ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Boxiong Wei,Xuejun Zhang,Cai Zhang,Ying Jiang,Yan-Yan Fu,Chunshui Yu,Shao-Kai Sun,Xiu-Ping Yan
High-performance and biocompatible contrast agents are the key to accurate diagnosis of various diseases in vivo via CT imaging. Fabrication of pure Bi nanoparticles is the best way to maximize X-ray absorption efficiency due to the ultrahigh X-ray attenuation ability of Bi and 100% content of Bi element. However, high-quality Bi nanoparticles prepared through a facile strategy are still lacking. Herein, we report a simple noninjection method to fabricate uniformly sized pure Bi nanoparticles using only two commercial reagents by simply heating the mixture of raw materials in a short time. The obtained Bi nanoparticles owned highly uniform size, excellent monodispersity, and impressive antioxidant capacity. After being modified with oligosaccharide, the “sweet” Bi nanoprobe with comfortable patient experience and favorable biocompatibility was successfully used in CT visualization of gastrointestinal tract in detail.
研究领域:
医学影像学
·
纳米医学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2018
·
IF 2.746
Xiaoke Zheng,Shanling Wang,Lan Wu,Xiandeng Hou
It is appealing to develop a facile way to prepare a binary CT contrast agent with good biocompatibility and CT contrast efficiency for potential clinical applications. In this work, a novel binary CT contrast agent based on the biocompatible nano-hydroxyapatite (nHAp, the main inorganic component of human bone and teeth) was prepared facilely and rapidly through doping two kinds of CT contrast ions (Ba 2+ and Ho 3+ ) into the nHAp host via microwave-assisted synthesis. The Ba/Ho co-doped nHAp with pure nHAp phase composition and good mono-dispersion was obtained simply with microwave heating for 30 min. The as prepared CT contrast agent is very promising as a novel binary CT contrast agent for CT imaging.
研究领域:
材料科学
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纳米技术
·
医学成像
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Nature Machine Intelligence
·
2021
·Vol. 3
·期 3
·199-217
·
IF 15.508
Roberts Michael,Driggs Derek,Thorpe Matthew,Gilbey Julian,Yeung Michael,Ursprung Stephan,Aviles-Rivero Angelica I.,Etmann Christian,McCague Cathal,Beer Lucian,Weir-McCall Jonathan R.,Teng Zhongzhao,Gkrania-Klotsas Effrossyni,Rudd James H. F.,Sala Evis,Schönlieb Carola-Bibiane
Machine learning methods offer great promise for fast and accurate detection and prognostication of coronavirus disease 2019 (COVID-19) from standard-of-care chest radiographs (CXR) and chest computed tomography (CT) images. Many articles have been published in 2020 describing new machine learning-based models for both of these tasks, but it is unclear which are of potential clinical utility. In this systematic review, we consider all published papers and preprints, for the period from 1 January 2020 to 3 October 2020, which describe new machine learning models for the diagnosis or prognosis of COVID-19 from CXR or CT images. All manuscripts uploaded to bioRxiv, medRxiv and arXiv along with all entries in EMBASE and MEDLINE in this timeframe are considered. Our search identified 2,212 studies, of which 415 were included after initial screening and, after quality screening, 62 studies were included in this systematic review. Our review finds that none of the models identified are of potential clinical use due to methodological flaws and/or underlying biases. This is a major weakness, given the urgency with which validated COVID-19 models are needed. To address this, we give many recommendations which, if followed, will solve these issues and lead to higher-quality model development and well-documented manuscripts.
研究领域:
医学影像学
·
人工智能
·
流行病学
✓ 已验证
DOI
高影响因子
ACTA PHYSICO-CHIMICA SINICA
·
2017
·Vol. 33
·期 5
·976-983
·
IF 0.767
BAI Guang-Yue,LIU Jun-Ling,WANG Jiu-Xia,WANG Yu-Jie,LI Yan-Na,ZHAO Yang,YAO Mei-Huan
This work presents the correlation of the enzymatic activity of α-chymotrypsin (α-CT) with the thermodynamics of interaction between α-CT and the cationic gemini surfactant decanediyl-α,ω-bis (dodecyldimethylammonium bromide)
(12-10-12). The enzymatic activity was assessed by the rate of 2-naphthyl acetate (2-NA) hydrolysis obtained from UV-Vis absorption spectra. The superactivity of α-CT in the catalytic hydrolysis of 2-NA was obtained by activation with 12-10-12 in a short incubation time; the activated
α-CT showed faster denaturation kinetics. The larger superactivities appeared in a bell shape below the critical aggregation concentration (cac12-10-12,CT) of the mixed gemini/α-CT systems in buffered aqueous solution. The results obtained from the variation
of the activity with the incubation time highlight that the protein incubated in 12-10-12 has a high catalysis activity and a weakened conformational stability. The mechanism of the superactivity of α-CT in the presence of 12-10-12 has been proposed by combining the results from
isothermaltitration calorimetry (ITC), steady state fluorescence, and differential scanning calorimetry (DSC). The superactivity arises from perturbation of the internal structure of α-CT by an interaction between the positively charged 12-10-12 and α-CT, which makes
the conformation of α-CT looser than the native one, in the balance of a weak interaction. Such a conformation is favorable for release of the acidic product of 2-NA hydrolysis, whereas it simultaneously leads to instability of the α-CT structure.
研究领域:
生物化学
·
分子生物学
·
酶学
✓ 已验证
DOI
高影响因子
BMC CANCER
·
2022
·Vol. 22
·期 1
·1-9
·
IF 4.638
Chen Zibo,Yuan Tao,Yan Fangjie,Ye Song,Xie Qin,Zhang Bo,Lin Nengmin,He Qiaojun,Yang Bo,Zhu Hong
Background Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Sorafenib is the first-line treatment for advanced HCC, but the anti-cancer effects remain to be improved as indicated by its low response rates and failure to prolong the progression-free survival (PFS). Thus, it is urgent to explore approaches to improve the clinical outcome.Materials and methodsThe effect of Sorafenib in HCC was analyzed by SRB (sulforhodamine B) assay in normoxia and hypoxia, respectively. The different dose combination effect of CT707 and sorafenib was analyzed by SRB assay in hypoxia. Flow cytometry assay was used to detect the cell apoptosis rate with CT707 and sorafenib treatment in hypoxia. Western blotting was used to detect the expression levels of apoptosis -related proteins and the mechanism of CT707 overcome the resistance of sorafenib in hypoxia.Results Our study showed that the characteristic intratumor hypoxia of advanced HCC is one of the major factors which mediated the drug resistance towards sorafenib in HCC. And CT-707, a novel multi-kinase inhibitor, could sensitize the hypoxic HCC cells towards sorafenib. Further studies showed that CT-707 abolished the nuclear translocation of Yes Associate-Protein (YAP), which has been demonstrated as one of mechanism of hypoxia-mediated sorafenib-resistance in HCC.Conclusion sOverall, this study not only favors the development of this novel multi-kinase inhibitor CT-707 as a therapeutic agent against HCC, but also provides a potential strategy to overcome the hypoxia-mediated resistance to sorafenib in HCC patients.
研究领域:
肿瘤学
·
药理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Heliyon
·
2024
·
IF 3.4
Ziyang Hu,Yanni Hu,Shi Xu,Jia Zhuang,Dantong Cao,Antian Gao,Xin Xie,Zitong Lin
Objectives This study aims to investigate the use of sodium iodide (NaI), dimethyl sulfoxide (DMSO), ethyl alcohol, and ethyl acetate as cone-beam CT (CBCT) contrast agents for diagnosing cracked teeth. The optimal delay time for detecting the number of crack lines beyond the dentino-enamel junction (Nd), the number of cracks extending from the occlusal surface to the pulp cavity (Np), and the depth of the crack lines was explored. Methods 14 human extracted cracked teeth were collected, 12 were used for enhanced scanning, and 2 were used for exploring the characteristic of crack lines. The teeth were scanned in 3 CBCT enhanced scanning (ES) modes: ES1 using meglumine diatrizoate (MD); ES2 using NaI and DMSO, ES3 using NaI, DMSO, ethyl alcohol and ethyl acetate. Three delay times (15mins, 30mins, and 60mins) were set for scanning. Nd, Np, and depth of crack lines were evaluated. Results There were totally 24 crack lines on 12 cracked teeth. Nd was 10 in ES1 at 60mins, 24 in ES2 at 60mins and 24 in ES3 at 15mins. Np was 1 in ES1 at 60mins, 10 in ES2 at 60mins and 21 in ES3 at 60mins, and there were significantly different among them ( p < 0.01). The average depth presented on ES3 was significantly deeper than ES1 and ES2 ( p < 0.01). Conclusion NaI, DMSO, ethyl alcohol and ethyl acetate show potential as contrast agents for enhanced CBCT scanning in diagnosis of cracked teeth and their depth in vivo . A delay time of 15 min is necessary to confirm the existence of crack lines, while a longer delay time is required to ascertain if these crack lines extend to the pulp cavity.
研究领域:
牙医学
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影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NANOTECHNOLOGY
·
2014
·Vol. 25
·期 29
·295103
·
IF 3.672
Jun Chen,Xiao-Quan Yang,Yuan-Zheng Meng,Huan-Huan Huang,Meng-Yao Qin,Dong-Mei Yan,Yuan-Di Zhao,Zhi-Ya Ma
Probe bismuth sulfide modified with Pluronic F127 (Bi2S3-PF127), which has high biocompatibility and dispersibility, is synthesized using triblock copolymer Pluronic F127 to modify hydrophobic Bi2S3 nanoparticles that are prepared by a hot injection method. TEM results show that most of the probe has a length of about 14.85 ± 1.70 nm and a breadth of about 4.79 ± 0.63 nm. After injected into the tail vein of a mouse, the probe has obvious CT contrast enhancement capability from x-ray CT imaging results. Meanwhile, the probe's in vivo toxicity is also studied. It is found that hematoxylin and eosin stains of major organs have no change. A biochemical analysis (alanine aminotransferase and aspartate aminotransferase) prove the probe has no adverse effects. The results of a blood analysis (white blood cell count, red blood cell count, hemoglobin, and platelet count) are also normal. The biological distribution of Bi by ICP-AES shows that most of nanoparticles are cleaned out after injection 48 h, and the circulation half-life of the probe is 5.0 h, suggesting that Bi2S3-PF127 has a long circulation and indicating that the Bi2S3-PF127 probe has good biocompatibility and safety.
研究领域:
医学影像学
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纳米医学
·
毒理学
✓ 已验证
DOI
高影响因子
Nanoscale
·
2018
·Vol. 10
·期 28
·13402-13409
·
IF 7.233
Sihan Ma,Jiaxin Zhang,Shibo Xia,Wenyan Yin,Yanxia Qin,Runhong Lei,Jianglong Kong,Linqiang Mei,Juan Li,Gengmei Xin,Gongping Li
Designing nanosized multi-modality contrast agents for high-resolution imaging is challenging since most agents are only useful for single-mode imaging. In this work, we successfully synthesized biocompatible polyethylene glycol (PEG-) and L-glutamine (GLN-) modified Ba4Yb3F17:Lu3+,Gd3+ nanoparticles (LNPs@PEG@GLN) that can be employed as a multi-modality contrast agent. Fluorescence dye-modified LNPs@PEG@GLN nanoparticles can be used for computed tomography (CT), magnetic resonance imaging (MRI), and fluorescence imaging (FI). They display high X-ray absorption, outstanding T2-weighted imaging capability, and good fluorescence uptake. Furthermore, LNPs@PEG@GLN enhances contrast efficiencies for different imaging modalities in vivo. Interestingly, LNPs@PEG@GLN is a promising agent for CT angiography. These nanoparticles could be a promising contrast agent for multi-modality imaging and diagnosing vascular diseases.
研究领域:
医学影像学
·
纳米医学
·
分子影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2018
·Vol. 14
·期 45
·1803101
·
IF 9.598
Quan Zou,Jiani Huang,Xuejun Zhang
Theranostic materials are of great significance to a personalized precise medicine. However, conventional theranostic agents are mainly fabricated by combining presynthesized independent imaging probes and therapeutic agents, suffering from multiple synthesis procedures, poor morphological control, and time/reagent-consuming process. Herein, iodinated polypyrrole (I-PPy) nanoparticles are fabricated via a one-step synthesis strategy combining chemical oxidation and iodination for computed tomography (CT) imaging-guided photothermal therapy. Iodic acid with a high standard electrode potential enables the chemical oxidation polymerization of pyrrole monomers. Meanwhile, the iodination of PPy induced by the corresponding reduction product I 2 takes place during the polymerization process to generate I-PPy nanoparticles. The prepared I-PPy nanoparticles possess a uniform size, excellent colloidal stability, intense near-infrared absorption, strong X-ray attenuation ability, and favorable biocompatibility. The as-synthesized I-PPy nanoparticles not only guarantee remarkable contrast-enhanced CT imaging of blood pool and tumors, but also realize effective tumor suppression in vitro and in vivo by I-PPy nanoparticles-mediated CT imaging-guided photothermal therapy. To the best of the authors' knowledge, it is the first time that multifunctional PPy nanoparticles are fabricated through a one-step synthesis process. The proposed strategy opens up a new way for the fabrication of high-performance theranostic agents via a one-step strategy under mild conditions.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2021
·
IF 5.268
Liwen Fu,Shuguang Yang,Shichao Jiang,Xiaojun Zhou,Zhou Sha,Chuanglong He
Advances in nanotheranostics have promoted the development of precision medicine, which has great potential as a weapon for clinical diagnosis and therapy of tumors. However, the combination of three functional principle components (imaging probes, therapeutic agents and surface coating) in traditional theranostic system is difficult to be achieved in only one step, while undergoing multiple synthesis procedures, time-consuming process and unknown toxicity. Herein, we fabricated iodinated polyaniline ( [email protected] ) nanoparticles via a facile one-step synthesis approach integrating chemical oxidative polymerization and iodine-doping process for computed tomography (CT) imaging and photoacoustic (PA) imaging-guided photothermal therapy (PTT). Iodic acid (HIO 3 ) as an oxidant induces chemical oxidation polymerization of aniline monomers. Meanwhile, iodine is incorporated into the polyaniline structural units in the process of polymerization to obtain [email protected] nanoparticles. Moreover, the l -cysteine (LC) has an effect on diameter of [email protected] nanoparticles, which enables nanoparticles have size-controlled spherical morphology and good colloidal stability. The hemolysis assay and cytotoxicity assessment verified the good biocompatibility of [email protected] Moreover, our [email protected] nanoparticles could not only exhibit appealing PTT efficiency, but also achieve excellent CT/PA dual-mode imaging effect. The histological evaluations suggested the negligible toxicity of [email protected] in vivo . This is the first time to our knowledge that multifunctional [email protected] nanoparticles were prepared by an ingenious one-step method. This work not only highlights a one-step strategy that simplified the complex synthesis of [email protected] nanoparticles, but also provides insight for further biomedical application of “all-in-one” theranostic agent.
研究领域:
纳米医学
·
肿瘤学
·
影像医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2023
·
IF 4.3
Chen Jia-Wei,Shen Yi,Yu Qing-Song,Gan Zhi-Hua
Nanotheranostics, which combine the therapeutic and diagnostic functions in one integrated system, have received extensive attentions in cancer treatments because they enable non-invasive diagnosis, tumor-targeted drug delivery, and real-time monitoring of therapeutic response. However, due to the high systemic toxicity of commonly used chemotherapeutics, current treatment still has limitations. Herein, to simultaneously achieve safe cancer therapy and therapeutic response monitoring, an iodinated prodrug strategy was proposed. 2,3,5-Triiodobenzoic acid (TIBA) was used to modify both paclitaxel (PTX) and the polymeric vehicle, so that the encapsulation efficiency of PTX could be increased and the systemic toxicity could be reduced. As-prepared prodrug nanoparticles could accumulate passively in the tumor site and promptly release loaded drugs in response to the overexpressed GSH in cancer cells, which then caused efficient cell cycle arrest and apoptosis like that of the parent PTX. With this rational design, safe and efficient antitumor therapy and real-time computer tomography (CT) imaging could be simultaneously realized, facilitating potential CT imaging-guided therapy of metastatic breast cancer.
研究领域:
癌症治疗
·
纳米技术
·
药学
·
医学成像
·
药物递送系统
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Deyi Zhao,Yongqi Han,Yamei Chen,Zhenyang He,Qian Xia,Ding-Kun Ji,Weihong Tan
Triple-negative breast cancer (TNBC) is one of the most malignant cancer types, characterized by a lack of efficient diagnostic and treatment methods in clinical practice. The development of effective targeted diagnosis and treatment for TNBC has become an important research focus. Here, we report the first proof-of-concept evidence of a glycoaptamer dual-target radionuclide probe (GDRP) for positron emission tomography/computed tomography (PET/CT) imaging of TNBC. The GDRP was created through precise molecular engineering of the aptamer AS1411, combined with three mannose ligands. The GDRP exhibited significantly increased serum stability and a high affinity for TNBC cells through a dual targeting mode. The advantages of our developed GDRP were further demonstrated by its excellent in vivo PET/CT dynamic imaging performance, featuring a long imaging window and high spatiotemporal resolution. This flexible method allows for the preparation of glycosylated functional nucleic acid molecular probes with high serum stability and tumor specificity. We anticipate that this PET/CT molecular probe will expand the development of glycoaptamer-based radioactive drugs and provides molecular tools for the clinical diagnosis of TNBC.
研究领域:
医学影像学
·
分子生物学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）