BMC Pregnancy and Childbirth
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2023
·Vol. 23
·期 1
·1-10
·
IF 3.1
Ding Ailing,Wan Huimin,Peng Juan,Wang Huizi,Zhu Shaodan,Dong Xudong
Background Hypertensive disorders complicating pregnancy (HDCP) and gestational diabetes mellitus (GDM) can affect the placental barrier function to varying degrees. However, current studies show that the transfer and distribution characteristics of trace elements in the maternal-fetal system are still unclear. This study investigated the effect of the placental barrier on the transfer of trace elements from mother to fetus and its relationship with HDCP and GDM. Methods A case-control method was used in this study. 140 pairs of samples were collected; 60 were from healthy pregnant women, and 80 were from patients with pregnancy complications. The contents of trace elements in paired samples were determined by inductively coupled plasma–mass spectrometry (ICP-MS). SPSS software was used to analyze the differences in trace element levels in matched samples of each group. The correlations were analyzed based on Pearson’s correlation factor (r). Results The distribution characteristics of Fe content in the pathological group (HDCP group and GDM group) were the same as those in the normal group (umbilical cord blood > maternal blood > placenta), but there was no significant difference in the iron content in maternal blood and cord blood of pathological group. The distribution characteristics of Mn content in the pathological group (placenta > umbilical cord blood > maternal blood) were changed compared with those in the normal group (placenta > maternal blood > umbilical cord blood). In addition, the placental Cr content and cord blood Cr and Ni content of the pathological group were higher than those of the normal group. HDCP placental Cr and GDM placental Fe levels were significantly correlated with the Apgar score. Conclusions The transfer of Fe and Mn and the placental barrier function of Cr and Ni in the maternal-fetal system of HDCP and GDM are significantly altered, which directly or indirectly increases the maternal and fetal health risk.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·
IF 5.8
Liu Yongli,Chen Letian,Su Xiaoyan,Wang Li,Jiao Ya,Zhou Penghui,Li Bin,Duan Ruijuan,Zhu Guifen
Mercury ion (Hg 2+ ) is a highly toxic and ubiquitous pollutant, whose effective detection has aroused widespread concern. A novel ratiometric fluorescent sensor has been designed to rapidly and efficiently detect Hg 2+ based on blue/red carbon dots (CDs) with environmental friendliness. This sensor was well characterized via TEM, FTIR, XPS, UV–vis, and zeta potential analysis and displayed excellent fluorescence properties and stability. The fluorescence of blue CDs at 447 nm was significantly quenched with the addition of Hg 2+ resulted from the static quenching, whereas that of red CDs at 650 nm remained invariable. A sensitive method for Hg 2+ determination was constructed in the range of 0.05–7.0 nmol mL −1 with optimal conditions, and the detection limit was down to 0.028 nmol mL −1 . Meanwhile, compared to other 17 metal ions, the ratiometric fluorescent sensor exhibited high selectivity for Hg 2+ . Furthermore, satisfied recoveries had also been obtained for measuring trace Hg 2+ in practical environmental samples. This developed ratiometric fluorescent sensor provided a reliable, environmental-friendly, rapid, and efficient platform for the detection of Hg 2+ in environmental applications.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2023
·
IF 2.5
Zhang Xiaodong,Zhang Guofeng
The materials conventionally used for electrocatalysis in electrocatalytic Fenton applications are unstable and perform poorly. Based on the fact that iron and copper are common electrocatalytically active metals, they can provide abundant electron transfer capacity to facilitate electron transfer in the reaction and further promote the electrical conductivity of nitrogen-doped doped carbon materials Here, FeCu alloy/N-doped carbon composites (FeCu/N-C) are prepared for the electrocatalytic degradation of naproxen (NPX). Characterization results reveal that FeCu/N-C has more active sites, a larger surface area, and faster charge transport than N-doped carbon composites (N-C). Meanwhile, the increased number of active sites, surface area, and electron transport result in excellent NPX electrocatalytic degradation efficiency. The FeCu/N-C composite exhibits higher degradation efficiency than N-C under optimal conditions. In addition, the degradation efficiency is sustained at around 100% after five cycles. A detailed analysis of the mechanism reveals that 1 O 2 and ·OH are the primary active species responsible for NPX degradation through bursting studies. A potential pathway for the NPX degradation is proposed. This study provides a new and feasible method for developing carbon-based electrocatalysts to expand their applications in the environmental field.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-11
·
IF 16.6
Zhang Fenghua,Li Zhong,Wang Xun
Inorganic nanowires-based organogel, a class of emerging organogel with convenient preparation, recyclability, and excellent mechanical properties, is in its infancy. Solidifying and functionalizing nanowires-based organogels by designing the gelator structure remains challenging. Here, we fabricate Ca 2 -P 2 W 16 and Ca 2 -P 2 W 15 M nanowires utilizing highly charged [Ca 2 P 2 W 16 O 60 ] 10 − and [Ca 2 P 2 W 15 MO 60 ] 14 − /13 − cluster units, respectively, which are then employed for preparing organogels. The mechanical performance and stability of prepared organogels are improved due to the enhanced interactions between nanowires and locked organic molecules. Compressive stress and tensile stress of Ca 2 -P 2 W 16 nanowires-based organogel reach 34.5 and 29.0 kPa, respectively. The critical gel concentration of Ca 2 -P 2 W 16 nanowires is as low as 0.28%. Single-molecule force spectroscopy confirms that the connections between cluster units and linkers can regulate the flexibility of nanowires. Furthermore, the incorporation of fluorophores into the organogels adds fluorescence properties. This work reveals the relationships between the microstructures of inorganic gelators and the properties of organogels, guiding the synthesis of high-performance and functional organogels.
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Lipids in Health and Disease
·
2023
·Vol. 22
·期 1
·1-16
·
IF 4.5
Li Hanxiao,Dong Yingyue,Han Chunmiao,Xia Lisha,Zhang Yue,Chen Tongsheng,Wang Huamin,Xu Guoheng
Background Previous studies demonstrated that mast cells with their degranulated component heparin are the major endogenous factors that stimulate preadipocyte differentiation and promote fascial adipogenesis, and this effect is related to the structure of heparin. Regarding the structural and physiological properties of the negatively charged polymers, hexasulfonated suramin, a centuries-old medicine that is still used for treating African trypanosomiasis and onchocerciasis, is assumed to be a heparin-related analog or heparinoid. This investigation aims to elucidate the influence of suramin on the adipogenesis.Methods To assess the influence exerted by suramin on adipogenic differentiation of primary white adipocytes in rats, this exploration was conducted both in vitro and in vivo. Moreover, it was attempted to explore the role played by the sulfonic acid groups present in suramin in mediating this adipogenic process.Results Suramin demonstrated a dose- and time-dependent propensity to stimulate the adipogenic differentiation of rat preadipocytes isolated from the superficial fascia tissue and from adult adipose tissue. This stimulation was concomitant with a notable upregulation in expression levels of pivotal adipogenic factors as the adipocyte differentiation process unfolded. Intraperitoneal injection of suramin into rats slightly increased adipogenesis in the superficial fascia and in the epididymal and inguinal fat depots. PPADS, NF023, and NF449 are suramin analogs respectively containing 2, 6, and 8 sulfonic acid groups, among which the last two moderately promoted lipid droplet formation and adipocyte differentiation. The number and position of sulfonate groups may be related to the adipogenic effect of suramin.Conclusion sSuramin emerges as a noteworthy pharmaceutical agent with the unique capability to significantly induce adipocyte differentiation, thereby fostering adipogenesis.
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MICROCHIMICA ACTA
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2017
·Vol. 184
·期 10
·3945-3951
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IF 4.58
Xu Hui-Huang,Deng Hao-Hua,Lin Xiao-Qing,Wu Yan-Yu,Lin Xiu-Ling,Peng Hua-Ping,Liu Ai-Lin,Xia Xing-Hua,Chen Wei
This work describes a colorimetric glutathione (GSH) assay that is taking advantage of (a) the peroxidase-like activity of a nanocomposite prepared from platinum nanoparticles and graphene oxide (PtNP/GO), (b) the decolorizing reaction of GSH with oxidized 3,3′,5,5′-tetramethylbenzidine (TMB), and (c) the GSH-induced scavenging of hydroxy radicals produced from H 2 O 2 . The assay has a detection limit as low as 4 nM of GSH. It is flexible because it involves a single step reaction. The method was successfully applied to the determination of GSH in hemolyzed human blood. The concentrations determined by this method in GSH-spiked blood samples ranged from 95.0 to 112.5%, with relative standard deviations between 0.5 and 4.2%.
Schematic of a rapid and sensitive colorimetric method is developed for the detection of GSH in hemolyzed human blood. It is based on the peroxidase-mimicking property of a platinum nanoparticle/graphene oxide (PtNP/GO) composite and the inhibitory effect of GSH.
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CATALYSIS LETTERS
·
2018
·Vol. 148
·期 7
·1893-1903
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IF 2.911
Wang Ying,Shen Shuguang,Li Meina,Sun Yujuan,Li Binbin
Abstract Magnesium aluminum layered double hydroxide (MgAl–LDH) was first successfully deposited in situ on η -Al 2 O 3 applied to catalyze urea hydrolysis. Characterization by AAS, XRD, SEM, EDS, DSC, FT-IR, N 2 -BET, determination of base strength and basicity and experiments on hydrolysis activities of in situ MgAl–LDH catalysts show that the crystallinity and coverage degree of MgAl–LDH on η -Al 2 O 3 gradually increase with increasing initial c (Mg 2+ ). When initial c (Mg 2+ ) = 2 mol L −1 , η -Al 2 O 3 is completely covered and the smallest particle size, the highest crystallinity, basicity and urea degradation rate of in situ MgAl–LDH are obtained. The basicity is mainly from Mg–OH at the edges of MgAl–LDH on η -Al 2 O 3 . The highest basicity corresponds to the highest urea degradation rate, Mg–OH is the active sites for catalytic hydrolysis of urea. The specific surface area, basicity and catalytic activity of MgAl–LDH by in situ synthesis are evidently higher than MgO and MgAl–LDH purchased. The urea concentration is 8.162 mg L −1 at 165 °C after 120 min with in situ MgAl–LDH ( c (Mg 2+ ) = 2 mol L −1 ) as catalyst, which is below the effluent standard. In situ MgAl–LDH also shows excellent recycling ability and the slight loss of activity should be due to the reduction of basicity, which is caused by hydrothermal conditions. In addition, a possible catalytic mechanism of urea hydrolysis over MgAl–LDH is proposed. Graphical Abstract
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POLYMER BULLETIN
·
2017
·Vol. 74
·期 11
·4525-4536
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IF 1.43
Huang Zengfang,Zhang Xiqi,Zhang Xiaoyong,Wang Shiqi,Yang Bin,Wang Ke,Yuan Jinying,Tao Lei,Wei Yen
Abstract In this paper, a fluorescein methacryloyl monomer (named Flu-MA) was firstly fabricated by the esterification reaction of fluorescein and methacryloyl chloride; subsequently, a novel amphiphilic fluorescent copolymer (Flu-PEG) with smart pH sensitivity was successfully prepared by RAFT copolymerizing of Flu-MA and poly(ethylene glycol) monomethacrylate (PEGMA). The result of 1 H NMR and FTIR implied that both Flu-MA and PEGMA monomers were successfully incorporated into Flu-PEG copolymers, the molecular weight ( M
n ) of which was about 39,800 with polydispersity index (PDI) as about 1.30. In aqueous solution, Flu-PEG copolymers could self-assemble into fluorescent organic nanoparticles (FONs) with about 200 nm diameters due to high water dispersibility and good fluorescence, respectively, endowed by PEGMA and Flu-MA, the fluorescence intensity of which was high sensitive to pH value of solution. More importantly, due to their high water dispersibility, excellent biocompatibility and good fluorescence, the as-prepared Flu-PEG FONs were high attractive for the application in cell imaging. Graphical abstract A novel amphiphilic fluorescent copolymer (Flu-PEG) with smart pH-sensitivity was successfully fabricated by RAFT copolymerizing of Flu-MA and PEGMA, which showed high water dispersibility, uniform size and excellent biocompatibility, making them be highly potential for bioimaging application.
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CELLULOSE
·
2019
·Vol. 26
·期 3
·1961-1976
·
IF 3.917
Sun Lijian,Ding Chunyue,Qian Xueren,An Xianhui
Abstract An efficient and simple way to generate “clickable” cellulose modules called alkyne-functionalized cellulose fibers (ACFs) for click reaction was presented. This method is only based on one step reaction: propargyl methacrylate (PMA) with pendant alkynyl groups was grafted onto the surface of cellulose fibers (CFs) using ceric ammonium nitrate as the initiator in aqueous medium. This has been providing a new and versatile platform for the wide utilization of cellulose resources and creation of novel functional materials. The effect of process variables on grafting copolymerization of PMA was investigated and suitable preparation conditions were identified. The clickability of ACFs was evaluated by reacting with two azides. The antibacterial cellulose functional material was achieved through incorporation of a “clickable” handle (alkynyl groups) to cellulose fibers followed by rapid attachment of β-cyclodextrin with an azide tag using copper-catalyzed click reaction and loading with ciprofloxacin hydrochloride (CipHCl). Pure CFs and ACFs showed a little affinity to CipHCl, whereas click products (ACFs@Azide-β-CD) increased the loading amount dramatically because the equilibrium amount was higher than pure CFs and ACFs. Meanwhile, the release process of CipHCl from ACFs@Azide-β-CD was prolonged to reaches the equilibrium. The ACFs@Azide-β-CD loaded with CipHCl showed excellent antibacterial activity against Escherichia coli . The ACFs@Azide-β-CD loading CipHCl have considerably longer bacterial activity against E. coli compared to CFs and ACFs. Graphical abstract
研究领域:
材料科学
·
生物医学工程
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AMINO ACIDS
·
2019
·Vol. 52
·期 3
·361-369
·
IF 2.52
Li Jinlei,Lu Kui,Lv Mingxiu,Liu Guangbin,Ma Li,Qi Jianzhao
Breast cancer susceptibility gene 2 ( BRCA2 ) is an important tumor suppressor, which is participated in repair of damaged DNA by its highly conserved BRC repeat motifs regulating RAD51 protein homologous recombination and thereby preventing cell carcinogenesis. In this study, the BRCA2(1524–1548)–RAD51(241–260) complex structure was obtained based on PDB bank data 1N0W, which provided the basis for site-specific mutation of BRCA2(1524–1548). The BRC4 and BRC4 analogous peptides were synthesized, and the interaction between BRC peptide and RAD51(241–260) was studied by fluorescence spectroscopy, circular dichroism spectroscopy and microscale thermophoresis (MST). The results of circular dichroism showed that the changes in secondary structures of RAD51(241–260) occurred after adding BRC4 analogous peptides, and the α-helix content increased significantly. Fluorescence spectral data demonstrated that the model of BRC peptide binding to RAD51(241–260) was static quenching, and the binding constants of BRC4, P1, P2, P4 with RAD51(241–260) were 1.647 × 10 −4 L mol −1 , 2.532 × 10 −4 L mol −1 , 3.161 × 10 −4 L mol −1 , 1.705 × 10 −4 L mol −1 , respectively. The results of MST indicated that P2 and RAD51(241–260) have better affinity for dissociation constant 44.286 μM. The strongest affinity between P2 and RAD51(241–260) indicated that the mutation of amino acid residue constituting BRC α-helix affects the structure and interaction of BRC peptide and RAD51(241–260).
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-14
·
IF 16.6
Niu Jicheng,Liu Wenjing,Li Jasmine Xinze,Pang Xianglong,Liu Yulin,Zhang Chao,Yue Keyang,Zhou Yulin,Xu Feng,Li Xiaoguang,Li Fei
Due to the inherent disorder and fluidity of water, precise machining of water through laser cutting are challenging. Herein we report a strategy that realizes the laser cutting machining of water through constructing hydrophobic silica nanoparticle-encased water pancakes with sub-millimeter depth. Through theoretical analysis, numerical simulation, and experimental studies, the developed process of nanoparticle-encased water pancake laser cutting and the parameters that affect cutting accuracy are verified and elucidated. We demonstrate that laser-fabricated water patterns can form diverse self-supporting chips (SSCs) with openness, transparency, breathability, liquid morphology, and liquid flow control properties. Applications of laser-fabricated SSCs to various fields, including chemical synthesis, biochemical sensing, liquid metal manipulation, patterned hydrogel synthesis, and drug screening, are also conceptually demonstrated. This work provides a strategy for precisely machining water using laser cutting, addressing existing laser machining challenges and holding significance for widespread fields involving fluid patterning and flow control in biological, chemical, materials and biomedical research.
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2021
·Vol. 37
·期 5
·1085-1091
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IF 1.307
Sun Di,Gao Wenqing,Wu Peng,Liu Jie,Li Shengmei,Li Shilin,Yu Meili,Ning Meng,Bai Ru,Li Tong,Liu Ying,Chen Chunying
E xtracorporeal membrane oxygenation(ECMO) has emerged as a viable treatment in severe cases of acute respiratory distress syndrome, acute respiratory failure, and adult respiratory distress syndrome. However, thromboembolic events stemming from the use of ECMO devices results in significant morbidity and mortality rates; the inner surface of the ECMO tubing comes into contact with the blood and can readily initiate coagulation. In addition, the tubing needs to be continually replaced due to thromboses on the inner tube wall, which not only increases the risk of infection but also the economic burden. Despite considerable effort, a surface modification strategy that effectively addresses these challenges has not yet been realized. In this study, we developed an integrated hollow core-shell-shell hydrogel tube of gelatin/alginate/acrylamide-bacterial nanocellulose(GAA) that meets the anticoagulant requirements for the inner tubing layer as well as the highly elastic soft material needed for the outer layer. Using static blood from healthy volunteers, we confirmed that the platelets or coagulation is not stimulated by the GAA tubing. Importantly, experiments with dynamic blood also demonstrated that the inner layer of the tubing does not elicit blood clotting. The one-pot-synthesized process may provide guidance for the design of anticoagulation tubes used clinically.
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