JOURNAL OF APPLIED POLYMER SCIENCE
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2016
·Vol. 134
·期 10
·
IF 1.866
Yuanyuan Liu,Xueqin Li,Yun Qin,Ruili Guo,Jianshu Zhang
Novel facilitated-transport mixed-matrix membrane (MMM) were prepared through the incorporation of polydopamine (PDA) microspheres into a poly(amide- b -ethylene oxide) (Pebax MH 1657) matrix to separate CO 2 –CH 4 gas mixtures. The Pebax–PDA microsphere MMMs were characterized by Fourier transform infrared spectroscopy, scanning electron microcopy, X-ray diffraction, differential scanning calorimetry, and thermogravimetric analysis. The PDA microspheres acted as an adhesive filler and generated strong interfacial interactions with the polymer matrix; this generated a polymer chain rigidification region near the polymer–filler interface. Polymer chain rigidification usually results in a larger resistance to the transport of gas with a larger molecular diameter and a higher CO 2 –CH 4 selectivity. In addition, the surface of PDA microspheres contained larger numbers of amine, imine, and catechol groups; these were beneficial to the improvement of the CO 2 separation performance. Compared with the pristine Pebax membrane, the MMM with a 5 wt % PDA microsphere loading displayed a higher gas permeability and selectivity; their CO 2 permeability and CO 2 –CH 4 selectivity were increased by 61 and 60%, respectively, and surpassed the 2008 Robeson upper bound line. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44564.
研究领域:
材料科学
·
环境工程
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DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 6
·3521-3527
·
IF 3.108
Jie Hou,Fen Zhang,Delin Cheng,Xuetao Shi,Xiaodong Cao
Mineralization on bone repair devices is beneficial for osteoconductivity and thus osteogenesis. Surface chemistry modification by plasma treatment can significantly improve mineralization. In this study, superficially porous poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) microsphere scaffolds (PH) were processed by oxygen and ammonia plasma followed by incubation in simulated body fluids (SBF) for mineralization. The effect of plasma treatment and incubation time on the features of the mineralization layer was investigated. The results showed that novel porous mineralization layers were obtained on the unmodified PH (As-grown), oxygen pretreated PH (OPH) and ammonia pretreated PH (NPH). The mechanical property and superficially porous structures of scaffolds changed little after plasma treatment. However, OPH produced the most significant apatite layer with an increasing roughness with mineralization time. In contrast, As-grown just had a smooth mineralization layer. Moreover, the mineralization layer on As-grown was easy to peel off compared with those on OPH and NPH, demonstrating that plasma treatment could enhance the bonding force between apatite and the substrate surface. The surface chemical analysis proved that the difference in outcome of mineralization was because plasma treatment introduced additional polar domains onto the scaffolds. This work provided a promising mineralization material system for bone repair application.
研究领域:
材料科学
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生物医学工程
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生物材料
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DOI
高影响因子
Biomaterials Advances
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2022
·
IF 0
Xueqing Yang,Shizhen Wang,Xiang Zhang,Changqing Ye,Shige Wang,Xiao An
The development of tissue adhesive embolization microspheres with imaging ability is one of the important methods to improve the efficacy of interventional embolization. This study reported the synthesis of iodine (I)-polyvinyl alcohol (PVA)@polydopamine (PDA) microspheres to achieve the computed tomography image, drug loading and controlled release, and the enhanced embolization of liver portal vein. The [email protected] microspheres with a diameter of 147.9 μm showed an excellent computed tomography imaging ability. Moreover, the introduction of PDA endowed the [email protected] microspheres with tissue adhesive ability and therefore the in vivo embolization effect was improved. The in vivo embolization results showed that focal necrosis of hepatocytes with necrotic cell fragments and inflammatory cell infiltration was observed in the liver tissue, proving that the [email protected] microspheres have an enhanced embolization effect than PVA particles. The [email protected] microspheres were further used to deliver and release of chemotherapeutic drugs (5-fluorouracil), which displayed an initial fast release (release amount: 29.74%) in the first 24 h and then a sustained release of 34.48% within 72 h. Moreover, as a universal platform, the [email protected] microspheres could combine with other imaging agents like Bi 2 S 3 , thus holding a great potential in the interventional treatment of different diseases.
研究领域:
医学影像
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药学
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介入放射学
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生物材料
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产品关联
DOI
PubMed
JOURNAL OF PEPTIDE SCIENCE
·
2022
·Vol. 28
·期 10
·e3411
·
IF 2.408
Shu Bai,Jie Zhang,Liyan Zhu,Xiaoxing Gong,Linling Yu,Yan Sun
Oriented immobilization of antibodies is important for the effective recognition of target antigens. In this paper, a heptapeptide ligand, HWRGWVC (HC7), was modified onto non-porous monosized poly(glyceryl methacrylate) (pGMA) microspheres (named pGMA-HC7) to explore the antibody immobilization behaviors. Characterization of the microspheres by particle size analyzer, scanning electron microscopy, Fourier transform infrared spectroscopy, and reversed-phase chromatography proved the success of each fabrication step. The capacity and activity of antibody immobilization through HC7 were studied using immunoglobulin G (IgG) as a model antibody and horseradish peroxidase (HRP) as a model antigen. Additionally, IgG immobilizations on pGMA microspheres by nonspecific adsorption and covalent coupling through carbodiimide chemistry were conducted for comparison. pGMA-HC7 exhibited an IgG adsorption capacity of 3–4 mg/g in 10 min by the specific binding of HC7 without nonspecific interactions. Notably, the ligand HC7 showed a by two orders of magnitude stronger affinity for IgG than its original hexapeptide ligand HWRGWV. Moreover, the capacity and activity of the immobilized anti-HRP antibody on pGMA-HC7 were 1.6-fold and 3-fold higher than those of the covalent coupling, respectively. The results proved the superior role of HWRGWVC in the affinity binding of antibody and the potential of pGMA-HC7-25 in immunoassay and immunodiagnostic applications.
研究领域:
生物化学
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生物技术
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材料科学
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免疫学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
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2022
·
IF 6.14
Jing-Yuan Ma,Kai-Xuan Wang,Ming Ma,Yu Zhang
As an emerging storage medium, DNA is a crucial carrier for future data storage. DNA has a better storage density and a longer storage life than conventional storage media. However, DNA’s key limitations as a storage medium are the precision of information reading and storage stability. Herein, we designed and successfully developed a switchable DNA storage nanocomposite structure (MM-DNA/DNA’-SiO2). The composite structure employs magnetic microspheres (MMs) based on Fe3O4 nanoparticles as the DNA carrier for storing information (MM-DNA) and silicon dioxide nanoparticles modified with complementary strands as the protective outer layer (DNA’-SiO2), and its switchability and DNA sequence reading accuracy were both validated in this study. This method provides a novel nanostructure medium and technical proposal for efficient DNA storage with potential application value.
研究领域:
纳米技术
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生物技术
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数据存储
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Yuxia Pang,Peiyi Lin,Zhengsong Chen,Mingsong Zhou,Dongjie Yang,Hongming Lou,Xueqing Qiu
In this study, a porous polyamine lignin microsphere (PPALM) was prepared through the inverse suspension polymerization combined with freeze-drying, during which sodium lignosulfonate and polyetheramine (PEA) were crosslinked with epichlorohydrin (ECH) as the cross-linker. By adjusting the amount of ECH and PEA, the optimized PPALM exhibited suitable crosslinking degree, ensuring a balance of framework flexibility and rigidity, thereby facilitating the formation of abundant and fine pores. PPALM demonstrated good mechanical properties comparable to commercial sulfonated polystyrene cationic resin, with a porosity of 61.12 % and an average pore size of 283.51 nm. The saturation adsorption capacity of PPALM for Pb 2+ was measured to be 156.82 mg/g, and it remained above 120 mg/g after five cycles of regeneration. Particularly, the concentration of 50 mg/L Pb 2+ solution could be reduced to 0.98 mg/L after flowing through the PPALM packed bed, indicating the great potential of PPALM for application in wastewater treatment.
研究领域:
材料科学
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环境科学
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产品关联
DOI
PubMed
高影响因子
Regenerative Biomaterials
·
2024
·
IF 5.6
Hu Zhaofan,Zhang Yunyang,Zhang Jingjing,Zheng Ran,Yang Yang,Kong Fei,Li Haoran,Yang Xinyan,Yang Shuhui,Kong Xiangdong,Zhao Ruibo
Biomineralization-based cell-material living composites ex vivo showed great potential for living materials construction and cell regulation. However, cells in scaffolds with unconnected pores usually induce confined nutrient transfer and cell–cell communications, affecting the transformation of osteoblasts into osteocytes and the mineralization process. Herein, the osteoblast-materials living hybrids were constructed with porous PLLA microspheres using a rational design, in which cell-based living materials presented an improved osteoblast differentiation and mineralization model using rationally designed cell-microsphere composites. The results indicated that the microfluidic-based technique provided an efficient and highly controllable approach for producing on-demand PLLA microspheres with tiny pores (<5 μm), medium pores (5–15 μm) and large pores (>15 μm), as well as further drug delivery. Furthermore, the simvastatin (SIM)-loaded porous PLLA microsphere with ε-polylysine (ε-PL) modification was used for osteoblast (MC3T3-E1) implantation, achieving the cell-material living microhybrids, and the results demonstrated the ε-PL surface modification and SIM could improve osteoblast behavior regulation, including cell adhesion, proliferation, as well as the antibacterial effects. Both in vitro and in vivo results significantly demonstrated further cell proliferation, differentiation and cascade mineralization regulation. Then, the quantitative polymerase chain reaction or histological staining of typical markers, including collagen type I, alkaline phosphatase, runt-related transcription factor 2 and bone morphogenetic protein 2, as well as the calcium mineral deposition staining in situ, reconfirmed the transformation of osteoblasts into osteocytes. These achievements revealed a promising boost in osteogenesis toward mineralization at the microtissue level by cell-microsphere integration, suggesting an alternative strategy for materials-based ex vivo tissue construction and cell regulation, further demonstrating excellent application prospects in the field of biomineralization-based tissue regeneration.
研究领域:
组织工程
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再生医学
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生物材料学
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产品关联
DOI
PubMed
高影响因子
Materials Today Communications
·
2024
·
IF 3.7
Yang Yang,Huanxi Zhou,Zicheng Zou,Xiangjun Yang,Haijun Du
In this paper, Vanadium doped CeO 2 microsphere were synthesized using a facile hydrothermal method, and three distinct molar ratios of Ce:V precursors (15:1, 11:1 and 7:1) were investigated. The as-prepared materials were then utilized for the sensitive detection of volatile organic compounds (VOCs), specifically acetone. Results show that the V doping leads to a significant improvement in acetone response compared to the pure CeO 2 sensor. Notably, the V-doped CeO 2 sensing material with the optimal ratio of 11:1 has the highest response value of ∼12 for 100 ppm acetone at a low working temperature of 230 °C. Additionally, this sensor exhibits fast response time (15 s) and recovery time (10 s). Moreover, the V-doped CeO 2 (11:1) sensor exhibits a broad concentration range of 0.5–500 ppm for acetone detection. This material also demonstrates great cycle stability, maintaining high stability over a 60-day testing period (RSD = 0.91 %). The as-prepared V-doped CeO 2 sensor exhibits excellent sensitivity, response and recovery time, and cycle stability, making it a promising candidate for practical applications in acetone sensing.
研究领域:
材料科学
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化学传感器
·
环境监测
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产品关联
DOI
高影响因子
Surface Topography-Metrology and Properties
·
2024
·Vol. 12
·期 2
·025016
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IF 2
Shengli Chen,Jiyuan Zhu
Rapid corrosion rate is limiting the engineering application of magnesium alloys. In this paper, an attempt was made to produce a corrosion resistant coating on the surface of AZ91D magnesium alloy using hydrothermal method. The coating surface is covered with microspheres and has a dense structure, which effectively isolates the contact between the outside world and the substrate. The corrosion potential(E) raised from −1.57 V to −0.45 V compared to the bare sample. The corrosion current density and corrosion rate of the coating can be reduced by 6 orders of magnitude, and the polarization resistance raised by 6 orders of magnitude. The thickness of the coating is 45.4 μm at the moment, with a minimum of defects on the surface, resulting in excellent corrosion resistance in the immersion test. The coating also has good adhesion strength at 4B, which can expand the application range of magnesium alloy in corrosive environments.
研究领域:
材料科学
·
腐蚀与防护
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DOI
高影响因子
CHEMICAL ENGINEERING COMMUNICATIONS
·
2019
·
IF 1.431
Lijuan Yang,Hong Yuan,Siyu Wang,Jie He,Ning Yan
In this study, concave carbon microspheres (CCMSs) were synthesized using glucose as the raw material in the presence of an anionic surfactant sodium dodecyl sulfate (SDS) by a hydrothermal method. Sulfonic acid groups (−SO3H) were attached on the CCMSs surfaces by sulfonation using concentrated sulfuric acid, affording a solid acid catalyst (CCMSs catalyst). Scanning electron microscopy (SEM) results revealed that the diameters of the microspheres are 1–3 μm, and the diameters of the concave are 1–2 μm; hence, micron or submicron reaction cells can be formed Furthermore, sulfonation did not change the morphology of the carbon microspheres. N2-BET measurement results revealed that at a hydrothermal temperature and time of 180 °C and 8 h, respectively, and an SDS dosage of 0.10 g, the Brunauer-Emmett-Teller (BET) surface area of CCMSs could reach up to 7.7 m2/g. X–ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR) results confirmed that CCMSs are successfully modified by sulfonation. The surface acid amounts of CCMSs before and after sulfonation were 3.7 and 5.6 mmol H+/g, respectively. CCMSs catalyst was used to catalyze the transesterification of waste frying oil, affording fatty acid methyl ester in 93% yield. CCMSs catalyst was used to catalyze the epoxidation of waste frying oil, achieving a double-bond conversion of 79% and a relative epoxy yield of 57%.
研究领域:
材料科学
·
催化化学
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DOI
高影响因子
MACROMOLECULAR RESEARCH
·
2020
·Vol. 28
·期 6
·644-649
·
IF 2.047
Zhen Shuang,Zhao Cheng,Zhao Xin,Ji Wu,Li Jieshou
Gut microbiota play an important role in many diseases. However, few researches evaluated the effect of faecal bacteria transplantation in protecting gut barrier during colitis. In this study, we focused on the effect of faecal microbiota encapsulated alginate microsphere on dextran sulfate sodium (DSS) induced colitis mice. Bacteria are sensitive to gastric juice and digestive enzymes, which is the dilemma of utilizing microbiota. Through taking advantage of alginate, microspheres that could protect its contents were fabricated. In vitro drug release experiment demonstrated their ability in protecting contents in simulated gastric fluid and release contents in simulated intestinal fluid. Thus, the resultant microsphere could be used in faecal microbiota transplantation. In vivo , the transplantation of faecal microbiota from healthy mice showed protection against DSS induced oxidative stress and gut barrier damage. Our findings suggest that the faecal microbiota transplantation could be a potential effective treatment for protecting gut barrier in inflammatory bowel diseases (IBD) colitis with faecal microbiota encapsulated alginate microsphere.
研究领域:
胃肠病学
·
微生物学
·
药剂学
✓ 已验证
DOI
高影响因子
ACS Applied Bio Materials
·
2024
·
IF 4.6
Juan Zhou,Yanling Zhao,Yan Ling,Peng Zhao,Hui Gao,Yang Yang,Jinghua Chen
By recruiting stem cells into scaffolds and differentiating them into osteoblasts, stem cells can be mobilized to directly repair bone defects, which avoids a series of disadvantages of exogenous stem cell implantation. In this study, a microsphere-composite hydrogel for the recruitment and osteogenic differentiation of stem cells was constructed. Methacrylic anhydride modified gelatin (GelMA) and heparin (HepMA), as well as nanohydroxyapatite (nHAP), were used to prepare microspheres followed by adsorbing platelet-derived growth factor BB (PDGF-BB) whose loading efficiency was 53.7 ± 2.2%. Then the microspheres were compounded to the GelMA hydrogel encapsulated with simvastatin (SIM) to obtain microsphere-composite hydrogel GHnH-P@GS. GHnH-P@GS hydrogel could slowly release SIM and PDGF-BB, and the extents of release within 7 days were 44.1 ± 2.0% and 32.8 ± 1.1%. The synergistic effect of small molecule drugs and growth factors not only induced the recruitment of rabbit bone marrow-derived mesenchymal stem cells, but also promoted the osteogenic differentiation of stem cells, which was confirmed by experiments of cell migration, alkaline phosphatase, and alizarin red staining. Collectively, the microsphere-composite hydrogel GHnH-P@GS has a certain reference significance for the design of scaffolds for alveolar bone repair and regeneration.
研究领域:
组织工程
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再生医学
·
生物医学材料
·
干细胞生物学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）