Science China-Chemistry
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2026
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IF 9.8
Cheng Baijie,Wang Ruixue,Xu Peipei,Wu Xueying,Xia Zhenhao,Jin Yexi,Xu Hongyao,Guang Shanyi
Conductive gel-based flexible wearable devices have emerged as transformative platforms for emerging applications in human-machine interaction. However, environmental humidity fluctuations can impair material performance through mechanisms such as water uptake-induced swelling/dehydration-induced embrittlement, as well as signal baseline drift. In this study, inspired by the strong hydration mechanism of natural moisturizing factors (NMF) and the sebum barrier in the skin, a biomimetic heterophase liquid-locking (BHL) design is proposed. This design precisely recapitulates the dual protective characteristics of skin. An internal hydrophilic phase, formed by zwitterionic polymers, achieves NMF-like high moisturization via hydrogen bonding/ion-dipole interactions. Meanwhile, a stable hydrophobic phase, mimicking the sebum barrier, is constructed on the surface through the covalent grafting of nanoscale hydrophobic polyhedral oligomeric silsesquioxane (POSS). The resulting gel exhibits ultra-stable mechanical and sensing performance over an ultra-wide humidity range (RH = 10%–90%), with less than 5% variation over 108 days. Furthermore, the eutectogel possesses softness, self-healing capability, high transparency, a wide temperature operating window, and ionic conductivity. By integrating gel-based electrode arrays and devices, human-machine collaboration and virtual reality (VR)-based human-machine interaction are realized. Moreover, an intelligent human-machine interaction system developed by further incorporating deep learning technology achieves a recognition rate of up to 99.68% for various gesture signals.
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Mu Zhangyan,Ma Zhibin,Zhao Weiyi,Dai Luhan,Xu Dan,Ran Pan,Zhang Panke,Wu Xuejun,Ge Junjie,Ding Mengning
Electrocatalytic alcohol oxidation is pivotal for renewable energy conversion, yet its widespread application is hindered by generally low efficiency, necessitating the development of advanced catalytic systems with boosted electro-oxidation kinetics. In an alkaline electrolyte, the effect of alkali metal cations has been identified as a key impacting factor on the alcohol oxidation activity, but the underlying mechanistic interactions remains insufficiently explored. Here we elucidate the fundamental cation effects on hydroxyl (OH ads ) adsorption and subsequent surface bi-molecular kinetics in Pt (and alloys)-catalyzed alcohol electro-oxidations through combined electrochemical voltammetry, in situ surface enhanced infrared absorption spectroscopy (SEIRAS) and in situ electrical transport spectroscopy (ETS). Systematic evaluations reveal that alkali metal cations regulate the micro-electro-kinetics by modulating the surface coverage of OH ads , which acts bi-functionally as both reactant species and spectator in alcohol oxidations. A matching adsorption kinetics of OH ads and alcohol is key towards the optimal alcohol oxidation activity, providing valuable insights into the cation-mediated alloy catalyst systems and high-concentration conditions in alcohol fuel cells.
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PubMed
高影响因子
CELLULOSE
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2026
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IF 4.6
Han Qiuxia,Xu Yanmeng,Wang Fei,Zhang Qiang,Chen Yong,Lv Shaoping
In a synergistic unit of N -halamine and cationic salt, an increased ratio of the N -halamine elicited a higher biocidal efficacy. However, the upper limit to the N -halamine content where the synergism is not impaired because of the diminished role of the cationic salt is still unknown. Herein, 4 N -halamine sites, one more than the current maximum, were combined with 1 cationic salt in a composite unit for the evaluation of the effect of such a ratio on synergism. Briefly, 4-aminopyridine was quaternized with 1-chlorohexane to form a cationic pyridinium. Uramil and the cationic pyridinium were successively bonded to allylsuccinic anhydride via ammonolysis and amidation to form a product with 1 cationic salt and 4 N–H bonds as N -halamine precursors. The allylic C=C of the product subsequently reacted with Si–H of poly(methylhydrosiloxane) via hydrosilylation to prepare a polysiloxane that was interpenetrated into cotton cellulose at 50 °C and 28 MPa in supercritical CO 2 . Chlorination of N–H bonds transformed each polysiloxane pendant to the target composite unit that existed in a 71 nm modification layer on the interpenetrated cotton. Antibacterial tests showed that the designed composite units completely eradicated ~ 10 7 CFU of Staphylococcus aureus and Escherichia coli in 15 min, an efficacy between those of a counterpart with only 4 corresponding N -halamine sites and a reported unit with 1 N -halamine and 1 cationic center under comparable conditions, which suggested that the increase of N -halamine to such a ratio did not further benefit synergism. Evaluations of biocidal stability and rechargeability indicated that the modifier was chemically robust and scCO 2 interpenetration produced a durable connection between the modifier and cellulose. Graphical
The alternative text for this image may have been generated using AI.
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Scientific Reports
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2026
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IF 4.9
Chen Cong,Tao Wen,Chen Fei,Gong Jie
Cerebral ischemia–reperfusion (I/R) injury remains a major therapeutic challenge, primarily due to complex mechanisms involving oxidative stress and apoptosis. Growth arrest and DNA damage-inducible protein α (Gadd45α), a stress sensor linked to cellular stress responses, has been implicated in I/R injury, yet its precise role in ischemic stroke is incompletely understood. This study aimed to elucidate the function and underlying mechanisms of Gadd45α in cerebral I/R injury using both in vivo and in vitro models. In rats subjected to middle cerebral artery occlusion (MCAO) and in neurons exposed to oxygen–glucose deprivation/reperfusion (OGD/R), Gadd45α expression was significantly upregulated. Lentivirus-mediated knockdown of Gadd45α (sh-Gadd45α) reduced infarct volumes, improved neurological function and increased miniature excitatory postsynaptic current (mEPSC) amplitude. In primary cortical neurons exposed to OGD/R, Gadd45α knockdown decreased reactive oxygen species (ROS) production, DNA damage, and apoptosis, while Gadd45α overexpression exacerbated these effects. Mechanistically, Gadd45α directly interacts with forkhead box O1 (FOXO1) and positively regulates its transcriptional activity. Gadd45α knockdown attenuated the ischemia-induced upregulation of both total FOXO1 and its phosphorylated form (p-FOXO1), thereby suppressing FOXO1 signaling and mitigating cerebral I/R injury. Furthermore, FOXO1 overexpression reversed the neuroprotective effects of Gadd45α silencing, confirming that FOXO1 acts as a critical downstream mediator. These findings demonstrate that Gadd45α silencing alleviates cerebral I/R injury by suppressing FOXO1 signaling, suggesting the Gadd45α/FOXO1 axis as a promising therapeutic target for ischemic stroke.
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PubMed
高影响因子
Microsystems & Nanoengineering
·
2026
·Vol. 12
·期 1
·214
·
IF 11.1
Holman Joseph Benjamin,Mushiana Talifhani,Yang Chen,Jin Yue,Shi Zhengdi,Qiu Bensheng,Li Chengpan,Ding Weiping
Continuous glucose monitoring (CGM) is a promising approach for managing blood glucose levels in individuals with diabetes. However, the emerging microneedle (MN) technologies for colorimetric or electrochemical detection of glucose in sampled dermal interstitial fluid (ISF) remain far from practical CGM due to many concerns. Herein, we propose a new disposable solid MN array on a flexible paper substrate, integrated with reusable electronics and a mobile application, for electrochemical glucose sensing in ISF. The paper substrate was prepared by infusing paper with UV-cured flexible gingiva mask resin, ensuring body comfort. The solid MN array was fabricated from a newly developed composite of UV-cured biocompatible surgical guide resin (SGR) and microcrystalline cellulose (MCC), using a simple self-developed fabrication technique, ensuring safe skin interaction. The paper-based composite MN arrays were converted into conductive biosensing electrodes by coating them with graphene ink and additional functional modifiers via airbrushing, and subsequently integrated into a wearable patch for continuous ISF glucose monitoring. The resulting MN array electrodes exhibited excellent analytical performance in monitoring glucose of ex vivo porcine plasma, hydrogel-based artificial skin, and in vivo mice, with high sensitivity, selectivity against interferents, and robust stability. This study provides a simple, cost-effective, and eco-friendly path for the development of wearable electroanalytical devices toward practical CGM. The alternative text for this image may have been generated using AI.
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高影响因子
Nature Communications
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2026
·
IF 18.1
Liu Chong,Wang Ruoyu,Wang Dewen,Zhao Liyun,Li Taiguang,Wang Tenghui,Chen Butian,Zhang Tianran,Liu Xiangfeng
Sulfides-based all-solid-state lithium batteries show great potential due to their high safety and high energy density, yet severely suffer from sulfide electrolytes/Li interfacial instability and short cycle life. Here we propose a Li-In-S composite foil comprising Li 2 S, Li x In, and LiInS 2 to stabilize the Li/Li 6 PS 5 Cl interface by constructing built-in electric fields, thereby enabling long-life all-solid-state lithium batteries. The work function difference between Li 2 S and Li x In generates built-in electric fields at the heterointerface, which traps the interfacial electrons and restricts their transfer to Li 6 PS 5 Cl, thereby suppressing the interfacial side reactions. Simultaneously, the built-in electric fields promote Li + adsorption and diffusion inhibiting lithium dendrite growth. Li symmetrical cells display high critical current density over 4 mA cm −2 and Li plating/stripping stability over 2000 h at 1 mA cm −2 . The assembled full cells with LiCoO 2 and LiNi 0.8 Co 0.1 Mn 0.1 (NCM811) demonstrate high capacity retention of 93% over 2000 cycles at 1 C and 87.7% over 1000 cycles at 1 C, respectively. Moreover, Li-In-S|Li 6 PS 5 Cl|NCM811 full cell shows rate capability up to 4 C. This work offers useful insights into the design of stable interfaces in all-solid-state batteries.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Haibin Wu,Jixiang Zhang,Xinqing Huang,Bo Zhang,Yuting Xie,Qingyu Li,Li Yang,Weiqi Wu,Ziying Zheng,Ziyan Huang,Fanru Gao,Zhongqing Cai,Jiahe Chen,Guohuan Zeng,Daishun Ling,Guang Liang,Qian Chen
Inflammatory bowel disease (IBD) is a chronic relapsing disorder primarily driven by the self-amplified vicious cycle of colonic barrier disruption-inflammation (VCBI). Especially, these pathogenic mediators of the VCBI often exist in different phases, such as ROS (inflammatory mediators) in the liquid phase and H 2 S (colonic barrier disruptors) in the gas phase, poses a formidable challenge to their concurrent elimination. Herein, a gas-liquid biphasic nanocleaner (GLBN) is developed for breaking the self-amplified VCBI in IBD by concurrently scavenging the pathogenic factors derived from both liquid and gaseous phases. Benefiting from its high specific surface area, superior intrinsic activity, and ultrasmall size, GLBN provides abundant adsorption and active sites, thereby exhibiting highly efficient H 2 S-capturing capability with a scavenging efficiency of 88.6% and attenuating H 2 S-mediated colonic barrier dysfunction. Meanwhile, owing to its highly efficient ROS-scavenging capacity, with respective scavenging efficiencies of 84.3% for H 2 O 2 and 82.7% for •O 2 - , GLBN effectively suppresses inflammation and promotes macrophage repolarization from the M1 toward the M2 phenotype. Moreover, density function Sal theory (DFT) calculations attribute the biphasic scavenging capabilities to heterogeneous facets and metal-sulfur bonding. Consequently, highly efficient therapy of IBD is achieved in a mouse model. Our study marks a critical breakthrough in the therapeutic application of biphasic scavenging nanozymes for inflammatory diseases triggered by multiphase pathogenic factors.
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PubMed
高影响因子
Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·385
·
IF 38.5
Wen Pengfei,Luo Pan,Gao Fuqiang,Yang Mingyi,Li Junyou,Yang Zhi
Pd-Ni 5 P 4 /dual-channel electrocatalytic flexible system (DCEFS) employs a bifunctional catalyst, dual-channel electrodes, and microneedle array to achieve continuous, decoupled-free coupling of nitric oxide sensing and hydrogen treatment.
Pd-Ni 5 P 4 /DCEFS pioneers a single-cycle “sense-hydrogen treatment-sense” strategy for closed-loop inflammation resolution, delivering efficient reactive nitrogen species/reactive oxygen species clearance with real-time nitric oxide-based feedback for precise therapeutic control.
Pd-Ni 5 P 4 /DCEFS innovatively establishes a closed-loop ‘sense-hydrogen treatment-sense’ paradigm guided by lesion-specific NO levels, enabling on-demand hydrogen intervention to potently resolve inflammation, robustly drive tissue regeneration, and markedly accelerate diabetic wound healing with excellent biocompatibility.
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PubMed
高影响因子
Systems Microbiology and Biomanufacturing
·
2026
·Vol. 6
·期 3
·97
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IF 3.5
Zhang Yulong,Cao Xupeng,Guo Xin,Li Can
Efficient transmembrane electron transfer plays a critical role in regulating extracellular electron uptake and intracellular redox distribution in microbial cell factories and biohybrid biomanufacturing systems. However, the molecular mechanisms of how exogenous electrons enter cellular redox networks remain poorly understood, particularly in quinone-mediated pathways. Herein, organic semiconductor-ubiquinone model interfaces are constructed to simplify biological complexity and investigate interfacial electron transfer. Steady-state absorption spectroscopy, femtosecond transient absorption spectroscopy, and electron paramagnetic resonance spectroscopy are combined to establish a kinetic framework for electron transfer from organic semiconductors to ubiquinone. Ultrafast spectroscopy reveals charge transfer on femtosecond-to-picosecond timescales, confirming rapid interfacial electron transfer from organic semiconductors to ubiquinone. Furthermore, a structure-dynamics relationship is identified in which molecular planarity, π-conjugation, and interfacial electronic coupling govern electron transfer rates and charge delocalization. These results provide mechanistic insight into ubiquinone-mediated electron transfer and highlight its role as a universal and structurally adaptable electron acceptor. This work provides a molecular-level design framework for optimizing electron delivery and redox regulation in organic semiconductor-biohybrid systems for biomanufacturing. Graphic abstract The alternative text for this image may have been generated using AI.
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高影响因子
COLLOID AND POLYMER SCIENCE
·
2026
·
IF 2.9
Abdirym Adila,Yan Pu,Wu Xue,Liu Bin
Lipophilic compounds encapsulated in Pickering emulsions can be inhibited the access of oxygen, prooxidants, and free radicals and therefore be applied to the controlled bioactive delivery. Cellulose nanofibrils (CNFs) stabilized Pickering emulsions (PE) for encapsulation and delivery of β-carotene (β-C) were prepared through high intensity ultrasound (HIU), high-pressure homogenization (HPH) or the HIU + HPH dual emulsifying process. Emulsion properties, encapsulation efficiency (EE), retention rate (RR), bioaccessibility of β-C and free fatty acids rate (FFA%) impacted by single or dual emulsifying process, the oil fraction Φ and the concentration of CNFs suspension (CNFs%) was investigated. Compared to the single HPH or HIU which usually cannot enhance emulsification effect through increasing accounts or times, the HIU + HPH dual emulsification method is beneficial to gain the more homogeneous fine emulsion droplets and durable stable emulsion status. All of β-C-encapsulated PE samples (Φ ≤ 0.5) prepared by 2.0%w/w CNFs suspension had long-term stability for at least 150 days storage. Although EE of β-C in the HIU + HPH samples was lower than that in the HPH or HIU samples, EE of β-C in the HIU + HPH samples at high Φ (= 0.4) condition was closed to the maximum of that in the HIU samples, and RR of β-C in the HIU + HPH samples during storage are much better than that in the HPH or HIU samples. Furthermore, RR of β-C in the HIU + HPH samples at Φ = 0.4 was changed insignificantly after storage intervals, and bioaccessibility of β-C in the HIU + HPH samples at Φ = 0.2 and CNFs%=1.2 can reach the highest value 26.76 ± 0.13% after simulating intestinal digestion. There is a positive relation between the final FFA% and bioaccessibility of β-C. These findings indicate that PE prepared by HIU + HPH at appropriate Φ and CNFs% is an excellent carrier and controlled deliverer for lipophilic bioactive substances.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·Vol. 24
·期 1
·389
·
IF 15
Zhan Yuhang,Zhang Zhihan,Zhang Zhiyue,Lin Mengru,Liu Hui,Abulimiti Dilihumaer,Aihemaiti Shami,Kan Yun,Tan Jinhai,Chen Xi,Tao Shengxiang
Chronic non-healing of diabetic wound (DW) remains a critical clinical challenge worldwide. Sustained oxidative stress and prolonged inflammatory responses disrupt the wound microenvironment, while bacterial colonization and biofilm formation on the wound bed compromise drug penetration, consequently leading to suboptimal outcomes with conventional approaches. Here, we developed a core-shell structured microneedle (MN) patch system, designated as MN@Ple/Exo Q10 , to precisely regulate the DW microenvironment through sequential drug release. The photothermal-responsive microneedle patch MN@Ple/Exo Q10 features a dual-phase release: the outer shell’s antimicrobial peptide (Pleurocidin) addresses initial infection, while the core’s engineered exosomes (Exos Q10 ) mitigate oxidative stress and subsequently regulate immune responses. When combined with near-infrared (NIR)-triggered photothermal therapy, this system effectively promotes the healing of DW. This study details that the sustained release of Exos Q10 effectively inhibits high glucose (HG)-induced ferroptosis in vitro, demonstrating potent antioxidant activity and anti-inflammatory capacity. Furthermore, in a S. aureus -infected diabetic mouse wound model, MN@Ple/Exo Q10 demonstrates potent antibacterial activity while mitigating oxidative stress, suppressing inflammation and promoting angiogenesis, thereby accelerating wound healing. Collectively, the developed spatiotemporally controlled MN system overcomes bacterial barriers and stabilizes exosomal delivery, enabling comprehensive regulation of the microenvironment in DWs. This breakthrough approach presents a novel and translational strategy for DW therapy. Graphical abstract The alternative text for this image may have been generated using AI.
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高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2026
·
IF 4.6
Xie Zhi-Hui,Tang Pei-Chun,Xu Dan,Ouyang Yue-Jun,Fan Xiao-Qiang,Tang Jun-Lei,Alwan Maadh Hasan,Khalaf Ali Hussein,Al-Najafi Saba Abdulhussein A.,Yong Qi-Wen
Magnesium alloys suffer from severe corrosion in chloride-containing environments, which significantly restricts their structural application. In this study, a core-shell smart nanocontainer (PHIO@ZIF-8/PST, denoted as PZS) was constructed by integrating a pH-responsive metal–organic framework reservoir with an in situ assembled poly(sodium thioctate) (PST) functional shell, and further incorporated into an epoxy matrix to develop an intelligent anticorrosion coating. The ZIF-8 core serves as an efficient loading platform for a chelating corrosion inhibitor (PHIO) and provides pH-triggered release capability, whereas the PST shell simultaneously enhances interfacial compatibility and introduces additional chemical protection. Structural analyses confirmed the successful construction of the core-shell architecture and the preservation of crystallinity after functional modification. Electrochemical and ion-release studies demonstrated that PZS nanocontainers exhibited pronounced pH-responsive behavior, enabling accelerated inhibitor release under acidic or alkaline conditions. When incorporated into the epoxy (EP) coating, PZS significantly improved the interfacial densification, reduced the defect density, and prolonged the diffusion pathways for aggressive species. Long-term electrochemical impedance spectroscopy and salt spray tests revealed that the PZS/EP coating maintained impedance values three orders of magnitude higher than that of the pristine epoxy after 28 days of immersion, indicating outstanding corrosion resistance. The enhanced performance arises from the synergistic coupling of the physical barrier reinforcement, inhibitor chelation, and in situ formation of protective Mg–PST complexes at active corrosion sites. This study provides a generalizable strategy for constructing multifunctional smart coatings for the durable protection of lightweight metal substrates.
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高影响因子
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