JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2025
·
IF 6.2
Qianwen Cao,Luyao Liu,Xiaoge Ma,Chaomin Zhong,Mengqi Tang,Mengge Liu,Ling-Bo Qu,Bo Wei,Xia Xu
1, 8-Cineole (Cin), a cyclic monoterpenoid derived from tea trees and eucalyptus species, exhibits diverse pharmacological properties. Yet, its therapeutic impact and underlying mechanism against Staphylococcus aureus (S. aureus) pneumonia remain to be elucidated. In this study, metabolomics based on UPLC-MS/MS was integrated with network pharmacology, molecular biology, and molecular docking to investigate the effects of Cin. The findings demonstrated that Cin markedly reduced mortality and lung bacterial load, lessened pulmonary damage while suppressing the levels of proinflammatory factors, including tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in the bronchoalveolar lavage fluid (BALF) of infected mice. Additionally, 19 metabolites, primarily involved in tryptophan metabolism and arginine biosynthesis, were notably modified by Cin via suppressing the enzymatic activity of indoleamine 2, 3-dioxygenase 1 (IDO1) and inducible nitric oxide synthase (iNOS), thereby attenuating the inflammatory response. Notably, knockdown of IDO1 or iNOS significantly diminished the anti-inflammation effect of Cin. In conclusion, our study validates the therapeutic potential of Cin against S. aureus pneumonia via anti-inflammation by downregulating IDO1 and iNOS. Our results provide a theoretical basis of natural substances applied in bacterial pneumonia treatment.
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PubMed
高影响因子
SCIENTIA HORTICULTURAE
·
2025
·
IF 4.2
Peng Zhang,Miaomiao Lin,Gloria De Mori,Congcong Li,Guido Cipriani,Sumei Li,Qina Zhang,Zhenzhen Zhang,Yihang Li,Leiming Sun,Jinbao Fang,Xiujuan Qi
Kiwifruit has extremely high nutritional value, but its rootstock strongly influences the physiology and metabolism of its scion fruit. Here, we evaluated the influence of a new kiwifruit rootstock, Actinidia valvata ′Zhongmikangzhen No. 2′, on the leaves and fruits of the scion A. deliciosa ′Zhongmi 2′. The leaf size, leaf mineral element contents, fruit size (single-fruit weight, longitudinal diameter and transverse diameter), and fruit quality traits (soluble sugar content, vitamin C content, total acidity and dry matter content) of ′Zhongmi 2′ grafted on ′Zhongmikangzhen No. 2′ (zk) and A. deliciosa seedling (zp) rootstock were measured at five fruit developmental stages (30, 60, 90, 120, and 150 days after flowering (DAF)). The zk fruits were significantly larger than those of zp and their leaves were also longer. The leaf length and width of the zk fruits was significantly greater than those of the zp fruits. The leaf contents of Cu, P and Mo significantly differed at 60, 120 and 120 DAF, respectively. The fruits of the two stock–scion combinations may presented different flavors. UPLC–MS/MS analysis of the fruit metabolome revealed 1697 differentially expressed metabolites. These metabolites, which were divided into multiple categories through KEGG analysis, indicated significant differences in fruit quality and resistance. Decanoic acid (decreased in zk-hard) and 9-oxononanoic acid (increased in zk-hard) may collectively affect fruit aroma. Moreover, α-linolenic acid and 12-oxo-phytodienoic acid (a precursor of jasmonic acid), both of which increase in zk-hard, contribute to increased nutritional value and are involved in the abiotic stress response, respectively. This study revealed the effects of different rootstock–scion combinations on fruit quality traits and leaf mineral elements and provides a basis for studying the mechanisms of rootstock–scion interactions.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yuerui Ma,Peng Chen,Jiazhen Liao,Xing’an Dong,Wenjie He,Wendong Zhang
Selective photocatalytic oxidation of NO to nitrate (NO 3 – ) over toxic NO 2 remains challenging due to low selectivity and inefficient charge migration in existing systems. This study introduces Fe 3+ as an electron acceptor beneath a Bi 4 TaO 8 Cl/Bi 2 O 2 CO 3 heterojunction to precisely regulate electron pathways and promote targeted hydroxyl radical ( • OH) generation. Combined experimental and DFT analyses reveal Fe 3+ ’s dual role: enhancing interfacial electron transfer and activating H 2 O at surface sites to form • OH. The optimized heterojunction achieves 68.19 % NO conversion with minimal NO 2 selectivity (10.98 %). ESR and ROS quenching confirm Fe 3+ -driven electron migration enriches surface holes, boosting H 2 O adsorption and • OH production (2.76-fold increase). The strong oxidation capacity of • OH suppresses NO 2 formation, favoring complete NO oxidation to NO 3 – . This work provides a strategic approach for selective NO removal by electron-pathway engineering, advancing the design of eco-friendly photocatalysts for air pollution control.
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高影响因子
Reaction Chemistry & Engineering
·
2025
·
IF 3.1
Xue Luo,Jiahui Liu,Danhui Li,Lili Zhao,Hualiang An
Cyclopentanone self-condensation to 2-cyclopentylidenecyclopentanone is one of the key steps in synthesizing high-density fuels. In this study, MgAl-LDO(NO3−) catalysts, prepared via coprecipitation, demonstrated good catalytic performance. Meanwhile, Mg2Al-LDO(NO3−) catalysts with different Mg/Al ratios were explored. Characterization by XRD, NH3-TPD and CO2-TPD revealed that Mg2Al-LDO(NO3−) possessed appropriate acid–base active sites, correlating with its enhanced catalytic performance. Under optimized reaction conditions, cyclopentanone conversion reached 85.9% with 98.8% selectivity toward 2-cyclopentylidenecyclopentanone. Furthermore, the reusability of the catalyst was investigated. XRD, SEM, and N2 adsorption–desorption analyses indicated that structural changes in the Mg2Al-LDO(NO3−) catalyst led to its deactivation. GC-MS analysis of the reaction system identified the primary by-product as 2,5-dicyclopentylidenecyclopentanone. Based on these findings, a plausible reaction network is proposed.
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高影响因子
Frontiers of Environmental Science & Engineering
·
2017
·Vol. 12
·期 1
·1-7
·
IF 1.716
Shi Jin,Zhang Zihao,Chen Mingxia,Zhang Zhixiang,Shangguan Wenfeng,Gu Shunchao,Shin-ichi Hirano
Fe-BEA catalysts are active for the NH3-SCR of NO. For industrial application, a binder should be added to the Fe-BEA catalysts to make them tightly adhere to the monoliths. The addition of alumina and zirconia as binders to the Fe-BEA led to a different effect on NO conversion. The catalytic activity of the mixed samples was evaluated by the temperature programmed procedure in a flow-reactor system, and the mechanism was analyzed via SEM, BET, XRD and XPS. It was found that larger iron particles were formed by the migration of parent iron particles in the Fe-BEA catalyst with alumina. This led to the increase of Fe 3+ magnitude and iron cluster, enhancing the abilities of NO oxidation and storage. Accordingly, the SCR activity increased slightly in low temperature but decreased sharply in high temperature. For the Fe-BEA with zirconia sample, NO oxidation and storage abilities decreased due to the less iron clusters. The increase of Fe 3+ magnitude resulted in higher catalytic oxidation ability, which gave rise to little change in the SCR activity compared with the Fe-BEA.
研究领域:
催化
·
环境科学
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高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 37
·7725-7733
·
IF 6.331
Lubing Liu,Qingqing Wang,Huaiwei Liao,Jing Ye,Jinjun Huang,Shisheng Li,Haichuan Peng,Xiang Yu,Huicai Wen,Xiaolei Wang
Skin necrosis is the most serious complication of flap plastic surgery, which means the failure of the operation. Systemic administration rarely benefits the local area and can lead to side effects, while topical administration has poor permeability due to the skin barrier function. Currently, few of these common medical interventions can totally respond to the blood supply of the skin after surgery. Herein, a soluble microneedle (MN) patch made of hyaluronic acid was used to target the ischemic area in a painless and precise manner for transdermal drug delivery. Based on the important role of nitric oxide (NO) in angiogenesis, the thermosensitive NO donor (BNN6) and gold nanorods (GNRs) acting as photothermal agents were introduced into the microneedles (MNs). The hyperthermia induced by GNRs under near infrared (NIR, 808 nm) irradiation could enhance the penetration of drugs and facilitate NO release from BNN6. A series of corresponding experiments proved that the system played a significant promotion role in vascular regeneration, providing a painless, precise and NO-assisted treatment method for the ischemic perforator flaps.
研究领域:
生物医学工程
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药学
·
材料科学
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PubMed
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 7
·3068
·
IF 4.6
Yuanyuan Ma,Wanting Liu,Zhifang Li,Yuhang Sun,Mingyuan Shi,Zheng Nan,Ruotong Song,Liying Wang,Jingqi Guan
TS-1 zeolite with desirable pore structure, an abundance of acidic sites, and good thermal stability promising as a support for the selective catalytic reduction of NO with NH3(NH3-SCR). Herein, a series of Mn–Fe/TS-1 catalysts have been synthesized, adopting tetraethylenepentamine (TEPA) as a metal complexing agent using the one-pot hydrothermal method. The introduced TEPA can not only increase the loading of active components but also prompts the formation of a hierarchical structure through decreasing the size of TS-1 nanocrystals to produce intercrystalline mesopores during the hydrothermal crystallization process. The optimized Mn–Fe/TS-1(R-2) catalyst shows remarkable NH3-SCR performance. Moreover, it exhibits excellent resistance to H2O and SO2at low temperatures. The characterization results indicate that Mn–Fe/TS-1(R-2) possesses abundant surface Mn4+and Fe2+and chemisorbed oxygen, strong reducibility, and a high Brønsted acid amount. For comparison, Mn–Fe/TiO2displays a narrower active temperature window due to its poor thermostability.Keywords:Mn-Fe/TS-1;one-pot synthesis;NH3-SCR;metal complexing;resistance to H2O and SO2
研究领域:
催化化学
·
环境科学
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高影响因子
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2019
·Vol. 95
·期 3
·862-874
·
IF 2.659
Fei Rao,Gangqiang Zhu,Miaomiao Wang,Siyaka Mj Zubairu,Jianhong Peng,Jianzhi Gao,Mirabbos Hojamberdiev
BACKGROUND Photocatalysis is one of the effective ways to solve the problem of water and gas pollution. An excellent photocatalyst should have the following advantages: efficient photocatalytic activity for gas and water pollutants, recyclable and stable characteristics, non-toxic and low-cost. Constructing heterojunctions and introducing oxygen vacancies (OVs) are two effective measures to achieve these targets. RESULTS It is found that the 1.0% Pd/PdO/β-Bi 2 O 3 exhibits the best photocatalytic activity with an efficiency of 97.4% for Bisphenol A (BPA) degradation and 47.6% for nitric oxide (NO) removal within 30 min. The 1.0% Pd/PdO/β-Bi 2 O 3 composite shows 23.3% efficiency in the photodegradation of BPA under 595 nm monochromatic light irradiation, while β-Bi 2 O 3 tends to be invalid. Moreover, the OVs promote the removal of NO without irradiation. CONCLUSION In this work, a novel ternary Pd/PdO/β-Bi 2 O 3 material as high-performance photocatalyst for the BPA degradation and NO removal was synthesized. The presence of OVs promotes the activation of the oxygen molecule, thereby facilitating the photocatalytic process. The p - n junction of PdO/β-Bi 2 O 3 and the Schottky barrier of Pd/β-Bi 2 O 3 significantly limit the recombination of photoinduced electron–hole pairs in the composite. Furthermore, an artifact in the electron spin resonance (ESR) spectrum obtained by spin trapping with 5,5-dimethyl-1-pyrroline N -oxide (DMPO) as adducts confirms that both hydroxyl radical (•OH) and superoxide radical (•O 2 − ) species are involved in the photocatalytic process. The present work offers a new perspective for developing the composite photocatalysts with high efficiency through loading of metal nanoparticles and creating an heterojunction. © 2019 Society of Chemical Industry
研究领域:
环境科学
·
材料科学
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高影响因子
BIOMATERIALS
·
2020
·
IF 10.317
Zhifang Ma,Shi Liu,Yue Ke,Haozheng Wang,Runhai Chen,Zehong Xiang,Zhigang Xie,Qiang Shi,Jinghua Yin
Platelets attribute to the hypercoagulation of blood and maintenance of the tumor vascular integrity, resulting in limited intratumoral perfusion of nanoparticle into solid tumors. To overcome these adversities, we herein present an antiplatelet strategy based on erythrocyte membrane-enveloped proteinic nanoparticles that biomimic nitric oxide synthase (NOS)with co-loading of l -Arginine (LA) and photosensitizer IR783 for local NO release and inhibition of the activation of tumor-associated platelets specifically, thereby enhancing vascular permeability and accumulation of the nanoparticles in tumors. A cRGD-immobolized membrane structure is constructed to actively target platelets and cancer cells respectively, through overexpressed integrin receptors such as integrin α IIb β 3 and α v β 3 , accelerating the inhibition of platelet activation and endocytosis of nanoparticles by tumor cells. Bio-mimicking the arginine/NO pathway in vivo , synergistical delivery of LA and IR783 enables LA molecules readily oxidize to NO with O 2 that is mediated by activated IR783, the resulted NO not only retards the activity of platelets to disrupt the vascular integrity of tumor but also enhances toxicity to cancer cells. In addition, NIR-controlled release localizes the NO spatiotemporally to tumor-associated platelets and prevents undesirable systemic bleeding substantially. The reduction of the hypercoagulable state is further demonstrated by the down-regulation of tissues factor (TF) expression in tumor cells. Our study describes a promising approach to combat cancer, which advances the biomimetic NOS system as the potent therapeutic forces toward clinic applications.
研究领域:
癌症治疗
·
纳米技术
·
药理学
·
仿生学
·
分子生物学
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PubMed
高影响因子
STARCH-STARKE
·
2021
·
IF 2.741
Meidong Li,ZiMu Zhang,Ying Luo,Xiufang Huang,Kai Luo
Four new water-soluble polysaccharides has previously been isolated from Cardamine hupingshanensis . In this experiment, the structure of C. hupingshanensis polysaccharide NO. 3 (CHP-3) is analyzed and its in vitro anti-tumor activity is assessed. Through structural analysis, CHP-3 is found to have a molecular weight of 80.64 kDa, and be mainly composed of glucose, galactose, and L -arabinose; The backbone of CHP-3 is mainly composed of →5)-α-L-Araf-(1→ and →4)-α-D-Glc(p)-(1→), respectively. By studying its anti-tumor activity in vitro, it can be concluded that treatment with different concentrations of CHP-3 exerted diverse effects on A549 cells, with an obvious dose-dependent relationship. Moreover, after treatment with 12.8 mg mL −1 CHP-3, significant inhibitory effects are observed on the proliferation, migration, and invasion of A549 cells, indicating that it can be used as an anti-tumor agent for continued in-depth research.
研究领域:
药理学
·
肿瘤学
·
分子生物学
·
化学
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Haiyang Wang,Le Guo,Jiaxing Li,Chi Zhang,Yuxiang Gao,Jiaqi Ma,Jiabao Xiong,Siyu Huang,Qinfen Wu,Jingtao Wang,Yaqi Cui,Biao Dong,Nuernisha Alifu
cRGD-modified ITC NPs target αvβ3 integrin for BBB/BTB traversal in GBM. • NIR-triggered ITC NPs combine TMZ chemotherapy and phototherapy. • ITC NPs generate NO in situ to improve perfusion and modulate resistance. • NIR-II fluorescence imaging and LSCI enable GBM diagnosis and perfusion monitoring. Glioblastoma (GBM) remains one of the most lethal brain malignancies, largely due to the blood-brain barrier (BBB) and the pathologically heterogeneous blood-tumor barrier (BTB), which severely restrict drug delivery. To achieve targeted BBB/BTB traversal, we developed cRGD-modified ICG/TMZ@Lips nanoparticles (ITC NPs). The nanoplatform actively targets αvβ3 integrin overexpressed on tumor endothelial cells and GBM cells, thereby promoting receptor-mediated transport and tumor penetration. Under near-infrared (NIR) irradiation, ITC NPs trigger temozolomide (TMZ) release and photo-responsive NO-associated effects. These effects are accompanied by heat shock protein 70 (HSP70) downregulation and modulation of resistance-related pathways, which may contribute to enhanced chemosensitivity. Furthermore, we integrated near-infrared II (NIR-II) fluorescence imaging with laser speckle contrast imaging (LSCI) for real-time GBM diagnosis and perfusion monitoring. To the best of our knowledge, among existing BBB/BTB traversal strategies, this is the first study to apply cRGD peptide for specific and efficient BBB/BTB penetration in GBM therapy. This strategy directly addresses the fundamental limitations imposed by the heterogeneous and efflux-active BTB, offering a precise nanomedicine approach for improved therapeutic outcomes. Download: Download high-res image (353KB) Download: Download full-size image
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Liuqing Yang,Zhuoting Xiong,Haowen Zou,Bin Zhao,WingKei Ho,Dingze Lu
Improving the efficiency of nitric oxide (NO) removal while reducing the formation of toxic nitrogen dioxide (NO 2 ) is a challenge. Nonetheless, it remains uncertain regarding the distinct roles of carbon versus nitrogen vacancies in graphitic carbon nitride (g-C 3 N 4 ) in governing the oxidation pathway. In this study, g-C 3 N 4 enriched with carbon or nitrogen vacancies, along with the corresponding polyvinylidene fluoride (PVDF)-supported composite films, are prepared. The adsorptions and anchoring of NO and its intermediates are significantly enhanced by the carbon vacancies. Despite a high free energy barrier of the conversion from nitrite to nitrate, the strong anchoring suppresses the release of gaseous NO 2 . The formation of Nitrogen vacancies gives rise to polarization of the spin, leading to a significant negative displacement of the potential of the conduction band and increased carrier lifetime along with a considerable decrease in the barrier for the conversion of nitrite to nitrate. This mechanism leads to enhanced reaction flux that will improve deep oxidation. The incorporation of these materials into the PVDF film greatly enhances performance and provides reusability. This work elucidates the distinct mechanisms by which carbon and nitrogen vacancies regulate NO oxidation, providing a theoretical basis for designing efficient and selective air purification materials.
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