Journal of Materials Chemistry A
·
2015
·Vol. 3
·期 9
·4976-4982
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IF 7.443
Hao Huang,Xun Feng,Cuicui Du,Siyuan Wu,Wenbo Song
Uniform iron carbide nanoparticles (Fe3C, ∼10 nm), size evolved from nano-scaled Fe-MIL-88b, were one-pot pyrolytically embedded in 3D porous N-rich graphene. Extra ORR catalytic activity with four-electron selectivity was achieved in an alkaline electrolyte. The onset and peak potential were 10 mV and 40 mV more positive, respectively, than commercial Pt/C.
研究领域:
材料科学
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电化学
·
纳米技术
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DOI
高影响因子
TALANTA
·
2024
·
IF 5.6
Kexin Ren,Mengxia Duan,Tingting Su,Dichen Ying,Shijia Wu,Zhouping Wang,Nuo Duan
Shiga toxin type II (Stx2), the major virulence component of enterohemorrhagic Escherichia coli , is strongly associated with the life-threatening hemolytic uremic syndrome thus posing a substantial risk to food safety and human health. In this work, a dual-mode aptasensor with colorimetric and surface-enhanced Raman scattering was developed for Stx2 specific detection based on noble metal nanoparticles and Raman reporter loaded metal-organic framework (Mn/Fe-MIL(53)@AuNSs-MBA). The Mn/Fe-MIL(53)@AuNSs could catalyze the H 2 O 2 -mediated oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB), thereby enabling visual detection. Meanwhile, the SERS signal from MBA can be enhanced by the decorated AuNSs. Under optimal conditions, a linear range of 0.05–500 ng/mL with limit of detection (LOD) of 26 pg/mL was achieved in colorimetric mode and a linear range of 5–1000 ng/mL with LOD of 0.82 ng/mL in SERS mode, in which the dual-mode results complement each other, widening the linear range, increasing the accuracy and reliability of the detection. The method was further applied to the detection of Stx2 in milk with average recovery of 101.1 %, demonstrating its superior potential for bacterial toxin monitoring.
研究领域:
生物传感
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食品科学
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分子诊断
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Jiayi Qin,Jia Su,Hong Li,Ling Zhang,Ling Zhang,Ke Jiang
The development of novel antibacterial strategies as alternatives to antibiotics is of great significance but remains considerable challenges due to the lack of safe, effective, and broad-spectrum agents. Here, we explored the potential of a biocompatible metal–organic framework Fe-MIL-53-NH 2 (FM) for reactive oxygen species (ROS)-based antibacterial applications. However, FM was found to be catalytically inert due to the very weak reducibility of Fe 3+ toward H 2 O 2 . To address this challenge, we incorporated a small amount of Co 2+ (0.98 %) into FM (CFM), successfully activating Fenton chemistry and achieving a notable 5.5-fold improvement in Fenton activity. Density functional theory (DFT) calculations revealed that a very small amount of Co 2+ doping significantly reduces the energy barrier of the Fenton reaction by shifting the d-band center to the Fermi level and optimizing the charge density of active Co atoms. We further enhanced the antibacterial properties of CFM by modifying it with the photothermal agent polydopamine (PDA), resulting in CFMP. Through the synergistic effects of ROS and photothermal properties, CFMP exhibited remarkable antibacterial activity, with bacterial eradication rates exceeding 99 % against both E. coli and S. aureus . Moreover, in vivo experiments demonstrated the exceptional efficacy of CFMP in sterilizing S. aureus -infected wounds, while causing negligible damage to other major organs. This study not only highlights the role of atom engineering in activating Fenton reaction, but also provides rational designs for a synergistic antibacterial strategy via powerful MOFs chemistry.
研究领域:
材料科学
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纳米技术
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生物医学工程
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化学
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微生物学
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DOI
高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 2
·1-8
·
IF 5.479
Cheng Ting,Li Xiang,Huang Peng,Wang Han,Wang Meixia,Yang Wenming
An electrochemical and colorimetric dual-readout method is described for the determination of thrombin. A platinum nanoparticle (Pt NP) modified metal organic framework (MOF) acts as a peroxidase (POx) mimic that causes the formation of a blue product from 3,3′,5,5′-tetramethylbenzidine (TMB) and hydrogen peroxide, with an absorption maximum at 650 nm. In addition, gold nanoparticles enrich initiators that trigger the hybridization chain reaction for dual signal amplification to generate an electrochemical current typically measured at 0.31 V (from −0.5 to −0.1 V) and allow quantitation of thrombin with high sensitivity and over a wide detection range. The colorimetric and electrochemical (dual) thrombin assay produces two kinds of signals which warrants accuracy, diversity, and an option for visual inspection. The dual-channel sensor allows for the quantitative determination of thrombin with a low detection limit (0.33 fM) for the electrochemical method and 0.17 pM for the colorimetric method) and over a wide detection range (1 fM to 10 nM for electrochemical method and 0.5 pM to 1 nM for colorimetric method). The electrochemical detection limit is lower than that of colorimetry, and the linear range is wider, which is more suitable for further quantitative analysis of the target.
Schematic representation of a colorimetric and electrochemical (dual) thrombin assay based on the use of a platinum nanoparticle modified metal-organic framework for color development and hybridization chain reaction for electrochemical signal. C-TBA: complementary sequences of thrombin aptamer, TBA: thrombin aptamer, I-Au NPs: initiators enriched by gold nanoparticles, S-AuE: sensing gold electrode, RS-AuE: reacted sensing gold electrode, TB: thrombin, MB: Methylene Blue, HCR: hybridization chain reaction.
研究领域:
分析化学
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纳米技术
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生物传感器
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生物化学
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产品关联
DOI
PubMed
高影响因子
FUEL
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2022
·
IF 8.035
Chenxi Lu,Yuanzhuo Zhou,Liangzhi Li,Hongwei Chen,Lishi Yan
Catalytic production of 5-hydroxymethylfurfural (5-HMF) from glucose is a promising routine for generation of varied value-added chemicals. Herein, Mixed-Metal metal–organic frameworks (MOFs)–Fe/MIL-101(Cr) and MIL-101(Cr, Fe) obtained from post-synthesis modification and one-pot synthesis approach respectively were applied for catalytic converting glucose to 5-HMF. The synthesized Mixed-Metal MOFs were characterized by PXRD, SEM, N 2 adsorption–desorption analysis, TGA, XPS and NH 3 -TPD. Cr-and Fe-containing Mixed-Metal MOFs Fe/MIL-101(Cr) and MIL-101(Cr, Fe) presented synergistic effect with enhanced catalytic ability for glucose transformation to 5-HMF compared with typical single-metal MOFs and sulfonic acid-functionalized MOFs. Moreover, these two Mixed-Metal MOFs also presented better thermal stability than single-metal MOFs like MIL-101(Cr). Fe/MIL-101(Cr) was found to possess higher catalytic performance than MIL-101(Cr, Fe). 55.8 % 5-HMF yield was obtained with Fe/MIL-101(Cr) at 170 °C for 2 h in DMSO/water system. In addition, Fe/MIL-101(Cr) demonstrated desired recyclability for five times without incredible loss in its activity. This study provides a Mixed-Metal strategy on MOFs for improving catalytic efficiency of glucose conversion to 5-HMF.
研究领域:
化学工程
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材料科学
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催化
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DOI
高影响因子
MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 9
·3121-3130
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IF 4.58
Yuan Guolin,Wang Lei,Mao Dayong,Wang Fang,Zhang Jicai
The β1 receptor blocker metoprolol targets the hypertension-carrying adrenergic receptor gene (ADRB1), but therapy is often hindered by a lack of evidence-based medical information. The authors describe an assay for the ADRB1 gene. It is based on the electrocatalytic oxidation of H 2 O 2 by a nanocomposite consisting of hemin and platinum nanoparticles in an amino-modified metal-organic framework of the type Fe-MIL-88-NH 2 and heavily loaded with Cu(II) ions. The nanocomposite was placed on a glassy carbon electrode (GCE), and the resulting sensor displays increased electrocatalytic activity with the addition of H 2 O 2 because of the synergistic effects of hemin and the platinum nanoparticles (Pt NPs). Next, a capture DNA probe for the target ADRB1 gene was immobilized on the modified GCE. Binding of the target gene results in a distinct change in the electrocatalytic activity of H 2 O 2 . The amperometric i–t curves were recorded at −0.4 V in 5 mL of phosphate buffered saline at room temperature. The electrode responds to ADRB1 in the 1 f. to 10 nM concentration range and has a 0.21 f. detection limit (at a S/N ratio of 3). In our perception, this detection scheme can simplify and accelerate the identification of drug response and therapeutic efficacy. Conceivably, it may be applied to other mutations, and it may enable a more precise clinical prognosis and thus facilitate personalized medical diagnostics.
Schematic presentation of an electrode for the determination of the adrenergic receptor gene (ADRB1). The assay is based on the electrooxidation of added H 2 O 2 by using a glassy carbon electrode (GCE) coated with a composite prepared from platinum nanoparticles (Pt NPs), hemin and a metal-organic framewok of type Fe-MIL-88NH 2 loaded with Cu(II). This versatile platform simplifies studies on the response of hypertension drugs and the effectiveness of therapy.
研究领域:
生物化学
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医学诊断
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纳米材料科学
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产品关联
DOI
高影响因子
SYNTHETIC METALS
·
2019
·
IF 2.87
Zhengsong Yu,Na Li,Xiaosong Hu,Yulin Dong,Yawei Lin,Hongwei Cai,Zhizhong Xie,Deyu Qu,Xi Li
Based on the electrode modified by the carboxyl-functionalized graphene, a highly sensitive electrochemical sensor for Pb 2+ detection was proposed by using 8–17 DNAzyme as the recognition element and the reaction of H 2 O 2 catalyzed by Fe-MIL-101 as the signal probe. Due to the high selectivity of the 8–17 DNAzyme to Pb 2+ , the excellent catalytic ability of Fe-MIL-101 and the advantages of graphene, the proposed electrochemical sensor exhibited an excellent sensing performance with a wide linear range of 10 −13 to10 −7 mol·L −1 , a lower detection limit of 1.74 × 10 −14 mol·L −1 and high selectivity to Pb 2+ . Tap water and river water were analyzed by the developed sensor with satisfying recoveries and RSD, demonstrating a promising practicability for the determination of Pb 2+ in the real sample analysis. Furthermore, the proposed strategy could be extended to the determination of other metal ions just by changing the specific DNAzymes.
研究领域:
分析化学
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环境科学
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纳米技术
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生物传感器
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Jia Ding,Fei Liu,Chunling Qi,Yunlei Zhou,Huanshun Yin,Shiyun Ai
A novel photoelectrochemical (PEC) biosensor was constructed for DNA hydroxymethylation detection based on Bi 4 NbO 8 Cl/PTC-NH 2 heterojunction and Fe-MIL-88NH 2 , where Bi 4 NbO 8 Cl/PTC-NH 2 was employed as photoactive material and Fe-MIL-88NH 2 was adopted as artificial hydrogen peroxide mimic enzyme. Based on the structure of hydroxymethylated cytosine in DNA sequence, 5-hydroxymethyl-2’-deoxycytidine (5hmdC) was employed as detected target molecule for the first time using PEC technique. After Bi 4 NbO 8 Cl/PTC-NH 2 heterojunction was modified on the substrate electrode, thioglycolic acid (TGA) was captured by forming amide bond, where the sulfhydryl group (-SH) of TGA was employed as the specific recognition of 5hmdC. Under M. HhaI catalysis, the −CH 2 OH of 5hmdC reacted selectively with the –SH. Finally, Fe-MIL-88NH 2 was modified on the electrode based on the crosslinker of 4-formylphenylboronic acid (FPBA), where FPBA possessed two active groups of formyl and boronic acid group, reacting with glycosyl of 5hmdC and amino of Fe-MIL-88NH 2 . Under the catalysis effect of Fe-MIL-88NH 2 , the insoluble substance was produced on the surface of electrodes, resulting in distinct lessening of PEC response. Under optimal conditions, the photocurrent shows a linear relationship with the logarithm value of 5hmdC concentration from 0.01-100 nM with a low detection limit of 6.48 pM. More importantly, this method can be applied to investigate the influence of exogenous phytohormone on 5hmdC content in the genomic DNA of rice seedling roots and leaves.
研究领域:
材料科学
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分析化学
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生物传感器
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生物化学
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纳米技术
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电化学
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基因组学
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产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 50
·108774-108782
·
IF 5.8
Xu Jinjie,Li Yongli,Yu Lihong,Pang Yuehong,Shen Xiaofang,Liu Jun
In this work, metal–organic frameworks (MOFs) including Fe-MIL-101 and Ti-MIL-125 were prepared and fixed on the melamine foam (MF) by polyvinylidene fluoride (PVDF) to prepare MF/PVDF/MOFs, which was used as adsorbents in pipette-tip solid-phase extraction (PT-SPE) for rapid extraction of organophosphorus pesticides (OPPs). Then, a gas chromatograph-flame thermionic detector (GC-FTD) was used for simultaneous analysis of Dimethoate (DMT), Iprobenfos (IBF), Parathion-methyl (PAM), and Chlorpyrifos (CPF). The morphology, crystal structure, and functional groups of MF/PVDF/MOFs were characterized, indicating that Ti-MIL-125 and Fe-MIL-101 were successfully synthesized and distributed on MF. The Fe-MIL-101 and Ti-MIL-125 showed good extraction ability for OPPs, which was mainly due to the π-π interaction and the multiple porous structures. Under the optimal conditions, the limit of detection (LODs) of four OPPs was 0.03–0.14 μg L −1 and the RSDs were less than 9.9%. The developed PT-SPE method showed a short extraction time (<3 min). The recoveries in fruits and vegetables (Celery, cabbages, and oranges) ranged from 75.3%–118.8% (RSDs<9.6%). The prepared MF/PVDF/MOFs demonstrated the efficient extraction performance of OPPs, contributing to the rapid pretreatment of OPPs from food and the environment.
研究领域:
分析化学
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环境科学
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食品科学
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产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2023
·Vol. 15
·期 3
·343-352
·
IF 3.1
Ling-Juan Wang,Wei Han,Ting-Ting Lou,Lin-Lin Ma,Ya-Bing Xiao,Zhou Xu,Mao-Long Chen,Yun-Hui Cheng,Li Ding
For environmental safety, it is important to establish a simple, rapid, and sensitive method for emerging pollutants. Here, a dispersive solid-phase extraction (d-SPE) method based on an iron-based metal–organic framework (Fe-MIL-88-NH2) combined with high-performance liquid chromatography (HPLC) was developed for tetrabromobisphenol A (TBBPA) in water samples. Fe-MIL-88-NH2 was synthesized using a solvothermal method and completely characterized. Fe-MIL-88-NH2 had good water stability and gave a maximum adsorption capacity of 40.97 mg g−1 for TBBPA. The adsorption of TBBPA on Fe-MIL-88-NH2 followed Langmuir adsorption models and a pseudo-second-order kinetic model. The bromine ion and the hydroxyl group of TBBPA could form strong hydrogen bond interactions with the amino protons around the cavity of Fe-MIL-88-NH2, which was in accord with the molecular simulation calculations. Furthermore, several important d-SPE parameters were optimized, such as the amount of materials, extraction time, pH, ionic strength, elution solvent type, and volume. The established method showed good linearity in the concentration range of 0.005–100 μg g−1 (r2 ≥ 0.9996). This method's limits of detection (LOD) and quantification (LOQ) were 0.001 μg g−1 and 0.005 μg g−1, respectively. The recoveries in spiked water samples ranged from 87.5% to 104.9%. The proposed method was applied successfully to detect TBBPA in environmental water samples.
研究领域:
环境科学
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分析化学
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材料科学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）