RSC Advances
·
2020
·Vol. 10
·期 73
·44835-44840
·
IF 3.119
Xiang Qin,Rong Cao,Jingjing Zheng,Guojun Shi,Lijun Ji,Aiping Zhu,Hang Yao
A new strategy for preparing mesoporous metal-doped bioactive glass fibers (MBGFs) was designed, which included electrospinning and sulfonating mesoporous PS fibers, precipitating metal ions and bioactive glass sol–gel precursor into the mesoporous polystyrene (PS) fibers and calcinations. Silver-doped mesoporous BGFs (Ag-MBGFs) with a uniform diameter of 1–2 μm and a specific surface area of 40.22 m2 g−1 were prepared as an example and characterized by SEM, XRD, TG, ICP and FTIR. These Ag-MBGFs showed excellent bioactivity, antibacterial properties and drug loading and release performance due to their special mesoporous and fibrous structure. The concentration of Staphylococcus aureus decreased from 1 × 108 colony-forming units per mL (CFU mL−1) to 2.5 × 106 CFU mL−1 in 2 h and then to 2 × 102 CFU mL−1 in 12 h when the concentration of the Ag-MBGFs reached 16 mg mL−1. BGFs of different compositions and functions could be prepared by the same strategy in a mesoporous PS fiber template, which could enrich materials for constructing orthopedic implants.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
MATERIALS TECHNOLOGY
·
2021
·
IF 3.846
Pengfei Yang,Zhihuan Zhao,Xiao Zhang,Wen Liu,Jimin Fan,Jianying Lin,Shasha Yang,Bing Zhang,Shu Yin
Cesium tungsten bronze nanoparticles have excellent near infrared lightresponse characteristics, easy surface modification and low cytotoxicity, which are attractive for tumor photothermal therapy. In this paper, cesium tungsten bronze nanoparticles were synthesized by a simple hydrothermal reaction method using cesium hydroxide as raw material. In order to improve the properties of dispersion and drug loading, the modification of two different surfactants was investigated. Themorphology of cesium tungsten bronze nanoparticles modified with polyvinylpyrrolidone had no significant change in scanning electron microscope, but it had high photothermal properties, with a photothermal conversion efficiency of 23.1%. The drug loading capacity of CTAB-Cs0.32WO3 is 47.9 mg/mL accordingly. The michigan cancer foundation-7 (MCF-7) cell activity was only 27.33% when the concentration of CTAB-Cs0.32WO3-DOX was 1mg/ml under irradiation of 980nm. These results showed that cesium tungsten bronze nanoparticles surface modified with hexadecyltrimethyl ammonium bromide (CTAB) had excellent anti-tumor ability.
研究领域:
材料科学
·
生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Advances
·
2022
·
IF 0
Xianming Zhang,Qinghua Yu,Ping Zhou,Shiyu Yang,Jiashan Xia,Tao Deng,Chao Yu
The blood-brain barrier (BBB) is the major obstacle limiting the reach of therapeutic drugs into the brain. Herein, an aspirin-based anti-inflammatory replenisher (aspCD) was fabricated by carbonizing aspirin to deliver drugs into the brain visually. The as-prepared aspCD combined the BBB-penetrating and anti-inflammatory effects of aspirin with the fluorescent and drug-loading properties of carbon dots (CDs), thereby delivering therapeutic drugs into the brain and acting as imaging agent as well as anti-inflammatory replenisher. In vivo experiments of mice and zebrafish revealed that fluorescence aspCD could effectively penetrate BBB. In vitro and in vivo inflammatory models demonstrated that aspCD could be regarded as an excellent anti-inflammatory replenisher. In addition, as a functional carrier, aspCD was proved to be capable of loading drugs with different polarity. In summary, carbonization of active precursors (therapeutic drugs) into CDs could be a promising strategy to achieve the loading and visualization of drugs as well as the retainment of their biological activities.
研究领域:
神经科学
·
药学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
·
2022
·
IF 3.915
Fengmao Zou,Honghui Zhao,Aijinxiu Ma,Danni Song,Xiangrong Zhang,Xu Zhao
To improve the solubility and anti-hyperuricemia activity of the insoluble natural flavonoid isorhamnetin (ISO), an isorhamnetin phospholipid complex (ISO-PC) was prepared. ISO-PC was prepared through solvent evaporation and its prescription process was optimized. The formation of ISO-PC was verified via multiple characterization methods. Parameters such as drug loading, solubility, octanol-water partition coefficient, stability, and in vivo anti-hyperuricemia activity of ISO-PC were investigated. The complexation efficiency of ISO-PC was 95.1% ± 0.56%. The characterization results confirmed that ISO-PC was bound by intermolecular interactions between ISO and phospholipids. Compared with ISO, the solubility of ISO-PC in water and 1-octanol increased by 122 and 16.5 times, respectively. In addition, the octanol-water partition coefficient decreased to 1.08. Pharmacodynamic studies have reported that ISO-PC has a more significant effect on reducing serum uric acid levels and renal protection. In conclusion, the findings of this study suggested that ISO-PC could be used as a promising formulation to improve the solubility and the anti-hyperuricemia activity of ISO.
研究领域:
药学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2024
·Vol. 14
·期 43
·31868-31876
·
IF 3.9
Shuai Liu,Yuzhu Xiong,Fuping Dong
The development of non-toxic drug carrier materials with high loading capacity, sustained release properties, stability, and biocompatibility holds significant medical value and potential for loading and releasing poorly soluble drugs. In this study, we synthesized a biocompatible, non-toxic, environmentally friendly CD-MOF porous material with high specific surface area and tunable structure. By incorporating SiO2 to enhance the stability of MOF materials, the synthesized CD-MOF@SiO2 material shows promising applications in drug delivery. The obtained CD-MOF@SiO2 nanocomposite was utilized as a carrier for the poorly soluble drug, folic acid. Characterization of the drug-loaded composite before and after drug loading was performed using scanning electron microscopy, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, N2 adsorption–desorption, and X-ray diffraction analyses, showing improved stability as indicated by thermogravimetric analysis and derivative thermogravimetry data. UV spectrophotometry was used to investigate the loading and sustained release of folic acid under different conditions in PBS buffer, demonstrating that the well-structured CD-MOF@SiO2 material exhibits high drug loading and controllable release properties. The CD-MOF@SiO2 achieved a high drug loading efficiency (166.78%) and encapsulation rate (83.39%) for folic acid, leading to a significant increase in apparent solubility from 1.6 μg mL−1 in its free form to 21.74 mg mL−1, a 13 588-fold expansion. This work presents a novel, efficient, and highly valuable approach for the development of carrier materials for loading and releasing poorly soluble drugs.
研究领域:
药剂学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Asian Journal of Pharmaceutical Sciences
·
2018
·
IF 4.56
Xin Wang,Chang Li,Na Fan,Jing Li,Haotian Zhang,Lei Shang,Zhonggui He,Jin Sun
In the present paper, chiral mesoporous silica nano-cocoon (A-CMSN) functionalized with amino group was synthesized, and its loading and release of indomethacin (IMC), a poorly soluble drug, was studied. Due to the use of chiral anionic surfactants as a template, A-CMSN possessed 2D hexagonal nano-cocoon morphology with curled channels on its surface, which was quite different from another 2D hexagonal mesoporous silica nanoparticles (MCM-41) with straightway channels. After being loaded into the two silica carriers by hydrogen bond, crystalline IMC converted to amorphous form, leading to the improved drug dissolution. And IMC loading capacity of A-CMSN was higher than MCM-41 because curled loading process originating from curvature chiral channels can hold more drug molecules. Compared with IMC, IMC loaded A-CMSN presented obviously fast release throughout the in vitro release experiment, while IMC loaded MCM-41 released faster than IMC at the initial 5 h then showed controlled slow release afterwards, which was closely related to the mesoporous silica nanoparticles and different channel mesostructures of these two carriers. A-CMSN possessed nano-cocoon morphology with curled 2D hexagonal channel and its channel length was shorter than MCM-41, therefore IMC molecules can easily get rid of the constraint of A-CMSN then to be surrounded by dissolution medium.
研究领域:
药剂学
·
纳米医学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2022
·
IF 18.027
Xi Hu,Yu Sun,Xiaoqi Zhou,Bo Zhang,Hanxi Guan,Fan Xia,Shuangying Gui,Xueqian Kong,Fangyuan Li,Daishun Ling
The rigidity of polymeric micelles plays an important role in their biological behaviors. However, how drug loading affects the rigidity of polymeric micelles remains elusive. Herein, the indomethacin (IMC)-loaded Pluronic F127 micelle is used as a model system to illustrate the impact of drug loading on the rigidity and biological behaviors of polymeric micelles. Against expectations, micelles with moderate drug loading show higher cellular uptake and more severe cytotoxicity as compared to both high and low drug loading counterparts. Extensive one- and two-dimensional nuclear magnetic resonance (NMR) measurements are employed to reveal that the higher drug loading induces stronger interaction between IMC and hydrophilic block to boost the micellar rigidity; consequently, the moderate drug loading imparts micelles with appropriate rigidity for satisfactory cellular uptake and cytotoxicity. In summary, NMR spectroscopy is an important tool to gain insight into drug loading regulated micellar rigidity, which is helpful to understand their biological behaviors.
研究领域:
药学
·
生物物理学
·
材料科学
·
核磁共振波谱学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CELLULOSE
·
2024
·Vol. 31
·期 14
·8539-8554
·
IF 4.9
Li Yang,Liu Xiaoyan,Liu Zhongming,Wang Shoujuan,Kong Fangong
The development of effective drug delivery systems is crucial for improving the efficacy of cancer drugs, in order to overcome the issues of low drug loading and drug burst release. Nanocellulose composite aerogel was prepared as a drug carrier for 5-fluorouracil, which had the advantages of three-dimensional network structures, high porosity and good biocompatibility, and its loading capacity was much higher than that of other bio-based drug carriers. Fourier-transform infrared, scanning electron microscopy, X-ray photoelectron spectroscopy, cytotoxicity analysis, and other analytical techniques were used to analyse the physical and chemical structures of nanocellulose composite aerogels. The analysis revealed that the introduction of β-cyclodextrin and sodium hyaluronate led to good compressibility, rich network structure, and abundant adsorption active sites of the nanocellulose composite aerogel, which was more suitable as a drug carrier. The maximum amount of 5-fluorouracil on the nanocellulose composite aerogel through coating and hydrogen bonding reached 486.93 mg/g. The drug release curves of the nanocellulose composite aerogels depended on pH and conformed to the first-order kinetic model and Korsmeyer-Peppas model. Nanocellulose composite aerogels exhibited a high loading capacity and controllable release of 5-fluorouracil, with great potential for biomedical applications. Graphical abstract Nanocellulose composite aerogels for efficient drug loading and sustained release
研究领域:
生物材料学
·
药剂学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2019
·
IF 3.683
Jinli Wang,Wei Zhang,Shuhuan Li,Dandan Miao,Guopei Qian,Gaoxing Su
Core–shell nanostructures, specifically gold nanorods coated with porous silica (GNR@p-SiO2), were successfully fabricated by surface-protected etching. The nanostructures, photothermal effects, drug loading and drug release behaviors, cellular uptake, and combined chemo–photothermal therapy were investigated. The results showed that the as-prepared GNR@p-SiO2 had a uniform porous silica outer layer. Etching process could be modulated by adjusting the etching time, concentrations of etching agents, and concentrations of protective agents. With doxorubicin (DOX) as the model drug, the drug loading capacity reached 18.9%, which was dependent on the DOX concentrations. The drug release profiles were dual stimulus-responsive to pH and laser irradiation. In addition, the GNR@p-SiO2 nanoparticles were biocompatible and effectively internalized by cancer cells. Compared with chemotherapy or photothermal therapy administered individually, combined chemo–photothermal therapy using GNR@p-SiO2 exhibited higher efficiency in killing cancer cells both in vitro and in vivo. Therefore, surface-protected etching is a powerful method for preparing core–shell nanostructures capped with mesoporous silica for combined cancer chemo–photothermal therapy.
研究领域:
纳米医学
·
生物材料
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Chuanyi Gu,Yongqiang Yang,Chunru Wang,Junyao Li,Qing Jin,Xiaochen Wu
Antibacterial materials play an essential role in the modern life, and many efforts have been made to establish effective ones. Mental organic frameworks (MOFs) were deposited on aramid nanofibrils (ANF) to form antibacterial ANF/MOFs composites, and utilized as drug encapsulation carriers. The ANF/MOFs composites possessed high drug loading capacity and sustained drug release property (e.g., sustained release for > 8 h), their combination with antibacterial drugs provided a feasible strategy for the efficient bacterial sterilization favorable in broad fields.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
·
2024
·Vol. 94
·期 2
·456-470
·
IF 0.9
Xia J.,Li X.,Lv C.,Jiang J.,Zhu T.,Liu T.,Li J.,Zhang W.
Abstract Resveratrol (Res), a non-flavonoid polyphenolic compound extracted from natural plants, has many pharmacological effects such as anti-tumor, organ protection, improvement of cardiovascular disease, and anti-inflammation. However, due to its poor water solubility and light-degradable property, its bioavailability is restricted. In this study, the hyaluronic acid (Ha)-coated poloxamer 188 (F68) and poloxamer 407 (F127) and Ha-coated Res nanomicelles (Ha-F68/F127-Res-Mc) were prepared by film dispersion method. The nanomicelles were evaluated by indicators of encapsulation efficiency ( EE ), drug loading ( DL ), particle size, polydispersity index and ζ-potential. Besides, using the Box–Behnken design (BBD) based response surface methodology (RSM), obtained the optimum prescription process to obtain the Ha-F68/F127-Res-Mc. Compared with the Res active pharmaceutical ingredient (API), Ha-F68/F127-Res-Mc had higher water solubility and photostability, and could achieve sustained release. Compared with the Res active pharmaceutical ingredient (API), Ha-F68/F127-Res-Mc had higher water solubility and photostability, and could achieve sustained release. In conclusion, the prepared nanomicelles have stronger cytotoxic effect on MCF-7 than doxorubicin (DOX). This will provide a basis for the development of Res antitumor injection, and provide a reference for the research on nano-delivery systems of other BCS II drugs in the future.
研究领域:
药剂学
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Yifeng Wang,Yi Sun,Jine Wang,Yang Yang,Yulin Li,Yuan Yuan,Changsheng Liu
In this study, we demonstrate a facile strategy (DL–SF) for developing MSN-based nanosystems through drug loading (DL, using doxorubicin as a model drug) followed by surface functionalization (SF) of mesoporous silica nanoparticles (MSNs) via aqueous (3-aminopropyl)triethoxysilane (APTES) silylation. For comparison, a reverse functionalization process (i.e., SF–DL) was also studied. The pre-DL process allows for an efficient encapsulation (encapsulation efficiency of ∼75%) of an anticancer drug [doxorubicin (DOX)] inside MSNs, and post-SF allows in situ formation of an APTES outer layer to restrict DOX leakage under physiological conditions. This method makes it possible to tune the DOX release rate by increasing the APTES decoration density through variation of the APTES concentration. However, the SF–DL approach results in a rapid decrease in drug loading capacity with an increase in APTES concentration because of the formation of the APTES outer layer hampers the inner permeability of the DOX drug, resulting in a burst release similar to that of undecorated MSNs. The resulting DOX-loaded DL–SF MSNs present a slightly negatively charged surface under physiological conditions and become positively charged in and extracellular microenvironment of solid tumor due to the protonation effect under acidic conditions. These merits aid their maintenance of long-term stability in blood circulation, high cellular uptake by a kind of skin carcinoma cells, and an enhanced intracellular drug release behavior, showing their potential in the delivery of many drugs beyond anticancer chemotherapeutics.
研究领域:
纳米医学
·
药剂学
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）