Advanced Science
·
2025
·
IF 14.1
Ziyi Lu,Ruisi Cai,Tianao Xie,Sheng Zhao,Sarun Juengpanich,Win Topatana,Shijie Li,Jiasheng Cao,Jiahao Hu,Tianen Chen,Jiachen Chen,Jicheng Yu,Tao Sheng,Wentao Zhang,Hao Wang,Jiahuan You,Yukai Shan,Yuchao Sun,Ruijing Shen,Zhengjie Zhao,Kangfan Ji,Ziqi Gao,Xinmin Yu,Xiujun Cai,Zhen Gu,Yuqi Zhang,Mingyu Chen
Monitoring neutrophil levels plays an essential role in diagnosing infections and various diseases, as well as for managing specific treatments such as chemotherapy and radiotherapy. However, the traditional complete blood count technique is invasive and challenging for quick and frequent monitoring of neutrophil. Herein, a button-like microneedle patch for rapid and convenient detection of neutrophil levels is reported without vascular invasion. This patch consists of a hollow microneedle array with a vacuum chamber for extraction of interstitial fluid, a hydrogel sheet for colorimetric detection of neutrophil level based on neutrophil-specific enzyme (myeloperoxidase), and a mobile phone application for data recording and quantification. The detection ability is validated both in vitro and in vivo in a chemotherapy-induced neutropenic rat model. Moreover, this button patch achieves precise measurement of the neutrophil levels in patients’ urine and abdominal drainage fluid. This minimally invasive colorimetric patch can potentiate in situ neutrophil monitoring without blood sampling procedures or in-lab apparatus, which can serve as a substitution for routine blood counts especially for patients in less developed areas.
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DOI
PubMed
高影响因子
DRUG METABOLISM AND DISPOSITION
·
2024
·Vol. 52
·期 8
·911-918
·
IF 4.4
Jingyu Zhang,Weiwei Li,Ying Liu,Yan He,Zihao Cheng,Ximei Li,Yu Chen,Aihua Zhang,Ying Peng,Jiang Zheng
Arsenite is an important heavy metal. Some Chinese traditional medicines contain significant amounts of arsenite. The aim of this study was to investigate subacute exposure of arsenite on activities of cytochrome P450 enzymes and pharmacokinetic behaviors of drugs in rats. Midazolam, tolbutamide, metoprolol, omeprazole, caffeine, and chlorzoxazone, the probe substrates for cytochrome P450 (CYP) s3A, 2C6, 2D, 2C11, 1A, and 2E, were selected as probe drugs for the pharmacokinetic study. Significant decreases in areas under the curves of probe substrates were observed in rats after consecutive 30-day exposure to As at 12 mg/kg. Microsomal incubation study showed that the subacute exposure to arsenite resulted in little change in effects on the activities of P450 enzymes examined. However, everted gut sac study demonstrated that such exposure induced significant decreases in intestinal absorption of these drugs by both passive diffusion and carrier-mediated transport. In addition, in vivo study showed that the arsenite exposure decreased the rate of peristaltic propulsion. The decreases in intestinal permeability of the probe drugs and peristaltic propulsion rate most likely resulted in the observed decreases in the internal exposure of the probe drugs. Exposure to arsenite may lead to the reduction of the efficiencies of pharmaceutical agents coadministered resulting from the observed drug–drug interactions.
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DOI
PubMed
高影响因子
Green Processing and Synthesis
·
2021
·Vol. 10
·期 1
·219-229
·
IF 2.83
Yiming Xu,Suli Liu,Weijun Meng,Hua Yuan,Weibao Ma,Xiangqian Sun,Jianhong Xu,Bin Tan,Ping Li
Heavy alkyl benzene sulfonates are inexpensive surfactants that are extensively used as oil-displacing agents during tertiary oil recovery. Among these, C 16–18 heavy alkyl benzene sulfonates possess an excellent ability to reduce the oil-water interface tension. In this study, hexadecylbenzene sulfonic acid (HBSA) was synthesised in a continuous stirred-tank microreactor using a continuous method with 1,2-dichloroethane (EDC) dilution. Post-sulfonation liquid SO 3 solution was used as a sulfonating agent for hexadecylbenzene (HDB). The effects of reaction conditions, such as the SO 3 :HDB molar ratio, sulfonation temperature and sulfonation agent concentration, on the yield and purity of the product were investigated. Optimisation of the reaction process yielded high-quality HBSA samples with a purity exceeding 99 wt%. The continuous sulfonation process significantly enhanced the production and efficiency in the case of a considerably short residence time (10 s) in the reactor, without the need for aging. The results of this study demonstrate significant potential for application in industrial production.
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高影响因子
Frontiers in Plant Science
·
2023
·
IF 5.6
Chen Qingbing,Gao Kang,Xu YuRan,Sun YaHui,Pan Bo,Chen Dongliang,Luo Chang,Cheng Xi,Liu Hua,Huang Conglin
Chrysanthemums are one of the top ten most well-known traditional famous flowers in China and one of the top four cut flowers worldwide, holding a significant position in landscape gardening. The cold temperatures of winter restrict the cultivation, introduction, and application of chrysanthemum, resulting in high costs for year-round production. This severely impacts the ornamental and economic value of chrysanthemum. Therefore, research on cold tolerance is of vital importance for guiding chrysanthemum production and application. With the development of genomics, transcriptomics, metabolomics, and other omics approaches, along with high-throughput molecular marker technologies, research on chrysanthemum cold tolerance has been continuously advancing. This article provides a comprehensive overview of the progress in cold tolerance research from various aspects, including chrysanthemum phenotype, physiological mechanisms, the forward genetics, molecular mechanisms, and breeding. The aim is to offer insights into the mechanisms of cold tolerance in chrysanthemum and provide reference for in-depth research and the development of new cold tolerance chrysanthemum varieties.
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DOI
高影响因子
npj 2D Materials and Applications
·
2024
·Vol. 8
·期 1
·1-6
·
IF 9.1
Cui Yuanyuan,Wang Tingjun,Hu Deng,Wang Zhiwei,Hong Jiawang,Wang Xueyun
2-dimensional (2D) piezoelectric materials have gained significant attention due to their potential applications in flexible energy harvesting and storage devices. Recently, niobium oxide dihalides NbOI 2 stands out as a multifunctional anisotropic semiconductor family with an exceptionally high lateral piezoelectric constant (~21.8 pm/V), making it a promising candidate for energy conversion applications. Here we report the experimental observation of anisotropic in-plane piezoelectricity in multilayer NbOI 2 . Current-voltage relationships reveal a significant piezotronic effect in two typical crystalline orientations. Additionally, cyclic tensile and release experiments demonstrate an intrinsic current output of up to 140 pA when subjected to a tensile strain of 0.51%. A flexible piezoelectric nanogenerator prototype is demonstrated on the human finger and wrist, which opens up new avenues for the development of wearable electronic devices and provides valuable insights for further exploration in this field.
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DOI
高影响因子
LUMINESCENCE
·
2023
·Vol. 38
·期 8
·1465-1476
·
IF 2.9
Sheng Wu,Puxian Xiong,Kexin Qin,Yao Xiao,Binli Xiao,Kang Chen,Dongliang Jiang,Yinzhen Wang
Mechanoluminescence (ML) materials have found potential applications in information storage, anti-counterfeiting, and stress sensing. Conventional stress sensing based on absolute ML intensity is prone to significant mistakes owing to the unpredictability of measurement surroundings. However, implementing a ratiometric ML sensing technique may considerably ameliorate this issue. In this study, a single activator-doped gallate material (LiGa 5 O 8 :Pr 3+ ) is proposed to determine the relationship between the ML intensity and the change in local positional symmetry that occurs when the material is subjected to stress. The sensing reliability of the ML intensity ratio under different factors (Force; Content; Thickness and Materials) is systematically analyzed, where the factor that has the greatest effect on the proportional ML is the concentration, with the ML intensity asymmetry ratio decreasing from 1.868 to 1.300 varying concentration at constant stress. The colour-resolved visualization of stress sensing is further realized, which opens a new path for a ratiometric ML-based strategy to improve the reliability of stress sensing.
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高影响因子
Nature Communications
·
2011
·Vol. 2
·期 1
·1-8
·
IF 0
Sandnes B.,Flekkøy E.G.,Knudsen H.A.,Måløy K.J.,See H.
Pattern-forming processes in simple fluids and suspensions have been studied extensively, and the basic displacement structures, similar to viscous fingers and fractals in capillary dominated flows, have been identified. However, the fundamental displacement morphologies in frictional fluids and granular mixtures have not been mapped out. Here we consider Coulomb friction and compressibility in the fluid dynamics, and discover surprising responses including highly intermittent flow and a transition to quasi-continuodynamics. Moreover, by varying the injection rate over several orders of magnitude, we characterize new dynamic modes ranging from stick-slip bubbles at low rate to destabilized viscous fingers at high rate. We classify the fluid dynamics into frictional and viscous regimes, and present a unified description of emerging morphologies in granular mixtures in the form of extended phase diagrams.
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DOI
Biocatalysis and Agricultural Biotechnology
·
2024
·
IF 3.4
Amjad Ali,Fatih Ölmez,Muhammad Ahmad Zeshan,Mustansar Mubeen,Yasir Iftikhar,Ashara Sajid,Muhammad Abid,Ajay Kumar,Praveen Kumar Divvela,Manoj Kumar Solanki
Yeast species found in the phyllosphere and rhizospheric soil of plants are acknowledged as proficient biocontrol agents against the soilborne and airborne fungal plant pathogens . The unicellular yeasts are particularly valuable due to their ease of cultivation and effectiveness as biocontrol agents against various yeast genera. This review article thoroughly described the fundamental exploration of yeast biocontrol mechanisms, including myco-parasitism, volatile metabolites, killer toxin production, toxic enzyme secretion, induction resistance in the host plant, and competition for resources on plant surfaces and in the soil. Antagonistic yeasts are highlighted for their productions of killer toxins, that disrupt vulnerable segments of the targeted pathogen, such as cell wall degradation, plasma membrane disruption, tRNA linkage breakage, and DNA mutation. The use of beneficial microbe-based products those derived from yeast is a multifaceted strategy to controlling post-harvest fungal pathogens and enhancing plant health. Commercially available yeast-based products, namely Boni-protect® (Aureobasidium pullulans), Nexy® (Candida oleophilic), Candifruit® (Candida sake), Shemer® (Metschnikowia fructicola), Pantovital® (Pantoea agglomerans), and Romeo® ( Saccharomyces cerevisiae )." For example: “Boni-protect® (Aureobasidium pullulans), Nexy® (Candida oleophilic), Candifruit® (Candida sake), Shemer® (Metschnikowia fructicola), Pantovital® (Pantoea agglomerans), and Romeo® ( Saccharomyces cerevisiae ) are discussed for their efficacy against postharvest fungal pathogens. This review article enhances the understanding of biocontrol mechanism and formulation strategies for yeast based commercial products, supporting future research efforts in fungal pathogen managements.
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高影响因子
Current Nanoscience
·
2022
·Vol. 18
·期 1
·94-105
·
IF 1.513
Ailing Yang,Lele Wang
Background: Semiconductor nanomaterials are being employed for the degradation of organic compounds under solar light irradiation. Introduction: Cu2O nanomaterial is suitable for visible-light photocatalysis because the narrow band-gap (∼2.17 eV) allows it to absorb visible light. However, the morphological changes of Cu2O during photocatalysis have been rarely investigated. Methods: Porous Cu2O nanoshells (NSs) with a nearly 100% hollow structure were synthesized by a two-step addition of reducer. The synthesized NSs were characterized and employed for the photocatalysis of methyl orange (MO) in a neutral solution at 30 °C in air. Results: The Cu2O NSs exhibited high adsorption and good photocatalysis rates with respect to the degradation of MO. Certain new phenomena were observed upon photocatalysis. Nearly all the chemical bonds in MO were fractured; however, a portion of the sulfur-containing group in MO remained on the NSs. The morphology of the Cu2O NSs changed and a large amount of nano-debris was produced. Further experimental analysis indicated the presence of some nano-debris after adsorption- desorption equilibrium (ADE). A negligible amount of nano-debris appeared during the light irradiation of the Cu2O suspension in the absence of MO. The results obtained via X-ray diffraction (XRD), scanning transmission electron microscopy (STEM) and high-resolution transmission electron microscopy (HRTEM) proved that the nano-debris was composed of Cu2O, and essentially comprised nanosheets that were discarded from the Cu2O NSs. Conclusion: The porous NSs were composed of Cu2O nanosheets with exposed {111} facets, which resulted in their strong adsorption ability and catalysis performance for the degradation of MO. Light irradiation accelerated this interaction and led to the discarding of Cu2O nanosheets from the Cu2O NSs. Because of the strong interaction between Cu+ and S, a portion of the sulfur-containing group in MO remained on the NSs after photocatalysis.
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高影响因子
Light-Science & Applications
·
2014
·Vol. 3
·期 8
·e193
·
IF 8.476
Qin Wei-Ping,Liu Zhen-Yu,Sin Chol-Nam,Wu Chang-Feng,Qin Guan-Shi,Chen Zhe,Zheng Ke-Zhi
Cooperative luminescence (CL) occurs in spectral regions in which single ions do not have energy levels. It was first observed more than 40 years ago, and all results reported so far are from a pair of ions. In this work, upconverted CL of three Yb 3+ ions was observed in the ultraviolet (UV) region under near-infrared (NIR) excitation. The UV CL intensity showed a cubic dependence on the NIR pump power, whereas the luminescence lifetime was nearly one-third the luminescence lifetime of single Yb 3+ ions. The triplet CL (TCL) has a clear spectral structure, in which most emission peaks are consistent with the self-convoluted spectra from single Yb 3+ ions. Blue shifts were observed for certain peaks, indicating complex interactions among the excited Yb 3+ ions. The probability of the TCL process versus the average distances among three Yb 3+ ions was derived via the first- and second-order corrections to the wave functions of lanthanide ions, indicating that the formation of Yb 3+ clusters containing closely spaced ions favors the occurrence of the multi-ion interaction processes. Furthermore, the cooperative sensitization of one Gd 3+ ion by four excited Yb 3+ ions (Yb 3+ -tetramer) was demonstrated experimentally, which exhibited a novel upconversion mechanism—cluster sensitization. Our results are intriguing for further exploring quantum transitions that simultaneously involve multiple ions.
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DOI
高影响因子
Materials Chemistry Frontiers
·
2020
·Vol. 5
·期 1
·430-437
·
IF 6.788
Mengyu Hong,Jingjing Meng,Huihui Yu,Junli Du,Yang Ou,Qingliang Liao,Zhuo Kang,Zheng Zhang,Yue Zhang
Zinc oxide (ZnO) has been widely considered as a promising candidate in electro-chemical devices due to the high electrical transport performance and easy-fabrication. However, the active chemical properties of ZnO nanobelts restrict their application in practical electro-chemical devices. Here, we adopted an indium doping strategy to improve the corrosion resistance of ZnO nanobelts. Compared with other atomic doping methods, the indium doping method not only formed several layers of indium atoms in the body of ZnO nanobelts but also created a ZnxIn1−xO passivated layer on the ZnO nanobelt surface. After doping indium atoms into ZnO nanobelts, the self-corrosion potential increased and the self-corrosion current decreased which greatly reduced its corrosion rate in the electrochemical solution. Furthermore, the electrical transport properties of indium-doped zinc oxide (In–ZnO) nanobelts presented ultrahigh stability even after being soaked in the electrochemical solution for 43 hours. The enhanced anticorrosive quasi-2D ZnO nanobelts offer a promising development of ZnO-based electro-chemical devices.
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高影响因子
Diagnostics
·
2021
·Vol. 11
·期 8
·1466
·
IF 3.706
Piotr Kanclerz,Ramin Khoramnia,Xiaogang Wang
Introduction: Accurate assessment of the corneal shape is important in cataract and refractive surgery, both in screening of candidates as well as for analyzing postoperative outcomes. Although corneal topography and tomography are widely used, it is common that these technologies are confused. The aim of this study was to present the current developments of these technologies and particularly distinguish between corneal topography and tomography. Methods: The PubMed, Web of Science and Embase databases were the main resources used to investigate the medical literature. The following
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高影响因子
危险品化学品经营许可证（带存储）