CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Liu Ming,Ehsan Ghasali,Ye Cheng,Congya Zhu,Junsheng Ye,Pengfei Zhang,Saleem Raza,Asif Hayat,Yasin Orooji
High entropy oxide (HEO) has shown great potential in the field of new photocatalytic materials due to its tunable composition and excellent thermal stability. In this paper, a high entropy rare earth oxide Er 2 Tm 2 Yb 2 Lu 2 Ho 2 O 15 composed of pure rare earth elements was synthesized by solid phase reaction method (SRM). Its structural and optical properties were investigated by various characterization techniques such as XRD, TEM, SEM and UV-DRS. The results showed that the material elements were uniformly distributed, with a wide light absorption range and abundant defects. To study the photocatalytic properties of the samples, Congo Red (CR) dye was degraded under visible light irradiation. The results show that the Er 2 Tm 2 Yb 2 Lu 2 Ho 2 O 15 high entropy material has excellent photocatalytic activity, showing a degradation rate of 99.2% to 20 mg/L Congo Red (CR) under visible light, showing remarkable stability in the cycle experiment, showing its potential to degrade organic pollutants. At the same time, free radical scavenging experiments and degradation mechanisms are also discussed. This work has reference value for the study of rare earth-based high entropy oxides.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2014
·Vol. 39
·期 1
·589-594
·
IF 3.159
Zhaogui Ba,Yumin Zhang,Junpei Wei,Jiwu Han,Zhenqiang Wang,Guangrui Shao
Nanoparticulate contrast agents have drawn considerable attention and interest because of their potential application in medical diagnosis and prognosis. In the present study, we designed and constructed high-performance nanoparticulate contrast agents based on PEGylated lutetium hydroxycarbonate nanoparticles (PEG-LuNPs) for X-ray computed tomography imaging, which were synthesized via a green and large-scale route. Under the daily clinical voltage, our PEG-LuNPs provided much more enhanced contrast than the routinely used iodine-based molecules. More importantly, PEG-LuNPs could act as liver-targeted contrast agents for the further detection of hepatic metastases. Both in vitro and in vivo toxicity studies indicated that these nanoparticles possess extremely high biocompatibility, revealing their overall safety. Based on these results, PEG-LuNPs with intrinsic physicochemical properties and excellent imaging capability demonstrated a useful nanoplatform for biomedical applications.
研究领域:
医学影像学
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生物材料学
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纳米医学
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产品关联
DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2015
·Vol. 33
·期 5
·792-796
·
IF 1.835
Liu Bo,Han Bao-yu,Zhang Chun-ling,Li Shi-hui,Sun Guang-ping,Cui Dong-mei
β -imidophosphonamido ligated lutetium alkyl complex (NPN Dipp )Lu(CH 2 SiMe 3 ) 2 (THF) (NPN Dipp = Ph 2 P(NC 6 H 3
i Pr 2 -2,6) 2 ) with the activation of Al i Bu 3 and [Ph 3 C][B(C 6 F 5 ) 4 ] exhibited high catalytic activity, medium syndio-(rr = 66%) but remarkably high 3,4-regioselectivity for the polymerization of β -myrcene (MY). In sharp contrast, high isotactic 3,4-polymyrcene (PMY) (mm = 95%) was obtained by the precursor (NPN Et )Lu(CH 2 SiMe 3 ) 2 (THF) (NPN Et = PPh 2 (NC 6 H 3
i Pr 2 -2,6)(NC 6 H 4 -Et-2)) with less bulky substituents on the N -aryl ring.
研究领域:
有机化学
·
材料科学
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产品关联
DOI
高影响因子
Separations
·
2025
·Vol. 12
·期 8
·215
·
IF 2.7
Jiuquan Qi,Qianwen Chen,Chuanying Liu,Chengliang Xiao,Shuainan Ni
Due to the nearly identical chemical properties of Lu and Yb, the production of no-carrier-added (NCA)177Lu faces significant challenges in their separation. Achieving efficient and streamlined separation of Lu and Yb is crucial for the production of NCA177Lu. This study systematically investigated the separation performance of the commercial Rext-P350 extraction resin for Lu and Yb. Static adsorption experiments revealed that, at a solid–liquid ratio of 8 g/L, both Lu3+and Yb3+were nearly completely adsorbed, with saturation adsorption capacities of 25.8 mg/g and 21.5 mg/g, respectively. An increase in the nitric acid concentration in the aqueous phase significantly inhibited adsorption, but the separation factor for Lu3+/Yb3+remained above 1.88. The adsorption kinetics followed a pseudo-second-order model (R2> 0.99), with equilibrium reached within 15 min, demonstrating fast adsorption kinetics. Characterization by SEM, FT-IR, and XPS confirmed the chemical coordination between the resin and Lu3+/Yb3+. Dynamic chromatographic separation experiments showed that the Rext-P350 resin exhibited significantly better separation performance for Lu3+/Yb3+compared to 2-ethylhexylphosphoric acid mono-2-ethylhexyl ester (P507) extraction resin. Leveraging the excellent performance of Rext-P350 resin, a two-stage continuous extraction chromatography process was designed, achieving efficient separation of 0.045 mg of Lu3+from 200 mg of Yb3+with a Lu3+purity of 90.9% and a yield of 98.4%. This study provides a feasible separation technique for the purification of NCA177Lu.
研究领域:
核化学
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放射性同位素生产
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分离科学
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无机化学
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核医学
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DOI
高影响因子
JOURNAL OF RARE EARTHS
·
2025
·
IF 7.2
Guodong Zhang,Yue Lu,Yaning Zhao,Peipei Dang,Hao Suo,Zhijun Wang,Panlai Li
Incorporating rare-earth (RE 3+ ) ions into lead-free halide double perovskites represents a promising strategy for modulating their optical properties through energy transfer mechanisms. In this study, Dy 3+ ions were successfully incorporated into Cs 2 NaLuCl 6 :Sb 3+ double perovskites via a facile hydrothermal method. The synthesized crystals not only exhibit intense blue emission originating from self-trapped excitons (STEs) but also display effective Dy 3+ characteristic emissions, thereby broadening the emission spectrum from the visible to the near-infrared region. The energy transfer from STEs to Dy 3+ is confirmed and extends across various RE 3+ ions. Temperature-dependent photoluminescence spectra reveal insights into the excitation and emission processes, as well as thermal quenching mechanism. Additionally, the characteristic emissions of Dy 3+ demonstrate varied anti-thermal quenching behaviors, indicating the remarkable thermal stability of the synthesized crystals. The thermally coupled sub-levels of Dy 3+ ions are employed to develop optical thermometers with notable sensitivity. Finally, the light-emitting diodes fabricated by encapsulating the optimized samples onto commercial chips highlight the great potential of Dy 3+ -doped Cs 2 NaLuCl 6 :Sb 3+ materials for photoelectric applications.
研究领域:
材料科学
·
光学物理
·
固体物理
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无机化学
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纳米技术
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光子学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Science
·
2024
·
IF 14.3
Zi-He Ming,Yong-Qu Zhang,Liang Song,Min Chen,Lin-Ling Lin,Yue-Yang He,Wan-Ling Liu,Yuan-Yuan Zhu,Yun Zhang,Guo-Jun Zhang
Radiotherapy demonstrates a synergistic effect with immunotherapy by inducing a transformation of “immune cold” tumors into “immune hot” tumors in triple negative breast cancer (TNBC). Nevertheless, the effectiveness of immunotherapy is constrained by low expression of tumor-exposed antigens, inadequate inflammation, and insufficient tumor infiltrating lymphocyte (TILs). To address this predicament, novel lutecium-based rare earth nanoparticles (RENPs) are synthesized with the aim of amplifying radiation effect and tumor immune response. The nanoprobe is characterized by neodymium-based down-conversion fluorescence, demonstrating robust photostability, biocompatibility, and targetability. The conjugation of RENPs with a CXCR4 targeted drug enables precise delineation of breast tumors using a near-infrared imaging system and improves radiation efficacy via lutetium-based radio-sensitizer in vivo. Furthermore, the study shows a notable enhancement of immune response through the induction of immunogenic cell death and recruitment of TILs, resulting in the inhibition of tumor progression both in vitro and in vivo models following the administration of nanoparticles. Hence, the novel multifunctional nanoprobes incorporating various lanthanide elements offer the potential for imaging-guided tumor delineation, radio-sensitization, and immune activation post-radiation, thus presenting an efficient radio-immunotherapeutic approach for TNBC.
研究领域:
肿瘤学
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纳米技术
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免疫学
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放射学
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生物医学工程
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Ranxi Liang,Feize Li,Xijian Chen,Fuyuan Tan,Tu Lan,Jijun Yang,Jiali Liao,Yuanyou Yang,Ning Liu
Nano-metal–organic frameworks (nano-MOFs) labeled with radionuclides have shown great potential in the anticancer field. In this work, we proposed to combine fluorescence imaging (FI) with nuclear imaging to systematically evaluate the tumor inhibition of new nanomedicines from living cancer cells to the whole body, guiding the design and application of a high-performance anticancer radiopharmaceutical to glioma. An Fe-based nano-MOF vector, MIL-101(Fe)/PEG-FA, was decorated with fluorescent sulfo-cyanine7 (Cy7) to investigate the binding affinity of the targeting nanocarriers toward glioma cells in vitro, as well as possible administration modes for in vivo cancer therapy. Then, lutetium-177 (177Lu)-labeled MIL-101(Fe)/PEG-FA was prepared for high-sensitive imaging and targeted radiotherapy of glioma in vivo. It has been demonstrated that the obtained 177Lu-labeled MIL-101(Fe)/PEG-FA can work as a complementary probe to rectify the cancer binding affinity of the prepared nanocarrier given by fluorescence imaging, providing more precise biodistribution information. Besides, 177Lu-labeled MIL-101(Fe)/PEG-FA has excellent antitumor effect, leading to cell proliferation inhibition, upregulation of intracellular reactive oxygen species, tumor growth suppression, and immune response-related protein and cytokine upregulation. This work reveals that optical imaging and nuclear imaging can work complementarily as multimodal imaging in the design and evaluation of anticancer nanomedicine, offering a MIL-101(Fe)/PEG-FA-based pharmaceutical with potential in tumor endoradiotherapy.
研究领域:
纳米技术
·
放射学
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肿瘤学
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药学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Small
·
2014
·Vol. 10
·期 12
·2429-2438
·
IF 7.514
Zhen Liu,Kai Dong,Jianhua Liu,Xueli Han,Jinsong Ren,Xiaogang Qu
Nanomaterials have gained considerable attention and interest in the development of novel and high-resolution contrast agents for medical diagnosis and prognosis in clinic. A classical urea-based homogeneous precipitation route that combines the merits of in situ thermal decomposition and surface modification is introduced to construct polyethylene glycol molecule (PEG)-decorated hybrid lutetium oxide nanoparticles (PEG–UCNPs). By utilizing the admirable optical and magnetic properties of the yielded PEG–UCNPs, in vivo up-conversion luminescence and T 1 -enhanced magnetic resonance imaging of small animals are conducted, revealing obvious signals after subcutaneous and intravenous injection, respectively. Due to the strong X-ray absorption and high atomic number of lanthanide elements, X-ray computed-tomography imaging based on PEG–UCNPs is then designed and carried out, achieving excellent imaging outcome in animal experiments. This is the first example of the usage of hybrid lutetium oxide nanoparticles as effective nanoprobes. Furthermore, biodistribution, clearance route, as well as long-term toxicity are investigated in detail after intravenous injection in a murine model, indicating the overall safety of PEG–UCNPs. Compared with previous lanthanide fluorides, our nanoprobes exhibit more advantages, such as facile construction process and nearly total excretion from the animal body within a month. Taken together, these results promise the use of PEG–UCNPs as a safe and efficient nanoparticulate contrast agent for potential application in multimodal imaging.
研究领域:
纳米技术
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生物医学工程
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材料科学
·
医学影像
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Huimin Zhao,Lixin Zang,Jianyu Hua,Bo Yuan,Qinyu Liu,Bingjie Ma,Chengshan Guo
A temperature-sensing method immune to oxygen interference is established based on phosphorescent metalloporphyrins on regenerated cellulose (RC). A series of metalloporphyrins (hematoporphyrin monomethyl ether coordinated to Pd, Gd, and Lu ions: Pd-, Gd-, and Lu-HMME) are designed to be embedded in RC. The phosphorescence emissions of these metalloporphyrins are effectively enhanced on RC, affording phosphorescence quantum yields of 1.8%, 3.3%, and 2.2%, respectively. The phosphorescence emissions of these metalloporphyrins on RC (metalloporphyrins/RC) are independent of oxygen concentration because RC provides an oxygen-impermeable microenvironment. Meanwhile, the phosphorescence emissions are effectively quenched with increasing temperature. The phosphorescence lifetimes also decrease with temperature, indicating an increase in non-radiative relaxation, which weakens phosphorescence emission. The oxygen-independence and temperature-dependence of these metalloporphyrins/RC reveal that they could serve as promising anti-oxygen-interference temperature indicators. Temperature-response plots are obtained in the range from −75 to 50 °C. The temperature sensitivities of Pd-, Gd-, and Lu-HMME on RC are evaluated to be 0.50, 0.28, and 0.36%/°C based on the temperature-response plots. The temperature resolution values of Pd-, Gd-, and Lu-HMME on RC are 0.5, 1.3, and 1.2 °C. These temperature indicators have high photostability under extended irradiation, making them suitable for practical use. The method offers attractive new insights into phosphorescent temperature-sensing materials and the development of oxygen sensors with temperature compensation.
研究领域:
材料科学
·
光学传感
·
温度传感
·
磷光材料
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产品关联
DOI
高影响因子
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2025
·
IF 7.8
Xiaoqi Ban,Jin Yao,Wanzhong Yin,Weifan Du,Taozhong Zhang,Yu Xie,Wenju Sun,Yulian Wang
Magnesite and dolomite exhibit similar crystal structures, chemical compositions, and surface properties, which pose significant challenges to their flotation separation. In response to the growing need for efficient and environmentally sustainable decalcification of magnesite, this study introduces luteolin (LUT), a novel eco-friendly depressant. The selective depression efficiency of LUT on dolomite within the magnesite flotation system was systematically assessed. Optimal flotation conditions (pH 11.0, LUT concentration of 60 mg/L, and NaOl concentration of 120 mg/L) resulted in a concentrate with 43.05 % MgO and 4.98 % CaO, effectively achieving the separation of magnesite from dolomite. The depression mechanism of LUT was thoroughly investigated through a combination of zeta potential, contact angle, FTIR, XPS, and AFM analyses. The results indicate that LUT’s hydroxyl groups preferentially adsorb onto the calcium sites of dolomite, preventing subsequent adsorption of sodium oleate, while exhibiting minimal interaction with magnesium sites on magnesite, thus preserving its flotation behavior. This study offers a promising, environmentally friendly solution for the selective separation of magnesite from dolomite.
研究领域:
矿物加工工程
·
环境科学
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产品关联
DOI
高影响因子
Food & Function
·
2020
·Vol. 11
·期 11
·10033-10046
·
IF 4.171
Xiaodong Ge,Chang'e Wang,Huiling Chen,Tingting Liu,Ligen Chen,Ying Huang,Feng Zeng,Bin Liu
Luteolin (LU) is a flavonoid compound and metformin hydrochloride (MH) is a kind of drug. Studies have shown that both LU and MH have the function of hypoglycemic effect. However, there are few reports indicating that LU cooperated with MH (LU·MH) can relieve lipid metabolism disorders and optimize intestinal flora compositions of high-fat diet mice. In this research, we investigated the effects of LU, MH and LU·MH on lipid metabolism disorders and intestinal flora composition in high-fat diet mice. The study found that compared with high-fat diet (HFD) alone, LU, MH and LU·MH could significantly reduce the lipid metabolism disorder. Furthermore, compared with LU or MH alone, the biochemical indicators of LU·MH were significantly improved and the results of the histopathological section also showed that LU·MH has stronger liver repair ability. It revealed that the potential mechanisms of the LU·MH alleviating lipid metabolism disorders were involved in the simultaneous regulation of SREBP-1c/FAS and SREBP-1c/ACC/Cpt-1. In addition, LU·MH could regulate the intestinal flora compositions. This includes significantly reducing the ratio of Firmicutes and Bacteroidetes(F/B) and at the family level, increasing the relative abundance of Lachnospiraceae, Helicobacteraceae, Marinifilaceae and Peptococcaceae to relieve lipid metabolism disorders. In conclusion, the work found that LU·MH regulates the signal pathway of SREBP-1c/FAS and SREBP-1c/ACC/Cpt-1 simultaneously and decreases the ratio of F/B, as well as increases the relative abundance of certain microbiota to alleviate the lipid metabolism disorders of HFD-fed mice.
研究领域:
药理学
·
营养学
·
微生物学
·
代谢性疾病
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产品关联
DOI
PubMed
高影响因子
CHEMICO-BIOLOGICAL INTERACTIONS
·
2022
·
IF 5.168
Kaichao Song,Liping Zhou,Cuicui Wang,Zhixin Yuan,Qilong Cao,Xianggen Wu,Mengshuang Li
A novel nanoformulation with the small molecule phytochemical dipotassium glycyrrhizinate as a nanomaterial was developed for the oral delivery of luteolin (Lut), a widely used phytochemical, but it suffered from poor water solubility and low oral bioavailability . This novel nanoformulation, named [email protected] , can be fabricated with a simple process. [email protected] can instantly dissolve into aqueous mediums and formulate through self-assembly a clear phytomicelle solution with a Lut encapsulation efficiency of 99.16 ± 0.90%, a small micelle size of 30.32 ± 0.12 nm , and a narrow polydispersity index of 0.138 ± 0.024. The optimized formulation demonstrated that Lut had solubility in up to 50 mg/ml of water as a result of its encapsulation within DG phytomicelles. [email protected] exhibited excellent characteristics, including good storage stability, a fast in vitro release profile, improvement in in vitro antioxidant activity , and high safety potential. In the oral bioavailability evaluation, a shorter Tmax, increased Cmax, and improved AUC0-t were obtained with [email protected] when compared to bare Lut. The distribution evaluation further showed that [email protected] could effectively increase the concentrations of Lut in all the tested organs and gastrointestinal segments. In the protection efficacy evaluation, 100 mg/kg [email protected] demonstrated strong effects against acetaminophen-induced hepatotoxicity. The mechanisms of inhibiting high-mobility group box 1 signaling and suppressing oxidative stress were involved in this strong treatment effect. These results showed that simple but novel Lut [email protected] provided a new, promising nano-delivery system for Lut with a significantly improved in vivo profile.
研究领域:
药理学
·
纳米技术
·
毒理学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）