Environmental Science & Technology Letters
·
2018
·
IF 5.869
Di Zhang,Wenhai Chu,Yun Yu,Stuart W. Krasner,Yang Pan,Jun Shi,Daqiang Yin,Naiyun Gao
2-Chlorophenylacetonitrile (2-CPAN) and 3,4-dichlorophenylacetonitrile (3,4-DCPAN), representatives of a new class of nitrogenous aromatic disinfection byproducts, were first identified and quantified in chlorinated and chloraminated drinking waters. The impacts of pH, disinfectant residuals, and quenching agents on the stability of two chlorophenylacetonitriles (CPANs) were investigated. The two CPANs slightly degraded with increasing pH (5–9) and chlorination doses (0–4 mg/L) after 5 days, and NH2Cl did not cause degradation of CPANs. Among the commonly used quenching agents, the reaction between sodium sulfite and CPANs was negligible, whereas the others reduced CPANs by varying extents after 7 days. Notably, the two CPANs in finished water collected from seven drinking water treatment plants were quantified. 2-CPAN was detected between 170 and 530 ng/L with a median concentration of 220 ng/L, whereas 3,4-DCPAN ranged from below method detection limit (100 ng/L) up to 320 ng/L with a median concentration of 130 ng/L. Moreover, cytotoxicity of the CPANs and their aliphatic counterparts was determined using Chinese hamster ovary cells. The LC50 values are 133, 83, 436, 260, 905, 4150, and 8900μM for 2-CPAN, 3,4-DCPAN, chloroacetonitrile, dichloroacetonitrile, chloroacetic acid, dichloroacetic acids, and trichloromethane, respectively. Because of the relatively high stability and high toxic potencies of CPANs, the occurrence of CPANs in drinking water deserves attention.
研究领域:
环境科学
·
水处理
·
毒理学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2015
·
IF 4.097
Kangming Xiong,Fangjun Huo,Caixia Yin,Yueying Chu,Yutao Yang,Jianbin Chao,Anmin Zheng
We have developed two new colorimetric and fluorescent probes for hypochlorite based on a novel recognition mechanism: amido oxidized nitroso-group by hypochlorites, which realized the preparation of nitroso compounds. Furthermore, 1 H NMR, ESI-MS and theoretical calculation proved the recognition mechanism. In addition, the probe 2 was applied in practical applications such as detecting the hypochlorite concentration of sodium hypochlorite disinfectant and bioimagings.
研究领域:
分析化学
·
生物化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Microbiology
·
2025
·
IF 4.5
Guang Yang,Ying Huang,Ning Ma,Kai Li,Xiao-mei Wang,Lian-bo Zhang,Wen-bo Yang,Wan-li Zhang,Lei Xia,Hong-Yu Zhang,Li-lai Yuan
Aeromonas hydrophila is a major pathogen responsible for significant economic losses in global aquaculture. Inhibitory and bactericidal activities of seven disinfectants were tested against 10 aquatic pathogens, including A. hydrophila, A. veronii, A. salmonicida, A. sobria, Edwardsiella tarda, E. ictaluri, Pseudomonas aeruginosa, and Yersinia ruckeri. Minimal effective concentrations were determined via quantitative suspension tests, while a scale-trauma zebrafish model assessed in vivo protection. Methylene bis(thiocyanate) (MBT) exhibited the strongest antimicrobial activity, with minimum inhibitory concentrations and minimum bactericidal concentrations of 0.1–0.4 mg/L and 0.2–0.8 mg/L, respectively. At 0.01 mg/L, MBT achieved a 3-log pathogen inactivation, equivalent to 0.2 mg/L Trichloroisocyanuric acid (TCCA). In vivo, 0.01 mg/L MBT provided 100% protection in zebrafish after 6 and 12 h exposure, whereas 0.2 mg/L TCCA yielded 95.83 ± 3.61% survival after 1 h. The safe concentrations of MBT and TCCA for zebrafish were 0.0364 and 0.0677 mg/L, respectively. The results showed that both TCCA and MBT effectively controlled A. hydrophila infection; however, MBT demonstrated greater potential for aquaculture applications due to its lower effective concentration (0.01 mg/L) and reduced sensitivity to interference from organic matter. In addition, this study presents a systematic protocol for evaluating the efficacy of disinfectants.
研究领域:
水产养殖
·
微生物学
·
抗菌剂
·
传染病
·
鱼类健康管理
✓ 已验证
DOI
PubMed
高影响因子
ENZYME AND MICROBIAL TECHNOLOGY
·
2022
·
IF 3.705
Hao Zhang,Zhao-Miao Gong,Yan Li,Feng-Qing Yang
A convenient and green method was developed using a personal glucose meter (PGM) for direct determination of hydrogen peroxide and hypochlorite in household disinfectants based on the acetylthiocholine iodide (ATCI)-mediated reaction. In this method, acetylcholinesterase catalyzes the hydrolysis of ATCI to generate thiocholine iodide, which can trigger the reduction of K 3 [Fe(CN) 6 ] to K 4 [Fe(CN) 6 ] and generate a PGM detectable signal. When the hydrogen peroxide or hypochlorite is pre-incubated with the ATCI, the yield of thiocholine will be decreased because the iodine molecules can initiate the oxidation of thiocholine to disulphides , leading to a lower PGM readout. Thus, the hydrogen peroxide or hypochlorite can be directly quantified by PGM as simple as detecting glucose in blood. After being systematically investigated, the optimum conditions of the PGM method are as follows: 5.0 min of enzymatic reaction time, 6.0 mM final concentration of ATCI solution, and 10.0 min of reaction time between ATCI/H 2 O 2 and thiocholine. Moreover, the recoveries of hydrogen peroxide in real sample spiked with three different concentrations (final concentrations of 5.0, 10.0, and 20.0 mM) are in the range of 96.3–108.4%. The recoveries of hypochlorite in real sample spiked with three different concentrations (final concentrations of 1.0, 5.0, and 10.0 mM) are in the range of 99.4–117.0%. These results indicate that the developed method can be employed for the detection of hydrogen peroxide and hypochlorite in household disinfectants.
研究领域:
分析化学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2024
·
IF 7.6
Xin Zhang,Liping Li,Xinhui Liu,Handan Zhang,Lu Dong,Pengcheng Li,Mengzhu Xue,Linshuai Duan,Xiqin Liu,Bohan Li,Guohui Xia
Extracellular antibiotic resistance gene (eARG) has emerged as a global crisis in recent years, yet commonly used disinfectants have proven ineffective for their elimination. Seeking to enhance the degradation efficiency of eARG, this study explored the potential of carbon nanotubes-activated persulfate (CNTs + PS) system as a novel method for eradicating eARG. Our findings demonstrated that CNTs + PS effectively disrupted the intact structure of eARG, inhibited their genetic replication and horizontal transfer capability, achieving remarkable degradation of eARG contamination. Further experiments revealed that 1 O 2 played a predominant role in eARG degradation, while electron transfer played minor roles in the degradation process. The carbonyl groups served as the primary sites for activating PS to generate 1 O 2 . CNTs can enhance the efficiency of electron transfer from eARG to PS. Moreover, the degradation efficacy of eARG by CNTs + PS was influenced by various factors including the dosage ratio between CNTs and PS, initial concentrations of eARG, pH values, inorganic anions and humic substances and water matrix. Reusability experiment demonstrated that CNTs + PS exhibited stable degradation performance after multiple uses. These findings offer a new perspective for the efficient degradation of eARG in environmental remediation.
研究领域:
环境科学
·
化学工程
·
微生物学
·
纳米技术
·
水处理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Toxics
·
2024
·Vol. 12
·期 11
·808
·
IF 3.9
Dongmei Yang,Jiale Huang,Fenli Min,Huixian Zhong,Jialu Ling,Qun Kang,Zhaohua Li,Lilian Wen
In this study, samples from the Yangtze River, Han River, and Liangzi Lake in Wuhan City were utilized to characterize the formation of disinfection by-products (DBPs) from chlorine-based disinfection residues in drinking water sources. The results indicated that the main DBPs in drinking water sources were trichloromethane (TCM) and trichloroacetic acid (TCAA). The generation of DBPs was significantly positively correlated with oxidative substances, aromatic compounds, pH, and ammonia nitrogen (NH 3 -N) content in the water. The concentration of TCAA increased from 0 to 2.45 ± 0.31 mg/L when the reaction time increased to 72 h. As the NaClO concentration increased from 5 mg/L to 15 mg/L, the concentrations of TCAA, TBM, and DCAN increased from 2.03 ± 0.04 mg/L, 0 mg/L, and 0 mg/L to 2.49 ± 0.34 mg/L, 0.21 ± 0.07 mg/L, and 0.10 ± 0.04 mg/L before decreasing to 1.75 ± 0.19 mg/L, 0.17 ± 0.07 mg/L, and 0.04 ± 0.05 mg/L, respectively. The orthogonal experimental results showed that Br − , NH 3 -N, and pH all had significant influences on the TCM generation, whereas temperature affected the formation of TCAA in the Han River. This work reveals the factors influencing the generation of DBPs from chlorine-based disinfection residues, offering a prevention and control method for DBPs in drinking water sources from a theoretical perspective.
研究领域:
环境科学
·
水处理
·
公共卫生
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Ying Liu,Jingfeng Gao,Qian Wang,Hao Chen,Yi Zhang,Xiaoyu Fu
Whether it’s necessary to extra chemical synthesis steps to modify nZVI in peroxymonosulfate (PMS) activation process are worth to further investigation. The 56 mg/L nZVI/153.65 mg/L PMS and 56 mg/L sulfidated nZVI (S-nZVI) (S/Fe molar ratio = 1:5)/153.65 mg/L PMS) processes could effectively attain 97.7% (with k obs of 3.7817 min −1 ) and 97.0% (with k obs of 3.4966 min −1 ) of the degradation of 20 mg/L sulfadiazine (SDZ) in 1 min, respectively. The nZVI/PMS system could quickly achieve 85.5% degradation of 20 mg/L SDZ in 1 min and effectively inactivate 99.99% of coexisting Pseudomonas . HLS-6 (5.81-log) in 30 min. Electron paramagnetic resonance tests and radical quenching experiments determined SO 4 •− , HO•, 1 O 2 and O 2 •− were responsible for SDZ degradation. The nZVI/PMS system could still achieve the satisfactory degradation efficiency of SDZ under the influence of humic acid (exceeded 96.1%), common anions (exceeded 67.3%), synthetic wastewater effluent (exceeded 90.7%) and real wastewater effluent (exceeded 78.7%). The high degradation efficiency of tetracycline (exceeded 98.9%) and five common disinfectants (exceeded 96.3%) confirmed the applicability of the two systems for pollutants removal. It’s no necessary to extra chemical synthesis steps to modify nZVI for PMS activation to remove both chemical and biological pollutants.
研究领域:
环境科学
·
化学工程
·
水处理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2023
·
IF 12.8
Lin Huang,Weixia Zhang,Difei Tong,Lingzheng Lu,Weishang Zhou,Dandan Tian,Guangxu Liu,Wei Shi
Recently, increased production and consumption of disinfectants such as triclosan (TCS) and triclocarban (TCC) have led to massive pollution of the environment, which draws global concern over the potential risk to aquatic organisms. However, the olfactory toxicity of disinfectants in fish remains elusive to date. In the present study, the impact of TCS and TCC on the olfactory capacity of goldfish was assessed by neurophysiological and behavioral approaches. As shown by the reduced distribution shifts toward amino acid stimuli and hampered electro-olfactogram responses, our results demonstrated that TCS/TCC treatment would cause deterioration of the olfactory ability of goldfish. Our further analysis found that TCS/TCC exposure suppressed the expression of olfactory G protein-coupled receptors in the olfactory epithelium, restricted the transformation of odorant stimulation into electrical responses by disturbing the cAMP signaling pathway and ion transportation, and induced apoptosis and inflammation in the olfactory bulb. In conclusion, our results demonstrated that an environmentally realistic level of TCS/TCC would weaken the olfactory capacity of goldfish by constraining odorant recognition efficiency, disrupting olfactory signal generation and transduction, and disturbing olfactory information processing.
研究领域:
环境科学
·
水生毒理学
·
神经生物学
·
鱼类生理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2024
·
IF 7.6
Xinxin Jiang,Jingfei Long,Yanzhen Song,Xiaoyu Qi,Ping Li,Kuiquan Pan,Chenyang Yan,Hongzhou Xu,Haixia Liu
The transmission of antibiotic resistance genes (ARGs) in pathogenic bacteria affects culture animal health, endangers food safety, and thus gravely threatens public health. However, information about the effect of disinfectants - triclosan (TCS) on ARGs dissemination of bacterial pathogens in aquatic animals is still limited. One Citrobacter freundii ( C. freundii ) strain harboring tet (X4)-resistant plasmid was isolated from farmed grass carp guts, and subsequently conjugative transfer frequency from C. freundii to Escherichia coli C600 ( E. coli C600) was analyzed under different mating time, temperature, and ratio. The effect of different concentrations of TCS (0.02, 0.2, 2, 20, 200 and 2000 μg/L) on the conjugative transfer was detected. The optimum conditions for conjugative transfer were at 37 °C for 8h with mating ratio of 2:1 or 1:1 ( C. freundii : E. coli C600). The conjugative transfer frequency was significantly promoted under TCS treatment and reached the maximum value under 2.00 μg/L TCS with 18.39 times that of the control group. Reactive oxygen species (ROS), superoxide dismutase (SOD) and catalase (CAT) activities, cell membrane permeability of C. freundii and E. coli C600 were obviously increased under TCS stress. Scanning electron microscope showed that the cell membrane surface of the conjugative strains was wrinkled and pitted, even broken at 2.00 μg/L TCS, while lysed or even ruptured at 200.00 μg/L TCS. In addition, TCS up-regulated expression levels of oxidative stress genes ( kat E, hem F, bcp , hem A, kat G, ahp F, and ahp C) and cell membrane-related genes ( fim C, bam E and omp A) of donor and recipient bacteria. Gene Ontology (GO) enrichment demonstrated significant changes in categories relevant to pilus, porin activity, transmembrane transporter activity, transferase activity, hydrolase activity, material transport and metabolism. Taken together, a tet (X4)-resistant plasmid could horizontal transmission among different pathogens, while TCS can promote the propagation of the resistant plasmid.
研究领域:
微生物学
·
分子生物学
·
环境科学
·
水产养殖
·
公共卫生
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）