ACS Sustainable Chemistry & Engineering
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2025
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IF 7.3
Liang Wang,Fengshuo Xi,Jie Yu,Shaoyuan Li,Jijun Lu,Zhongqiu Tong,Xiuhua Chen,Kuixian Wei,Wenhui Ma
The trend of large-scale wafer thinning has led to increased surface activity, oxidation, and uneven oxidation interfaces in photovoltaic silicon cutting waste (SCW) produced by diamond wire cutting, posing significant challenges for its use as a silicon–carbon anode material. To address these issues, we propose a green recycling method that utilizes alkaline solutions to recover silicates from etched SCWs, avoiding the highly corrosive HF acid. By combining inexpensive chitosan (CTS) as a soft template, we achieve controllable reshaping of silicates into amorphous oxide layers (1 to 16 nm) on submicron SCW surfaces. This process involves a one-step method in a vacuum autoclave, which simultaneously eliminates the chitosan template and forms both the oxide layer and the phenolic resin. Unlike self-crystallizing oxide layers, the amorphous layers ensure uniform expansion and contraction, facilitate Li+ transfer, and introduce structural defects, enhancing lithium storage performance. The resulting Si@SiOx@C composite with a 5 nm thick oxide interface significantly improves the cycling performance, coulombic efficiency, and rate capability of the silicon–carbon material, achieving a reversible capacity of over 1000 mAh g–1 after 200 cycles at 1 A g–1. This work demonstrates the value-added utilization of submicron SCWs in the commercial production of high-performance silicon-based lithium-ion battery anodes.
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JOURNAL OF CATALYSIS
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2025
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IF 6.5
Huacheng Ying,Zeyu Wen,Jia Yao,Mowei Zhou,Yongtao Wang,Haoran Li
Constructing N−O bond in amines via aerobic oxidation is of high interest for producing cyclohexanone oxime; however, the mechanism remains disputed. Concerning TiO 2 /NHPI co-catalyzed aerobic oxidation of cyclohexylamine, here a convincing mechanism involving α-C radical and oxaziridine as key intermediates is demonstrated. All the evidences from electron paramagnetic resonance, mass spectrometry, and product analysis with methylated substrates lead to the same story about the mechanism, where both radical translocation of cyclohexylamino radical and epoxidation of 1-hydroperoxycyclohexylamine are mediated by double proton transfer and are the key to convert amine into oxime. Near IR analysis indicate that surface hydroxyl groups on TiO 2 facilitate the double proton transfer process. Here the unveiled role of surface hydroxyl on TiO 2 highlights its potential for broader applications in amine activation. Additionally, the well-established radical mechanism provides valuable insight into the construction of N−O bonds in amines.
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Theranostics
·
2022
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IF 11.6
Xiaotong Yu,Jing Yu,Hong Dai,Chenyun Deng,Xudong Sun,Sijie Long,Zhujun Jiang,Hongyan Jin,Zhu Guan,Zhenjun Yang
Rationale: Cyclic dinucleotides (cDNs) are a promising class of immunotherapeutic agent targeting stimulator of interferon genes (STING). However, enzymatic instability and transmembrane barriers limit the extensive clinical application of cDNs. Thus, a novel delivery system, composed of a neutral cytidinyl lipid DNCA and a cationic lipid CLD (Mix) that interacts with cDNs via H-bonding, pi-stacking and electrostatic interaction, is developed and optimized to overcome the above issues. Methods: The optimal composition of Mix for cDNs encapsulation was explored with RAW-Lucia ISG cells. The physicochemical properties of resulted nanoparticles were characterized. To validate the anti-tumor immunity of cDNs/Mix both in vitro and in vivo , immunogenic cell death (ICD) related markers and tumor inhibition efficacy were evaluated in cancer cells and tumor models, respectively. The mechanism by which cdG/Mix exerted the antitumor effects was explored by flow cytometric analysis and in vivo depletion. Results: Based on our developed and optimized delivery system, neutral cytidinyl lipid DNCA/cationic lipid CLD (Mix), cdG (500 nM in vitro , 1-10 μg in vivo )/Mix not only more potently stimulated production of IFNβ and related cytokines including CXCL9 and CXCL10, promoted ICD, led to NK and CD8 + T cell activation, inhibited tumor growth in both EO771 and B16F10 models and increased their survival rate (~43%), but also obviously reversed the T cell exhaustion (Tex) in tumor, meanwhile down regulated the mRNA expression of Tox and Nr4a , which are key regulators of Tex. Conclusion: cdG/Mix triggered ICD in various cancer cells and reversed the Tex systemically in tumor-burden mice, which would be a promising alternative strategy for cancer immunotherapy.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
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2023
·Vol. 21
·期 1
·1-17
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IF 10.2
Wu Xinzhou,Jiao Zhouguang,Zhang Junying,Li Feng,Li Yuhua
Background Currently, high doses of cytarabine arabinoside (Ara-C)-based combined chemotherapy are commonly used in acute myeloid leukemia (AML) therapy, but severe adverse effects and poor suppression effects in leukemia cells limit the clinical therapeutic efficiency of Ara-C-based chemotherapy due to a lack of targeting selectivity. To improve the therapeutic effect of Ara-C in AML, here, since we confirmed that transferrin receptor 1 (TFRC) expression in AML cells was constant, we generated Ara-C@HFn by encapsulating free Ara-C into self-assembled heavy ferritin chain (HFn, the ligand of TFRC) nanocages.Results The analysis of clinically relevant data suggested that the high expression levels of TFRC from AML cells would not decrease significantly after treatment with Ara-C. Ara-C@HFn can be efficiently internalized by leukemia cells, showing stronger cytotoxic effects in vitro and reducing the burden of leukemia in AML mice more effectively in vivo than free Ara-C. Ara-C@HFn treatment showed no acute toxicity in visceral organs of mice. Moreover, the analysis of clinically relevant data also suggested that there are several drugs (such as tamibarotene and ABT199) that would not cause significant expression down-regulation of TFRC in AML cells (after treatment).Conclusion The above results suggested that TFRC can be used as a constant and effective target for drug targeting delivery of AML cells. Thus Ara-C@HFn treatment can become a safe and efficient strategy for AML therapy by specifically delivering Ara-C to AML cells. Besides, the HFn nanocages are promising for improving antineoplastic effect of other AML-related therapy drugs that do not cause downregulated expression of TFRC in AML cells.Graphical Abstract
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ACS Applied Optical Materials
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2025
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IF 3.8
Huan Zhou,Meng Cheng,Zhihua Yang,Shilie Pan
Birefringent materials are crucial optical materials that enable the control of polarized light in optical technologies, yet achieving high birefringence in systems dominated by non-π-conjugated units in the deep-ultraviolet (UV) region remains a significant challenge. Herein, a birefringent material, [C(NH2)3]2PO3(OH), was successfully synthesized by integrating π-conjugated [C(NH2)3] units and heteroleptic tetrahedra [PO3(OH)]. The short UV cutoff edge (<200 nm) and large birefringence (0.086 @ 546 nm) make [C(NH2)3]2PO3(OH) a potential deep-UV birefringent crystal. This study provides the experience for the design of deep-UV optical crystals.
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Science China-Materials
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2025
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IF 7.4
Peng Chunli,Tang Baoling,Zhang Xuejie,Molokeev Maxim S.,Zhang Haoran,Lei Bingfu
Near-infrared (NIR) spectroscopy has significantly advanced NIR light sources. However, creating NIR emitters with optimal luminescence properties, high thermal stability, and adjustable emission peaks poses a critical challenge for future smart NIR devices. We introduced a chemical unit cosubstitution strategy by incorporating Ca 2+ and Sn 4+ ions into the garnet structure. Through this approach, Y 3− y Ca y Ga 4.95− y Sn y G 12 :0.05Cr 3+ ( y = 0–1) phosphors were developed by modulating the A&C ligands, resulting in emission centers ranging from 708 to 768 nm. The modified local environment of Cr 3+ accounts for the increased light intensity (2.71 times) and broadening observed. Furthermore, this study investigated the impact of varying Cr 3+ concentrations (Y 2.6 Ca 0.4 Ga 4.6− x Sn 0.4 G 12 : x Cr 3+ ) on the production of high-performance phosphors. Compared with Y 3 Ga 4.93 G 12 :0.07Cr 3+ , the optimized phosphor exhibited exceptional external quantum efficiency (EQE = 34.96%). The luminescence enhancement is attributed to an increase in radiative transitions caused by octahedral Jahn-Teller distortion, whereas the notable thermal stability (91.3% at 423 K) is attributed to the presence of weak electron-phonon coupling (EPC) and oxygen vacancy (O V ) defects. Finally, by combining it with a 450 nm blue LED chip, we constructed a near-infrared phosphor-converted LED (NIR pc-LED) device with superior electroluminescence efficiency (18.8% @ 100 mA), increasing the ultralow quenching rate (< 5% intensity loss after 30 days of operation) and demonstrating remarkable performance in plant lighting applications.
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CERAMICS INTERNATIONAL
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2025
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IF 5.6
Mengchuan Li,You Zhou,Tongsheng Zhang,Rensheng Li
The sluggish advancement in technology for the recovery of rare earth elements from secondary resources can be largely attributed to an inadequate understanding of the thermodynamic properties of cerium oxide-based slag systems. This study systematically investigates the phase equilibrium of the Ce 2 O 3 -CaO-SiO 2 -5 wt% MgO quaternary system at 1500 °C and 1600 °C. High-temperature equilibrium experiments followed by rapid quenching were conducted, and phase assemblages were characterized by XRD, SEM and EPMA. For the first time, the results accurately determined the isothermal liquidus lines for the first time and identified the stable regions of key phases such as SiO 2 , Ce 2 Si 2 O 7 , CaO·2Ce 2 O 3 ·3SiO 2 , CaO·Ce 2 O 3 ·2SiO 2 , the Ce-doped dicalcium silicate (i.e., (Ca, Ce) 2 SiO 4 ), and the monticellite (i.e., CaMgSiO 4 ), as well as their coexistence relationships. Furthermore, the isothermal sections at 1500 °C and 1600 °C were constructed based on experimental data and fundamental thermodynamic principles. This study not only fills a critical gap in the thermodynamic database for rare-earth slag systems but also provides a theoretical basis for optimizing slag design and enhancing cerium recovery from waste slags.
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NEW JOURNAL OF CHEMISTRY
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2025
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IF 2.5
Qian Zhang,Qianrui Yang,Tianci Liu,Yuchen Yue,Jingran Zhang,Guifu Zuo
In this work, a novel Faraday cage-type electrochemiluminescence (ECL) biosensor was constructed for the ultrasensitive "turn on" detection of CEA. The capture unit was prepared by immobilizing the Carcinoembryonic antibody Ab 1 onto the functionalized magnetic Fe 3 O 4 nanoparticles, while the detection unit consisted of modified g-C 3 N 4 labeled with antibody Ab 2 . The recognition scaffold was assembled as follows: the capture unit was first fixed onto the magnetic electrode surface; the target CEA was then captured; followed by further hybridized with the detection unit; ultimately forming the Faradaycage biosensor structure. In this configuration, the signal unit became part of the electrode surface, enabling all electrochemiluminophores in the signal unit to participate in the electrode reaction, thereby significantly enhancing the detection sensitivity. Utilizing the proposed Faraday-cage cascade, the ECL intensity increased with the rising CEA concentration. The linear range was from 0.01 to 100 ng/mL, with a detection limit of 0.35 pg/mL. The sensor was validated for its selectivity, stability, reproducibility, precision, and application potential. This Faraday cage-type ECL biosensor shows promising prospects for clinical CEA detection.
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Advanced Electronic Materials
·
2025
·Vol. 11
·期 8
·2400738
·
IF 5.3
Guodong Han,Song Zhao,Sai Sui,Bo Feng,Yudeng Wang,Junxiang Zhou,Zhuolun Li,Xiaoxia Tian,Yuxiang Jia,Jiafu Wang,Shaobo Qu
Metal–Organic-Frameworks (MOFs) are commonly used as microwave-absorbing materials after pyrolysis treatment. Rare researchers treat MOFs as non-conductive materials and use them as absorbing materials directly. In this paper, MOFs@P-C-800 composite materials are prepared adopt to hydrothermal and ultrasonic dispersion methods by regulating the morphological characteristics of MOFs and the content of P-C-800. As for the Co-BDC-P-C-800, the maximum reflection loss reaches −18.4 dB at 14.29 GHz and the effective absorption bandwidth (EAB) achieves 3.87 GHz from 13.5 to 17.37 GHz. After the contents of P-C-800 is adjusted, the Co-BDC-P-C-800 (0.05 g) exhibited excellent microwave absorption performance, the maximum RL value of −60 dB at 13 GHz with a thickness of 2.0 mm, and the EAB achieves 5.91 GHz from 12.02 to 17.93 GHz. This paper not only provides new application direction for MOFs, but also offers a promising direction for the research and development of absorbing materials.
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JOURNAL OF HAZARDOUS MATERIALS
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2025
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IF 11.3
Hengli Qian,keyuan Zhang,Chao Xie,Qidong Hou,Ruite Lai,Guanjie Yu,Tianliang Xia,Xinyu Bai,Meiting Ju
To achieve efficient degradation of pharmaceuticals and personal care products (PPCPs), the g-C₃N₄-WO₃@FePc system was in-situ constructed using a calcination method, with g-C₃N₄-WO₃ serving as the support matrix. This approach effectively resolved the issue of FePc aggregation and self-degradation in aqueous environments. The g-C₃N₄-WO₃@FePc catalyst demonstrated excellent performance in the photo-Fenton degradation of acetaminophen (ACE), achieving over 90% degradation within just 20 minutes under simulated sunlight. The catalyst's superior performance is attributed to the synergistic effects between the reaction centers. The π-π conjugation between g-C₃N₄-WO₃ (the photocatalytic center) and FePc (the Fenton catalytic center) facilitates the transfer of photo-generated electrons from the photocatalytic center to the Fenton catalytic center, enabling rapid regeneration of Fe(II) and generating a significant amount of active species (•O₂⁻ and 1 O₂). To validate the stability of the catalytic system, factors such as ionic impurities and water types affecting performance were investigated and analyzed. Additionally, cell toxicity and antimicrobial tests were conducted to evaluate the toxicity of ACE degradation intermediates and the ecological stability of g-C₃N₄-WO₃@FePc, revealing its potential for practical wastewater treatment applications.
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PHYTOMEDICINE
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2016
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IF 2.937
Kai-Li Jian,Chao Zhang,Zhi-Chun Shang,Lei Yang,Ling-Yi Kong
ABSTRACT Background Eucalyptus extracts have anti-cancer activity against various cancer cells . Formyl-phloroglucinol meroterpenoids (FPMs), which are typical secondary metabolites of the genera Eucalyptus, have many important pharmacological activities . Purpose Eucalrobusone C (EC), a new bioactive phytochemical , was first isolated from the leaves of Eucalyptus robusta in our laboratory. EC is a FPM, and our previous research revealed that EC showed strongest cytotoxicity in three cancer models than other compounds isolated from the leaves of E. robusta . This study investigated its anti-tumor effects on human hepatocellular carcinoma (HCC) and its underlying mechanisms. Methods Cell viability was measured by MTT assay . Cell cycle, apoptosis and mitochondrial transmembrane potential were determined by flow cytometry. Immunofluorescence was determined by a laser scanning confocal microscope . Protein levels were analyzed by Western blotting . Results Our results showed that EC exerted strong anti-proliferative activity against HCC cells in a concentration- and time-dependent manner. EC markedly induced apoptosis through the caspase-dependent mitochondrial pathway, and the cell cycle was arrested at S phase. SB203580 , a p38 MAPK inhibitor, effectively decreased cell death caused by EC. Moreover, the ROS scavenger N-acetyl cysteine (NAC) significantly attenuated apoptosis induced by EC and reversed EC-induced p38 MAPK activation. Conclusion Our findings indicate that EC induces mitochondrial-dependent apoptosis in HCC cells through ROS generation and p38 MAPK activation, making EC a promising candidate for further development as an anticancer agent for HCC cells.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Lian Duan,Weiyao Yang,Hongda Zhang,Mengmeng Huang,Le Sang,Jisong Zhang
In this work, high-efficiency and continuous production of tetrahydrofurfuryl alcohol (THFA) over a Ru/C catalyst was performed in micropacked bed reactors (μPBRs). The excellent reaction performance demonstrated by the combination of μPBRs and the Ru/C catalyst resulted in a 100% furfural (FUR) conversion and a 98.5% yield of THFA within 3.5 min at 25 °C. Subsequently, a kinetic model was developed to describe the continuous hydrogenation of FUR in μPBRs. Utilizing the established kinetic model, the concentrations of various substances were predicted at different residence times between 25 and 45 °C, with an error of less than ±25%. The apparent activation energies for the FUR conversion to furfuryl alcohol (FA) and for the subsequent hydrogenation of FA to THFA were found to be 18.9 and 30.6 kJ/mol, respectively. Furthermore, the space-time yield (STY) of the μPBR system reached 0.21 kgTHFA L–1 h–1, significantly surpassing stirred tank reactors (STRs). These results demonstrate the superior efficiency and productivity of the μPBR system, providing a scalable and sustainable solution for the THFA synthesis.
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