Cancer Management and Research
·
2024
·
IF 2.5
Yantao Yu,Chenkai Zhang,Qiannan Sun,Shantanu Baral,Jianyue Ding,Fanyu Zhao,Qing Yao,Shuyang Gao,Bin Liu,Daorong Wang
Background Gastric cancer (GC) is a highly phenotypically heterogeneous disease and is caused by a combination of factors. Retinol binding protein 4 (RBP4) is a member of a family of lipid transport proteins that are involved in the transport of substances between cells and play a crucial role in a variety of cancers. However, the expression and role of RBP4 in GC remain unknown.Methods In this study, we explored the expression, prognostic significance, immune microenvironment, drug responsiveness and function of associated signaling pathways of RBP4 in GC using web-based bioinformatics tools. Immunohistochemistry and real-time quantitative PCR were utilized to analyze the tissue and cell expression levels of RBP4. CCK-8, colony formation, EDU incorporation, wound healing and transwell assays were applied to demonstrate the effect of RBP4 on GC cell function. Flow cytometric detection of apoptosis after RBP4 knockdown. Nude mice xenograft model elucidates the role of RBP4 for GC in vivo. Related proteins of the RAS signaling pathway were analyzed by employing Western blot assays.Results RBP4 is highly expressed in GC. RBP4 is closely associated with patient survival and sensitivity to a wide range of antitumor agents. Knockdown of RBP4 promoted apoptosis and inhibited cell proliferation, invasion and migration. RBP4 promotes GC tumorigenesis in vivo. Finally, RBP4 modulates the RAS/RAF/ERK axis.Conclusion RBP4 may promote gastric carcinogenesis and development through the RAS/RAF/ERK axis and is expected to be a novel target for GC treatment.
研究领域:
肿瘤学
·
分子生物学
·
癌症生物学
·
生物信息学
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PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Shuai Ma,Lifeng Dong,Hongzhou Dong,Jie Wang,Yingjie Chen,Beili Pang,Jianguang Feng,Liyan Yu,Mei Zhao
We concretely report feasible synthesis procedures of colloidal Cu 2 ZnSn(S 1- x ,Se x ) 4 -Au (CZTSSe-Au) nano-heterostructured composites, and creatively employ them as the counter electrodes (CEs) of all-solid-state solar cells with inorganic CsSnI 2.95 F 0.05 perovskite hole conductor. Acquired optical characterization indicates that integration of noble metal nanoparticles with cuprum-chalcogenide could heighten light absorption within visible-band due to localized surface plasmon resonance (LSPR) generated by Au, and the forbidden gap of nanocomposites gets adjustment accordingly. It is demonstrated that this novel photocathode alternative with favorable conductivity can not only match the energy level within the device band structure construction, but also restrain recombination so that accelerate charge transfer and extraction occurring on the photocathode. The photocurrent and photoelectric conversion efficiency (PCE) of cells conjugating CZTS-Au photocathodes turn to be respectively 43% and 25% higher than those using pure CZTS. Moreover, it has been demonstrated that CZTS-Au, coupling very well with inorganic perovskite, owns comparable electrocatalytic performance and even higher output photocurrent with respect to platinum CEs, which portends a potential substitution for conventional costly photocathodes. A comprehensive analysis on impedance spectroscopy data is subsequently carried out for the sake of deep understanding charge accumulation and transfer response at CsSnI 2.95 F 0.05 /CE interface, attempting to orient further optimization of device performance.
研究领域:
材料科学
·
能源科学
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2018
·Vol. 29
·期 21
·18566-18572
·
IF 2.324
Zhang Wenna,Zhang Wenwen,Xue Zexu,Xue Yu,Xu Jingkun,Chen Shuai,Zhang Ge
Poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS) is a hotspot among current researched conducting polymers and its conductivity could be significantly enhanced by post-treatment with dimethyl sulphoxide (DMSO). In this work, five S and Se analogues of 3,4-ethylenedioxythiophene (EDOT) were synthesized, and chemically oxidative polymerized (COP) to obtain corresponding free-standing films of Poly(3,4-ethylenedioxythiophene)s:poly(4-styrenesulfonate) (PEDOTs:PSS). The effect of chalcogen substitution on the physicochemical properties and conductive performances of PEDOT:PSS film have been demonstrated. In contrast to the conductivities about 10 −2 –10 −1 S cm −1 for PEDOT:PSS and poly(3,4-ethylenedioxyselenophene):poly(4-styrenesulfonate) (PEDOS:PSS), other PEDOTs:PSS films had the conductivities about 10 −4 –10 −5 S cm −1 . The conductive enhancement effect of DMSO second-doping is suitable for PEDOTs:PSS films except the all-sulfur analogs of PEDOT:PSS (PEDTT:PSS and PEDTS:PSS), and the critical role of the presence of the O atoms in the ethylene bridges and the S atom in the thiophene ring has been illustrated. This work may help understand the structure-performance relationship of PEDOT family and the further development of PEDOTs in areas where the PEDOT seems monotonous and the high conductivity is not necessary, such as antistatic coating, anticorrosive coating, multi-colored electrochromics and so on.
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高影响因子
MICROCHIMICA ACTA
·
2014
·Vol. 182
·期 3
·823-829
·
IF 3.719
Wang Jinshou,Shi Zhen,Jin Jing,Liu Qi,Zhang Shenghui
A three-dimensionally ordered macroporous (3DOM) film of polycysteine (poly-Cys) was used to modify a glassy carbon electrode (GCE) to result in a sensor for 4-aminophenol. The new electrode was used to study the behavior of 4-aminophenol by cyclic voltammetry and differential pulse voltammetry. In comparison to a bare GCE and a GCE modified with poly-Cys without using template, this electrode displays a larger peak current which may be attributed to the structure of poly-Cys and the large surface area of the macroporous structure. The anodic peak current at a working voltage of 195 mV is linearly related to the concentration of 4-aminophenol in two concentration intervals: 0.02 to 20 μM and 20 to 200 μM, respectively. The detection limit is 8 nM (at an S/N ratio of 3). The method was successfully applied to the determination of 4-aminophenol in spiked water samples.
A glassy carbon electrode modified with three-dimensionally ordered macroporous polycysteine film was developed to serve as a sensor for determination of 4-aminophenol. The modified electrode presents lower detection limit, wider linear range and long-term stability for the determination of 4-aminophenol.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Mengru Zhao,Minghui Sun,Qi Kang,Xuemei Ma,Dazhong Shen
Herein, we report a differential strategy to enhance the anti-interference ability of the electrochemical molecularly imprinted polymers (MIP) based sensors for the determination of 4-acetamidophenol (AP) and sulfamerazine (SMR). Polypyrrole MIP membranes for AP or SMR were grown independently on the surface of Ni 2 P/GCE, with the imprinting factors of 6.13 for MIP AP and 5.82 for MIP SMR . At the potentials of 0.42 V and 0.89 V (vs. Ag/AgCl), MIP AP /Ni 2 P/GCE and MIP SMR /Ni 2 P/GCE exhibit sensitive current responses to AP and SMR, respectively. However, the non-specific adsorption of various interferents on the surface of MIP suppresses the selectivity of the MIP sensors. For example, 20 μM ascorbic acid (AA) and sulfamethoxazole (SMZ) were determined falsely as 5.2 μM AP and 4.7 μM SMR, respectively. In the proposed differential strategy using the current differences between MIP AP /Ni 2 P/GCE and MIP SMR /Ni 2 P/GCE as the signal indicators, 20 μM of AA and SMZ are equivalent only to 0.25 μM AP and 0.33 μM SMR, respectively, enhancing significantly the anti-interference ability of MIP sensors. Moreover, the limit of detection for AP and SMR are 0.011 and 0.019 μM, respectively. AP and SMR in actual urine samples were determined with the recoveries from 94% to 105%.
研究领域:
分析化学
·
电化学传感器
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2020
·
IF 7.489
Qiao Yan,Xiao-Yu Wang,Jiu-Ju Feng,Li-Ping Mei,Ai-Jun Wang
Water pollution caused by organic pollutants has aroused great concern to earth sustainability in the last several decades. Herein, a facile one-pot solvothermal approach was developed to construct bimetallic platinum-rhodium alloyed nano-multipods (PtRh ANMPs) in oleylamine (OAm) by adopting creatinine and cetyltrimethylammonium chloride (CTAC) as the co-structure-directing agents. The as-fabricated nanocatalyst exhibited extraordinary catalytic behaviors towards 4-nitrophenol (4-NP) and rhodamine B (RhB) reduction by sodium borohydride (NaBH 4 ). Impressively, the resultant catalyst showed highly facilitated rate constant ( k : 0.209/0.354 min −1 ) and turnover frequency (TOF: 1.0 × 10 −3 /0.44 × 10 −3 mol g −1 min −1 ) towards 4-NP and RhB reduction in comparison with commercial Pt black under the same conditions. This research offers some valuable insights for facile preparation of advanced nanostructures as efficient and recyclable catalyst in environmental remediation field.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Min Xu,Zhayun Gong,Yangyang Wu,Zhiyong Zhu,Kun Wang,Hefeng Xu,Cong Yu,Xiaodong Chu
4-Nitrophenol (4-NP) pollution in the chemical, dye, and other industries poses significant risks to humans and aquatic organisms. In this study, we prepared metal oxide-supported gold nanoparticles (AuNPs/Al2O3, AuNPs/TiO2, and AuNPs/ZnO) and applied them to the catalytic reduction of 4-NP. The Bader charge and differential charge, dos and d band centers, work function, and reaction free energy of AuNP composites were analyzed through DFT calculations. The influence of metal oxide carriers on the catalytic activity of AuNPs was explored, which decreased in the following order: AuNPs/Al2O3 > AuNPs/TiO2 > AuNPs/ZnO. In addition, the catalytic reduction performance of these AuNP composites for 4-NP in the presence of NaBH4 was investigated. The results showed that the AuNPs/Al2O3 catalyst exhibited the best performance (3.62 ± 0.17 min–1), consistent with the theoretical calculations. Meanwhile, the AuNPs/Al2O3 catalyst exhibited good reusability. More relevantly, the catalytic reduction mechanism of metal oxide-supported AuNPs for 4-NP was proposed from both experimental and theoretical calculations.
研究领域:
催化化学
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环境科学
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纳米技术
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材料科学
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理论化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
·
2019
·
IF 4.027
Yu-Heng Hu,Jie Yang,Yun Zhang,Ke-Chun Liu,Teng Liu,Jie Sun,Xiao-Jing Wang
The work is focused on the design of drugs that prevent and treat Alzheimer’s disease (AD) and its complications. A series of 3–(4-aminophenyl)-coumarin derivatives designed, synthesised, fully characterised and evaluated in vitro/vivo. The biological assay experiments showed that some compounds displayed a clearly selective inhibition for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Among all compounds, compound 4m exhibited the highest AChE inhibition with an IC50 value of 0.091 ± 0.011 µM and compound 4k exhibited the highest BuChE inhibition with an IC50 value of 0.559 ± 0.017 µM. A zebrafish behaviour analyser (Zebrobox) was used to determine the behavioural effects of the active compound on the movement distance of the aluminium chloride-induced zebrafish. Compound 4m offered a potential drug design concept for the development of therapeutic or preventive agents for AD and its complications.
研究领域:
药理学
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神经科学
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药物设计
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DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Cong Zhang,Yangkun Xiong,Mingyang Gong,Haixia Zhao,Shan Li,Xin Chen,Xiaochuan Ye,Zhenpeng Qiu
Hyperuricemic nephropathy, a common subtype of chronic kidney disease (CKD), has become an important global public health issue and is closely related to the dramatic increase in fructose consumption. Pachymic acid, the primary active ingredient of the edible fungal herb Poria cocos, has demonstrated the protective capacity against renal injury, but its beneficial effect on hyperuricemic nephropathy remains unclear. In this study, a fructose-diet-induced hyperuricemia nephropathy mouse model was established to reveal the efficacy of pachymic acid in inhibiting hyperuricemic nephropathy the progression. Our results showed that pachymic acid restored abnormal renal function indexes and pathological manifestations such as tubular dilatation and glomerular fibrosis in fructose-fed mice. Transcriptome sequencing results showed marked alterations in glutathione metabolism and ferroptosis signaling pathways in the kidneys of fructose-fed mice after pachymic acid treatment. Mechanistically, pachymic acid activated the Nrf2/GPX-4 signaling pathway by directly binding to Nrf2 and promoting its nuclear translocation, thereby inhibiting ferroptosis, oxidative stress, and inflammatory responses in the kidneys of fructose-fed mice. Consistent results were observed in uric acid-treated HK-2 cells. Notably, both Nrf2 inhibitor ML385 and GPX-4 inhibitor RSL3 treatments reversed the protective effects of pachymic acid against renal injury by suppressing ferroptosis in vitro and in vivo. Summary, our study provides compelling evidence that pachymic acid ameliorates renal injury in fructose-fed mice by inhibiting ferroptosis through targeted activating an Nrf2/GPX-4 pathway, suggesting that dietary supplementation with Poria cocos or pachymic acid might be an effective strategy for CKD prevention, particularly in the subtype of fructose-diet-driven hyperuricemic nephropathy.
研究领域:
药理学
·
肾脏病学
·
生物化学
·
分子生物学
·
营养学
·
药物化学
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产品关联
DOI
PubMed
高影响因子
Chemical Biology & Drug Design
·
2025
·Vol. 106
·期 1
·e70158
·
IF 3.3
Yong Zhu,Chuanmin Yi,Jin Zhao,Lei Wang,Tao Huang,Bo Xiang,Lvhai Zhang,Xiangfang He,Linke Wu
Platinum-based and pyrimidine drugs are first-line treatments for gastric cancer (GC), but their efficacy is often affected by drug resistance. High spalt-like transcription factor 4 (SALL4) expression is associated with poor prognosis, but its role in 5-fluorouracil (5-FU) resistance is not yet clear. In this study, we investigated the effect of SALL4 on 5-FU resistance in GC cells by bioinformatics analysis, real-time quantitative reverse transcription polymerase chain reaction, cell counting kit-8, colony formation assay, and western blot. The results showed that SALL4 was highly expressed in GC and significantly correlated with the fatty acid oxidation (FAO) pathway. Knockdown of SALL4 resulted in a notable attenuation of cellular proliferative capacity and heightened susceptibility to 5-FU resistance in GC cells, while overexpression of SALL4 enhanced 5-FU resistance. Rescue assays confirmed that SALL4 fostered 5-FU resistance in GC cells by enhancing FAO. Our research confirmed that SALL4 promoted the resistance of GC cells to 5-FU by enhancing the FAO pathway. This suggests that drug development targeting SALL4 may help overcome chemotherapy resistance in GC.
研究领域:
肿瘤学
·
分子生物学
·
药理学
·
生物化学
·
癌症研究
·
细胞生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2020
·Vol. 167
·期 6
·066512
·
IF 3.721
Nannan Dou,Jianying Qu
A novel highly sensitive nanoelectrochemical sensor was prepared using graphene oxide/titanium dioxide/gold nanoparticles composites (GT@AuNPs) modified glassy carbon electrode (GCE) to measure paracetamol (PA) and 4-aminophenol (4-AP) simultaneously. It can be found that PA and 4-AP could be completely separated on the GT@AuNPs/GCE using cyclic voltammetry and differential pulse voltammetry technique. Under the best conditions, the linear responses for PA from 0.10 to 300.00 μM with the detection limits of 0.78 nM. And the linear responses for 4-AP from 0.10 to 150.00 μM with the detection limits of 2.36 nM. This sensor can be used to detect acetaminophen in pharmaceutical formulations with satisfactory results, indicating that the electrochemical sensor has potential application value.
研究领域:
分析化学
·
材料科学
·
药物分析
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DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Shuxin Wang,Hui Li,Gen Zhou,Jingmei Xu,Baoju Li,Xiangzi Wei,Zhe Wang
Traditional proton exchange membranes (PEMs), such as Nafion, often rely on perfluorosulfonic acid, posing ecological risks. To address this, sulfonated poly(arylene ether ketone sulfone) containing amino group (Am-SPAEKS) membranes were created as an eco-friendly alternative. This study further innovates by incorporating sulfonatocalix[4]arene (SC4A)-functionalized UiO-66-NH2 (SC4A@UiO-66-NH2) into Am-SPAEKS to produce ASUS-X wt % hybrid membranes. This combination not only boosts proton conductivity without sacrificing mechanical properties but also leverages the unique functionalities of supramolecular macrocycles and metal–organic frameworks (MOFs) to create efficient proton transport channels. The resultant hybrid membrane ASUS-6 wt % exhibits remarkable properties, including a swelling ratio of 16.75% at 80 °C, tensile strength of 41.08 MPa, and proton conductivity of 163.11 mS cm–1 at 80 °C and 100% RH, 89.13% higher than pristine Am-SPAEKS, with over 86% conductivity remaining after 432 h. Remarkably, the maximum power density reaches 392.73 mW cm–2, twice that of pristine Am-SPAEKS. The unique properties of supramolecular macrocycles and MOFs can provide tailored functionalities to address key challenges in PEMs applications.
研究领域:
材料科学
·
高分子化学
·
电化学
·
能源材料
·
膜科学与技术
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高影响因子
危险品化学品经营许可证（带存储）