MICROCHIMICA ACTA
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2020
·Vol. 187
·期 12
·1-10
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IF 6.232
Zhong Yingying,Li Qing-lan,Lu Minglei,Wang Tiantian,Yang Huiyi,He Qiyi,Cui Xiping,Li Xiangguang,Zhao Suqing
A highly sensitive colorimetric sensing strategy based on enzyme@metal-organic framework (GAA@Cu-MOF) and IrO 2 /MnO 2 nanocomposite was exploited innovatively for screening of α-glucosidase (GAA) inhibitors. IrO 2 /MnO 2 nanocomposite exhibits excellent oxidase-mimicking activity which can directly catalyze the oxidation of 3,3 , 5,5 , -tetramethylbenzidine (TMB) into a blue product with an absorption maximum at 652 nm. And GAA@Cu-MOF can decompose L-ascorbic acid-2-O-α-D-glucopyranosyl (AAG) to ascorbic acid (AA). The produced AA can destroy the IrO 2 /MnO 2 nanocomposite and reduce its oxidase-like activity. However, the generation of AA is restricted when GAA inhibitors are added to the system, which allows the oxidase-like activity of the IrO 2 /MnO 2 nanocomposite to be maintained. In view of this, a method for screening of GAA inhibitors was developed. In addition to enhancing the stability of GAA, the method can also effectively avoid the potential interference of H 2 O 2 in the screening process of GAA inhibitors, which helps to improve the sensitivity of the method. Therefore, highly sensitive determination for acarbose and ascorbic acid are achieved with detection limits of 6.27 nM and 1.23 μM, respectively. The proposed method was successfully applied to screen potential GAA inhibitors from oleanolic acid derivatives.
Graphical abstract
研究领域:
生物化学
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药物开发
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分析化学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2022
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IF 16.744
Huachang Jin,Xuejiao Zhang,Yang Yu,Xueming Chen
The extensive evaporation-induced aggregation of scale inhibitors in the wastewater of recirculating cooling systems causes severe environmental pollution . In this study, Amino Trimethylene Phosphonic Acid (ATMP), an ordinary scale inhibitor, was degraded via electrochemical oxidation using a multi-layered Ti/IrO 2 -RhO x -TiO 2 /α-PbO 2 /β-PbO 2 electrode. The electrochemical oxidation experimental results verified the superior electro-catalytic properties of the β-PbO 2 electrode. Accelerated lifetime tests suggested that Ti/IrO 2 -RhO x -TiO 2 /α-PbO 2 /β-PbO 2 possesses a service lifetime of 201 h under a current density of 40000 A/m 2 , which is 3.4–100.5 times as long as other β-PbO 2 electrodes reported by other researchers. Four major operational parameters, namely electrolyte, current density, initial ATMP concentration, and pH, were discovered to significantly affect the ATMP degradation rate and electrical efficiency. The direct oxidation mechanism predominated in the degradation process of ATMP, achieving a 55.11% and 38.82% removal efficiency in Na 2 SO 4 and NaCl solutions, respectively. In addition, two possible degradation pathways of ATMP were proposed: induced by the breaking of either C-P or C-N bonds.
研究领域:
环境工程
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电化学
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废水处理
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Ruiqi Guo,Zhenglong Fan,Qiwei Zhou,Mengjie Ma,Wenxiang Zhu,Fan Liao,Hao Yang,Jiajie Wang,Zhenhui Kang,Minqi Sheng
Iridium oxide (IrO 2 ) has traditionally been considered to exhibit limited oxygen-reducing capacity. An effective approach to improve the oxygen reduction reaction (ORR) activity in parent catalytic materials is through atomic intercalation. However, the challenge lies in achieving a delicate balance between high ORR activity, structural stability, and minimizing the use of precious metals. Herein, we fabricate 3R-phase iridium oxide (3R-IrO 2 ) with superior ORR activity by intercalating a tiny amount of Pt (3.6 wt% Pt) into the interlayers of 3R-IrO 2 (3.6 wt% Pt-3R-IrO 2 ). When employed as an acidic ORR electrocatalyst, 3.6 wt% Pt-3R-IrO 2 shows a high half-wave potential (E 1/2 ) of 0.92 V (vs. RHE) in O 2 -saturated 0.1 M HClO 4 electrolyte, much better than those of Pt/C (0.850 V), 3R-IrO 2 (0.616 V), and Pt nanoparticles on 3R-IrO 2 surface (3.6 wt% Pt@3R-IrO 2 ) (0.618 V) electrocatalysts. It achieves high mass activity of 0.170 A mg Ir −1 at the potential of 0.9 V, which is 5.5 and 11.3 times than that of Pt/C (0.031 A mg Ir −1 ) and 3.6 wt% Pt@3R-IrO 2 (0.015 A mg Ir −1 ), respectively. Density functional theory (DFT) calculations and experiment results co-jointly demonstrate that the active center of Pt-3R-IrO 2 is anchored to the activated Ir atoms of the 3R-IrO 2 rather than Pt atoms. The d -band center of Ir 5 d orbitals of Pt-3R-IrO 2 is simultaneously regulated, which optimizes the energy barrier of adsorption/desorption toward the ORR process. Intriguingly, the intercalation of Pt atoms into trigonal rhodium oxide (Tri-RhO 2 ) also activates the ORR activity of Rh, suggesting the universality of this strategy. This discovery may provide a new and general way for activation of ORR activity of other precious metal-intercalated nonprecious metal oxide electrocatalysts.
研究领域:
材料科学
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电化学
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催化
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能源材料
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产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
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2024
·
IF 5.7
Yingying Zhong,Qing Wang,Zi-Jian Chen,Hongwu Wang,Suqing Zhao
Background In vitro screening strategies based on the inhibition of α-glucosidase (GAA) activity have been widely used for the discovery of potential antidiabetic drugs, but they still face some challenges, such as poor enzyme stability, non-reusability and narrow range of applicability. To overcome these limitations, an in vitro screening method based on GAA@GOx@Cu-MOF reactor was developed in our previous study. However, the method was still not satisfactory enough in terms of construction cost, pH stability, organic solvent resistance and reusability. Thence, there is still a great need for the development of in vitro screening methods with lower cost and wider applicability. Results A colorimetric sensing strategy based on GAA/(Au–Au/IrO 2 )@Cu(PABA) cascade catalytic reactor, which constructed through simultaneous encapsulating Au–Au/IrO 2 nanozyme with glucose oxidase-mimicking and peroxidase-mimicking activities and GAA in Cu(PABA) carrier with peroxidase-mimicking activity, was innovatively developed for in vitro screening of GAA inhibitors in this work. It was found that the reactor not only exhibited excellent thermal stability, pH stability, organic solvent resistance, room temperature storage stability, and reusability, but also possessed cascade catalytic performance, with approximately 12.36-fold increased catalytic activity compared to the free system (GAA + Au–Au/IrO 2 ). Moreover, the in vitro GAA inhibitors screening method based on this reactor demonstrated considerable anti-interference performance and detection sensitivity, with a detection limit of 4.79 nM for acarbose. Meanwhile, the method owned good reliability and accuracy, and has been successfully applied to the in vitro screening of oleanolic acid derivatives as potential GAA inhibitors. Significance This method not only more effectively solved the shortcomings of poor stability, narrow scope of application, and non-reusability of natural enzymes in the classical method compared with our previous work, but also broaden the application scope of Au–Au/IrO 2 nanozyme with glucose oxidase and peroxidase mimicking activities, and Cu(PABA) carrier with peroxidase mimicking activity, which was expected to be a new generation candidate method for GAA inhibitor screening.
研究领域:
生物技术
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催化
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药物发现
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酶学
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分析化学
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产品关联
DOI
PubMed
高影响因子
TALANTA
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2019
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IF 4.916
Xueliang Liu,Xinhuan Wang,Qiusen Han,Cui Qi,Chen Wang,Rong Yang
In this work, we reported a novel nanozyme synthesized by decorating highly dispersed ultrafine IrO 2 nanoparticles on reduced graphene oxide (rGO) nanosheets via a simple hydrothermal method . The as-prepared IrO 2 /rGO nanocomposites exhibited intrinsic peroxidase-like activity and could catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to produce blue product in the presence of H 2 O 2 . Catalytic kinetic of IrO 2 /rGO nanocomposites followed Michaelis-Menten behavior, exhibiting a higher affinity to TMB than horseradish peroxidase (HRP) enzyme. Catalytic mechanism studies suggested that the peroxidase-like activity of IrO 2 /rGO nanocomposites originated from their ability of electron transfer between substrate and H 2 O 2 . On the basis of high peroxidase-like activity of IrO 2 /rGO nanocomposites, a colorimetric strategy for rapid and sensitive detection of low weight biothiols was developed. The colorimetric detection assays for low weight biothiols showed high selectivity against other amino acids . Therefore, the IrO 2 /rGO nanozyme is expected for promising potential applications in the biosensor, diagnostics and environment.
研究领域:
纳米材料
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催化
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分析化学
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生物传感器
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生物技术
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产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2021
·Vol. 13
·期 9
·1164-1171
·
IF 2.896
Minglei Lu,Qiyi He,Yingying Zhong,Junkang Pan,Zhiting Lao,Mingxia Lin,Tiantian Wang,Xiping Cui,Jinlong Ding,Suqing Zhao
Progesterone (P4) belongs to a factor that affects stress response and is a potential carcinogen, and saliva levels are expected to be a standard measurement for clinical diagnosis. In this study, a new type of nanoflower with both recognition functionality and catalytic substrate ability was prepared by copper phosphate, Pt/IrO2 nanocomposites (Pt/IrO2 NPs), streptavidin (SA) and horseradish peroxidase (HRP) via a one-pot co-precipitation strategy. Due to the enhanced catalytic activity and stability of Pt/IrO2@SA@HRP nanoflowers, we developed a powerful and sensitive multiple-catalysis ELISA to monitor progesterone in saliva. Multiple-catalysis ELISA based on a specific antibody and Pt/IrO2@SA@HRP nanoflowers exhibited a linear interval range from 0.217 ng mL−1 to 7.934 ng mL−1. The median inhibitory concentration (IC50) for progesterone is 1.311 ng mL−1 and the limit of detection (LOD = IC10) is 0.076 ng mL−1 in the proposed method. Satisfactory recoveries were in a range of 79.6–107% with an acceptable coefficient of variation (below 10.6%). Results of the multiple-catalysis ELISA and LC-MS/MS had a good coincidence. Our result unraveled that multiple-catalysis ELISA is a potentially serviceable tool for the detection of progesterone in saliva.
研究领域:
分析化学
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生物化学
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纳米技术
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临床诊断
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
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IF 9.229
Yingying Zhong,Tiantian Wang,Zhiting Lao,Minglei Lu,Shan Liang,Xiping Cui,Qing-lan Li,Suqing Zhao
Herein, a Au-Au/IrO2 nanocomposite with tandem enzyme-mimicking activity was innovatively synthesized, which can show outstanding glucose oxidase (GOx)-like activity and peroxidase-like activity simultaneously under neutral conditions. Moreover, a Au-Au/IrO2@Cu(PABA) reactor was prepared via encapsulation of the Au-Au/IrO2 nanocomposite in a Cu(PABA) metal organic framework. The reactor not only exhibits excellent organic solvent stability, acid resistance, and reusability but also displays better cascade reaction catalytic efficiency (kcat/Km = 148.86 min–1 mM–1) than the natural free enzyme system (GOx/HRP) (kcat/Km = 98.20 min–1 mM–1) and Au-Au/IrO2 nanocomposite (kcat/Km = 135.24 min–1 mM–1). In addition, it is found that the reactor can catalyze glucose or dissolved oxygen to produce active oxygen species (ROS) including HO, 1O2, and O2–· through its enzyme-mimicking activity. Finally, the novel reactor was successfully used in organic dye degradation and antibacterial application. The results show that it can effectively degrade methyl orange, methylene blue, and rhodamine B, which all can reach a degradation rate of nearly 100% after interacting with Au-Au/IrO2@Cu (PABA) for 3.5 h. Furthermore, the reactor also exhibits excellent antibacterial activity, so as to achieve a complete bactericidal effect to Staphylococcus aureus and Escherichia coli at a concentration of 12.5 μg mL–1.
研究领域:
纳米材料
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催化
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环境科学
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材料科学
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生物技术
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DOI
PubMed
高影响因子
Materials Today Energy
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2023
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IF 9.3
Shanfu Sun,Guopan Sun,Pengfei Cheng,Ruiqi Liu,Chunfu Zhang
‘Outstanding’ electrocatalysts towards oxygen evolution reaction (OER) are springing up at present, to the extent that one questions if most nanomaterials are inherently highly active electrocatalysts . The answer is negative for certain easy-to-ignore data processing errors could lead to potential misjudgment of electrocatalytic activity. Combing through 100 highly cited papers (ESI 1% in Web of Science) concerning OER published in the last three years, the applications of uncompensated potential ( iR s )-correction rates are severely inconsistent. Herein, taking the benchmarks RuO 2 and IrO 2 as model catalysts, the authors investigated the effects of various iR s -correction rates on OER performance (overpotential, Tafel slope, and turnover frequency). The unanticipated discoveries may provoke a re-examination of those reported as ‘great’ OER electrocatalysts as well as help draw attention to iR s -correction rates in the field of electrocatalysis .
研究领域:
材料科学
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电化学
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Wang Dawei,Lin Fangxu,Luo Heng,Zhou Jinhui,Zhang Wenshu,Li Lu,Wei Yi,Zhang Qinghua,Gu Lin,Wang Yanfei,Luo Mingchuan,Lv Fan,Guo Shaojun
Using metal oxides to disperse iridium (Ir) in the anode layer proves effective for lowering Ir loading in proton exchange membrane water electrolyzers (PEMWE). However, the reported low-Ir-based catalysts still suffer from unsatisfying electrolytic efficiency and durability under practical industrial working conditions, mainly due to insufficient catalytic activity and mass transport in the catalyst layer. Herein we report a class of porous heterogeneous nanosheet catalyst with abundant Ir-O-Mn bonds, achieving a notable mass activity of 4 A mg Ir −1 for oxygen evolution reaction at an overpotential of 300 mV, which is 150.6 times higher than that of commercial IrO 2 . Ir-O-Mn bonds are unraveled to serve as efficient charge-transfer channels between in-situ electrochemically-formed IrO x clusters and MnO x matrix, fostering the generation and stabilization of highly active Ir 3+ species. Notably, Ir/MnO x -based PEMWE demonstrates comparable performance under 10-fold lower Ir loading (0.2 mg Ir cm −2 ), taking a low cell voltage of 1.63 V to deliver 1 A cm −2 for over 300 h, which positions it among the elite of low Ir-based PEMWEs.
研究领域:
材料科学
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能源技术
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Jing Luo,Yanbin Wang,Di Cao,Ke Xiao,Tao Guo,Xu Zhao
In this paper, a TiO 2 /Ru-IrO 2 bifacial electrode constituted of TiO 2 nanotubes and Ru-IrO 2 coating was prepared and used for the degradation of 2,4-dichlorophenol (2,4-DCP) under UV light irradiation. The TiO 2 /Ru-IrO 2 bifacial electrode exhibited a synergetic effect on the degradation of 2,4-DCP with the pseudo-first-order rate constant of 0.1664 min −1 , which was 3.6 and 5.7 times higher than that of TiO 2 electrode and Ru-IrO 2 electrode, respectively. Influencing factors on the degradation of 2,4-DCP were investigated and the removal of 2,4-DCP was favored at basic condition, higher cell voltage, NaCl concentration and ion strength. In addition, the bifacial electrode also exhibited high efficiency for the photoelectrocatalytic treatment of landfill leachate and 59% of COD was removed with initial COD of 850 mg/L. The bifacial electrode exhibited good stability and showed the promising potential for practical treatment of wastewater.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2024
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IF 8.1
Hao Wu,Guoxiang Wang,Xinxin Zhang,Qingwang Min,Jiacheng Wang,Dazhi Wang,Longsheng Cao
Water electrolysis is one of the most promising green hydrogen production technologies. However, using precious metal materials as electrodes for these electrolyzers incurs high costs. To address these challenges and simultaneously retain the catalytic activity of precious metals, we synthesize a low-iridium catalyst, Nd–IrO 2 . At 10 and -10 mA/cm 2 , this catalyst exhibits 233 and 36 mV overpotentials. Nd – IrO 2 maintains stability over prolonged operation in acidic environments, as evidenced by its consistent overpotential. Advanced calculations using density functional theory (DFT) have demonstrated that incorporating Nd and an ample amount of oxygen vacancies can modulate the d-band center of Ir and reduce the adsorption energy of electrochemical reaction intermediates. In summary, we present the synthesis of a low-iridium catalyst, which provides valuable insights for the design and development of catalysts with improved electrocatalytic performance.
研究领域:
材料科学
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电化学
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产品关联
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2014
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IF 2.871
Hao Li,Qingni Yu,Bin Yang,Zhongjian Li,Lecheng Lei
Galvanostatic anodic oxidation of artificial human urine (AHU) was carried out by using boron doped diamond (BDD) and IrO 2 electrodes respectively. It was found that organic compounds in urine could be almost completely mineralized in a few hours and ammonia may be oxidized into N 2 by the electro-catalytic process. However, the oxidation processes were highly dependent on the electrode materials. On the non-active BDD electrode complete oxidation occurred, and the final oxidation products of inorganic ions, including ClO 4 − and NO 3 − , were formed. Whereas on the active IrO 2 electrode, the final products generated and left in solution were highly toxic substances, including N 2 H 4 and NO 2 − , because the oxidizing activity on the IrO 2 electrode surface is relatively low. The pH values during the degradation process were monitored and the corresponding degradation mechanisms and pathways on both electrodes are proposed based upon the measured inorganic intermediates.
研究领域:
环境科学
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电化学
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水处理技术
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生物医学工程
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分析化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）