MATERIALS CHEMISTRY AND PHYSICS
·
2023
·
IF 4.6
Ziheng Li,Binbin Wang,Qihang Xu,Deqiang You,Wei Li,Xiaojian Wang
Due to similar properties to that of cartilage, hydrogels are considered as promising candidates for cartilage repair. However, it is still a challenge to synthesize hydrogel combining high strength and low friction like natural cartilage. In this work, we synthesized a dual-crosslinked zwitterionic P(AAm-co-AAc-co-SBMA)/Fe 3+ hydrogel, in which a zwitterionic monomer [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)(SBMA) was used to improve the hydrophilicity of the polymer chain. The results showed that the hydrogel exhibited significantly improved tensile strength (9.9 MPa) and compressive strength (207.6 MPa), which was due to the physical crosslinking points introduced by SBMA. Moreover, the zwitterionic hydrogel achieved an ultra-low friction coefficient (CoF) of 0.04 in water. The results provide a new approach for cartilage repair materials with considerable strength and low friction.
研究领域:
材料科学
·
生物医学工程
·
组织工程
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产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2026
·
IF 2.6
Yiting Geng,Yiwei Wang,Qingyu Meng,Ningbo Huang,Shan Huang,Xiaojun Chen
Conventional antimicrobial strategies relying on multiple antibiotics are becoming increasingly ineffective against drug-resistant strains, highlighting the urgent need for non-antibiotic-dependent therapeutic approaches. In this context, nanotechnology-based multifunctional platforms have emerged as a promising frontier in antimicrobial research due to their resistance-free mechanisms, high controllability, and precise targeting capability. This study presents a multifunctional nanoscale system, Fe₃O₄@polydopamine -Vancomycin @DC 2.4 cell membrane (FPVM), designed for the enrichment, recognition, and synergistic eradication of S. aureus. The system features an Fe 3 O 4 core coated with polydopamine, which enhances both photothermal performance and biocompatibility. Vancomycin is subsequently conjugated to the surface to enable specific recognition and bactericidal activity. Finally, the nanoparticles are encapsulated with stimulated dendritic cell (DC) membranes, further reinforcing the targeting ability toward S. aureus. Under 808 nm near-infrared irradiation (1.2 W cm -2 ), the FPVM platform (400 µg mL -1 ) reduced the survival rate of S. aureus to below 5% within 9 h and disrupted over 90% of pre-formed biofilms, demonstrating high photothermal conversion efficiency. In summary, the FPVM system integrates enhanced targeting and antibacterial functions, offering a versatile blueprint for constructing next-generation antimicrobial platforms.
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DOI
高影响因子
Biomaterials Advances
·
2024
·
IF 5.5
Wenying Wei,Haifei Kang,Chenxi Lian,Jiawei Liu,Jinwei Lin,Junwei Yang,Zhangmancang Xu,Ziqi Wang,Meizhen Yin,Honglian Dai
Chemodynamic therapy (CDT) guided by Fenton chemistry and iron-containing materials can induce ferroptosis as a prospective cancer treatment method, but the inefficient Fe 3+ /Fe 2+ conversion restricts the monotherapeutic performances. Here, an iron-based nanoplatform (Fe 3 O 4 -SRF@FeTA) including a magnetic core and a reductive film is developed for combined CDT and photothermal therapy (PTT) through ferroptosis augmentation. The inner iron oxide core serves as a photothermal transducer, a magnet-responsive module, and an iron reservoir for CDT. The coated Fe 3+ -tannic acid film (FeTA) provides extra iron and reductants for Fe 3+ /Fe 2+ conversion acceleration, and functions as a door keeper for the pH- and light-responsive release of the embedded ferroptosis inducer sorafenib (SRF). The in vitro results demonstrate that the iron-based nanocomplexes promote the production of lipid peroxide through the amplified Fenton activity, and downregulate glutathione involved in lipid peroxide repair system through the responsively released SRF. Upon accumulation in tumor by magnetic targeting and sequential laser irradiation locoregionally, Fe 3 O 4 -SRF@FeTA nanocomplexes present prominent in vivo anticancer efficacy by leveraging PTT and CDT-enhanced ferroptosis.
研究领域:
纳米技术
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癌症治疗
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材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
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2021
·
IF 4.821
Qiang Zou,Xinchen Ai,Tao Xue
In this work, an environment-friendly and label-free SERS probe was synthesized through Tollens' reagent and phytic acid to detect Fe 3+ ions in the integrated circuit cleaning solution waste. The synthesis process was greatly shortened to 30 min compared with the traditional synthesis time of 6 h. In addition, this SERS probe can be directly used and avoid the environmental pollution caused by the further modification in the synthesis process. This probe has a high sensitivity (LOD = 0.1 μmol L −1 ) and a wide detection range from 0.5 μmol L −1 to 500 μmol L −1 .As a practical application, it has been successfully applied to detect Fe 3+ ions in the standard clean two solution (SC-2). This method provides a feasible detection way for whether integrated circuit cleaning solution waste meets the emission criteria.
研究领域:
环境科学
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分析化学
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材料科学
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2021
·
IF 7.312
Haocheng Song,Qiang Li,Yuxuan Ye,Fei Pan,Dajie Zhang,Dongsheng Xia
Antibiotic contamination has become a serious environmental problem and much attention has been paid to its purification. The sulfate radical (SO 4 − ) based advanced oxidation processes (AOPs) exhibited significant potential in the treatment of antibiotics. In this study, the magnetic biochar (Fe 2 O 3 @LBC) derived from loofah was prepared to activate persulfate (PS) for cephalexin (CEX) degradation. Under the optimal conditions, 73.9% of CEX was removed in the Fe 2 O 3 @LBC/PS system. Free radicals quenching experiments and electron paramagnetic resonance (EPR) analysis revealed that HO and SO 4 − were responsible for the degradation of CEX. The C-OH of the catalyst played a crucial role in the degradation process. In addition, the conversion between Fe 3+ and Fe 2+ enhanced the degradation of CEX by producing SO 4 − . The degradation performance of other antibiotics and CEX in different water matrices indicated the broad adaptability and applications of Fe 2 O 3 @LBC. The main intermediates and the possible transformation pathways were proposed. These results provided a potential insight into biochar based catalysts for the degradation of antibiotics by activation of persulfate.
研究领域:
环境科学
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化学工程
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材料科学
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产品关联
DOI
高影响因子
Applied Materials Today
·
2021
·
IF 10.041
Renting Jiang,Xin Li,Dun Hu,Min Zhu,Di Zhou,Mengying Yuan,Xin Hu,Shengdan Nie,Jiajia Liu,Haoyue Xiang,Hua Yang,Yi Zhang,Shan Wang
Upregulating the susceptibility of cancer cells to ferroptosis is crucial to upgrade anti-cancer efficiency of ferroptosis drug system. At present, optimizing the sensitizer for ferroptosis with expected mechanism and improved transport via facile nanocarriers still heavily rely on serendipitous discovery and repetitious assignment. Herein, we employ the tannic acid (TA)-templated silicon nanoparticle as nanocore to descend the lysosome-controlled disintegratable Fe 3+ @ [email protected] micelles (REFSM) to identify rapamycin as a ferroptosis sensitizer through autophagy-dependent/independent pathways. The as-prepared REFSM dissociates responding to the acidic condition and enzyme system of lysosomes, permitting Fe 3+ and erastin release to irritate ferroptosis, which is reinforced by released rapamycin via irritating ferritinophagy and lipophagy, and suppressing HIF-1α. The rapamycin-reinforced ferroptosis is demonstrated to be specific to H 2 O 2 -overloaded cancer cells. Moreover, the introduction of rapamycin reduces the positive charge of micelle and improves its distribution in tumors. Both the controllable dissociation and the improved charge of REFSM ensure its anti-cancer efficiency at trace amount of erastin (0.3 mg kg −1 ) and rapamycin (2.2 mg kg −1 ) and minimize the systematic toxicity. This archetypical template provides a versatile platform for rapamycin as sensitizer to enhance ferroptosis by displaying its multiple pharmacological mechanism, controlling its release and improving its distribution in vivo .
研究领域:
药理学
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纳米技术
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癌症研究
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细胞生物学
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材料科学
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产品关联
DOI
高影响因子
Materials Today Physics
·
2024
·
IF 10
Junyu Wang,Xiaomin Li,Yan Xu,Shenglin Li,Jian Song,Yuhong Liu
Osteoarthritis (OA) is one of the most common joint disorders all over the world and hydrogels could be an effective tool to solve this problem. In this work, we explore the mechanism of tribology properties of double-network hydrogel (DN hydrogel) under effect of free radical polymerization inhibitors. Fe 3+ is added to the DN hydrogel as highly efficient and easily adjustable inhibitor, and the friction coefficient can be reduced to 0.0038 by adjusting the concentration. Even after 6 h of continuous tribological testing, the DN hydrogel remains a surprising sustained superlubricity. Furthermore, the strength of the hydrogel can reach 2.36 MPa, which is 20 times higher than that of the single-network hydrogel (SN hydrogel). The introduction of the inhibitor reduces covalent crosslinking that enables the hydrogel to form a sparser mesh structure conducive to the reduction of the friction coefficient, especially the additional physical cross-linking delivered from the electrostatic interaction between Fe 3+ and carboxyl groups increases strength. The optimum concentration of Fe 3+ is explored to achieve the synergetic improvement of lubricative and mechanical properties. This work opens innovative technology routes for developing superlubricious and tough hydrogels, which is a brighter future for artificial cartilage applications.
研究领域:
材料科学
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生物医学工程
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摩擦学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2023
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IF 15.1
Qi Meng,Jia Tan,Weifang Tong,Changxiao Chen,Zhendong Liu,Sainan Liu,Meifang Wang,Ziyong Cheng,Binbin Ding,Ping'an Ma,Jun Lin
Chemodynamic therapy (CDT) is an antitumor strategy based on the Fenton response. However, the mild acidity in the tumor microenvironment (TME) limits the efficiency of the Fenton response. Lactic acid has the potential to regulate pH in TME by regulating its metabolism. α-cyano-4-hydroxycinnamic acid (CHCA) can block lactate transport and induce lactate accumulation in cells, thus enhancing intracellular acidity. Nevertheless, CHCA is insoluble in water and the existing nanodrug delivery systems have complex synthesis and low drug-loading. Herein, we use Fe 3+ and CHCA to form ultrahigh drug-loading supramolecular nanoparticles (FC NPs) by an ultrafast self-assembly strategy at room temperature for only 5 min. Polyethylene glycol (PEG) modified FC (FCP) NPs undergo lactate metabolism regulation-enhanced CDT in tumor cells to generate toxic hydroxyl radicals to induce apoptosis. Besides, glutathione is consumed and glutathione peroxidase 4 is down-regulated to induce ferroptosis due to the oxidation of Fe 3+ . In vitro and in vivo experiments show FCP induced synergetic effect of CDT and ferroptosis as well as the excellent therapeutic effect compared with either CHCA or Fe 3+ alone. We believe that the ideal design of the CHCA supramolecular nanosystem will provide more revelations on the future research about CDT and lactate metabolism therapy.
研究领域:
癌症治疗
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纳米技术
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药学
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生物化学
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2021
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IF 6.165
Binbin Zhang,Qi Zhou,Xinwei Zhang,Jiao Ma,Xin Cong,Qin Wang,Yonggui Liao,Yajiang Yang,Hong Wang
In this work, 5,5′,5′′-(1,3,5-triazine-2,4,6-triyl)tris(azanediyl)triisophthalate (H 6 L) was used as a gelator to prepare thermostable supramolecular gels (H 6 L gels). The lowest critical gelation concentration of H 6 L was found to be only 0.14 wt%. H 6 L gels remained stable after being placed at 85 °C for 1 h, indicating that its gel-sol phase transition temperature ( T gel ) was not<85 °C. H 6 L gels can be formed in just a few seconds in comparison with the longer gelation time of a conventional thermostable gel. Moreover, a thermostable H 6 L/Fe 3+ gel was also prepared by the coordination interactions of H 6 L and Fe 3+ ions. The studies of FT-IR, UV–vis, XRD and SEM reveal that multiple hydrogen bonds, π-π interactions as well as coordination interactions were the main driving forces for the formation of thermostable three-dimensional network structure of H 6 L gels. In addition, the fluorescence spectra of H 6 L gels showed that the dual emission at 396 nm and 469 nm was derived from the structure of melamine and 5-aminoisophthalic acid contained in H 6 L structure. The gel formed at high temperature had relatively high transparency and strong fluorescence signal, and the fluorescence intensity is affected by the external H + concentration. Using this characteristic, 14 organic acids can be effectively identified with the help of principal component analysis (PCA). L-cysteine can be identified with the naked eye by the color and state changes of H 6 L/Fe 3+ gels.
研究领域:
材料科学
·
化学
·
分析化学
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超分子化学
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产品关联
DOI
高影响因子
CHEMOSPHERE
·
2023
·
IF 8.8
Qidi Liu,Jun Hou,Yuan Zeng,Jun Wu,Lingzhan Miao,Zijun Yang
Sulfamethoxazole (SMX) is an extensively applied antibiotic frequently detected in municipal wastewater , which cannot be efficiently removed by conventional biological wastewater processes. In this work, an intimately coupled photocatalysis and biodegradation (ICPB) system consisting of Fe 3+ -doped graphitic carbon nitride photocatalyst and biofilm carriers was fabricated to remove SMX. The results of wastewater treatment experiments showed that 81.2 ± 2.1% of SMX was removed in the ICPB system during the 12 h, while only 23.7 ± 4.0% was removed in the biofilm system within the same time. In the ICPB system, photocatalysis played a key role in removing SMX by producing hydroxyl radicals and superoxide radicals. Besides, the synergism between photocatalysis and biodegradation enhanced the mineralization of SMX. To understand the degradation process of SMX, nine degradation products and possible degradation pathways of SMX were analyzed. The results of high throughput sequencing showed that the diversity, abundance, and structure of the biofilm microbial community remained stable in the ICPB system at the end of the experiments, which suggested that microorganisms had accommodated to the environment of the ICPB system. This study could provide insights into the application of the ICPB system in treating antibiotic-contaminated wastewater.
研究领域:
环境工程
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水处理
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光催化技术
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微生物学
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Zihua Wang,Chijia Wang,Weihao Fan,Shuyi Liu,Kaka Li,Hongxin Luo,Shupei Liu,Huaiyuan Wang
A robust bifunctional platform (FA-PANI-Fe-F) with both shielding performance and corrosion inhibition activity was prepared and observed for its structure and morphology. During the corrosion test , Fe 2+ /Fe 3+ and perfluorinated groups effectively strengthened the shielding performance and corrosion inhibition activity of the coating. The results show that the perfluorinated group not only improved the hydrophobic performance of the functional filler but also provided effective inhibition against corrosion for the anode area. In addition, Fe 2+ /Fe 3+ resulted in the functional filler exhibiting anodic protection and cathodic inhibition properties, thereby forming a dense metal passivation film between the coating and the substrate interface. After the EIS test, the |Z| 0.01 Hz value of FPF-Fe 10% C still reached 7.91 × 10 8 Ω·cm 2 . Additionally, the FPF-Fe 10% C showed a lower cathodic corrosion trend in the SVET test, which indicated that Fe 2+ /Fe 3+ effectively inhibited the corrosion process in the cathode region. This study is expected to open new insights into the anti-corrosion inhibition process between the interior of the coating and the metal substrate, and prepare a robust bifunctional filler platform with long-term corrosion resistance .
研究领域:
材料科学
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腐蚀工程
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表面化学
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产品关联
DOI
高影响因子
ChemistrySelect
·
2023
·Vol. 8
·期 17
·e202300345
·
IF 2.1
Weijun Wu,Jie Mao,Yifei Lu,Sui Wang
Graphical In this study, We designed a double-emitting carbon quantum dots (G-CDs) and established a ratiometric fluorescence sensor. The semi-quantitative and visual detection of Fe 3+ was achieved based on the fluorescence color change of the probe. The method can be applied to the accurate determination of Fe 3+ in real samples and exhibits good interference resistance, selectivity and reproducibility. Based on the dual signal of double-emitting carbon quantum dots (G-CDs), a ratiometric fluorescence sensor is established to realize the analysis and detection of Fe 3+ in real samples. When the excitation wavelength is 360 nm and 480 nm, the double emission fluorescence peaks are located at the wavelengths of 477 nm and 523 nm. The former is the fluorescence response signal, and the latter is the fluorescence background signal. The semi-quantitative analysis of Fe 3+ was achieved based on the linear relationship between the ratio F 477 /F 523 of the two signals and the Fe 3+ concentration. The linear range of this method is 0.015–120 μM, and the limit of detection (LOD, S/N=3) is 5 nM. Meanwhile, the naked-eye visual detection of Fe 3+ can be realized according to the fluorescence color of the probe. The probe exhibits excellent anti-interference, selectivity and repeatability, and this method can be applied to the detection of Fe 3+ in actual samples.
研究领域:
分析化学
·
环境科学
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材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）