JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2021
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IF 3.205
Guangyang Liu,Mingshuo Tian,Meng Lu,Weiye Shi,Lingyun Li,Yuhang Gao,Tengfei Li,Donghui Xu
Detection of low levels of triazole fungicides in agricultural product matrices is important. Although several detection methods have been developed, all have some drawbacks, such as being time-consuming, requiring complex sample pretreatment, and consuming large volumes of organic solvents. There is an urgent need for a simple and rapid detection method for triazole fungicides. In this study, the adsorbent composite material magnetic MOFs based on Fe 3 O 4 -MWCNT was synthesized by in-situ polymerization at room temperature, and was applied to extract triazole pesticides from fruits and vegetables. High-performance liquid chromatography-tandem mass spectrometry was used for quantification. Under optimized conditions, the constructed detection method showed a low detection (LOD) of 0.52–1.83 μg/L (S/N = 3) and wide linear range of 5.00–500.00 μg/L for triazole fungicides in the fruit and vegetable samples. The method recovery for spiked fungicides (10, 50, and 100 μg/L) in cabbage, spinach, orange juice, and apple juice ranged from 62.80% to 94.20%. The constructed detection method has a lower detection limit than previously reported methods and has a higher sensitivity for triazole pesticide residues in complex matrices.
研究领域:
分析化学
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环境科学
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农业科学
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产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2023
·Vol. 11
·期 10
·3726-3736
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IF 6.6
Li Yang,Jun Guo,Liwen Wang,Sicheng Tang,Ai-fang Wang,Shengwu Zheng,Zhiyong Guo,Xingjie Zan
The oral delivery of protein-based drugs is of great significance, but faces various obstacles, including the deactivation of proteins by the low pH in the stomach and the high concentration of protease, poor transport through intestinal bio-barriers, etc. Herein, we present an acid-resistant metal–organic framework (MOF), NU-1000, in which insulin (Ins, a model protein) was loaded with high capacity (Ins@NU-1000) through the pseudo second-order kinetic model and Langmuir isotherm model. Ins@NU-1000 protects Ins from deactivation in the stomach acid environment and releases it in the intestine through the transformation of the micro-sized rod particles into spherical nanoparticles. Interestingly, the rod particles exhibit long-term retention in the intestine, and Ins is efficiently transported by the shrunk nanoparticles through intestinal bio-barriers and released into the blood, resulting in significant oral hypoglycemic effects (lasting more than 16 h after a single oral administration). Our findings demonstrate that switching the physical properties of the delivery vehicle, such as the shape and size, can contribute to the success of oral protein administration.
研究领域:
药学
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材料科学
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生物技术
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DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2023
·Vol. 30
·期 51
·110901-110912
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IF 5.8
Ai Huiying,Zhang Zhiyong,Ji Yuxi,Xu Lei,Fu Ming-Lai,Yuan Baoling
Excessive phosphorus in water would cause eutrophication and deterioration of the ecological environment. Herein, the La-MOFs/Al 2 O 3 composite was successfully prepared by the in situ hydrothermal synthesis method for granulation, which was conducive to exerting the phosphate adsorption capacity and facilitating practical application. The materials were characterized by SEM, EDX, XRD, BET, FTIR, and Zeta. In addition, the adsorption performance of La-MOFs/Al 2 O 3 was evaluated through adsorption kinetics and isotherms, showing that the Langmuir adsorption capacity was 16.34 mgP·g -1 (25 °C) and increased with the water temperature. Moreover, the batch influence experiments of intimal pH, adsorbent dosage, coexisting ions, and stability tests were performed to analyze the potential for practical applications and verified through the natural micro-polluted water samples from Houxi River and Bailu Lake (China). The results indicated that the La-MOFs/Al 2 O 3 was suited to a wide pH range of 4 to 10 and the phosphate removal efficiency remained above 70% after continuous use for four times, exhibiting excellent stability. It also had excellent selectivity in the presence of SO 4 2- , Cl - , NO 3 - , and HCO 3 - , only decreased to 70.24% at high HCO 3 - ion concentration of 60 mg/L, respectively. And the La-MOFs/Al 2 O 3 had excellent adsorption of total phosphorus, phosphate, and organic phosphorus in the actual river and lake water and completely removed dissolved phosphorus. Finally, a phosphate adsorption mechanism model involved in electrostatic interaction and ligand exchange was proposed. Therefore, La-MOFs/Al 2 O 3 could be considered to be an excellent phosphorus adsorbent for application in the actual water environmental remediation. Graphical abstract
研究领域:
环境科学
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水处理
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材料科学
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化学
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产品关联
DOI
PubMed
高影响因子
Environmental Technology & Innovation
·
2023
·
IF 7.1
Miao Wang,Jie Zhou,Meng Zhang,Sen Li,Lingyun Li,Ge Chen,Xiaodong Huang,Guangyang Liu,Jing Wang,Donghui Xu
The dye pollution in environmental water and food caused by industrial production and illegal addition is a serious problem worldwide, which endangers ecosystem, food safety and human health. To effectively overcome these challenges, a magnetic bioinspired hierarchical porous MOFs (BHP-MOFs) based on ZIF-8, Fe 3 O 4 and three-dimensional graphene was successfully prepared for selective adsorption of Congo red (CR) and Malachite green (MG) from aqueous solutions. The surface morphology, physicochemical structure and composition of BHP-MOFs were characterized by SEM, TEM, FT-IR, XRD, Zeta potential, TGA and VSM analysis. The prepared BHP-MOFs exhibited a large specific surface area (225.522 m 2 /g), high pore volume (0.248 cm 3 /g) and superparamagnetism, which made it an efficient adsorbent for fast adsorption of CR and MG. The adsorption kinetics studies showed that the adsorption mechanism of CR and MG followed the pseudo-second model and the adsorption process fitted well to Langmuir isotherm equation. Thermodynamic experiments have shown that the adsorption process is spontaneous and endothermic. The maximum adsorption capacities of CR and MG were 176.06 and 448.43 mg/g, respectively. Under the optimum conditions, BHP-MOFs were successfully used as magnetic adsorbents for the removal of CR and MG in environmental water and fruit juices, with removal efficiency ranged from 97.09% to 76.00%. The reusability of the BHP-MOFs was repeated with seven cycles and removal efficiency remained at 63.01% and 82.20% for CR and MG, respectively. It is proved that BHP-MOFs composite has excellent adsorption capacity for dyes and has a wide application prospect in practical applications.
研究领域:
环境科学
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材料科学
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化学工程
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水处理
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产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
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2015
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IF 2.679
Qi Yang,Xiaxia Song,Jing Ge,Guowei Zhao,Wendou Zhang,Gang Xie,Sanping Chen,Shengli Gao
A new energetic MOFs , {[Ni 2 (C 2 H 5 N 5 ) 2 (C 3 H 2 O 4 ) 2 (H 2 O)]·3H 2 O} n (Hdatrz (C 2 H 5 N 5 ) = 3,5-diamino-1,2,4-triazole, H 2 mal (C 3 H 4 O 4 ) = malonic acid), has been synthesized and characterized by element analysis, chemical analysis, IR spectroscopy, single-crystal X-ray diffraction and thermal analysis. X-ray diffraction analysis confirmed that the compound featured a 2D layer structure with dinuclear Ni(II) unit. Thermal analysis demonstrated that the compound after dehydration have good thermostability with decomposition temperature up to 633 K. The non-isothermal kinetics for the compound was studied by Kissinger’s and Ozawa’s methods. The Arrhenius equation of initial thermal decomposition process of compound can be expressed as ln k = 55.89 − 332.01 × 10 3 / RT . Furthermore, a reasonable thermochemical cycle was designed based on the preparation reaction of the compound, and standard molar enthalpy of dissolution of reactants and products were measured by RD496-2000 calorimeter. Finally, the standard molar enthalpy of formation of the compound was determined to be −(2766.3 ± 2.3) kJ · mol −1 in accordance with Hess’s law. In addition, the specific heat capacity of the compound at T = 298.15 K was determined to be 1.42 ± 0.11 J · K −1 · g −1 by RD496-2000 calorimeter.
研究领域:
材料科学
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化学
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热力学
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2021
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IF 8.742
Honghao Huang,Yefei Ma,Zhongqing Jiang,Zhong-Jie Jiang
The sulfonated spindle-like carbon derived from metal-organic framework, MOF- C -SO 3 H, has been employed as a filler for the SPEEK membrane. The obtained MOF- C -SO 3 H@SPEEK membrane shows improved properties as a PEM for DMFCs . In particular, with the presence of 3.0 wt% of MOF- C -SO 3 H, the MOF- C -SO 3 H@SPEEK membrane can exhibit higher proton conductivity and much lower methanol permeability than Nafion 115. The specific porous and sulfonated carbon structure is believed to play an important role in the high performance of the MOF- C -SO 3 H@SPEEK membrane. It helps the good dispersion of MOF- C -SO 3 H in the SPEEK matrix, decreasing the swelling ratio and methanol permeability of the membrane, and promotes the transport of protons through the membrane, improving the proton conductivity of the membrane. More interestingly, when used in the DMFCs , it can give maximum power density of 83.91 mW cm −2 , which is ~50% higher than that of Nafion 115. This, together with its higher stability of the DMFC with the MOF- C -SO 3 H@SPEEK membrane than that with Nafion 115, suggests that the MOF- C -SO 3 H@SPEEK membrane is a promising proton exchange membrane for fuel cells.
研究领域:
材料科学
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电化学
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能源工程
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高分子科学
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
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2022
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IF 9.231
Yan Guan,Peng-Bin Si,Tong Yang,Yuan Wu,Yun-Hui Yang,Rong Hu
Ochratoxin A (OTA) is a naturally occurring mycotoxin that poses serious threats, such as kidney damage, to human health. Therefore, we developed a DNA walker-based dual-signal electrochemical ratiometric platform for OTA detection, which could overlook the variations in environmental and instrumental factors and DNA load densities. Cobalt metal–organic frameworks (Co-MOFs) and toluidine blue were used as the electrochemical signal tag and internal reference probe, respectively. In the presence of OTA, this developed machine resulted in the DNA labelled-Co-MOFs far away from the electrode. Thus, Co-MOFs signal at −1.18 V decreased, while toluidine blue at −0.28 V increased. This proposed strategy has displayed superior sensitivity (limit of detection = 0.31 fg/mL, linear range = 1–50 ng/mL) and high reproducibility. The sensor was also applied for determining OTA content in red wine samples and the results were comparable to those of commercial enzyme-linked immunoassay kits with satisfactory results.
研究领域:
分析化学
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食品科学
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毒理学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2023
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IF 9.9
Guowen Qian,Yuqian Mao,Yang Shuai,Zhikui Zeng,Shuping Peng,Cijun Shuai
Bioceramics have been extensively used to improve osteogenesis of polymers because of their excellent bone-forming capabilities. However, the inadequate interfacial bonding between ceramics and polymers compromises their mechanical properties . In this study, zeolitic imidazolate framework-8 (ZIF-8) was grown in situ on strontium carbonate (SrCO 3 ) to construct a core–shell SrCO 3 @ZIF-8, which was then added to poly- l -lactic acid (PLLA) to print a SrCO 3 @ZIF-8/PLLA composite scaffold using selective sintering technology. First, ZIF-8 characterized by its multiple organic ligands, forms a robust interface with PLLA. Second, SrCO 3 characterized by its negative zeta potential in solution, exhibits the ability to adsorb positively charged zinc ions . This, in turn, promotes the in situ growth of ZIF-8 on SrCO 3 , eventually achieving perfect bonding between the second phase and the PLLA matrix. Our findings indicated that the composite scaffold exhibited the highest compressive strength (21.93 MPa) and significantly promoted the osteogenic differentiation of mouse mesenchymal stem cells. Moreover, the in vivo results established that the SrCO 3 @ZIF-8/PLLA scaffold significantly accelerated bone regeneration efficiency in rat femur defects. The prepared scaffold, with its favorable mechanical properties and osteogenic activity, shows considerable promise for applications in bone repair.
研究领域:
生物材料
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组织工程
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生物医学工程
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材料科学
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产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
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2020
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IF 5.977
Fa-Ting Xie,Xiao-Lan Zhao,Kuan-Neng Chi,Tong Yang,Rong Hu,Yun-Hui Yang
A ratiometric electrochemical aptasensor is proposed for the detection of thrombin. In the sensor, the iron metal-organic frameworks (Fe MOFs)-labeled aptamer as signal tags was used as signal probe (SP), and the electrolyte solution [Fe(CN) 6 ] 3-/4- was utilized as an inner reference probe (IR). In the presence of thrombin, the signal of Fe-MOFs can be detected. Meanwhile, the signal of [Fe(CN) 6 ] 3-/4 -IR almost remains stable. Accordingly, thrombin concentration can be monitored with the ratio response of I Fe-MOFs-SP /I [Fe(CN)6] 3-/4- -IR . The proposed ratiometric biosensor owns a strong ability to eliminate the disturbance that arises from different DNA loading densities, environmental impact and instrumental efficiency. DNA nanotetrahedron (NTH) with three-dimensional (3D) scaffold can effectively eliminate nonspecific adsorption of DNA and protein. The accessibility of target molecules and loading amounts of signal substances could be increased because of the enhanced mechanical rigidity of well-designed 3D NTH. Thus, detection reproducibility and sensitivity can be further improved. Moreover, the biosensor only requires conjugation with one electroactive substance. The modification procedure can be greatly simplified. The biosensor owns high sensitivity with the detection limit of 59.6 fM. We expect that it will emerge as a generalized ratiometric sensor that may be useful for detecting target analytes .
研究领域:
分析化学
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生物化学
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生物医学工程
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纳米技术
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产品关联
DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2023
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IF 8.4
Xiuli Ren,Linna Chang,Yanan Hu,Xingjun Zhao,Shibo Xu,Zepeng Liang,Xifan Mei,Zhenhua Chen
Bacterial biofilms often hinder the healing of infected chronic wounds. Hence, it is significant to explore ways to destroy bacterial biofilms. In this work, a photothermal therapy strategy of designing Au clusters modified ZIF-8 MOFs ( [email protected] ) as peroxidase-like catalytic nanozyme was proposed for bacterial infected wound healing. Under near-infrared laser (NIR), the prepared [email protected] present enhanced peroxidase-like activity and excellent photothermal response properties. [email protected] achieved bacterial membrane disruption rate of 66.3% and MRSA clearance rate up to 97%. [email protected] also catalyzed endogenous H 2 O 2 to OH and achieved almost 97.4% healing rate in animal experiments. The prepared [email protected] with peroxidase-like catalytic nanozyme properties has great potential in the treatment of infected diabetic wounds through bacterial membranes disruption and protein leakage promotion.
研究领域:
纳米技术
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生物医学工程
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材料科学
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伤口愈合
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传染病
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产品关联
DOI
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2025
·Vol. 39
·期 9
·e70363
·
IF 0
Zi-hang Yuan,Si-ya Zheng,Yu-mei Dai,En Tang
The escalating global challenges posed by antibiotic resistance and oxidative stress demand the urgent development of dual-functional materials integrating both antimicrobial and antioxidant capacities to address these intertwined biological threats. This raises a pivotal question: Why not engineer a material capable of simultaneously delivering antioxidant and antibacterial functionalities? To bridge this critical gap, we strategically designed two novel Co and Zn metal–organic frameworks (MOFs) through supramolecular interactions to achieve synergistic antimicrobial–antioxidant performance, rigorously validated via multimodal characterization. Different from traditional antibiotics, these MOFs exert antibacterial effects by controlling the release of metal ions and other mechanisms. Co and Zn-MOFs demonstrated robust antimicrobial efficacy against both Gram-negative and Gram-positive bacteria, coupled with potent antioxidant properties. Zn-MOFs exhibited enhanced antibacterial activity by intensifying membrane disruption via strengthened hydrophobic interactions with bacterial surfaces, whereas Co-MOFs showcased superior antioxidant capacity derived from their redox-active nature. This study unravels the critical mechanistic interplay between metal-bacteria interfacial dynamics and the preservation of cell wall structural integrity. These MOFs redefine multifunctional material paradigms for combating drug-resistant pathogens and oxidative damage, offering transformative potential for biomedical innovations and beyond.
研究领域:
材料科学
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纳米技术
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生物医学工程
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药物化学
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微生物学
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生物化学
✓ 已验证
产品关联
DOI
Chemical Engineering and Processing-Process Intensification
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2018
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IF 2.826
Ding Chen,Peng-fei Feng,Fu-hua Wei
Fe-based metal-organic frameworks(Fe(III)-MOFs)were synthesized by Fe 2 (SO 4 ) 3 and trimesic acid using microwave-assisted ball milling method. The structure of the Fe(III)-MOFs was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectrometry (FTIR). The thermostability of the MOFs was analyzed by thermogravimetric analysis (TGA). Fe(III)-MOFs were added in aqueous solutions to remove organic dyes. The removal efficiencies of Orange II, CR and MB reached 95.9%, 98.7%, 95.7% respectively at 10℃ and reached 97.7%, 99.7%, 97.5% respectively at 35℃ in 300 min.
研究领域:
材料科学
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环境科学
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化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）