TALANTA
·
2024
·
IF 5.6
Shurong Chen,Min Zhu,Ying Wang,Jinru Ding,Mingji Tan,Jindou Zhao,Jiahan Xie,Zhibing Wang
A novel temperature-responsive supramolecular solvent was prepared with cetyltributylphosphonium tetrafluoroborate and sodium citrate. It served as the extraction solvent of dispersive liquid-liquid microextraction for the extraction and enrichment of pyrethroids in tobacco samples. In this study, the preparation of the temperature-responsive supramolecular solvent and the extraction of the target analytes were integrated into one step, which simplified the experimental process. Due to the low melting point of the prepared supramolecular solvent, the traditional liquid-liquid separation can be converted to solid-liquid separation at low temperatures. This conversion facilitates precise collection of the supramolecular solvent and reduces the loss of target analytes. The composition, structure, physicochemical properties, and micromorphology of the supramolecular solvent were characterized. The formation and extraction mechanism of supramolecular solvent were explored, and the extraction conditions were optimized. The results indicated that good linearity of target analytes ( R 2 > 0.9998) was obtained within the linear range. The limits of detection and quantification for the five pyrethroids were in the range of 0.25–0.50 μg L −1 and 0.85–1.65 μg L −1 , respectively. The present method can be used for the analysis of pyrethroid pesticide residues in tobacco samples.
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ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Pan Tao,Yang Luo,Kai Zheng,Jing Cao,Li Zhu,Xunsi Wang,Wei Zhang,Shixun Dai,Qiushun Zou,Peiqing Zhang
Background Permethrin is a pesticide used to kill insects, and once used in excess, it poses a great threat to the environment and human health, therefore, it is necessary to realize the rapid and accurate detection of permethrin. Fiber optic surface enhanced Raman scattering (SERS) probes have the advantages of small volume and can be used for remote monitoring, which have great potential for application in achieving in-situ detection of pesticide residues. Results Fiber taper waist (FTW) SERS probes modified by silver nanocubes-graphene oxide (Ag NCs-GO) composite structures were prepared for in situ detection of permethrin in lake water. Evanescent wave was used to excite SERS signals from Ag NCs-GO composite substrates, which was designed to enhance signals through expanded excitation light-analyte contact area. Ag NCs can provide stronger hot spots, and GO further enhances the sensitivity of SERS through electron transfer and improves the stability of the detection. The detection limit of prepared FTW SERS probe for Rhodamine 6G (R6G) was calculated to be 8.5×10 -9 M and RSD were all below 5% using the drop-casting method. The in-situ detection limit of R6G and permethrin in water was tested to be 10 -6 M and 10 -5 M, respectively. Significance This work utilizes fiber optic evanescent waves to excite SERS signals, and adopts a special FTW structure and SERS substrates to achieve good performance. The synergistic enhancement of electromagnetism and chemistry is realized while increasing the contact area, which improves the sensitivity of in situ detection of the pesticide residue permethrin. It Promotes the application of fiber optic SERS sensors in pesticide residue detection.
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JOURNAL OF CHROMATOGRAPHY A
·
2025
·
IF 4
Sitian Gu,Wenli Zhu,Yufei Liu,Huixiao Duo,Qingli Yang,Xiudan Hou
Efficient enrichment of analytes and purification of matrices are crucial for the highly sensitive detection and monitoring of pesticides in traditional Chinese herbs. This work prepared magnetic ionic liquid-controlled covalent organic framework (IL-COF@Fe 3 O 4 ) as the sorbent via a simple in-situ precipitation polymerization and thiolene “click” strategy. The IL-COF@Fe 3 O 4 exhibited remarkable adsorption performance towards pyrethroids within 5 min. The adsorption of four pyrethroids on the surface of IL-COF@Fe 3 O 4 was according with Langmuir model and pseudo-second-order kinetic model. The adsorption energies were theoretically calculated, which were permethrin>cypermethrin>fenvalerate>bifenthrin. The modification of ILs improved extraction capacity mainly because of the interaction of imidazole and Cl or F and the pore size effect. This method was developed for the rapid extraction of four pyrethroids in Codonopsis pilosula and Angelica sinensis . The linear range was 0.05–200 μg L -1 . Matrix effects were ranging from -16.14% to 9.53%, indicating the strong matrix anti-interference ability of IL-COF@Fe 3 O 4 .
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TALANTA
·
2018
·
IF 4.244
Li’na Qiao,Sihua Qian,Yuhui Wang,Hengwei Lin
Pesticides play a critical role in improving crop yield in modern agriculture, but their residues significantly harm the environment and human health. Herein, a novel and simple colorimetric sensor array built on sulfuric acid assisted KMnO 4 fading strategy has been developed for pesticides detection and discrimination. This sensor array is facilely fabricated by KMnO 4 and sulfuric acid through simply adjusting their concentrations and ratios. Hierarchical clustering analysis (HCA) demonstrates that the as-fabricated colorimetric sensor array has a high dimensionality, and shows excellent capability to recognize common kinds of pesticides from potential interferants. Semi-quantitative detection was achieved through combining HCA and corresponding fitting curves. Moreover, the proposed sensor array was successfully applied to detect pesticide residues (e.g. carbaryl) in real samples. The strategy described herein will not only “maximally” simplify the design and fabrication approach, but expand the application fields of colorimetric sensor array methodology towards weak-reactive analytes.
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ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Shu Zhu,Shangying Qin,Chonghui Wei,Li Cen,Luyun Xiong,Xingyu Luo,Yilin Wang
Background Organophosphorus pesticides (OPs) play important roles in the natural environment, agricultural fields, and biological prevention. The development of OPs detection has gradually become an effective strategy to avoid the dangers of pesticides abuse and solve the severe environmental and health problems in humans. Although conventional assays for OPs analysis such as the bulky instrument required analytical methods have been well-developed, it still remains the limitation of inconvenient, inefficient and lab-dependence analysis in real samples. Hence, there is an urgent demand to develop efficient detection methods for OPs analysis in real scenarios. Results Here, by virtue of the highly efficient catalytic performance in Fe 7 S 8 nanoflakes (Fe 7 S 8 NFs), we propose an OPs detection method that rationally integrated Fe 7 S 8 NFs into the acetylcholine (ACh) triggered enzymatic cascade reaction (ATECR) for proceeding better detection performances. In this method, OPs serve as the enzyme inhibitors for inhibiting ATECR among ACh, acetylcholinesterase (AChE), and choline oxidase (CHO), then reduce the generation of H 2 O 2 to suppress the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) that catalyzed by Fe 7 S 8 NFs. Benefiting from the integration of Fe 7 S 8 NFs and ATECR, it enables a sensitive detection for OPs ( e.g. dimethoate). The proposed method has presented good linear ranges of OPs detection ranging from 0.1 to 10 μg mL −1 . Compared to the other methods, the comparable limits of detection (LOD) of OPs are as low as 0.05 μg mL −1 . Significance Furthermore, the proposed method has also achieved a favorable visual detection performance of revealing OPs analysis in real samples. The visual signals of OPs can be transformed into RGB values and gathered by using smartphones, indicating the great potential in simple, sensitive, instrument-free and on-site analysis of pesticide residues in environmental monitoring and biosecurity research.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Shuai Liu,Jingkai Zhao,Junfeng Wu,Ling Wang,Chuanan Yao,Jiandong Hu,Hao Zhang
A novel approach combing a fluorescent microfluidic paper strip with a portable smartphone-based sensing platform is developed for rapid and sensitive detection of omethoate pesticide. The detection mechanism of the microfluidic paper strip is based on the fluorescence quenching of graphene oxide (GO) toward the cyanine 3 (Cy3)-labeled aptamer (Cy3-APT). Upon exposure to omethoate, the Cy3-APT detaches from the surface of GO, resulting in considerable fluorescence recovery, which can be visualized through the smartphone-based sensing platform. The images are analyzed through a self-developed app embedded with a pretrained convolutional neural network model, achieving a high regression coefficient of 0.9964 at an omethoate concentration range of 0–750 nM. The smartphone-based platform enables rapid on-site detection of omethoate pesticide in real samples within 10 min, with results comparable to those obtained using standard methods. In short, the proposed microfluidic paper-based fluorescent sensor combined with the smartphone-based sensing platform enhances the detection performance toward organophosphorus pesticides.
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AQUATIC TOXICOLOGY
·
2024
·
IF 4.1
Afrasyab Khan,Bibimaryam Khan,Shakeel Hussain,Yuhan Wang,Weijun Mai,Yongzhong Hou
Permethrin (Per) is a widely used and frequently detected pyrethroid pesticide in agricultural products and the environment. It may pose potential toxicity to non-target organisms. Per has been reported to affect lipid homeostasis, although the mechanism is undefined. This study aims to explore the characteristic transcriptomic profiles and clarify the underlying signaling pathways of Per-induced lipid metabolism disorder in zebrafish liver. The results showed that environmental exposure to Per caused changes in the liver index, histopathology, and oxidative stress in zebrafish. Moreover, transcriptome results showed that Per heavily altered the pathways involved in metabolism, the immune system, and the endocrine system. We conducted a more in-depth analysis of the genes associated with lipid metabolism. Our findings revealed that exposure to Per led to a disruption in lipid metabolism by activating the KRAS-PPAR-GLUT signaling pathways through oxidative stress. The disruption of lipid homeostasis caused by exposure to Per may also contribute to obesity, hepatitis, and other diseases. The results may provide new insights for the risk of Permethrin to aquatic organisms and new horizons for the pathogenesis of hepatotoxicity.
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CHEMOSPHERE
·
2024
·
IF 8.1
Tianzhu Guan,Ning Li,Ya Gao,Mingyuan Gao,Qin Hu,Yajun Gao,Lixia Xiao,Zhenquan Yang,Qiaoquan Liu
Latest observations indicated that exposure of organic environmental neurotoxins may increase the potential risk of Alzheimer's diseases (AD). As a suspected food-derived risk factor, permethrin, composed of cis -isomer and trans -isomer, is widely used as a broad-spectrum pyrethroid insecticide in agricultural crops for the arthropod pests controlling. Thus, evaluating the impact of permethrin exposure is of great importance to human health. In this study, we performed the toxicological network approach to decipher AD-related mechanisms of cis -permethrin and trans -permethrin. Based on the toxicological network construction and central network topological analysis, human serum albumin (HSA) was selected as the core targets in AD-related developing. From the analysis of the steady state and time-resolved fluorescence quenching of HSA in presence of permethrin mixture, it has been inferred that the nature of the quenching mainly originates from the dynamic modes. Experimentally, the thermodynamic parameters revealed hydrophobic interactions and van der Waals forces played a major role during quenching process. Tryptophan synchronous fluorescence spectra were blue shifted whereas the position of tyrosine synchronous spectra was red shifted during the complex formation. Three-dimensional fluorescence together with FT-IR experiment confirmed that permethrin caused the secondary structure changes in HSA. To better understand the binding patterns between HSA and cis/trans -permethrin, theoretical calculation and molecular docking were implemented. According to the electrostatic potential map, the electrophilic attack region corresponds for electron rich oxygen atoms, while the nucleophilic attack regions were mainly located at over the benzene rings and methyl on cyclopropane ring of permethrins. Docking results shown that cis -permethrin and trans -permethrin located in hydrophobic pocket nearby Domain IIA with the different binding affinity (−7.6 and −9.2 kcal/mol), which consistent with the competitive displacement experiment. All these findings generated in the present study facilitated the elucidation of the molecular mechanism details between permethrin mixture and HSA, which provided fresh insights into the links between environmental exposure and AD-related adverse health outcomes.
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FOOD CHEMISTRY
·
2025
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IF 9.8
Qiang Yang,Xin Zhou,Jiayu Wang,Jie Hu,Xiupei Yang,Lianfang Chen
The increasing presence of pyrethroid pesticides (PYs) in agricultural products necessitates advanced analytical methods for food safety monitoring. This study introduces a novel metal–organic framework–covalent organic framework (MOF–COF) hybrid adsorbent, NH₂–MIL–101(Fe)@TpBD, for the rapid extraction of PYs from eggplants via pH/salt–independent dispersive solid–phase extraction (DSPE) coupled with high-performance liquid chromatography (HPLC). The optimized method achieved efficient extraction of four PYs (permethrin, cyfluthrin, esfenvalerate, and bifenthrin) within 4 min, using 20 mg of adsorbent and 1.5 mL of acetonitrile. The method demonstrated excellent linearity (0.12–8.00 mg·kg −1 ), high sensitivity (LODs: 0.0416–0.0515 mg·kg −1 ), and robust recoveries (85.5–107.6 %), with enrichment factors of 389–410. Adsorption mechanisms were dominated by chemisorption, facilitated by π–π stacking and hydrogen bonding. The rapidity and efficiency of this method highlight its potential for high-throughput food safety analysis. This work underscores the synergistic integration of MOF/COF hybrids as advanced adsorbents for pesticide monitoring in complex food matrices.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 11
·1-15
·
IF 5.3
Li Jin-Yu,Mei Li-Ping,Wang Zhi-Gang,Fang Ke-Ming,Wang Ai-Jun,Feng Jiu-Ju
Well-defined high-entropy alloy PtPbBiFeMn nanoplates (HEAPs) were synthesized by a wet-chemical co-reduction approach. The PtPbBiFeMn HEAPs exhibited excellent peroxidase (POD)-like activity. Leveraging this POD-mimicking property, a dual-mode sensor was developed for quantitative determination of a typical organophosphorus (OP) omethoate. Specifically, the nanozyme oxidizes colorless 3,3′,5,5′-tetramethylbenzidine (TMB) and o -phenylenediamine (OPD) with H 2 O 2 to its colored form. This reaction is regulated by alkaline phosphatase (ALP)-mediated hydrolysis of ascorbic acid 2-phosphate (AAP) to ascorbic acid (AA), which reduces oxidized TMB and modulates the detection signals. Additionally, ascorbic acid (AA) is converted to dehydroascorbic acid (DHAA). Consequently, an ALP-dependent fluorescence response is obtained through the condensation reaction between OPD and DHAA, yielding the fluorescent compound 3-(1,2dihydroxy ethyl) furo[3,4- b ] quinoxalin-1(3 H) with a maximum emission wavelength in the range 568 to 430 nm. When ALP existed, the colorimetric method for omethoate displayed a linear range of 10.02–167.10 × 10 −4 mg kg −1 with a limit of detection (LOD) of 8.76 × 10 −4 mg kg −1 ( S / N = 3), while a ratiometric fluorescence ( I 430 / I 568 ) approach had a linear range of 6.68 × 10 −4 –384.3 × 10 −4 mg kg −1 with an LOD of 6.63 × 10 −4 mg kg −1 ( S / N = 3). This work provides constructive insights to simplify biosensing platforms for food safety and environmental monitoring. Graphical
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Journal of the American Chemical Society
·
2025
·
IF 15.6
Yeqing Xu,Abuduheiremu Awati,Shan Zhou,Runhao Zhang,Xin Zhang,Hui Zeng,Yaxin Guo,Yuanbo Song,Chengmin Hu,Lei Xie,Qirui Liang,Kang Liang,Lei Jiang,Dongyuan Zhao,Biao Kong
Pesticides are vital for crop and seafood production but leave persistent residues that pose risks to ecosystems and human health through bioaccumulation. The detection of pesticide residues requires highly sensitive and selective technologies. Herein, a nanochannel sensor capable of dual recognition of ionic charge and molecular conformation based on molecular imprinting technology (MIT) is presented, offering a significant improvement in selectivity and sensitivity over traditional nanopore sensors. The MIT-based nanochannels with imprinting sites tailored to pesticide molecules go beyond recognizing the molecular size and surface functional groups, enabling the detection of molecular configurations. In this research, the approach enables the detection of 10 pesticide molecules with detection limits (LODs) ranging from 12.9 to 26.9 pM, achieving two orders of magnitude lower than fluorescence-based methods. Density functional theory (DFT) and molecular dynamics (MD) simulations revealed hydrogen bonding as the dominant interaction in the imprinting process. This versatile nanochannel construction method, proposed for the first time, provides dual recognition capabilities and is expected to advance nanochannel sensing while promoting sustainable environmental development.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Lin-Lin Zhang,Zeng Chen,Li Li,Wuying Yang,Dan Wang,Yanping Hong,Kaijie Tang,Jiaxin Hong,Lu-Ying Duan,Limin Lu
Developing a multifunctional sensor that can detect food-related multi-analytes is significant for food safety but remains challenging due to the difficulty of integrating multiple functions into one sensor. Herein, a dual-luminescent europium metal-organic framework (EuMOF) was elaborately synthesized through a simple self-assembly process, during which Eu 3+ coordinated with 2-hydroxyterephthalic acid (HTPA) and 1,10-phenanthroline that delivered strong characteristic fluorescence of HTPA and Eu 3+ . The resultant EuMOF exhibited good detection performance toward Sn 4+ and amitraz with different response behaviors. As for target Sn 4+ , the remarkably enhanced fluorescence from HTPA was observed and the fluorescence for Eu 3+ decreased significantly, which was attributed to the structural disintegration of EuMOF caused by Sn 4+ . Whereas, the presence of amitraz weakened both luminescence of HTPA and Eu 3+ owing to the synergistic function of inner filter effect and photoinduced electron transfer. Furthermore, an intelligent and miniature sensor that incorporated EuMOF-based test paper with color recognition application was exploited for portable visual analyzing Sn 4+ and amitraz in real samples, affording great possibilities for on-site monitoring of food hazards.
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危险品化学品经营许可证（带存储）