JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2017
·
IF 3.154
Mingshun Chen,Shujuan Yu
Grape seed proanthocyanidins, composed of flavan-3-ols of different degrees of polymerization, are natural food antioxidants. Flavan-3-ols in grape seed are usually polyhydroxy derivatives which exhibit hydrophilic character. Monomeric and oligomeric flavan-3-ols were modified structurally to improve their lipophilicity, expand their application in lipophilic media, and enhance their cellular absorption in the body. The esterification of the water-soluble flavan-3-ols was prepared by Lipozyme TL IM with lauric acid, and their enhanced lipophilicity was confirmed by a 1-octanol/water partition coefficient. The chemical structures of monomeric and oligomeric flavan-3-ol derivatives, identified by HPLC-MS-MS and 1H and 13C NMR, were 3′-O-lauroyl catechin, 3′-O-lauroyl epicatechin, 3′,5′-2-O-lauroyl epigallocatechin, 3′,3″,5″-3-O-lauroyl epicatechin gallate, 3′,3″-2-O-lauroyl procyanidin A2, 3′,3″-2-O-lauroyl procyanidin B1, and 3′,3″,3‴-3-O-lauroyl procyanidin C1. Flavan-3-ol derivatives exhibited the highest 1,1-diphenyl-2-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activities compared to that of parent flavan-3-ols, butylated hydroxytoluene and tert-butyl hydroquinone. The results suggest that flavan-3-ol derivatives may be used as potential lipophilic antioxidants in the food industry.
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ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES
·
2022
·Vol. 238
·期 1
·13-14
·
IF 0.365
Zhihong Zhu,Lilei Zhang
C 14 H 12 BrClN 2 O, monoclinic, P 2 1 / c (no. 14), a = 13.4072(6) Å, b = 8.6103(5) Å, c = 12.3824(6) Å, β = 100.475(4), V = 1405.60(12) Å 3 , Z = 4, R gt
( F ) = 0.0499, wR ref
( F
2 ) = 0.1215, T = 173 K.
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FITOTERAPIA
·
2019
·
IF 2.431
Yue Yang,Haihui Xie,Yueming Jiang,Xiaoyi Wei
Averrhoa carambola L. (Oxalidaceae) was widely cultivated for fruits (star fruit), whereas the value of leaves remains to be discovered. Our study on the leaves yielded five flavan-3-ols ( 1 – 5 ) and two 2-diglycosyloxybenzoates. Their structures were determined by spectroscopic and chemical methods. Epicatechin-(5,6-bc)-4β-( p -hydroxyphenyl)-dihydro-2(3 H )-pyranone ( 1 ) and benzyl 2-β- d -apiofuranosyl-(1 → 6)-β- d -glucopyranosyloxybenzoate ( 6 ) were new structures. 6-( S −2 -Pyrrolidinone-5-yl)epicatechin ( 4 ) and 6-( R -2-pyrrolidinone-5-yl)epicatechin ( 5 ) were obtained as monomeric diastereomer for the first time and their absolute configurations were determined by electronic circular dichroism (ECD) computation. Epicatechin-(7,8-bc)-4α-( p -hydroxyphenyl)-dihydro-2(3 H )-pyranone ( 2 ), epicatechin-(7,8-bc)-4β-( p -hydroxyphenyl)-dihydro-2(3 H )-pyranone ( 3 ), and methyl 2-β- d -apiofuranosyl-(1 → 6)-β- d -glucopyranosyloxybenzoate ( 7 ) were not previously reported from the genus Averrhoa . Compounds 1 – 5 showed more potent 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical cation and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities and ferric reducing antioxidant power (FRAP) than l -ascorbic acid. Meanwhile 1 and 3 exhibited lipase and α-glucosidase inhibitory activities, respectively. The results clarified the structures of flavan-3-ols and 2-diglycosyloxybenzoates in the leaves and their antioxidant, lipase, and α-glucosidase inhibitory activities.
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ADVANCED SYNTHESIS & CATALYSIS
·
2014
·Vol. 356
·期 5
·1038-1046
·
IF 5.542
Jun Zhou,Bo Li,Zhen-Chao Qian,Bing-Feng Shi
A rhodium(III)-catalyzed selective olefination of picolinamide derivatives has been developed. The reaction shows high regioselectivity, low catalyst loading (0.5 mol%), high yield and good functional group tolerance, providing a convenient strategy for the synthesis of 3-alkenylpicolinamides.
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JOURNAL OF ORGANIC CHEMISTRY
·
2019
·
IF 4.745
Jiashen Qiu,Di Wu,Lexia Yuan,Pingliang Long,Hongquan Yin,Fu-Xue Chen
An enantioselective thiocyanation of oxindoles has been developed for the first time using a bifunctional cinchona-derived organo-catalyst and N-thiocyanatophthalimide as the electrophilic thiocyanation source in the presence of 2-naphthol as the additive. Various enantioenriched 3,3′-disubstituted oxindoles with SCN-containing quaternary carbon stereocenters were synthesized under mild conditions in high yields (up to 99%) and good enantioselectivities (up to 6:94 er).
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2021
·Vol. 32
·期 5
·5821-5830
·
IF 2.478
Hu Peng,Deng Zhaoping,Wang Teshen,Li Zepeng,Ma Yanlin
In this study, a series of Eu 3+ -doped NaBaBi 2 (PO 4 ) 3 red phosphors were synthesized by high-temperature solid-phase reaction method, and the phase structure and photoluminescence properties of the samples were investigated in detail. All the diffraction peaks of the phosphors with various Eu 3+ concentrations are well matched with the NaBaBi 2 (PO 4 ) 3 standard phase, indicating that Eu 3+ ions have no effect on the host structure. Under the excitation of 391 nm wavelength, the emission spectra consisted of four characteristic emission peaks at 595, 617, 656 and 703 nm, respectively. The strongest emission peaking at 617 nm originates from the 5 D 0 → 7 F 2 electron transitions of Eu 3+ ions. The optimum concentration of Eu 3+ ions in NaBaBi 2 (PO 4 ) 3 :Eu 3+ is 9% concentration. The phosphor exhibits strong absorption capacity in the near-ultraviolet region. The Commission International de I’Eclairage chromaticity coordinates of the NaBaBi 2 (PO 4 ) 3 :Eu 3+ samples are located in the red region, indicating that the phosphors are suitable red component to applied in near-ultraviolet-based white light-emitting diodes.
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ACS Sustainable Chemistry & Engineering
·
2022
·
IF 9.224
Zixin Zhong,Haolan Liu,Ruru Zhou,Boyong Ye,Jie Fu,Zhaoyin Hou
3-Hydroxybutyric acid (3-HBA) is an important monomer for manufacturing biodegradable polymers such as polyhydroxyalkanoates, which are currently produced via an expensive and time-consuming microbial fermentation route. Herein, the catalytic synthesis of 3-HBA via the selective oxidation of 1,3-butanediol (1,3-BDO) in the presence of molecular oxygen is reported for the first time. It was found that the PtSb2 alloy could catalyze the selective formation of 3-HBA, and the selectivity of 3-HBA was 82.3% at a 1,3-BDO conversion level of 95.5%. The calculated turnover frequency of each surface Pt atom in the PtSb2/AC catalyst was 344.3 h–1 at 70 °C. The characterization results indicated that the prominent performance of the PtSb2 alloy over monometallic Pt nanoparticles could be because the alloy could promote the tandem oxidation of the 3-hydroxybutyraldehyde (3-HBAD) intermediate to 3-HBA and reduce the dehydration of 3-HBAD to the byproduct. At the same time, the PtSb2 alloy was also effective for the selective oxidation of several diols to hydroxyl-substituted acids.
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CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Jinpeng Ma,Ke Zhu,Da Huo,Bingzhong Shen,Yang Liu,Xudong Qi,Enwei Sun,Rui Zhang
The performances of 1–3 piezocomposite materials under various poling conditions were compared and analysed. The dielectric , piezoelectric , and electromechanical properties of 1–3 piezocomposite materials were studied with variations in the electric field amplitude ( E p ), poling frequency ( f ), and number of cycles ( C ). It was found that the piezoelectric coefficient ( d 33 ), free dielectric constant ( ε 33 T / ε 0 ), and electromechanical coupling factor ( k t ) of 1–3 piezocomposite materials exhibit an increase of 21.4%, 13%, and 10.7%, respectively, under the optimum alternating current poling (ACP) condition ( f = 1.25 Hz, E p = 2 kV/mm, C = 16), compared with that of the samples poled using the direct current polarisation (DCP) method. The studies of the domain pattern indicate that the performance enhancement originates from the remarkable regularly striped domain structure and high domain wall density in ACP-poled samples. Our results suggest that the ACP method is effective in enhancing the performance of composite piezoelectric materials , which possess great benefits and potential for application in acoustic/medical transducers.
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EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2025
·
IF 2
Yue-Ling Sun,An-Hua Gong
A new barium zincophosphite BaZn 2 (HPO 3 ) 3 is obtained via a simple hydrothermal reaction. BaZn 2 (HPO 3 ) 3 crystallizes in the P space group and exhibits a novel 3D crystal structure. It possesses a short ultraviolet cutoff edge of 205 nm, corresponding to a large experimental bandgap of 5.55 eV. BaZn 2 (HPO 3 ) 3 also has good thermal stability. This present work provides a comprehensive characterization of its crystal structure and optical properties. Additionally, first-principles calculations are employed to analyze the structure–activity relationship of BaZn 2 (HPO 3 ) 3 . Graphical BaZn 2 (HPO 3 ) 3 possesses a novel 3D anion framework, short ultraviolet cutoff edge, large bandgap, and good thermal stability.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Sitong Wu,Xingbo Yu,Haoyu Wang,Xing Guo,Chuangang Zhou,Dong Zhao,Shengbo Sang
Matrix metalloproteinase 3(MMP-3) has attracted increasing attention as a biomarker for osteoarthritis (OA) due to its crucial role in the early prevention and diagnosis of the disease. In this study, we achieved magnetic electric coupling and magnetic sensitization by doping magnetic nanoparticles into the conversion layer of the surface stress sensor to introduce magnetic force. Under a magnetic field, the magnetic effect of polydimethylsiloxane composite film doped with Fe 3 O 4 nanoparticles eliminates the gravity interference of sensitive film and magnifies its surface stress-induced concave convex deformation. The detection of OA-related MMP-3 is used as a proof-of-concept of the magnetic sensitization of the biosensor, which achieved a limit of detection (LOD) of 3.16 ng/mL, a significantly lower value than without a magnetic field. Moreover, the magneto-stress-electric coupled biosensor exhibited high specificity, selectivity, and stability. Overall,the results demonstrate that magnetic sensitization improves the performance of surface stress biosensors in detecting MMP-3. The biosensor also provides a platform for sensitive qualitative and quantitative clinical detection of OA markers.
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Microorganisms
·
2025
·Vol. 14
·期 1
·11
·
IF 4.2
Qianxin Lu,Huisha Du,Xin Jiang,Bingwen Zeng,Tianhui Li,Ying-Chun Dai
The GI.3 norovirus is the most detected and recombinant-rich genotype within genogroup I, yet the mechanistic basis for its epidemiological success remains poorly understood. This study integrates Bayesian evolutionary analysis with in vitro enzymology to investigate the link between RdRp function and the evolutionary dynamics of GI.3 NoV. We analyzed 831 GI.3 sequences, finding that prevalent strains (GI.3[P3] and GI.3[P13]) exhibited significantly higher evolutionary rates in both the RdRp and VP1 genes than non-prevalent strains (GI.3[P10] and GI.3[P14]). While the RdRp gene displayed a strong molecular clock signal, the VP1 gene’s evolution was more complex, showing cluster-specific trends. Functionally, the RdRps from prevalent strains demonstrated superior enzymatic activity and substrate affinity (Km: GI.3[P13] = 0.092 mM; GI.3[P3] = 0.176 mM) compared to non-prevalent strains (Km: GI.3[P14] = 0.273 mM). Notably, GI.3 RdRp required higher manganese ion concentrations for optimal activity than previously reported for GII strains, suggesting a potential biochemical constraint. Our findings demonstrate a clear correlation between RdRp enzymatic efficiency, evolutionary rate, and strain prevalence. We propose that a highly active RdRp may potentially accelerate VP1 evolution and confer a replicative advantage, underpinning the dominance of specific GI.3 lineages. This work provides crucial experimental evidence linking viral polymerase function to evolutionary and epidemiological outcomes.
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Toxics
·
2025
·Vol. 13
·期 12
·
IF 4.1
Huai-Fan Zhai,Ya-Nan Tian,Yu-Xin Sheng,Ya-Jia Pu,Yan-Rong Gao,Jia-Yi Chen,Jia-Di Liu,Jia Ma,Hai-Ming Xu,Peng-Bin Yang
Benzophenone-3 (BP-3), a widely used ultraviolet absorber in various scenarios, exhibits estrogenic toxicity at environmental concentrations—as demonstrated in our prior work. Given the importance of hepatic metabolism and the limitations of previous hepatotoxicity research (high-dose models, lack of mammalian data, etc.), we evaluated BP-3’s hepatic effects on postpartum mice at environmentally relevant levels. Postpartum mice were exposed to BP-3 via drinking water from postpartum day 1 (PPD1) to PPD35. Groups solvent control (0.001% DMSO), 10–1000 nM BP-3, and diethylstilbestrol (DES) were established. Basic growth performance, histopathological changes, and a range of molecular indicators were assessed. The results showed that BP-3 exposure induced dose-dependent increases in liver weight, histopathological alterations (sinusoidal dilation, hepatocyte edema, and necrosis), and significant upregulation of oxidative stress markers (Ros,Mda), chemokines (Ccl27a/b), and inflammatory factors (Tnf-α,Il-6,Nf-κb) at the mRNA level (allp< 0.05). Conversely, levels of antioxidant enzymes (Cat,Sod1/2) and anti-inflammatory factorHo-1were markedly decreased (p< 0.05). A clear dose-effect relationship was confirmed using the Integrated Biomarker Response (IBR) framework. This pioneering study establishes the hepatotoxicity of environmentally relevant BP-3 levels in mammals and offers methodological insights for endocrine disruptor assessment.
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