limited by low breakdown strength and recoverable energy density ( W reco ). In the present study, Ca/B/Si/K 0.01 /Na 0.02 (CBSKN) glass was introduced into 0.58BiFeO 3 –0.3BaTiO 3 –0.12NaNbO 3 ceramics via conventional solid-state reaction to improve their breakdown strength and recoverable energy storage density. The incorporation of CBSKN glass powder leads to a reduction in the Δ P ( P max – P r ) value of the samples, whereas an appropriate doping content can effectively enhance the electrical breakdown strength of the ceramics. Calculations of energy storage properties show that the CBSKN05 ceramic achieves a maximum energy storage density of 2.13 J/cm 3 under an electric field of 190 kV/cm. Moreover, the introduction of CBSKN glass effectively enhances the cycling fatigue, thermal and frequency stability, endowing the 0.58BiFeO 3 –0.3BaTiO 3 –0.12NaNbO 3 ceramic with great potential for high-performance energy storage capacitor applications.
✓ 已验证
DOI
高影响因子
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2026
·Vol. 118
·期 3
·55
·
IF 4.2
Zhang Siyu,He Ruitao,Cai Chaomin,Sun Yuxia,Li Ruiming,Yang Man,Liu Hongri
Antimony sulfide (Sb₂S₃) is a highly promising environmentally friendly semiconductor for the development of stable thin-film solar cells, owing to its high absorption coefficient, suitable bandgap ( ~ 1.7 eV), and the abundance of its constituent elements. Conventionally, CdS is employed as a buffer layer in CdS/Sb₂S₃/spiro/Au-structured solar cells. However, due to its intrinsic defects, various strategies have been implemented to enhance device performance and improve the power conversion efficiency (PCE) of Sb₂S₃ solar cells. In this study, we first fabricated a SnO₂ electron transport layer (ETL) and subsequently optimized the water bath temperature to achieve a smoother CdS layer. Furthermore, a La³⁺ ion doping process was introduced to further decrease the resistance of the CdS layer. The incorporation of an appropriate concentration of La³⁺ into the CdS layer effectively redeced its resistivity. By integrating these enhancements, we developed a La-doped CdS/SnO₂ double ETL structure. The grain size of Sb₂S₃ deposited on the 1% La-doped CdS/SnO₂ double ETL was significantly increased, leading to a substantial reduction in grain boundary density. This improvement minimized non-radiative recombination at both the grain boundaries and the CdS/Sb₂S₃ heterointerface while simultaneously enhancing charge-carrier transport across the heterojunction. Consequently, the optimized solar cell achieved an open-circuit voltage (V OC ) of 749 mV and a short-circuit current density (J s c ) of 17.01 mA/cm 2 , resulting in a power conversion efficiency (PCE) of 7.66%. This work presents an effective doping strategy to enhance the performance of the CdS buffer layer, offering valuable insights for the advancement of Sb₂S₃-based thin-film solar cells. Graphical The alternative text for this image may have been generated using AI.
✓ 已验证
DOI
高影响因子
Translational Cancer Research
·
2026
·Vol. 15
·期 4
·238
·
IF 2.1
Lin Xiang,Tian Peng,Guo-Bin Song,Hou-Qun Ying,Xue-Xin Cheng
Background The cell division cycle-associated ( CDCA ) gene family regulates cell cycle progression and is frequently dysregulated in multiple cancers. However, its roles in tumor stemness maintenance and drug sensitivity remain unclear. This study aimed to investigate the expression of the CDCAs in cancers and their associations with tumor stemness and drug sensitivity, with a particular focus on the effects of CDCA2 on stemness and drug sensitivity in lung and colorectal cancers. Methods CDCA s expression and prognostic value were analyzed using The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) datasets, while correlations with stemness [DNA methylation-based stemness scores (DNAss) and RNA-based stemness scores (RNAss)] and drug sensitivity [Genomics of Drug Sensitivity in Cancer (GDSC)] were assessed. Functional validation was performed by knocking down CDCA2 in lung and colorectal cancer cell lines. Results Pan-cancer analysis revealed that CDCA s were broadly upregulated across tumor types and were significantly associated with poor prognosis in multiple cancers (P<0.05). Most CDCA s showed positive associations with tumor stemness based on RNAss and DNAss analyses (r>0.3, P<0.05). Drug sensitivity analysis indicated that CDCA expression was closely related to responses to various anticancer agents. Experimental validation demonstrated that CDCA2 knockdown significantly inhibited proliferation of lung and colorectal cancer cells, reduced stemness marker expression, and increased sensitivity to oxaliplatin. Conclusions CDCAs are widely upregulated in cancers and associated with poor prognosis, enhanced tumor stemness, and drug resistance. CDCA2 promotes proliferation and chemoresistance, highlighting its potential as a prognostic biomarker and therapeutic target.
✓ 已验证
DOI
PubMed
高影响因子
Translational Cancer Research
·
2026
·Vol. 15
·期 3
·171
·
IF 2.1
Yan Zhang,Lu Lu,Qiuyu Zhao,Aiyu Ma,Meihua Jin,Xu Wang,Yuzhong Yang,Xuan Meng,Yiping Sun,Jinhua Zheng,Xiang Zheng
Background Lysosomal-associated protein transmembrane 5 (LAPTM5) is a transmembrane protein predominantly localized to late endosomes and lysosomes, with preferential expression in hematopoietic cells. Ferroptosis is an iron-dependent, non-apoptotic form of programmed cell death (PCD) that is driven by the lethal accumulation of lipid peroxides. Many studies have shown that ferroptosis is dependent on autophagy. Lipophagy is a selective form of autophagy by degrading lipid droplets (LDs) within autophagic vesicles to regulate lipid balance. Lipophagy can promote RAS-selective lethal 3 (RSL3)-induced ferroptosis. However, whether LAPTM5 regulates lipophagy to sensitize glioma cells to ferroptosis remains to be explored. Therefore, the objective of our study was to evaluate the potential role of LAPTM5 in ferroptosis. Methods The expression profile of LAPTM5 in human glioma tissues was analyzed by using The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases, and immunohistochemistry. Glioma cells were treated with ferroptosis inducer erastin, and then the cell viability, glutathione (GSH), and malondialdehyde (MDA) were detected. Lipophagy was tested by laser confocal microscopy and proteins expression were detected by western blot. Results Elevated expression of LAPTM5 was observed in glioma tissues compared to normal brain tissues, and its high expression level was associated with poorer patient prognosis. LAPTM5 promoted lipophagy in glioma cells. LAPTM5 enhanced the sensitivity of glioma cells to ferroptosis inducer erastin, while suppression of lipophagy inhibited LAPTM5-mediated sensitization to erastin. Conclusions The finding that glioma cells with high LAPTM5 expression were more sensitive to ferroptosis inducers suggests that glioma patients with high LAPTM5 expression may be more responsive to ferroptosis-inducing therapies.
✓ 已验证
DOI
PubMed
高影响因子
CELL DEATH AND DIFFERENTIATION
·
2026
·
IF 13.6
Sun Ya-Zhou,Li Xin-Yan,Wang Jia,Zeng Meng-Liu,Qu Wei-Yi,Cheng Xu,Luo Lei,Wang Wei,Yang Juan,Zhang Jun,Tian Han,Zhang Peng,She Zhi-Gang,Li Hongliang,Zhang Xiao-Jing
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe conditions lacking specific pharmacological treatments. Endoplasmic reticulum (ER) stress plays a pivotal role in their pathophysiology, yet the precise regulatory mechanisms remain elusive. In this study, we identify the E3 ubiquitin ligase ring finger protein 5 (RNF5) as a critical driver of ALI/ARDS. RNF5 is markedly upregulated in response to ALI and significantly exacerbates lung injury by stabilizing HSPA5 (heat shock protein family A member 5), a master regulator of the unfolded protein response (UPR). Notably, in vivo Rnf5 ablation effectively attenuated pulmonary edema, inflammatory cell infiltration, and apoptosis, whereas lung-specific Rnf5 overexpression worsened inflammation and cell death in mice. Mechanistically, RNF5 interacts with HSPA5 and competitively blocks its binding to PERK, facilitating PERK release. Furthermore, RNF5 promotes the retro-translocation of HSPA5 from the ER lumen to the cytosol. In the cytosol, RNF5 mediates the K6- and K63-linked polyubiquitination of HSPA5, enhancing its thermal stability and preventing its re-entry into the ER. This spatial sequestration sustains the persistent dissociation of the PERK-HSPA5 complex, leading to the hyperactivation of the pro-apoptotic and pro-inflammatory PERK-eIF2α-CHOP signaling cascade. The ability of RNF5 to promote ALI is strictly dependent on its E3 ligase activity. In conclusion, our findings uncover a compartment-specific regulatory mechanism of HSPA5, suggesting that the RNF5-HSPA5-PERK axis represents a promising therapeutic target for ALI/ARDS.
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Ding Zhengyuan,Zhu Linlian,Zhou Yaqiu,Li Mengwei,Yao Yi,Su Mengjie,Wu Zengqiang,Wang Li,Yu Chunmei
In this study, we presented the design and development of a flexible and non-enzymatic electrochemical sensor based on in situ growth of Au nanowires (AuNWs) on carbon cloth (CC) for the dynamic monitoring of uric acid levels in human sweat. The electrode was fabricated through a controllable process, resulting in a three-dimensional conductive network with high surface area and abundant electroactive sites on the electrode surface. Electrochemical analyses demonstrated that the electrode exhibits excellent sensitivity toward uric acid with a wide linear response range from 10 to 700 μM and a low detection limit of 1.4 μM. The electrode was further integrated into a wearable sensing platform and applied for real-time, non-invasive sweat sampling and monitoring during exercise. The results indicated that the sensor exhibited a high correlation between sweat and blood uric acid levels measured by a commercial device, validating its potential applicability for the daily monitoring of uric acid. This work provides a promising strategy for the development of facile and reliable wearable sensors, with significant potential in non-invasive healthcare monitoring. Graphical abstract
A flexible and wearable sensor by in situ growth of Au nanowires on carbon cloth was developed for the real-time and non-invasive monitoring of uric acid metabolite in sweat.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2026
·Vol. 17
·期 1
·1909
·
IF 15.7
Yang Bin,Li Deyang,Deng Renren,Zhao Jian,Wang Yubin,Xu Shiqing,Lei Lei
Persistent luminescence materials are promising for night-vision displays, background-free medical diagnostics, and high-resolution radiography, yet achieving efficient violet, yellow, and red emission within a single robust and scalable host remains a longstanding challenging. Here, we overcame this limitation by constructing Gd 3+ -mediated cluster traps within alkaline-earth fluorochlorides to minimize energy loss during electron migration. These clusters serve as both intrinsic emitters and efficient energy transfer platforms for various activators, including Eu 2+ , Sm 2+ , Tb 3+ , and Mn 2+ , enabling bright and spectrally tunable multicolor persistent luminescence upon X-ray irradiation. The persistent luminescence intensity of Eu 2+ is enhanced by up to 32.7-fold upon Gd 3+ codoping. Moreover, violet persistent luminescence from Eu 2+ is employed to excite perovskite quantum dots for full-color time-domain dynamic displays, while Sm 2+ emission facilitates low-dose, high-resolution delayed X-ray imaging. These findings establish a generalizable strategy for designing efficient multicolor persistent materials for advanced multifunctional optical technologies.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PHARMACEUTICAL RESEARCH
·
2026
·
IF 4.1
Jiang Qi,Qiu Yihe,Li Peirong,Yu Caini,Meng Tingting,Hu Fuqiang,Wang Cheng,Yuan Hong
Objective Cancer remains a critical public health challenge. Conventional anti-tumor drugs are often limited by their short half-life and the requirement for frequent and/or high-dose administration, highlighting the urgent need for drug delivery systems that can enhance intracellular drug accumulation. Methods Given that current research on drug delivery systems primarily focuses on developing active or passive targeting strategies to improve therapeutic efficacy, biocompatible cholesterol-based lipid nanoparticles (Cls-LNPs) were developed in this study. The Cls-LNPs were designed to function as an "intracellular drug reservoir" by enhancing cellular uptake and retention, thereby meeting the core requirement of enhanced intracellular drug accumulation. Results The reservoir capacity is likely attributed to the ability of Cls-LNPs to evade lysosomal degradation and target the endoplasmic reticulum (ER). When combined with the emerging anti-tumor technology of photodynamic therapy (PDT) and utilizing Ce6 as a model photosensitizer, the prepared Ce6@Cls-LNPs exhibited enhanced anti-tumor efficacy both in vitro and in vivo compared to free drugs. The therapeutic effect was achieved through the induction of ER stress, lipid peroxidation, and apoptosis, and it also exhibited a “bystander effect”. Conclusion This study offers valuable insights into the application of cholesterol in drug delivery systems and proposes innovative strategies for the development of retention-enhancing formulations. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 3
·144
·
IF 5.4
Su Yang,Cao Huiting,Xia Chengen,Gan Wei,Zhang He,Zhang Guoqi,Li Dapeng
A multi-aptamer, machine-learning–assisted sensor array is presented that integrates polyadenine (poly-A)–oriented aptamer functionalization with salt-stable, gold nanoparticles (AuNPs) colorimetry. Poly-A anchoring enables controlled aptamer orientation and improved colloidal stability under high ionic strength, allowing sensitive aggregation-based detection. Despite the inability of individual aptamers to discriminate glycated hemoglobin (HbA1c) from total hemoglobin (tHb), their combined multichannel responses provide distinct optical patterns that machine learning resolves into non-overlapping clusters. The platform successfully differentiated between clinical samples from diabetic and healthy individuals. This work establishes a generalizable strategy, interface engineering coupled with supervised pattern recognition, for resolving highly similar proteins and developing practical, low-cost point-of-care (POC) diagnostic tools.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Qiu Lingling,Tan Jiahui,Chen Jiayi,Qi Bing,Miao Ziyun,Wei Yurong,He Xuewen,Wang Jie
Luminescent thermometers have emerged as a powerful tool for monitoring physiological temperature variations that are critical to understanding biological processes and pathological conditions. However, measurement artifacts from instrumental fluctuations and spectral interference from tissue autofluorescence seriously decreased the accuracy and sensitivity of luminescent thermometers. To address these limitations, we developed Zn 2 GeO 4 :Bi,Tb (ZGO:Bi,Tb) nanoparticles that feature temperature-dependent ratiometric persistent luminescence through a bottom-up synthesis approach for the first time. ZGO:Bi,Tb exhibited temperature-dependent ratiometric persistent luminescence between 298 and 358 K. The self-calibration function of ZGO:Bi,Tb allowed the efficient elimination of interference from instrumental anomalies such as photomultiplier voltage fluctuations. Besides, ZGO:Bi,Tb efficiently avoided autofluorescence interference by collecting the ratiometric persistent luminescence after excitation ceases. The temperature quantified by the I 545 / I 585 ratio of ZGO:Bi,Tb well matched the real temperature with a deviation down to 0.88%. Furthermore, we engineered a theranostic platform with a temperature feedback function by integrating ZGO:Bi,Tb with indocyanine green (ICG), achieving simultaneous photothermal therapy (PTT) and temperature detection. The ZGO:Bi,Tb-ICG platform not only effectively eradicated bacterial pathogens by its photothermal effect but also accurately monitored the temperature during PTT. The PTT temperature determined by the I 545 / I 585 ratio of the ZGO:Bi,Tb-ICG platform well matched that measured by an infrared thermal camera with a correlation coefficient reaching 0.991. Our study establishes a paradigm for highly accurate and sensitive temperature monitoring and provides a promising tool for research on temperature-dependent physiological processes and pathological states of living organisms.
Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Food Measurement and Characterization
·
2026
·
IF 3.6
Chang Cuihua,Wang Yi,Su Yujie,Gu Luping,Yang Yanjun,Li Junhua
This study systematically investigated the synergistic effects of xanthan gum (XG) and guar gum (GG) as textural modifiers in ultra-low-fat salad systems containing egg white protein particles (EWPP). The results demonstrated that XG primarily contributed to initial viscosity through strong electrostatic interactions with EWPP, forming interconnected rigid networks that maintained structural integrity at low shear rates. The addition of GG would induce to the increase in viscosity from 380.36 Pa to 497.32 Pa, while the yield strain value decreased from 219% to 174%. Importantly, GG incorporation induced a fundamental transformation in material behavior-as evidenced by 3ITT shear tests and large amplitude oscillatory shear measurements, progressively weakening intermolecular forces while enhancing system resilience, with the optimal XG: GG ratio of 1:2 yielding superior elastic properties. Structural characterization revealed a controlled transition from electrostatic-dominated to entropic-driven network organization, directly correlating with improved mouthfeel characteristics. LF-NMR and SEM results provided insights into the water distribution and microstructure, showing that GG incorporation led to a looser internal structure with weaker water immobilization capacity. Overall, this research offers valuable insights into optimizing the texture and stability of ultra-low-fat and high protein salad products through the strategic use of XG and GG.
✓ 已验证
产品关联
DOI
高影响因子
NATURE
·
2026
·
IF 56.1
Peng Jingyu,Xue Xulan,Liu Shihao,Yang Yingguo,Yang Tianqi,Zhu Bingyan,Wang Xin,Zhang Hanzhuang,Xie Wenfa,Chen Gengsheng,Feng Shanglei,Li Lina,Tai Renzhong,Tang Aiwei,Lu Haizhou,Ji Wenyu
Metal halide perovskite light-emitting diodes (PeLEDs) have demonstrated excellent external quantum efficiency (EQE), easy colour tunability and low-cost processability, making them promising next-generation display techniques 1 , 2 , 3 . However, PeLEDs still underperform compared with organic light-emitting diodes (LEDs) with an EQE of about 40% because of insufficient charge confinement and defect-caused non-radiative recombination on the film surface. Here we report a spontaneously formed 3D/2D vertically oriented perovskite heterojunction by means of a simple one-step spin-coating method, which could effectively confine the charge carriers and shift the radiation zone away from the defect-rich surface region. Notably, the 2D perovskite on top exhibits a wrinkled surface morphology, which offers up to 45.4% light extraction efficiency. The resulting PeLEDs achieved an EQE of 42.9% for the green emission (certified 42.3%). Our work sheds light on the strategies for fabricating high-efficiency PeLEDs in the future.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）