RSC Advances
·
2015
·Vol. 6
·期 4
·2571-2581
·
IF 3.84
Yinwen Li,Xiuwen Zheng,Kun Wu,Mangeng Lu
The ternary graft copolymer PGMA-g-(PS-r-PDMAEMA-r-POEGMA) (TGC) was prepared by a one-pot method involving the quantitative grafting of alkyne-end polystyrene (PS–CCH), poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA-CCH) and poly(oligo(ethylene glycol)methacrylate) POEGMA-CCH onto P(GMA-N3) via click chemistry. TGCs self-assembled and produced stable water soluble PS-centered nano-micelles, and exhibited intriguing collapse upon suitable adjustment of the solution pH and temperature. Hydrophilic rhodamine B (RB) and hydrophobic doxorubicin (DOX) were used to investigate the encapsulation and release properties of the TGC as a drug carrier. The results showed that the TGC exhibited excellent loading capacities for both DOX and RB. For the hydrophilic RB, the TGC displayed two release stages; upon increasing the micelle solution pH from 7.0 to 9.0, the PDMAEMA block aggregated and caused the original stabilizing layer to aggregate and release RB initially; while on further increasing the temperature from 20 °C to 40 °C, the POEGMA block aggregated and caused the second release of RB. The rate and extent of RB release could be changed by matching the numbers of PDMAEMA and POEGMA blocks per graft copolymer. In addition, DOX was encapsulated in the hydrophobic core, upon increasing the temperature and pH, the TGC formed compact layers and inhibited DOX release.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Qian Wang,Xinmiao Wang,Dong Cai,Jinghan Yu,Xuan Chen,Weiyuan Niu,Siya Wang,Xiaoyang Liu,Dayong Zhou,Fawen Yin
Phospholipid complexes of alkyl gallates (A-GAs) including ethyl gallate (EG), propyl gallate (PG), and butyl gallate (BG) were successfully prepared by the thin film dispersion method. HPLC-UV analysis in an everted rat gut sac model indicated that A-GAs can be liberated from phospholipid complexes, which were further hydrolyzed by intestinal lipase to generate free gallic acid (GA). Both A-GAs and GA are able to cross the membrane, and the hydrolysis rate of A-GAs and the transport rate of GA are positively correlated with the alkyl chain length. Especially, compared with the corresponding physical mixtures, the phospholipid complexes exhibit slower sustained-release of A-GAs and GA. Therefore, the formation of phospholipid complexes is an effective approach to prolong the residence time in vivo and additionally enhance the bioactivities of A-GAs and GA. More importantly, through regulating the carbon skeleton lengths, controlled-release of alkyl gallates and gallic acid from phospholipid complexes will be achieved.
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Advanced Healthcare Materials
·
2024
·
IF 10
Qian Han,Jiahui He,Lang Bai,Ying Huang,Baojun Chen,Zhenlong Li,Meiguang Xu,Qiaonan Liu,Shuai Wang,Nuanyang Wen,Jing Zhang,Baolin Guo,Zhanhai Yin
Partial-thickness cartilage defect (PTCD) is a common and formidable clinical challenge without effective therapeutic approaches. The inherent anti-adhesive characteristics of the extracellular matrix within cartilage pose a significant impediment to the integration of cells or biomaterials with the native cartilage during cartilage repair. Here, an injectable photocrosslinked bioadhesive hydrogel, consisting of gelatin methacryloyl (GM), acryloyl-6-aminocaproic acid- g -N-hydroxysuccinimide (AN), and poly(lactic- co -glycolic acid) microspheres loaded with kartogenin (KGN) (abbreviated as GM/AN/KGN hydrogel), is designed to enhance interfacial integration and repair of PTCD. After injected in situ at the irregular defect, a stable and robust hydrogel network is rapidly formed by ultraviolet irradiation, and it can be quickly and tightly adhered to native cartilage through amide bonds. The hydrogel exhibits good adhesion strength up to 27.25 ± 1.22 kPa by lap shear strength experiments. The GM/AN/KGN hydrogel demonstrates good adhesion, low swelling, resistance to fatigue, biocompatibility, and chondrogenesis properties in vitro. A rat model with PTCD exhibits restoration of a smoother surface, stable seamless integration, and abundant aggrecan and type II collagen production. The injectable stable adhesive hydrogel with long-term chondrogenic differentiation capacity shows great potential to facilitate repair of PTCD.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yu Li,Chao Liu,Haiying Wei,Zhaochuan Yu,Chao Deng,Yuqian Liu,Xiaoqian Gai,Huining Xiao
The extensive utilization of non-biodegradable plastic agricultural mulch in the past few decades has resulted in severe environmental pollution and a decline in soil fertility. The present study involves the fabrication of environmentally friendly paper-based mulch with dual functionality, incorporating agrochemicals and heavy metal ligands, through a sustainable papermaking/coating technique. The functional paper-based mulch consists of a cellulose fiber web incorporated with Emamectin Benzoate (EB)@ Aminated sodium lignosulfonate (ASL). The spherical microcapsules loaded with the pesticide EB exhibited an optimal core-shell structure for enhanced protection and controlled release of the photosensitizer EB (Sustained release >75 % in 50 h). Meanwhile, the ASL, enriched with metal chelating groups (-COOH, -OH, and -NH 2 , etc.), served as a stabilizing agent for heavy metal ions, enhancing soil remediation efficiency. The performance of paper-based mulch was enhanced by the application of a hydrophobic layer composed of natural chitosan/carnauba wax, resulting in exceptional characteristics such as superior tensile strength, hydrophobicity, heat insulation, moisture retention, as well as compostability and biodegradability (biodegradation >80 % after 70 days). This study developed a revolutionary lignocellulosic eco-friendly mulch that enables controlled agrochemical release and soil heavy metal remediation, leading to a superior substitute to conventional and non-biodegradable plastic mulch used in agriculture.
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FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Shiqi Li,Ling Liu,Silong Yang,Xingnan Wang,Yahong Yuan,Tianli Yue,Rui Cai,Zhouli Wang
In this study, a double-layer intelligent packaging, which is designed by a layer-by-layer casting strategy, is employed for efficient food preservation and high contrast monitoring. Specifically, novel zein/tannic acid (TA) composite colloidal particles (ZTs) were prepared by manipulating the non-covalent interaction between zein and TA using an easy antisolvent method. The stable oregano essential oil (OEO) Pickering emulsion (ZTOEO) with varying concentrations of ZTs (0.1%–1.0%) was successfully prepared. The optimized ZTOEO, containing 0.8% ZTs, was then integrated into the emulsified hydrophobic layer of the konjac glucomannan (Kgm) matrix. Finally, the carrageenan (Car) matrix containing alizarine (Al) as an indicator was added to construct the bilayer structure. The outer Car/Al layer serves as an acid/base responsive indicator layer, while the inner Kgm/ZTOEO layer functions as a high-barrier bacteriostatic layer. The double-layer Kgm/ZTOEO-Car/Al is integrated through intermolecular hydrogen bonding and dehydration condensation. Kgm/ZTOEO-Car/Al exhibits excellent slow-release antibacterial and antioxidant activity, with a sensitive, repeatable and accurate visual response to pH/NH 3 . The composite film demonstrates good mechanical strength, thermal stability, light blocking, and water vapor and oxygen permeability. The individual inner Kgm/ZTOEO film effectively prolonged the shelf-life and quality of fruits, which the double-layer Kgm/ZTOEO-Car/Al film showed minimal changes in TVB-N (16.65 mg/100 g) even after monitoring and maintaining the shrimp freshness for 48 h. It can be easily processed on a large scale into packaging bags and indicator labels. This packaging is expected to be an eco-friendly, low-cost, bacteriostatic, suitable for applications requiring real-time monitoring and maintenance of fruit/seafood freshness.
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FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Jingyang Yu,Ge Du,Yishun Yao,Qiuhong Liao,Tong Zhou,Heping Cui,Shahzad Hussain,Khizar Hayat,Xiaoming Zhang,Chi-Tang Ho
The feasibility of preparing microcapsules of water-soluble ingredient via complex coacervation was explored. Gelatin and gum arabic were used as wall materials to encapsulate glutathione (GSH) through water in oil (W/O) emulsion. Soy lecithin at a concentration of 3 % (w/w) was used as an emulsifier, and the aqueous phase containing 15 % GSH (w/w) was emulsified with soybean oil at a ratio of 5:5 (w/w), which resulted in a stable W/O emulsion. Furthermore, GSH microcapsules produced under optimal conditions, core/wall ratio 1:1, wall material content 1 % (gelatin: gum arabic = 1:1), stirring rate 400 r/min, added 0.25 g glutamine transaminase (TGases) per gram of gelatin, exhibited good morphology, high encapsulation efficiency and yield, which being 92.88 % and 92.10 %, respectively. After comparing the effects of four different oil emulsions on the microencapsulation of GSH, it was found that all had excellent encapsulation efficiency, indicating that no specific oil phase was required for emulsions preparation. GSH microencapsulation by complex coacervation significantly enhanced its stability, reduced the loss ratio of GSH by 23.5 % when capsules were heated at 150 °C for 2 h. Moreover, GSH microencapsulation increased its retention by 23.25 % and 43.88 % during capsules storage at 40 °C and under light exposure, respectively. In addition, GSH microcapsules effectively prevented its degradation during simulated gastrointestinal digestion induced by salivary amylase, pepsin and acidic environments, while rapidly released GSH under trypsin and alkaline environments. This study provided new insights into water-soluble ingredients microencapsulation and its efficient application in the food and nutraceutical industries.
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FOOD RESEARCH INTERNATIONAL
·
2024
·
IF 7
Dong Cai,Xinmiao Wang,Qian Wang,Peiyong Tong,Weiyuan Niu,Xu Guo,Jinghan Yu,Xuan Chen,Xiaoyang Liu,Dayong Zhou,Fawen Yin
The β-cyclodextrin and short-chain alkyl gallates (A-GAs), which are representative of phenolipids, such as butyl, propyl, ethyl, and methyl gallates, were chosen to form inclusion complexes by the use of the freeze-drying process. In the everted rat gut sac model, HPLC-UV analysis demonstrated that the released A-GAs from inclusion complexes were degraded to yield free gallic acid (GA) (sustained-release function 1). The small intestine membrane may be crossed by both the GA and the A-GAs. A-GAs may also undergo hydrolysis to provide GA (sustained-release function 2) following transmembrane transfer. Clearly, a helpful technique for the dual sustained-release of phenolic compounds is to produce β-cyclodextrin inclusion complexes with short-chain phenolipids. This will increase the bioactivities of phenolic compounds and prolong their in vivo residence length. Moreover, changing the carbon-chain length of these β-cyclodextrin inclusion complexes would readily modify the dual sustained-release behavior of the phenolic compounds. Thus, our work effectively established a theoretical foundation for the use of β-cyclodextrin inclusion complexes containing short-chain phenolipids as new source of functional food components to provide the body with phenolic compounds more efficiently.
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JOURNAL OF FOOD ENGINEERING
·
2025
·
IF 5.8
Bo Li,Tianchi Tang,Mengyue Jiang,Hui Chen,Yanhong Bai
Sustained-release nanofilms incorporated with oregano essential oil (OEO) were developed by emulsion electrospinning using polyvinyl alcohol (PVA) and quaternary-ammonium chitosan (QAC). The SEM, FTIR and XRD results showed that OEO was successfully encapsulated in the PVA/QAC nanofiber with a diameter range of 158.0–179.6 nm. The incorporation of OEO significantly enhanced the mechanical and barrier properties of PVA/QAC nanofilm, concomitantly mitigating its hydrophilic nature. The prepared PVA/QAC-OEO nanofilms demonstrated excellent antioxidant properties and antimicrobial activities against S. aureus and E. coli (the maximum inhibition zones achieving 23.13 ± 0.72 mm). The release kinetics results showed sustained release of OEO from the PVA/QAC nanofilms, and the release kinetics of OEO adhered to the Fickian + First order dynamics model (R 2 = 0.9570–0.9997), indicating that a combination of random diffusion and polymer structural relaxation influenced the release of OEO. Furthermore, preservation research showed that the PVA/QAC-OEO nanofilms significantly inhibited the rise in pH, total volatile base nitrogen (TVB-N), thiobarbituric acid reactive substances (TBARs), and total viable count (TVC) in chicken breasts stored at 4 °C, while also maintaining their color and texture properties. Particularly, chicken breasts wrapped in PVA/QAC-OEO 3 film exhibited an extended shelf life for 4 days. Therefore, the PVA/QAC-OEO nanofilms could be a prospective packaging material for meat preservation.
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FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Xi Chen,Hang Liu,Yicheng Yang,Pengfei Li,Xingru Wang,Kai Zhang,Kaifang Zeng,Jian Ming,Xiaojuan Lei
Floating delivery system enhances bioavailability of bioactive substances by extending their upper gastrointestinal absorption window. Proanthocyanidins offer various health benefits but have low bioavailability due to high sensitivity and low solubility under intestinal conditions. Based on the noneffervescent multiple-unit floating delivery system, this study developed proanthocyanidins-loaded chitosan-starch floating emulsion gel beads (S-CS-PC) through emulsification and extrusion to improve proanthocyanidins bioavailability. FTIR, XRD and XPS analyses revealed interactions between chitosan and starch. SEM showed the distribution of oil phase and well-developed porous structure within the gel beads. Simulated gastric release profile of proanthocyanidins showed S-CS-PC prevented initial burst release observed in pure chitosan gel beads and achieved sustained release. Additionally, S-CS-PC demonstrated significant antioxidant capacity and antibacterial activity, maintaining stability and functionality of encapsulated bioactive substances. This straightforward method with greater scalability and cost-effectiveness, renders the delivery system suitable for industrial-scale production and potential use in functional foods and dietary supplements.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yue Zou,Qizheng Zheng,Yonglin Tang,Yawen Yan,Shiyuan Zhou,Hong-Gang Liao,Yu Qiao,Jun Bao,Shi-Gang Sun
Increasing the nickel content in high-nickel LiNi x Co y Mn 1-x-y O 2 cathode materials (NCM) can boost their energy density. However, the consequence of rising Ni content in NCM consists in the heightened stress buildup, intensified irreversible phase transition and severe electrolyte decomposition, and consequently accelerating the battery’s degradation. In the current study, we have revealed that the 4-fluoro-N, N dimethylbenzenesulfonamide (FBSN) as an electrolyte additive can refrain the typical dehydrogenation of EC. Furthermore, a continuously repaired cathode electrolyte interphase (CEI) is designed elaborately on LiNi 0.9 Co 0.05 Mn 0.05 O 2 (NCM90) surface by employing the FBSN as a sustained-release electrolyte additive to enhance cycling stability of NCM90||Li cells. This CEI, composed of high mechanical strength LiF and benzene ring skeleton, along with conductive Li + moieties (S-rich and N-rich species), can be effectively self-repaired in time when damaged, reduce the interaction between the NCM90 and sensitive electrolyte, and mitigate the devastation to the NCM90 cathode surface. As a result, the NCM90||Li cells with 2 % FBSN-containing electrolyte delivers a capacity retention of 90.2 % after 200 cycles at 1C, and 83.1 % after 200 cycles even at higher voltage of 4.5 V, superior than that of Base electrolyte (70.0 % at 4.3 V and 68.0 % at 4.5 V). This study provides an engaging approach to design electrolytes for high-nickel cathodes by autonomously interfacial repair.
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Gels
·
2025
·Vol. 11
·期 10
·813
·
IF 5.3
Bingbing Chen,Mengqi Hao,Hao Cui,Rui Zeng,Hang Ma,Anying Long,Xuegang Li
Periodontitis is a chronic oral inflammatory disease whose treatment is often hindered by poor drug retention, prolonged therapeutic regimens, and the rise of antibiotic resistance. In this study, we developed a Hydrogel@ZIF-8@metronidazole (Hydrogel@ZIF-8@MNZ) nanocomposite dressing for targeted, sustained, and in situ antimicrobial therapy. This system integrates ZIF-8, a pH-responsive metal–organic framework, with the antimicrobial agent metronidazole (MNZ), encapsulated within a crosslinked hydrogel matrix to enhance stability and retention in the oral environment. Drug release studies demonstrated that MNZ release was significantly accelerated under acidic conditions (pH 5.0), mimicking the periodontal microenvironment. The Hydrogel@ZIF-8 composite achieved a maximum MNZ adsorption capacity of 132.45 mg·g −1 , with a spontaneous and exothermic uptake process best described by a pseudo-second-order kinetic model, suggesting chemisorption as the dominant mechanism. The nanoplatform exhibited strong pH-responsive behavior, with enhanced drug release under acidic conditions and potent dose-dependent bactericidal activity against Fusobacterium nucleatum ( Fn ). At the highest tested concentration, bacterial survival was reduced to approximately 30%, with extensive membrane disruption observed through live/dead fluorescence microscopy. In summary, the stimuli-responsive Hydrogel@ZIF-8@MNZ nanocomposite offers an intelligent and effective therapeutic strategy for periodontitis. By tailoring its action to the disease microenvironment, this platform enables sustained and localized antibacterial therapy, addressing major challenges in the treatment of chronic oral infections.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Linlin Chen,Zhang Ming,Wei Li,Yingjie Zhou,Sicong Zhang,Xiyao Yang,Jiaying Xin,Na Zhang
Ferulic acid (FA) is a natural polyphenolic compound that has garnered significant attention due to its exceptional antioxidant, anti-inflammatory, and anticancer bioactivities. However, its poor chemical stability, low solubility, and insufficient bioavailability in practical applications severely limit its widespread use in the food, pharmaceutical, and cosmetics industries. To improve the stability and bioavailability of FA, this study used rice starch (RS), debranched starch (DBS) and soluble starch (SS) modified with octenyl succinic anhydride (OSA) as carriers to prepare three FA complexes, with the aim of improving their solubility and stability. The antioxidant activity, stability, and in vitro release behavior of the encapsulated FA were evaluated. Experimental results indicated that the encapsulation mechanism of ferulic acid by starch-based carriers involves hydrogen bonding, van der Waals force, and hydrophobic interactions. OSA-DBS exhibited the highest encapsulation efficiency, attributed to its compact cavity spiral structure. At the same time, OSA-SS and OSA-RS had lower encapsulation efficiencies due to their loose structure and mixed crystalline-amorphous structure, respectively. FA@OSA-DBS exhibited the strongest antioxidant activity and antibacterial ability, with significantly improved solubility and stability. In vitro release studies showed that FA@OSA-DBS exhibited a slow release rate in a simulated physiological environment, following a first-order kinetic model. The results indicate that the preparation of FA complexes using esterified starch can significantly improve the physical and chemical properties of FA by regulating the interfacial characteristics of starch. This finding lays the theoretical foundation for the development of phenolic acid-starch composite systems in the field of functional materials.
研究领域:
食品科学与技术
·
高分子科学
·
药物递送系统
·
功能食品
·
材料科学
·
纳米技术
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危险品化学品经营许可证（带存储）