ACS Applied Bio Materials
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2024
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IF 4.6
Fayang Li,Xianhuang Chen,Yuanqiao He,Zhiping Peng
The development of nanocarriers to prolong the residence time and enhance the permeability of chemotherapeutic drugs on bladder mucosa is important in the postsurgery treatment of superficial bladder cancers (BCs). Here, the mucoadhesive HA-SH/PF127 nanogels composed of a temperature-sensitive Pluronic F127 (PF127) core and thiolated hyaluronic acid (HA-SH) shell were prepared by the emulsification/solvent evaporation method. The nanogels were constructed through the thiol-maleimide click reaction in the HA-SH aqueous side of the oil–water interface and self-oxidized cross-linking thiols between HA-SH. The HA-SH/PF127 nanogels prepared at different thiol-to-maleimide group molar ratios, water-to-oil volume ratios, and cross-linking reaction times were characterized regarding hydrodynamic diameter (Dh) and zeta potential (ζ), and the optimal formulation was obtained. The excellent mucoadhesive properties of the HA-SH/PF127 nanogels were evaluated by using the mucin particle method. Doxorubicin (DOX) was encapsulated in the PF127 core of DOX@HA-SH/PF127 nanogels with a high loading efficiency (87.5%) and sustained release from the nanogels in artificial urine. Ex vivo studies on porcine bladder mucosa showed that the DOX@HA-SH/PF127 nanogels enhanced the penetration of the DOX into the bladder mucosa without disrupting the mucus structure or the bladder tissue. A significant dose-dependent cytotoxic effect of DOX@HA-SH/PF127 nanogels on both T24 and MB49 cells was observed. The present study demonstrates that the mucoadhesive HA-SH/PF127 nanogels are a promising intravesical drug delivery system for superficial BC therapy.
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PubMed
高影响因子
NANOTECHNOLOGY
·
2014
·Vol. 25
·期 29
·295103
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IF 3.672
Jun Chen,Xiao-Quan Yang,Yuan-Zheng Meng,Huan-Huan Huang,Meng-Yao Qin,Dong-Mei Yan,Yuan-Di Zhao,Zhi-Ya Ma
Probe bismuth sulfide modified with Pluronic F127 (Bi2S3-PF127), which has high biocompatibility and dispersibility, is synthesized using triblock copolymer Pluronic F127 to modify hydrophobic Bi2S3 nanoparticles that are prepared by a hot injection method. TEM results show that most of the probe has a length of about 14.85 ± 1.70 nm and a breadth of about 4.79 ± 0.63 nm. After injected into the tail vein of a mouse, the probe has obvious CT contrast enhancement capability from x-ray CT imaging results. Meanwhile, the probe's in vivo toxicity is also studied. It is found that hematoxylin and eosin stains of major organs have no change. A biochemical analysis (alanine aminotransferase and aspartate aminotransferase) prove the probe has no adverse effects. The results of a blood analysis (white blood cell count, red blood cell count, hemoglobin, and platelet count) are also normal. The biological distribution of Bi by ICP-AES shows that most of nanoparticles are cleaned out after injection 48 h, and the circulation half-life of the probe is 5.0 h, suggesting that Bi2S3-PF127 has a long circulation and indicating that the Bi2S3-PF127 probe has good biocompatibility and safety.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2012
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IF 1.289
Chun-Hui Du,Chun-Jin Wu,Li-Guang Wu
Amphiphilic copolymer Pluronic F127 was used as macromolecular additive to investigate the polymorphism and thermoresponsive properties of poly(vinylidene fluoride) (PVDF) membranes. Fourier transform infrared spectrometer (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were conducted to characterize the polymorphism and morphology of PVDF/F127 blend membranes. FTIR results indicated that F127 existed stably in the blend membranes, and lower F127 concentration in the cast solution was in favor of the formation of α-crystal phase, but higher F127 concentration could promote the formation of β- and γ-crystal phase in PVDF membranes. The results of XRD also confirmed these phenomena. With the increase of F127 in the cast solutions, a more sponge-like structure appeared at the bottom surface of the membranes as investigated by SEM. PVDF/F127 blend membranes also exhibited good thermoresponsive properties. The water flux of the membranes increased distinctly with the increase of the experimental temperature, decreased with the decrease of the temperature, and the increasing and decreasing curves were almost overlapped. Contact angle measurement and permeation experiment indicated that the blend membranes had good hydrophilicity and fouling resistance. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
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International Journal of Nanomedicine
·
2017
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IF 4.3
Xiaoyan Wu,Weihong Ge,Tengfei Shao,Weijun Wu,Jian Hou,Li Cui,Jing Wang,Zhenghai Zhang
Biochanin A (BCA), a natural dietary isoflavone, has been reported to show anticancer activities. However, its low biological availability and poor aqueous solubility limit its usefulness as a chemotherapeutic agent. We developed BCA-loaded micelles with Pluronic F127 and Plasdone S630 (BCA-FS). The optimized, spherical-shaped BCA-FS was obtained at a ratio of 1:1 (F127:S630). The particle size was 25.17±1.2 nm, and the zeta potential was −10.9±0.24 mV. BCA solubility in water increased to 5.0 mg/mL after encapsulation, and the drug-loading efficiency was 5.88%±0.76%. In vitro release experiments showed a delayed release of BCA from the mixed micelles. Furthermore, the BCA absorption permeability across a Caco-2 cell monolayer from the apical side to the basolateral side increased by 54% in BCA-FS. A pharmacokinetics evaluation showed a 2.16-fold increase in the relative oral bioavailability of BCA-FS compared with raw BCA, indicating that the mixed micelles may promote absorption in the gastrointestinal tract. A gastrointestinal safety assay was used to assess the reliability and safety of BCA-FS. On the basis of these findings, we conclude that this simple nanomicelle system could be leveraged to deliver BCA and other hydrophobic drugs.
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ACS Omega
·
2021
·
IF 3.512
Jingjing Zong,Hao Peng,Xin Qing,Zhe Fan,Wenjing Xu,Xuanlong Du,Ruihua Shi,Yewei Zhang
Combination therapy such as photodynamic therapy (PDT)-enhanced chemotherapy is regarded as a promising strategy for cancer treatment. Boron-dipyrromethene (BODIPY), as close relatives of porphyrins, was widely used in PDT. However, poor water solubility, rapid metabolism by the body and lack of targeting limits its clinical application. Lenvatinib, as the first-line drug for molecular-targeted therapy of liver cancer, restricted its clinical application for its side effects. Herein, to achieve the synergy between PDT and chemotherapy, we synthesized two halogenated BODIPY, BDPBr2 and BDPCl2, which were prepared into self-assembly nanoparticles with lenvatinib, and were encapsulated with Pluronic F127 through the nanoprecipitation method, namely, LBPNPs (LBBr2 NPs and LBCl2 NPs). The fluorescence quantum yields of LBPNPs were 0.73 and 0.71, respectively. The calculated loading rates of lenvatinib for LBBr2 NPs and LBCl2 NPs were 11.8 and 10.2%, respectively. LBPNPs can be hydrolyzed under weakly acidic conditions (pH 5.0) to generate reactive oxygen species (ROS), and the release rate of lenvatinib reached 88.5 and 82.4%. Additionally, LBPNPs can be effectively taken up by Hep3B and Huh7 liver cancer cells, releasing halogenated BODIPY and lenvatinib in the acidic environment of tumor cells to enhance the targeting performance of chemotherapeutics. Compared with free lenvatinib and separate halogenated BODIPY, LBPNPs can inhibit tumor growth more effectively through pH-responsive chemo/photodynamic synergistic therapy and significantly promote the cascade of caspase apoptotic protease. This study shows that LBPNPs can be a promising nanotheranostic agent for synergetic chemo/photodynamic liver cancer therapy.
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PubMed
高影响因子
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
·
2025
·
IF 2.9
Li Caixia,Zhou Qin,Chao Zhenzhen,Li Liang
In this study, the preparation of pH- and reduction-responsive doxorubicin (DOX)-loaded hyaluronate acid-F127 supramolecular hydrogels (DOX@Gels) with targeting ability due to the incorporation of hyaluronic acid is described. By combining Pluronic F127-modified hyaluronic acid (HA-F127), disulfide-modified β-cyclodextrin, α-cyclodextrin, and DOX, hydrogels were constructed through host–guest complexation and hydrogen bonding interactions, and a tailored platform for targeted drug delivery was provided. The chemical composition and rheological properties were comprehensively analyzed. Considering the controlled complexation between DOX and the hydrogel skeleton and the ability of HA to target cancer cells, controlled drug release from the hydrogel G[15,5,5] was investigated under various conditions in vitro. The cumulative amount of DOX released from hydrogel G[15,5,5] showed superior pH- and reduction-controlled release behavior. These results were likely caused by the HA-F127 ester bonds cleavage in acidic environments and the S‒S bond cleavage within the hydrogel networks in the presence of glutathione. Furthermore, the DOX release kinetics were analyzed using Higuchi and Korsmeyer-Peppas models. The results demonstrated that the experimental data was effectively fit with these two models, and the data fitted by using Korsmeyer-Peppas also indicated nonFickian diffusion kinetics of the DOX being released from hydrogels. Owing to the ability of HA to target SKOV-3 cells, the cytotoxicity experiments revealed that DOX@G[15,5,5] exhibited more significant anticancer effects than free DOX. Consequently, DOX@Gels containing HA have emerged as promising candidates for the targeted delivery and release of anticancer drugs.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Chengdong Li,Lingfeng Li
PA/F127 co-assembly forms robust Si–O–P bonds and uniform microstructure in silica xerogels. • Xerogels integrate high strength, monolithicity, self-extinguishing ability, and thermal insulation. • PA's dual role enables rapid gelation, bypassing conventional slow acid-catalyzed growth. • Excellent fire resistance with minimal flame damage outperforms commercial silica aerogel sheets. • A green, additive-free strategy overcomes the flame-retardancy vs. mechanical-integrity trade-off. Conventional flame-retardant additives often raise environmental and health concerns due to their toxicity and persistence. Developing high-performance, inherently fire-resistant silica xerogel monoliths via scalable ambient pressure drying remains a significant challenge, as mechanical robustness, monolithic integrity, and flame retardancy are typically mutually exclusive. This study addresses this issue by introducing a green and synergistic strategy using bio-derived phytic acid (PA) and the amphiphilic block copolymer Pluronic F127 to direct the sol-gel co-assembly of a methyltrimethoxysilane/tetraethoxysilane (MTMS/TEOS) system. PA serves dual roles: as a potent biobased acid catalyst, it accelerates precursor hydrolysis, and as a non-toxic, multidentate cross-linker, it forms persistent Si–O–P bonds that chemically reinforce the silica network. F127 acts as a microstructure director, templating a homogeneous gel network with robust inter-particle connectivity. This cooperative action enables rapid gelation (within 1–20 min) and yields monolithic phosphorus-incorporated silica (P-silica) xerogels. The optimized material exhibits excellent mechanical performance (compression strength = 0.140 MPa, strain = 60.3%), outstanding thermal stability (90.3 wt% residual mass at 1000 °C), and superior fire resistance, showing immediate self-extinguishment and minimal damage upon direct flame impingement. It also provides effective thermal insulation, surpassing commercial silica aerogel sheets at a thickness of 3 mm. By replacing conventional hazardous flame retardants with benign, biobased PA and achieving a unique property synergy, this work presents a viable and environmentally sound design principle for advanced thermal insulation materials in fire-risk environments, contributing to safer and more sustainable material solutions. Download: Download high-res image (123KB) Download: Download full-size image
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INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
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2026
·
IF 2
Ali Edalat Irani,Mohammad Reza Farahpour,Mohammad Reza Valilou,Zohreh Ghazi Tabatabaei
Hydrogels have emerged as effective tools in medication delivery and tissue engineering due to their adjustable characteristics and water retention capabilities. The purpose of this work was to investigate the potential of a novel thermosensitive hydrogel composed of Pluronic F127 and polyglutamic acid (PGA) to enhance the treatment of MRSA-infected full-thickness excision wounds. The viscosity and gelation temperature of the hydrogels were evaluated using viscometry and rheometry, while their injectability was assessed with a texture analyzer. Swelling and biodegradation were measured in PBS at 37°C, and antibacterial and antioxidant activity was determined using MIC/MBC tests and DPPH radical scavenging. In mouse infected wound healing investigations, hydrogels were applied to wounds, and tissue examination was done with Masson's Trichrome staining and biochemical assays for TAC and MDA. The F127/PGA hydrogel converted from a liquid to a gel at body temperature more efficiently than F127 alone, with lower gelation temperatures and improved mechanical characteristics. F127/PGA had higher swelling capacity and a slower degradation rate than F127. In antibacterial assays, the F127/PGA hydrogel showed stronger inhibitory and bactericidal activity against MRSA, as reflected by its lower MIC and higher MBC values. In addition, the hydrogel showed increased antioxidant activity and lower oxidative stress during wound healing, resulting in much better wound contraction and tissue regeneration than F127 and control treatments. These characteristics make F127/PGA an attractive choice for improved drug delivery systems and wound healing applications.
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高影响因子
RSC Advances
·
2015
·Vol. 5
·期 118
·97648-97657
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IF 3.84
Cong Wu,Guangmei Xia,Jing Sun,Rui Song
With dopamine as a reducing and sticking agent, triblock copolymer poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) (PEO–PPO–PEO), Pluronic F127, was employed to immobilize and stabilize silver nanoparticles (Ag NPs) by the chemical reduction of silver nitrate, AgNO3. Thus, a ternary system comprising Ag NPs, dopamine and F127, i.e. a Ag@DA@F127 system was constructed. In this ternary system, Ag NPs were anisotropically self-assembled and uniformly dispersed in network-like F127 micelles. As evidenced the dispersion stability of Ag NPs in this system was significantly enhanced compared to the Ag@DA and Ag@NaBH4@F127 system, which in turn resulted in a more sensitive and quantitative detection of H2O2. Further investigation demonstrated that the Ag@DA@F127 system exhibited a UV-vis absorption band at ∼405 nm and the intensity of this absorption band dramatically decreased linearly over the concentration range of 0.1–100 μM H2O2 (r2 = 0.99056), deriving a detection limit of 33 nM, which was superior to recent reports. Apart from its excellent performance in H2O2 detection, this Ag@DA@F127 system has other benefits including facile and simple, being environmentally friendly, and especially the formation of a specific network-like structure to fully disperse Ag NPs, which makes it practical in H2O2 detection.
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高影响因子
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2026
·
IF 4.8
Yunxiang Qi,Zhenghua Zhang,Xuan Wang,Haitao Long,Lumei Pu,Weibing Xu
Smart nanopesticides demonstrates excellent potential in the prevention of tomato gray mold. Herein, temperature, pH and GSH triple responsive of pyraclostrobin nanopesticide (CDC-F127-P) is fabricated base on Pluronic F127 and cinnamaldehyde-derived liposome. The maximum fungicide loading of Pyr reaches 52.9%. The particle size and zeta potential are 143 nm and + 29 mV. The release of Pyr increases from 38% to 61% after 48 h as the temperature rises from 5 °C to 35 °C. The value increases from 62% to 87% when the concentration of oxalic acid rises from 0 to 20 mM, which increases from 10% to 37% as the concentration of GSH rises from 0 to 20 mM. The EC₅₀ of CDC-F127-P is 1.96 μg/mL. The inhibition rates of CDC-F127-P for mycelial growth and spore germination are 69.3% and 73.0% at 10 μg/mL. The nucleic acid and protein leakage reaches 124.8 μg/mL and 113.5 μg/mL. A spore mortality rate of 66.4% is arrived. Mitochondrial membrane potential reduces by 96% after treatment with 2 μg/mL. The CDC-F127-P shows a hemolysis rate of 1.8% and a tomato seed germination rate of 60% at 10 μg/mL. The contact angle on the tomato leaf is 74.0 o . A solution retention capacity of 27.5 mg/cm 2 is retained after simulated rainfall. The disease inhibition rates of 64.9% and 71.0% in detached-leaf and potted-plant assays after treatment with 10 μg/mL CDC-F127-P. The triple-responsive CDC-F127-P nanopesticide offers a highly efficient and safe strategy for gray mold control and presenting a novel approach for developing green nano-pesticides.
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高影响因子
Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
Jinchao Chen,Chunmei Gao,Shuangquan Zhao,Shenghui Liu,Shifeng Ji,Yunqing Xing,Tianyang Wu,Jinjian Wu,Hongyu Chen,Peng Zou,Jiaonan Cai
In this work, the NH 2 -MIL-125/F127/PES membranes with superior ultrafiltration , anti-fouling and self-cleaning were constructed via the RTIPS method. Characterizations showed the successful fabrication of NH 2 -MIL-125 with good photocatalysis activities, together with its stable anchoring in PES membrane. The loss of NH 2 -MIL-125 was suppressed by hydrogen bond between F127 and NH 2 -MIL-125, where hydrophilic F127 significantly boosted permeability and anti-fouling property. The permeability-selectivity trade-off effect was alleviated by NH 2 -MIL-125 with a regular size window. It was observed that the membranes prepared by the RTIPS method occurred a spongy-like cross-section and a porous surface, which imparted the membrane with improved ultrafiltration and mechanical properties over the finger-like cross-section and dense skin caused by the NIPS method. The optimal membranes exhibited decent permeability (1511 L/m 2 h), BSA rejection rate (85.3%) and high COD removal rate over the commercial membranes, whose flux recovery rate was up to 76.91% after two cycles under light irradiation by the synergistic effect of F127 and NH 2 -MIL-125. The membrane fouled with RhB exhibited excellent regeneration properties benefiting from the holes (h + ) and superoxide free radicals ( • O 2 − ), as well as reactive •OH. Overall, the membrane with F127 and NH 2 -MIL-125 presented a highly promising in improving ultrafiltration and self-cleaning via the RTIPS method.
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高影响因子
RSC Advances
·
2018
·Vol. 8
·期 29
·15906-15914
·
IF 2.936
Zhaokun Yan,Qingtang Wang,Xiaolong Liu,Jun Peng,Qin Li,Ming Wu,Jiumao Lin
Ursolic acid (UA) has shown great potential in cancer therapy but their efficacy is seriously compromised by poor water-solubility and limited cellular uptake. In this paper, cationic nanomicelles self-assembled from Pluronic F127 with the cationic polymer of C18-polyethylenimine (C18-PEI) as a functional component are fabricated as delivery vehicles of Chinese herbal medicine active components of ursolic acid (UA) for colorectal cancer treatment. The inhibition effects of this drug loaded cationic nanomicelles (named as FUP) on cell viability and cell colony formation were more significant than the free UA, due to their cationic surface which can increase UA uptake by colorectal cancer cells. Cell cycle analysis showed that this inhibition effect was mediated by a cell cycle arrest at the G1 checkpoint, and the cell death induced by these nanomicelles occurred via apoptosis, which was detected by annexin V antibody and propidium iodide staining. Further western blot analysis demonstrated the apoptosis mechanism was associated with the regulation of Fas/FasL and activation of caspase-8 and caspase-3. Therefore, our cationic nanomicelles can potentially be used to enhance the therapeutic effect of UA for colorectal cancer treatment.
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高影响因子
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