CHEMICAL ENGINEERING SCIENCE
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2024
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IF 4.1
Ju Lv,Hua Tian,Lang Pan,Zihan Chen,Mengting Li,Reza A. Ghiladi,Ziyu Qin,Xueqiong Yin
We report the synthesis of multifunctional carbon dots (PAPBCDs) via a one-step hydrothermal method, and evaluated their therapeutic efficacy in wound healing in vivo using a Staphylococcus aureus -infected wound mouse model. The multifunctional carbon dots (CDs) were derived from biomass-based polysaccharide (PAP) and betaine (B), and retained the antioxidant and antibacterial activities, respectively, of their starting precursors. In addition to possessing favorable biocompatibility in cytotoxicity studies, the antibacterial activity of the PAPBCDs was 99.38% against Gram-negative bacteria and 90.80% against Gram-positive bacteria, respectively, suggesting that the betaine-derived quaternary ammonium groups in the PAPBCDs were able to electrostatically disrupt bacterial cell membranes leading to pathogen inactivation. ROS scavenging studies demonstrated that the PAPBCDs could effectively scavenge hydroxyl radicals, suggesting that the PAPBCDs could remove intracellular ROS and protect wound tissue from oxidative stress. In vivo studies using mouse models indicated that PAPBCDs could accelerate S. aureus -infected wound healing. These findings offer some interesting ideas for how to design of effective nanomaterials to treat wound infections, and suggest that multifunctional carbon-dot based materials may play a therapeutic role in tissue regeneration and healing.
研究领域:
材料科学
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生物医学
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药理学
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产品关联
DOI
高影响因子
Heliyon
·
2024
·
IF 3.4
Kun Jiao,Maolei Sun,Wenyuan Jia,Yun Liu,Shaoru Wang,Yuheng Yang,Zhihui Dai,Liping Liu,Zhiqiang Cheng,Guomin Liu,Yungang Luo
Electrospinning is a widely recognized method for producing Janus or core-shell nanofibers. In this study, nanofibrous membranes were fabricated through co-axial electrospinning utilizing polycaprolactone (PCL) and silk fibroin (SF) as the Janus shell, and taxifolin (TAX) and SF as the core. The resulting nanofibers had diameters of 816 ± 161 nm and core diameters of 73 ± 5 nm. The morphology and properties of the PCL-SF@SF/TAX nanofibers were subsequently analyzed. The results demonstrated that the nanofibrous membranes achieved physical and chemical characteristics potential for tissue engineering and drug delivery. Specifically, the membranes exhibited a Young's modulus of 9.64 ± 0.29 MPa, a water contact angle of 79.1 ± 1.3°, and a weight loss of 17.3 ± 1.0 % over a period of 28 days. The incorporation of TAX endowed the membranes with antibacterial properties, effectively combating Escherichia coli and Staphylococcus aureus . Furthermore, the membranes demonstrated antioxidant capabilities, with a DPPH radical scavenging efficiency of 38.5 ± 5.6 % and a Trolox-equivalent antioxidant capacity of 0.24 ± 0.01 mM. The release of the antioxidant was sustained over 28 days, following first-order release kinetics. The nanofibrous membranes, referred to as PSST, exhibit promising potential for use as biomaterials, characterized by their antibacterial activity, antioxidant and cytocompatibility.
研究领域:
生物材料学
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组织工程学
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药剂学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Yubo Ren,Shuaijie Li,Jingjun Dong,Zhihui Zhao,Zunyuan Wang,Guoxin Wang,Xiaoming Li,Weichao Chen
The urgent need for efficient wound dressing requires comfortability, reasonable humidity, and anti-inflammatory and pathogen anti-infectivity properties. Herein, the PET micronanofiber pads loaded with forsythin (FT) are successfully designed and prepared by electrospinning. The asymmetric wettability double-layer micronanofiber pad (PET@FT10%/PET) has been developed by utilizing the hydrophobic properties of PET. The addition of FT endows super hydrophobic PET with excellent hydrophilic properties and absorbent properties to ensure the dryness of the wound environment. Meanwhile, the hydrophobic PET layer avoids the adhesion of dust and bacteria, providing a barrier to prevent pollution of the complex external environment for the drug-carrying layer. Furthermore, the PET@FT10%/PET double-layer micronanofiber pad provides favorable conditions for wound healing with the validation by inhibition of representative pathogens Escherichia coli and Staphylococcus aureus, and the expression of pro-inflammatory factors (IL-6 and TNF-α), and the cell survival rate also achieved excellent results. Therefore, the PET@FT10%/PET double-layer micronanofiber pad designed in this paper provides a neoteric strategy with an asymmetric structure design to avoid contamination and accelerate drug delivery for wound healing.
研究领域:
生物医学工程
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材料科学
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药理学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xing Cao,Yuan-Yuan Huang,Xin-Yu Tian,Yan-Peng Ni,Yu-Zhong Wang
The development of bio-based flame retardants has garnered significant attention, however, significant challenges remain in achieving efficient flame retardancy and eco-friendly preparation methods. Herein, we propose a facile, atomic-efficient, and eco-friendly strategy for synthesizing a trinity chitosan-based flame retardant, phosphite-protonated chitosan (PCS). The chemical structure was systematically analyzed and the impact of varying degrees of protonation on the dissolution behavior and rheological properties were investigated. Benefiting from the promotion of dehydration and carbonization facilitated by phosphite groups, PCS exhibits high intrinsic flame retardancy with an LOI value of 80.7 %. Moreover, its favorable rheological and film-forming properties make it well-suited for easy application as a multifunctional coating in fabric finishing through blade coating processes. The finished cotton and polyester/cotton blended fabrics exhibit excellent flame retardancy, as evidenced by increased LOI values, successful passage of vertical burning tests, reductions of up to 65.0 % and 50.3 % in pHRR and THR values, respectively. Additionally, PCS imparts superior antibacterial properties to the fabrics, achieving a 99.99 % antibacterial rate against both E. coli and S. aureus . This study introduces a straightforward and atom-economical approach for preparing highly efficient chitosan-based flame retardants, along with the development of a transparent, green, and efficacious multifunctional coating system on textiles.
研究领域:
材料科学
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纺织工程
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化学工程
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产品关联
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
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2024
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IF 5.6
Xuanhao Huang,Xinyi Guo,Yao Meng,Shaobo Lou,Xinxing Wu,Yan Zhang,Renzhong Wei,Shuaibo Han,Fangli Sun,Hui Wang
Bamboo, which has excellent physical properties and environmental credentials, is widely used in the construction industry and furniture manufacturing. Bamboo is, however, susceptible to attack by molds and bacteria; protection by natural phenolic antimicrobial agents would be a green and environmentally friendly solution to this problem. The application of such protection has, so far, been hampered by poor stability and ease of volatilization of the antimicrobial agent. Here, an innovative strategy that uses the catalytic action of the laccase to chemically attach a natural antimicrobial agent, eugenol (EU), to bamboo, is described. This modification endows bamboo with both long-lasting and extensive mold resistance and antibacterial activity. Laccase-catalyzed covalent bonding of EU to bamboo reduces the volatilization rate of the EU from 1.72 % to 0.29 %. The outstanding mold resistance and antimicrobial activity of bamboo treated using this modified process is retained during a 50-day mold resistance test, with mold growth inhibited by as much as 87.5 %. The treated bamboo is also able to inhibit the growth of both Gram-positive and Gram-negative bacteria. The antimicrobial mechanism results shown that the bamboo lignin is the primary reaction site during laccase-catalyzed EU modification of bamboo, and the long-term mold resistance derived from modified lignin. Furthermore, we analyzed bacterial morphology through SEM, and the results demonstrated that modified enzymatic hydrolysis lignin (EHL) significantly disrupts bacterial morphology, including membrane invagination and collapse. This study provides a new direction for the green development of mold- and bacteria-resistant bamboo, which has potential for use in a wide range of application.
研究领域:
材料科学
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微生物学
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植物化学
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产品关联
DOI
高影响因子
E-POLYMERS
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2022
·Vol. 22
·期 1
·544-552
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IF 3.074
Sheng Ding,Jinxing Zhu,Saiqi Tian
Polyurethane-based retanning agents with antimicrobial properties were synthesized by the chemical incorporation of ciprofloxacin (CPFX) units into polyurethane chains. The chemical structures were characterized by Fourier transform infrared (FTIR) and gel permeation chromatography (GPC). Then, the retanning agents were applied in the leather retanning process. Owing to the conjugation of CPFX into polyurethane chains, the molecular weight increases, further leading to the decrease in hydroxyl value and increase in particle size. The shrinkage temperature was improved after retanning. Owing to the filling of retanning agents in the gap of collagen fibers, the average thickness of leather increased by 65.8%. The mechanical properties of leather were visibly improved because of the large number of –COOH coordinate with Cr 3+ and more hydrogen crosslinking with carboxyl group, amino group, and hydroxyl group of leather collagen. Furthermore, leather retanned by these polyurethane-based retanning agents presented good antimicrobial properties. The antibacterial activity could be conserved above 89% even after rinsing for ten times.
研究领域:
化学工程
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材料科学
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生物学
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DOI
高影响因子
JOURNAL OF INORGANIC BIOCHEMISTRY
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2021
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IF 4.155
Xiang Gao,Hongxia Li,Xiaohui Niu,Deyi Zhang,Yi Wang,Haiyan Fan,Kunjie Wang
The present study attempted to synthesize carbon quantum dots (CQDs) through Aldol polymerization reaction , wherein acetone was used as the carbon source. A nano composite CQDs/Ag 2 S/CS was developed by loading as prepared CQDs and Ag 2 S nanoparticles on a chitosan substrate (CS). An in-situation growth of nanocomposites was adopted to study their antibacterial properties . Staphylococcus aureus (Gram-positive), Escherichia coli (Gram-negative) and methicillin-resistant Staphylococcus aureus were selected as the model bacteria. The CQDs/Ag 2 S/CS nanocomposites exhibited excellent inhibition not only against common pathogenic bacteria, but also those well-known drug-resistant bacteria. Moreover, compared to traditional antibiotics, the as prepared nanocomposites in the present work do not likely cause bacterial drug resistance , which make them a potential candidate for a new type of clinically applicable antibiotics.
研究领域:
生物医学工程
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材料科学
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微生物学
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产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
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2020
·
IF 6.092
Jin Han,Qinyue Chen,Yupeng Shen,Zhixiong Liu,Xiaoyu Hao,Mingqiang Zhong,Zhengping Zhao,Michael R. Bockstaller
An efficient process for the synthesis of degradable hydrogels containing octa-betaine ester polyhedral oligomeric silsesquioxane (POSS) through efficient thiol–ene and Menschutkin click reactions was developed. The hydrogels exhibited a yield strength of 0.36 MPa and a compressive modulus of 4.38 MPa and displayed excellent flexibility as well as torsion resistance. Antibacterial efficacy of hydrogels (and degradation products) was evaluated using Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). Efficacy was found to increase with the concentration of cetyl chloroacetate (CCA) in the hydrogel network, reaching 93% and 99% for Escherichia coli and Staphylococcus aureus, respectively. Degradation of hydrogels was observed in weak alkali conditions (pH = 8) and at physiological conditions (pH = 7.4). The degradation time of the hydrogels could be finely tuned by variation of the CCA content in the hydrogel and environmental stimulus. The tunable degradation behavior under physiological conditions combined with high antibacterial efficacy could render the presented materials interesting for tissue engineering applications.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2020
·
IF 4.389
Jing Hu,Shanshan Liu,Weijun Deng
Linalool is a main component in different naturally derived essential oils, and widely used in household, personal care, food and therapeutic formulations. However, the application is limited due to its high volatility and low stability. In this study, an effective encapsulation with high loading ratio was built up together with thermal-redox dual responsiveness and controlled release properties. The emulsified linalool droplets were modified with carbon-carbon double bonds, followed by the precipitation polymerization with thermal sensitive monomer, N-vinyl caprolactam. The average size and the loading ratio of the prepared linalool capsules were 1.4 μm and 50.41 wt%. The linalool capsules exhibited thermal-redox dual responsive properties and the antioxidant-antibacterial performance. Especially, responding to the stimuli mimicking practical circumstance, the synthesized capsules presented excellent bacteria inhibiting effect. This work may open a new path for fragrance and essential oil encapsulation, enlarging them as the green biological antibacterial agents in different applications.
研究领域:
材料科学
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生物学
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产品关联
DOI
PubMed
高影响因子
Journal of Cleaner Production
·
2019
·
IF 6.395
Wen Zhang,Zhi-Yi Yang,Ren-Cheng Tang,Jin-Ping Guan,Yi-Fan Qiao
Traditional flame retardants (FRs) for textiles are limited by toxicity, environmental persistence and bioaccumulation. There is an urgent need to develop environmentally benign FRs. For this purpose, the combination of tannic acid (TA, a specific form of hydrolysable tannin) and ferrous ion was applied to simultaneously impart durable FR and antibacterial functions to silk fabric. A ternary TA-ferrous ion-silk complex was fabricated by adsorption of TA on silk followed by mordanting with ferrous salt. After treated with 20% TA (on the weight of fabric) and 2 g/L ferrous sulfate, silk fabric exhibited an obvious increase in limiting oxygen index from 23.6% to 27.5%, a significant decrease in damaged length from 30.0 to 11.2 cm after vertical burning, and a significant increase in antibacterial rate from 22% to 95%. Even after 20 washes, the treated fabric still had the same FR ability as the unwashed one, and an antibacterial rate of above 90%, exhibiting excellent washing durability. The high thermal stability of the treated fabric in nitrogen indicated the formation of a ternary TA-ferrous ion-silk complex which was responsible for excellent washing durability. The observation on the morphological structure of charred products from vertical burning revealed the good charring capability of the treated fabric which contributed to enhanced FR behavior. This research proposes an eco-friendly FR treatment for silk and a novel application of hydrolysable tannins in the FR modification of textiles.
研究领域:
材料科学
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纺织工程
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环境科学
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产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2020
·
IF 6.182
Yan Nie,Jiankun Huang,Shengyan Ma,Zhichao Li,Yongkang Shi,Xiaofang Yang,Xin Fang,Jingbin Zeng,Pengyu Bi,Jiantao Qi,Shengjie Wang,Yongqing Xia,Tifeng Jiao,Dongxiang Li,Meiwen Cao
Silanization is an effective green and pollution-free technology for metal surface treatment. However, the silane film is usually lack of anticorrosion durability due to low mechanical strength and existence of microdefects. In the present study, two-dimensional MXene (Ti 3 C 2 ) sheets have been hybridized into the γ-glycidoxypropyltrimethoxysilane (γ-GPS) film on AA2024 aluminum alloy surface to improve the anticorrosion property. MXene hybridization greatly enhanced the thickness and compactness of the silane film, producing uniform and dense films with fewer defects. The composite films also showed excellent adhesion to the substrate through Si-O-Al chemical bonding. The films inhibited both anode and cathode corrosions by reducing the corrosion current density as well as the diffusion rate of corrosion solution to metal surface. The neutral salt spray tests showed that the corrosion resistance of the MXene-hybridized silane film was better than that of the film obtained by traditional chromate treatment. Moreover, the composite films exhibited excellent antibacterial property by having MXene in the film for killing bacteria. The study develops a simple and effective strategy to improve the anticorrosion property of the silane film as well as to introduce antimicrobial ability, which is highly promising for practical applications in the industrial, medical and domestic fields.
研究领域:
材料科学
·
表面工程
·
腐蚀与防护
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Yuetong Kang,Yonghui Zan,Yujie Cong,Xiaoyu Wang,Yufeng Luo,Lidong Li
Non-biotic antibacterial materials have drawn increasing attention. Some natural clays are able to promote the generation of reactive oxygen species , rendering them as promising candidates in combination with their abundant reserves, low cost and biosafety. However, the antibacterial performance of raw clay is usually below satisfaction due to poor solubility and restricted surface area . Hence, the modulation on dispersion form and the surface modification are essential for the design and practical application of natural clays as antibacterial materials. Herein, we developed a facile method to prepare a Pickering nanoemulsion with chitosan-coated montmorillonite (MMT) nanosheet . The addition of chitosan benefited the exfoliation of raw MMT and the stabilization of resultant colloidal MMT nanosheets, which were subsequently employed for preparing Pickering emulsion . The emulsion exhibited good stability and small size endowing them with good diffusion ability to interact with bacteria. Furthermore, the Pickering emulsion inherited the MMT nanosheet peroxidase-like property and displayed good antibacterial activity .
研究领域:
材料科学
·
生物学
✓ 已验证
产品关联
DOI
高影响因子
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