Applied Materials Today
·
2024
·
IF 7.2
Xiao Yang,Miao Chen,Yuzhen Wang,Xiaoqin Si,Jiahui Hao,Changcan Shi
Self-expanding sponges with excellent water absorption capacity hold unique prospects for treating uncontrollable and noncompressible hemorrhage. However, fabrication of sponges with robust mechanical properties, effective pro-coagulation potential and desired infection prevention enabling for irregular or deep wound management including hemostasis and wound repair are the urgent challenge. Here, the halloysite nanotubes (HNTs) were assembled with modified starch (MSt) by hydrogen bond formation, and the composite sponge (HNTs/MSt) was finally developed after foaming technique, crosslinking reaction and lyophilization. The prepared sponge not only retained excellent water absorption and self-expanding ability, but also exhibited a two-fold increase in the maximum compressive stress and a 53 % reduction in clotting time in vitro due to assembled silicon-based nanotubes. As a result, the composite sponge had better hemostatic performance in SD rat/rabbit liver volume defect and artery transection hemorrhage models as compared with control and commercial hemostatic sponges. Furthermore, due to the drug-loading capacity of HNTs, composite sponge loaded with gentamycin could inhibit the growth of microorganism and promote rat full-thickness skin wound healing. All the results indicated that HNTs assembled sponge would be promising biomaterial for treating uncontrollable hemorrhage and wound repair.
研究领域:
材料科学
·
生物医学工程
·
药剂学
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产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2026
·
IF 6.8
Haixue Li,Meng Yan,Lisha Yin,Licui Zhang,Dongmei Li,Zhiyong Liu,Fangling Li,Zhongpeng Qiu,Lin Cui
Traditional wound dressings frequently exhibit issues such as inadequate adhesion to irregular wound surfaces, a tendency to induce secondary tissue damage, and limited multifunctionality, posing significant challenges in clinical practice. This study presents a novel injectable hydrogel dressing (CMCS/ODEX/TA/HNTs) that integrates multiple mechanisms, thereby imparting superior hemostatic, antioxidant and antibacterial properties. CMCS and ODEX form a reversible three-dimensional network via a rapid Schiff base reaction. Upon injection, these materials can rapidly gelatinize in situ, adaptively filling the cavities of complex wounds. TA serves as a multifunctional crosslinking agent, significantly enhancing the hydrogel’s mechanical strength, self-healing properties, antioxidant capacity, and broad-spectrum antibacterial activity through robust hydrogen bonds and covalent interactions. A crucial aspect of this enhancement is the incorporation of halloysite nanotubes (HNTs). By leveraging their excellent dispersibility in both the aqueous phase and polymer matrix, along with their unique tubular structure and high specific surface area, HNTs not only improve tissue adhesion and mechanical integrity but also promote platelet aggregation, facilitate the sustained release of bioactive factors, and markedly enhance the hemostatic effect. In vivo experiments on rat tail cut off and liver injury models have revealed that the hemostatic efficacy of CMCS/ODEX/TA/HNTs hydrogel surpasses that of commercial hemostatic sponges, ensuring swift hemostasis. In vitro studies have showcased its substantial antibacterial capabilities, while animal trials have further validated its superior hemostatic performance compared to conventional sponges. The synergistic combination of its multifunctional attributes, encompassing antibacterial, antioxidant, and highly effective hemostatic properties, presents a promising approach for managing wound infections. Particularly suited for challenging emergency scenarios, this hydrogel holds significant promise for clinical translation.
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Xiao-Lu Sun,Zan Liu,Zhi-Lin Cheng
This report introduced the facile synthesis of the carbon-nanofiber films reinforced by halloysite nanotubes (HNTs) via electrospinning. The HNTs-reinforced N-doped carbon-nanofiber films (PAN/HNTs-CNFs) possessed the higher strength and toughness while keeping the prospective adsorption capability for different sulfur compounds in oil due to the higher N doping content. The PAN/HNTs-CNFs were produced by firstly electrospinning for the HNTs-filled polyacrylonitrile (PAN) nanofiber films, followed by the high-temperature carbonization for the conversion of the polymer films into the carbon-nanofiber films with the N doping. The characterizations testified that the HNTs were capable of fulfilling the uniform and disordered dispersion in the carbon-nanofibers. For overcoming the toughness of the carbon-nanofiber film, the HNTs filling the obviously improved the mechanical performance of the carbon-nanofiber films by the pulling-out and bridging effect. Due to accessing the lipophilic and acid surface, abundant hierarchical pore structure and highly N-doping content, the PAN/HNTs-CNFs exhibited the remarkable adsorption performances for thiophene, benzothiophene, and dibenzothiophene (46.73 mg S/g, 38.4 mg S/g and 35.03 mg S/g for 800 ppm sulfur model oil), especially being suitable to the adsorption of thiophene. Furthermore, the study on the adsorption kinetics, equilibrium isotherms, and thermodynamics of thiophene over the PAN/HNTs-CNFs were conducted to discuss the adsorption mechanism.
研究领域:
材料科学
·
环境工程
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2014
·
IF 4.058
Pan Wang,Mingliang Du,Ming Zhang,Han Zhu,Shiyong Bao,Meiling Zou,Tingting Yang
Here we proposed a facile strategy to synthesize multi-layered gold nanoparticles/polyaniline/halloysite nanotubes (AuNPs/PANI/HNTs) nanostructures used for electrochemical sensors. The PANI/HNTs were firstly obtained by making use of the in situ polymerization as well as employing the thioglycollic acid (TA) as the dopant, thereafter, Au ions were anchored to TA and then reduced by PANI. Field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) observations implied that a large amount of uniform AuNPs were immobilized on the PANI/HNTs. The as-prepared AuNPs/PANI/HNTs nanostructures were also characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS), and the results confirmed the successful synthesis of AuNPs/PANI/HNTs nanostructures and explained the reactions in depth as well. Further investigations suggested that the AuNPs/PANI/HNTs nanostructures with well-separated AuNPs exhibited high electrochemical performance as sensors to detect hydrogen peroxide (H 2 O 2 ).
研究领域:
材料科学
·
分析化学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Zhuofan Huang,Qintie Lin,Haoyu Luo,Pengran Guo,Qingsong Weng,Yongqian Lei,Shuailong Cheng,Shuang-Shuang Liu
Progesterone (PGT), a widely used progestogen, has become a refractory pollutant present in urban runoff. The removal of PGT in wastewater is urgent owing to its endocrine disruption. In this study, a nano-CuO loaded halloysite nanotube (CuO/HNTs) was prepared by a simple hydrothermal method, which could be used as a catalyst to activate persulfate (PS) for the degradation of PGT. The characterizations showed that the nano-CuO was uniformly loaded on the HNTs to form corn-like structures with a large specific surface area. The optimal PGT degradation efficiency (100%) was achieved with the addition of 0.5 g/L catalyst and 7 mM PS. The effects of pH, HCO 3 – and Cl - on the catalytic activity of the CuO/HNTs-PS system were investigated. The results showed that 1) pH had little effect due to the buffer effect of Al 2 O 3 in HNTs, and nearly neutral solutions were obtained after reaction even in strong acidic or alkaline conditions, 2) low concentrations of HCO 3 – and Cl - had almost no impact on PGT degradation. Furthermore, the degradation mechanism was explored by quenching reactions, XPS, EPR studies and electrochemical experiments. The results demonstrated that the reaction was divided into the free radical pathway (SO 4 •- and •OH generation by the mutual transformation of PS, Cu(I), Cu(II), and Cu(III)) and the nonradical pathway (electron transfer process from the organic pollutant to the CuO/HNTs). In addition, the byproducts of PGT in the process were determined by LC-MS, and the possible transformation pathways were proposed. The CuO/HNTs-PS system might provide some new insights for the remediation of wastewaters.
研究领域:
环境科学
·
生物学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Yan Shi,Yang Zhang,Chengping Miao,Jianxing Yu,Xiaohua Tu,Jiayou Li
Plasma electrolytic oxidation (PEO) coatings with long-lasting active protection were prepared by incorporating 2-mercaptobenzothiazole (MBT)-loaded halloysite nanotubes (HNTs), followed by introduced insoluble Cu-MBT complex, has been achieved in present study. To further compare and analyze the corrosion characteristics of the sample, different halloysite nanotubes (HNTs, MBT@HNTs) profiles were also added to the electrolytes for the preparation of different oxide films (HNTs-PEO and MBT-HNTs-PEO). The coatings were characterized by scanning electron microscopy (SEM), film thickness meter, roughness meter, energy dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD). The corrosion behavior was evaluated by electrochemical impedance spectroscopy (EIS), and open circuit potential (OCP) tests. The results show that the long-term corrosion resistance of magnesium alloys can be improved by adding Cu - MBT-HNTs owning to the self-healing effect.
研究领域:
材料科学
·
电化学
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产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Fang Wang,Xianhong Zhang,Yuhong Ma,Wantai Yang
The hybrid composite of poly(3,4-ethylenedioxythiophene) (PEDOT) and halloysite nanotubes (HNTs) was synthesized by a two-step process. First, poly(sodium styrene sulfonate) (PSSNa) was grafted onto HNTs via surface initiated atom transfer radical polymerization. Then with the HNTs- g -PSS as a template and the grafted PSS chains as the counterion dopant, PEDOT was precipitated onto the template via in situ oxidization polymerization of EDOT to form HNTs@PEDOT hybrid composites. The conductivity of HNTs@PEDOT can reach up to 9.35 S/cm with the content of 40% HNTs- g -PSS, which increased almost 78 times than that of pure PEDOT (about 0.12 S/cm) prepared at the similar condition. Further treated with p -toluenesulfonic acid (TsOH) as external dopant, the conductivity of HNTs@PEDOT increased to 24.3 S/cm. The electrochemical properties of the composites were investigated with cyclic voltammetry, galvanostatic charge-discharge and electrochemical impedance spectroscopy with three-electrode cell configuration. The results showed that the capacitance of HNTs@PEDOT composite increased 55% than that of pure PEDOT.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Qiang Le,Zhilin Cheng
As the adsorption technique was concerned, the facile, intact and low-cost separation process of adsorbents was desirable to the prospective feasible application. In present work, the nano-Ag 2 O particles were encapsulated in the hollow nanostructure of halloysites (HNTs) with the aid of CTAB-stabilized HNTs micelle by the space confinement method, and then the nano-Ag 2 O@HNTs nanocomposite was assembled in PVP/PAN electrospinning nanofiber membrane (NFM), and finally PVP template was removed through etching method, so as to access the hierarchical-porous structure. The structure and composition of nano-Ag 2 O@HNTs/PAN NFM were resolved by a series of characterizations. The nano-Ag 2 O@HNTs/PAN NFM not only was of abundant multi-pore structure with larger specific surface area of 23.484 m 2 /g and higher pore volume of 0.111 mL/g, but also exhibited excellent mechanical performance, of which the tensile strength and Young's modulus were up to 6.1 MPa and 75.9 MPa, respectively. Thanks to the existence of the exclusive pore structure and nano-Ag 2 O, the nano-Ag 2 O@HNTs/PAN NFM showed better adsorption desulfurization performance in the simulated thiophene (TH) oil, of which the breakthrough and saturated adsorption capacity were as high as 35.269 mg/g and 54.481 mg/g, respectively. Ultimately, the adsorption mechanism of TH molecules on the nano-Ag 2 O@HNTs/PAN NFM could be taken into account the synergistic effect of the porous diffusion , interface adsorption and active site adsorption.
研究领域:
材料科学
·
环境工程
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Fan Wu,Jingqi Zheng,Zhixiong Li,Mingxian Liu
Three-dimensional (3D) printed polymer scaffolds can build engineered tissue constructs with complex and hierarchical structures, mechanical and biological heterogeneity. However, the interactions between the scaffolds and cells should be optimally designed for their practical application. In this work, 3D printed polylactic acid (PLA) pattern was functionalized by a polydopamine (PDA) interlayer to firmly bond the halloysite nanotubes (HNTs) on the surfaces of the PLA pattern for guiding cell orientation. A series of 3D printed PLA patterns with different stripe widths were characterized by scanning electron microscopy (SEM), polarized light microscopy (POM), 3D optical profiler and so on. The successful introduction of HNTs on PLA pattern was verified by field emission scanning electron microscopy (FE-SEM), X-ray photoelectron spectroscopy (XPS), water contact angle (WCA), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analyzer (TGA). The HNTs coating could effectively improve roughness and hydrophilicity of PLA pattern. In addition, in vitro human mesenchymal stem cells (hMSCs) culture experiments suggested that 3D printed PLA patterns with different strip widths exhibited different ability to induce cell orientation. The smaller the stripe width of the PLA pattern, the more suitable for cell orientation. When the layer height was set to 0.05 mm, the effect of inducing cell orientation was optimal. Meanwhile, the 3D printed PLA pattern with HNTs coating was more suitable for the adhesion and proliferation of cells. This works provides a general routine for improving the cell affinity of 3D printed PLA structure by the simple coating of nanoparticles, which shows the promising application in cell culture scaffolds, wound healing materials, and biosensors.
研究领域:
生物材料
·
组织工程
·
细胞生物学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Jingcheng Wu,Yi He,Liang Zhou,Xiangying Yin,Liyun Zhang,Jingyu Chen,Zhenyu Li,Yang Bai
As industrialization has spread all around the world, the problems of water pollution such as offshore oil spill and industrial sewage discharge have spread with it. Although many new separation materials have been successfully developed to deal with this crisis, a large number of water treatment materials only focus on the treatment of classified single water pollutant under mild conditions. It is a great challenge to treat soluble contaminants such as water-soluble dyes and insoluble contaminants, for example, emulsified oils simultaneously in a strong corrosive environment. Herein, in this work, corrosive resistance and multifunctional surface on a commercial polyvinylidene difluoride (PVDF) membrane via a tunicate-inspired gallic acid-assisted accurate-deposition strategy is created. Owing to the titanium–carboxylic coordination bonding and accurate-deposition strategy, the as-prepared membrane exhibits extraordinary stability, facing various harsh environmental challenges and incredibly corrosive situations (e.g., 4 M NaOH, 4 M HCl, and saturated NaCl solution). The robust multifunctional surface also endows commercial PVDF membrane with the ability for in situ separation and adsorption of surfactant-stabilized oil-in-water (corrosive and dyed) emulsions with high adsorption efficiencies up to 99.9%, separation efficiencies above 99.6%, and permeation flux as high as 15,698 ± 211 L/(m2·h·bar). Furthermore, the resultant membrane can be regenerated facilely and rapidly by flushing a small amount of HCl (4 M) or NaOH (4 M), making the corrosive resistance membrane attain a long-term and high-efficiency application for complex dyed wastewater treatment. Therefore, the multifunctional membrane has a broad application prospect in the industrial field.
研究领域:
环境科学
·
材料科学
·
化学工程
·
废水处理
✓ 已验证
DOI
PubMed
高影响因子
APPLIED THERMAL ENGINEERING
·
2026
·
IF 7.5
Yuxin Zhang,Jiayi Han,Yutong Yang,Yapeng Wang,Shaoxiang Li,Jiaji Cheng
HNTs are modified with DA, C and KH-560 as a flame-retardant filler. • The SDHs are first incorporated into MPCMs to build extra heat transfer channels. • SDH-MPCM/EP coatings significantly reduce indoor temperature fluctuation. • The composite coating reduces HRR and THR, showing excellent flame retardancy. Phase change material microcapsules (MPCMs) effectively address the leakage issue inherent in conventional phase change materials, while enabling efficient thermal energy storage and controlled heat release, thus providing an ideal material foundation for energy-saving building coatings. However, the defects of MPCMs—namely low thermal conductivity and flammability—seriously restrict their widespread application in practical engineering. To overcome these challenges, this study fabricated a novel modified phase change microcapsule (SDH-MPCMs) via in situ polymerization, using capric acid (CA) as the core and polymethyl methacrylate (PMMA) as the shell. Flame-retardant filler Si/DC-HNTs (SDHs) is incorporated into the system to endow the material with triple functionality: thermal energy storage, flame retardancy, and temperature regulation. The microcapsules are subsequently dispersed into epoxy resin (EP) to fabricate SDH-MPCM/EP composite coatings. Characterization techniques including TEM, XPS, and FTIR confirmed the successful synthesis of SDHs and SDH-MPCMs. When SDH-MPCMs dispersed in the EP, the composite coatings exhibit a 23.57% reduction in peak heat release rate (HRR), a 20.89% decrease in total heat release (THR). Small-scale room model test reveals that the coating reduces indoor temperature fluctuation effectively, enhancing thermal regulation capability. This research advances the development of multifunctional building coating materials by demonstrating a viable approach to simultaneously achieve efficient heat storage, enhanced flame safety, and improved temperature regulation.
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DOI
高影响因子
Membranes
·
2025
·Vol. 15
·期 7
·197
·
IF 3.6
Jiale Zhang,Huixin Dong,Fei Guo,Huijun Yi,Xiaobin Jiang,Gaohong He,Wu Xiao
In this work, HNTs@ZIF-67 composites were synthesized using the in situ growth method and incorporated into 6FDA-TFMB to prepare mixed-matrix membranes (MMMs). Scanning electron microscope (SEM) and transmission electron microscope (TEM) proved that the HNTs@ZIF-67 composite not only retained the hollow structure of HNTs, but also formed a continuous ZIF-67 transport layer on the surface of HNTs. The results of gas permeability experiments showed that with the increase in HNTs@ZIF-67 incorporation, the He permeability and He/CH4selectivity of MMMs showed a trend of increasing first and then decreasing. When the loading is 5 wt%, the He permeability and He/CH4selectivity of MMMs reach 116 Barrer and 305, which are 22.11% and 79.41% higher than the pure 6FDA-TFMB membrane. The results of density functional theory (DFT) and Monte Carlo (MC) calculations reveal that He diffuses more easily inside ZIF-67, HNTs and 6FDA-TFMB than CH4, and ZIF-67 shows larger adsorption energy with He than HNTs and 6FDA-TFMB, indicating that He is easily adsorbed by ZIF-67 in MMMs. Based on experimental and molecular simulation results, the mechanism of HNTs@ZIF-67 improving the He/CH4separation performance of MMMs was summarized. With the advantage of a smaller molecular kinetic diameter, He can diffuse through ZIF-67 on the tube orifice of HNTs@ZIF-67 and enter the HNTs’ hollow tube for rapid transmission. At the same time, He can also be rapidly transferred in the continuous ZIF-67 transport channel layer, which improves the He permeability and the He/CH4selectivity of MMMs.
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产品关联
DOI
PubMed
高影响因子
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