Journal of the Taiwan Institute of Chemical Engineers
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2026
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IF 6.9
Weibing Xu,Zhenghua Zhang,Tiantian Fu,Ming Niu,Haitao Long,Lumei Pu,Zhaojia Hang
Background Bacterial infections pose a serious threat to the livestock and poultry industry, necessitating effective and sustainable therapeutic strategies. Methods Herein, guided by the concept of "derived from animals and used for animals", red blood cell membranes (RBCM) are extracted from slaughterhouse waste and recycles to coat trimethoprim (TMP)-loaded mPEG-PLGA nanoparticles (RPTNS) via a co-extrusion method. The structure and antibacterial activities of the nanoparticles are studied in detain. Significant findings The protein bands in the three independently prepared samples remained unchanged. The TMP loading capacity of RPTNS 20/40/80 were 13.1, 21.3 and 34.8%. The average particle diameters of RPTNS 20/40/80 were 275.8, 532.3 and 755.7 nm. The cumulative release is 43.48% and 60.38% at artificial gastric and intestinal fluid within 48 h. The inhibition rate of RPTNS 20 reached 80.57 and 72.74% of for E. coli and S. aureus at the concentration of 240 μg/mL. The protein leakage amount was 2.23 and 3.08 mg/mL in the RPTNS 20 treated E. coli and S. aureus . RPTNS₂₀ can induce sustained membrane depolarization. The expression level of dihydrofolate reductase in the bacteria treated with the RPTNS₂₀ reduces to 20%. The AUC 0-48 of the mice in the RPTNS₂₀ group is 131.77 ± 6.25 h*µg/mL. The RPTNS can effectively inhibit bacterial infections without causing serious harm to liver and kidney. The RBCM camouflaged nanoparticles improve effectively the bioavailability of oral TMP formulations. This develops a novel utilization for the discarded blood cells from slaughterhouses.
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JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
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2025
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IF 2.4
You Ma,Bo-Yu Liu,Tian-Yu Li,Hang Yang,Han Meng,Guo-Xiang Wang,Dong-Lin Li,Yu-Dong Chen,Wen-Ming Xie
BACKGROUND Dissolved organic matter (DOM) in wastewater treatment systems plays a crucial role in the adsorption removal of antibiotics; however, this adsorption process remains underexplored. In this study, the effect of DOM components (protein, humic substances and polysaccharide) on the adsorption removal of trimethoprim (TMP) by activated sludge at environmentally relevant concentrations was investigated. RESULTS The humic substance had a positive effect on TMP adsorption, whose adsorption capacity was increased from 6.05 to 10.82 and 7.48 μg g −1 volatile suspended solids ( P < 0.05), respectively, when 60 mg L −1 humic acid and fulvic acid were added. The negatively charged protein (30 mg L −1 ) had an inhibition effect on TMP adsorption process, in which the adsorption capacity was reduced by 24.1% ( P < 0.05). However, the positively charged protein had a minor promotional effect. The polysaccharides (10 mg L −1 ) had a negligible effect on TMP adsorption. CONCLUSION Through infrared and X-ray photoelectron spectroscopy analysis, the hydrogen bond was found to be the main factor governing TMP adsorption by activated sludge with DOM interference. © 2025 Society of Chemical Industry (SCI).
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Yuanchuan Ren,Yan Hu,Nanqi Ren,Fenghui Wu,Dandan Chen,Xuejun Zhu,Qiang Niu
FeNi binary metal alloy anchored foam carbon composite electrode was successfully constructed by electrodeposition self-assembly strategy (FeNi@CF). FeNi with heterogeneous structure serves as a charge transfer bridge, promoting charge separation. The degradation efficiency of TMP within 20 min was 98.15 % (k = 0.1935 min −1 ). The contribution of active components to TMP degradation follows the order of SO 4 − · (63.22 %)>·OH (39.55 %)>·O 2 – (9.33 %)> 1 O 2 (5.27 %), which is consistent with the proposed charge separation mechanism. DFT calculations show that the introduction of FeNi alloy can disrupt the sp2 hybrid structure of carbon in graphite electrodes, resulting in the formation of nucleophilic and electrophilic atomic centers on their surfaces, reducing the steric hindrance of PMS adsorption (E ads = −3.28 eV), enhancing the adsorption strength of PMS, increasing the area of active centers, and improving the activation efficiency of PMS. The free radical quenching and intermediate identification experiments further confirmed the mechanism and pathway of TMP degradation. In addition, FeNi@CF has good repeatability and stability, making it suitable for treating pollutants in various water matrices. This work is expected to provide ideas for risk assessment of various toxic and persistent organic pollutants in drinking water and wastewater.
研究领域:
环境科学
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材料科学
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化学工程
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Journal of Water Process Engineering
·
2024
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IF 6.3
Yijun Chen,Hailiang Yang,Sanjian Ma,Meina Cheng,Zixia Lin,Long Jin,Xin Liu
As a representative antibiotic, trimethoprim (TMP), the emerging pollutant has been frequently detected in water bodies, and its potential harm has aroused the attention of society. Although the emerging pollutant could be efficiently degraded by the advanced oxidation process (AOP) represented by the Fenton reaction , both the problem of iron sludge disposal and the safe use of H 2 O 2 have plagued the further promotion of this technology. The H 2 (precursor of the active hydrogen [H]) and catalyst Pd/UiO-66(Zr) were introduced into the Fenton reaction in this paper. It was found that the process of reducing Fe(III) and self-generating H 2 O 2 could be facilitated due to the reduction of [H]. Under certain reaction conditions (initial pH 3, trace total iron 25 μM, H 2 30 mL·min −1 , catalyst 2 g·L −1 ) and without H 2 O 2 , a Fenton-like system was constructed, named MHORF-UiO-66(Zr). While achieving zero iron sludge discharge, 100 % of 20 mg·L −1 TMP was rapidly degraded within 1 h. It was found that the degradation of TMP could be attributed to the attack of singlet oxygen and hydroxyl radical . Furthermore, the performance changes of catalyst before and after six rounds of reactions were studied and it was found that Pd/UiO-66(Zr) had excellent and stable catalytic performance.
研究领域:
环境科学
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化学工程
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
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2024
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IF 8
Yijun Chen,Meina Cheng,Long Jin,Hailiang Yang,Sanjian Ma,Zixia Lin,Guoliang Dai,Xin Liu
The Fenton reaction is recognized as an effective technique for degrading persistent organic pollutants , such as the emerging pollutant trimethoprim (TMP). Recently, due to the excellent reducibility of active hydrogen ([H]), Pd–H 2 has been preferred for Fenton-like reactions and the specific H 2 activation of Pd-based catalysts. Herein, a heterogeneous Fenton catalyst named the hydrogen-accelerated oxygen reduction Fenton (MHORF@UiO-66(Zr)) system was prepared through the strategy of building ships in the bottle. The [H] has been used for the acceleration of the reduction of Fe(III) and self-generate H 2 O 2 . The systematic characterization demonstrated that the nano Pd 0 particle was highly dispersed into the UiO-66(Zr). The results found that 20 mg L −1 of TMP was thoroughly degraded within 90 min in the MHORF@UiO-66(Zr) system under conditions of initial pH 3, 30 mL min −1 H 2 , 2 g L −1 Pd@UiO-66(Zr) and 25 μM Fe 2+ . The hydroxyl radical as well as the singlet oxygen were evidenced to be the main reactive oxygen species by scavenging experiments and electron spin resonance . In addition, both reducing Fe(III) and self-generating H 2 O 2 could be achieved due to the strong metal-support interaction (SMSI) between the nano Pd 0 particles and UiO-66(Zr) confirmed by the correlation results of XPS and calculation of density functional theory. Finally, the working mechanism of the MHORF@UiO-66(Zr) system and the possible degradation pathway of the TMP have been proposed. The novel system exhibited excellent reusability and stability after six cyclic reaction processes.
研究领域:
环境科学
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材料科学
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化学工程
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CRYSTAL GROWTH & DESIGN
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2024
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IF 3.2
Yanshan Zhu,Qiongxi Lin,Hongying Fan,Li Zhang,Shiying Yang,Dezhi Yang,Yang Lu,Zhengzheng Zhou
This study aims to prepare a stable crystal-co-agglomeration (CCA) process for combining the antibiotics trimethoprim (TMP) and the anti-inflammatory niflumic acid (NFA) as well as the enhancement of powder properties. A novel TMP–NFA salt monohydrate was synthesized and characterized through multitechniques for the first time. Subsequently, the antibacterial effectiveness of TMP–NFA salt monohydrate against Staphylococcus aureus and Shigella flexneri was found to be improved (P < 0.05) compared with that of TMP at certain concentrations, achieving a synergistic effect of TMP and NFA. Based on these findings, spherical agglomerates of TMP–NFA salt monohydrate with superior powder properties including improved flowability (Carr’s index decreased by 37.5% and Hausner’s ratio decreased by 16.3%) and tabletability were produced using an efficient CCA process. Hence, the optimized spherical agglomerates of the drug–drug salt technique provide a promising approach to simultaneously enhance the powder properties and synergistic effect of active pharmaceutical ingredients. The development of such drug–drug salts holds great potential for advancing pharmaceutical formulations and therapeutic outcomes.
研究领域:
药学
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化学
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微生物学
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Scientific Reports
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2023
·Vol. 13
·期 1
·1-14
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IF 4.6
Alishiri Mahsa,Gonbadi Maryam,Narimani Mehdi,Abdollahi Seyyed Amirreza,Shahsavaripour Negin
The contamination of the aquatic environment with antibiotics is among the major and developing problems worldwide. The present study investigates the potential of adsorbent magnetite-chitosan nanoparticles (Fe 3 O 4 /CS NPs) for removing trimethoprim (TMP) and sulfamethoxazole (SMX). For this purpose, Fe 3 O 4 /CS NPs were synthesized by the co-precipitation method, and the adsorbent characteristics were investigated using XRD, SEM, TEM, pH zpc , FTIR, and VSM. The effect of independent variables (pH, sonication time, adsorbent amount, and analyte concentration) on removal performance was modeled and evaluated by Box–Behnken design (BBD). The SEM image of the Fe 3 O 4 /CS adsorbent showed that the adsorbent had a rough and irregular surface. The size of Fe 3 O 4 /CS crystals was about 70 nm. XRD analysis confirmed the purity and absence of impurities in the adsorbent. TEM image analysis showed that the adsorbent had a porous structure, and the particle size was in the range of nanometers. In VSM, the saturation magnetization of Fe 3 O 4 /CS adsorbent was 25 emu g −1 and the magnet could easily separate the adsorbent from the solution. The results revealed that the optimum condition was achieved at a concentration of 22 mg L −1 , a sonication time of 15 min, an adsorbent amount of 0.13 g/100 mL, and a pH of 6. Among different solvents (i.e., ethanol, acetone, nitric acid, and acetonitrile), significant desorption of TMP and SMX was achieved using ethanol. Also, results confirmed that Fe 3 O 4 /CS NPs can be used for up to six adsorption/desorption cycles. In addition, applying the Fe 3 O 4 /CS NPs on real water samples revealed that Fe 3 O 4 /CS NPs could remove TMP and SMX in the 91.23–95.95% range with RSD (n = 3) < 4. Overall, the Fe 3 O 4 /CS NPs exhibit great potential for removing TMP and SMX antibiotics from real water samples.
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NEW JOURNAL OF CHEMISTRY
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2026
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IF 2.6
Yijing Li,Xiaogang Luo,Piaowen Yang,Jian Xiao,Zhaoyan Chi
The effective removal of trace trimethoprim (TMP) from aquatic environments remains a significant challenge due to the limited efficiency of conventional adsorbents at low concentrations. In this study, a novel composite adsorbent, MMT/CMCBS, was successfully fabricated by incorporating montmorillonite (MMT) into a carboxymethylated cellulose (CMC) matrix through an optimized extrusion-dropping method. The structural and chemical properties of the beads were systematically characterized using FESEM-EDS, FT-IR, XRD and XPS revealing a stable macroporous structure (≈1.5 mm diameter) with well-dispersed MMT. Fixed-bed column experiments demonstrated that MMT/CMCBS exhibits exceptional performance for TMP removal, achieving a removal efficiency of 99.874% and maintaining over 90% performance after four regeneration cycles. The breakthrough curves were well-described by the Adams-Bohart models (R2 > 0.94), indicating favorable dynamic adsorption behavior. Mechanism analysis further revealed that the synergistic removal of TMP was driven by hydrogen bonding and chemisorption between the TMP molecules and the functional groups of the composite. This study provides a highly efficient, stable, and environmentally friendly strategy for the elimination of TMP from water, offering significant potential for continuous-flow water treatment.
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JOURNAL OF HAZARDOUS MATERIALS
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2023
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IF 13.6
Bao Pan,Miao Liao,Yanli Zhao,Yuzhu Lv,Jiani Qin,Virender K. Sharma,Chuanyi Wang
The increasing consumption of antibiotics and their subsequent release to wastewater or groundwater and ultimately to the water supply (or drinking water) has great concerns. This paper presents a visible light (VL) activated ferrate(VI) (Fe VI O 4 2- , Fe(VI)) system to degrade the selected antibiotic, trimethoprim (TMP), efficiently. An oxygen doped ZnIn 2 S 4 nanosheet (O-ZIS) coupled with a black phosphorus (BP) heterostructure (O-ZIS/BP), is fabricated by a simple electrostatic self-assembly method. The O-ZIS/BP photocatalyst is comprehensively characterized by surface and analytical techniques, which show superior separation efficiency of the photoinduced charge carriers in the heterostructure. A VL-O-ZIS/BP-Fe(VI) system achieves more than 80% removal in 1.0 min and complete removal of TMP in 3.0 min. Comparatively, only ⁓7% and ⁓24% of TMP are degraded by O-ZIS/BP and Fe(VI) in 1.0 min, respectively. The degradation experiments using probe molecules of reactive species and electron paramagnetic resonance (EPR) measurements reveal involvement of superoxide (O 2 -• ), hydroxyl radical ( • OH), and iron(V)/iron (IV) (Fe V /Fe IV ) species in the mechanism of TMP degradation. Oxidized products of TMP are identified and reaction pathways are given. Theoretical calculations predict the initial attack on the TMP molecule by the reactive species in the VL-O-ZIS/BP-Fe(VI) system. The activation of Fe(VI) by VL-heterostructure photocatalysts accelerates the degradation of antibiotics, demonstrating its potential for water depollution.
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FUEL
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2023
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IF 7.4
Zhonghua Xue,Yali Feng,Haoran Li,Chenglong Xu,Jinrong Ju,Lianping Dong,Chongyi Yang,Weiren Bao,Jiancheng Wang,Haoyu Wang,Ruiyu Ma
The search for efficient adsorbents to mitigate the impact of antibiotic pollutants on marine ecosystems, food security and human health is a burgeoning field of research. Further, Trimethoprim (TMP) and sulfamethoxazole (SMX) are widely distributed in the marine environment and are difficult to degrade. In this research, we used gravity separation to enrich the residual carbon from the coal gasification coarse slag and used the resulting carbon-high product (GC) as a low-cost and high-efficiency adsorbent. TMP and SMX were investigated for their adsorption behavior in seawater using GC under varied conditions. The findings indicated that the adsorption capacities of TMP and SMX by GC were 5.0017 mg/g and 5.1391 mg/g, respectively. The equilibrium durations of TMP and SMX by GC were 21 min and 40 min, respectively. Various adsorption models were fitted to the adsorption behavior of two pollutants by GC. The results showed that the adsorption processes of the two pollutants were consistent with the Freundlich equation and the quasi-secondary kinetic model, suggesting that both pollutants were adsorbed on GC surface by both physical and chemical processes. GC more effectively adsorbed TMP than SMX under a competitive adsorption procedure. When we introduced molecular dynamics simulation into this research, the microscopic procedures of GC adsorbing two pollutants were investigated. The energy composition and hydrogen bond types in the adsorption process were quantified. Finally, we summarized the adsorption mechanism of GC adsorbing two pollutants. This work will pave the way for developing effective, low-cost and environmentally friendly novel materials for the adsorption and purification of antibiotic pollutants in the marine environment. This research can produce positive economic and environmental effects in the comprehensive utilization of coal gasification slag.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Huanhuan Yang,Wenxin Xu,Lanting Xie,Han Wang,Xuhui Fang,Jian Qi,Jie Wang,Pan Hu,Sihui Zhan,Shuanglong Ma,Boqiang Gao
Adsorption as a typical water treatment technology can effectively remove trimethoprim (TMP). However, conventional micro-nano particle adsorbents are susceptible to loss and difficult to recover, resulting in limited practical application. Here, carboxymethyl modified lignin-based polyvinyl formal sponge (PLNC) adsorbents were prepared and evaluated its adsorption performance for TMP. PLNC exhibits abundant pore structures (pore size ~10 μm) with excellent mechanical strength and compressibility. Its adsorption capacity for TMP reaches 0.147 mmol/g, which is 36.75 times higher than that of polyvinyl formal sponge. Electrostatic attraction (EA), hydrogen bonding (HB), and π-π electron donor-acceptor (π-π EDA) interactions are primary adsorption contributors, exhibiting dynamic changes with solution pH. The molecular probe combined with density functional theory calculations reveals that EA between deprotonated carboxyl group of PLNC and aromatic nitrogen of aminopyrimidine in TMP is crucial for adsorption, which was enhanced by conjugation effect of 1,2,3-trimethoxybenzene in TMP. Furthermore, PLNC exhibits superior application potential, with less than 10.0 % mass loss after five reuses and recycling by simple screening. In dynamic adsorption bed experiments, PLNC maintains TMP effluent concentrations below 50 % during stable operation at ~40 × 10 3 bed volumes. This study provides theoretical guidance and practical foundations for the development and application of novel three-dimensional porous sponge adsorbents.
研究领域:
环境科学
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材料科学
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水处理技术
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吸附工程
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高分子化学
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SCIENCE OF THE TOTAL ENVIRONMENT
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2021
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IF 7.963
Zhengqing Cai,Yougui Song,Xibiao Jin,Chong-Chen Wang,Haodong Ji,Wen Liu,Xianbo Sun
A highly solar active AgBr/h-MoO 3 composite was constructed by a facile precipitation method, and the charge separation tuning was achieved by photoreduction of AgBr. The photoreduced Ag 0 on AgBr/h-MoO 3 acted as charge transfer bridge to form Z-scheme heterostructure, while the high degree of Ag reduction converted the material into type-II heterostructure. The synthesized optimal material promoted charge separation and visible light activity due to the incorporation of highly solar active AgBr, which showed ca. 2 times activity on trimethoprim (TMP) degradation than h-MoO 3 . The contribution of reactive species on TMP degradation followed the order of O 2 − > 1 O 2 > h + , which agree well with the proposed charge separation mechanism. The photocatalytic degradation mechanism of TMP was proposed based on the radical quenching, intermediate analysis and DFT calculation. The toxicity analysis based on QSAR calculation showed that part of the degradation intermediates are more toxic than TMP, thus sufficient mineralization are required to eliminate the potential risks of treated water. Moreover, the material showed high stability and activity after four reusing cycles, and it is applicable to treat contaminants in various water matrix. This work is expected to provide new insight into the charge separation tuning mechanism for the AgX based heterojunction , and rational design of highly efficient photocatalysts for organic contaminants degradation by solar irradiation.
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