ANTI-CANCER DRUGS
·
2019
·Vol. 30
·期 1
·46-55
·
IF 1.801
Lin Fuxing,Yang Jie,Muhammad Umair,Sun Jing,Huang Zhenghua,Li Wei,Lv Fengxia,Lu Zhaoxin
Bacillomycin D can inhibit the growth of Aspergillus ochraceus in food samples. In addition, it can induce apoptosis in and inhibit the proliferation of cancer cells, although the details of this mechanism are unknown. In this study, we separated bacillomycin D-C14, D-C15, D-C16
monomers from the Bacillus subtilis strain fmbJ. The bacillomycin D monomers containing longer fatty acid chains better induced apoptosis in Bgc-823, Sgc-7901, and Hgc-27 gastric cancer cells. The Bgc-823 cell line was the most sensitive. Acridine orange-ethidium bromide staining indicated
that bacillomycin D-C16-induced Bgc-823 cell death by triggering apoptosis, characterized by membrane blebbing, cellular shrinkage, and DNA fragmentation. Flow cytometric analysis showed a bacillomycin D-C16 dose-dependent trigger of Bgc-823 apoptosis. Bacillomycin D-C16-induced the mitochondrial
pathway, as indicated by a reduced Bcl-2/Bax expression ratio, enhanced cytochrome C release, and higher levels of cleaved caspase-3. Furthermore, bacillomycin D-C16 effectively repressed phosphorylation of the serine–threonine protein kinase Akt at Ser-473 and increased the levels of
the FoxO3a protein. The combination of the PI3K/Akt-inhibitor BEZ235 with bacillomycin D-C16 enhanced the apoptosis of Bgc-823 cells. Together, these findings indicated that bacillomycin D-C16 induces apoptosis through the PI3K/Akt and FoxO3a signaling pathways.
研究领域:
肿瘤学
·
分子生物学
·
细胞生物学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 20
·1565
·
IF 3.2
Yang Bowen,Zhang Siqi,Guan Mengxiang,Liu Lei,Yan Ziyu,Liang Yongri,Peng Guirong,Zhou Zhe
Owing to the outstanding ferroelectric properties, PVDF and its copolymers have emerged as the most promising piezoelectric polymer materials to date. To enhance the dielectric constant of P(VDF-HFP) while reducing its dielectric loss, BT@C@SiO 2 with a double-layer shell structure was synthesized and blended with P(VDF-HFP) to fabricate a piezoelectric film. Under mild conditions, PDA was synthesized as the precursor of the conductive carbon inner shell, which was carried out in a weakly alkaline Tris buffer system at room temperature, only involving stirring, centrifugation, water washing, and low-temperature drying, without any drastic reaction procedures. The results demonstrated that the incorporation of BT increased the dielectric constant of the film, whereas the introduction of the C layer formed micro-capacitors within the matrix, further enhancing the dielectric constant. Simultaneously, the C layer with high defect density captured freely mobile carriers in the film, thereby reducing AC conductivity and dielectric loss, which improved the energy harvesting efficiency of the piezoelectric film. The dielectric constant of the BT@C@SiO 2 /P(VDF-HFP) film could reach up to 15.8 (100 Hz), while the dielectric loss and conductivity were as low as 0.042 and 3.77 × 10 –9 S/m (100 Hz), respectively. The BT@C@SiO 2 acted as a nucleating agent in the P(VDF-HFP) matrix, and consequently induced the increase of the crystallization temperature and the formation of β phase in P(VDF-HFP). When the BT@C@SiO 2 content reached 5%, under a pressure of 40 N and a loaded resistance of 10 6 Ω, the composite film achieved its highest piezoelectric output with the output voltage of 1.1 V. Under a pressure of 40 N and a loaded resistance of 10 11 Ω, the piezoelectric output power reached its maximum value of 8.76 μW. A 5% BT@C@SiO 2 /P(VDF-HFP) film was fabricated into a piezoelectric sensor for practical applications. The output voltages of the film during finger bending, finger tapping and foot stepping were 0.40 V, 0.75 V, and 2.65 V, respectively. These results indicated that BT@C@SiO 2 /P(VDF-HFP) piezoelectric film exhibited potential application in motion monitoring.
✓ 已验证
DOI
高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2026
·
IF 3.1
Zhou Siliao,Zhou Wangdong,Zhou Jiahui,Liu Jing,Wei Yan
Developing sensing interfaces that simultaneously integrate catalytic activity, efficient charge transfer, and structural stability remains a major challenge for high-performance non-enzymatic glucose sensing. Herein, a CuS/Ti₃C₂/rGO ternary composite was fabricated through a combination of liquid-phase precipitation and self-assembly. Structural, surface, and electrochemical studies revealed that the enhanced sensing performance originated from the synergistic integration of catalytic CuS, conductive Ti₃C₂, and rGO-assisted structural protection. Under optimized conditions, the sensor exhibited a fast response time of 3.7 s, a wide linear range of 0.01–10.35 mM, and a low detection limit of 3.33 µM (S/ N = 3). In addition, satisfactory selectivity, stability, repeatability, and reproducibility were achieved. Recoveries of 98.1–105.0% were obtained in commercial oral liquids and fruit juice samples, demonstrating good analytical reliability in complex matrices. These findings indicate that the proposed catalysis-conduction-protection strategy provides an effective design principle for constructing high-performance non-enzymatic glucose sensing interfaces.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Ping Liang,Shuai Shao,Xiaocan Liu,Ziwen Zhang,Dandan Wang,Weiye Yang,Lijian Meng,Junfeng Zhang,Shihua Zhao
This study reports the construction of a g-C₃N₄/ZnTiO₃/BiOI ternary heterojunction photocatalyst for the efficient degradation of organic dyes. The optimized g-C₃N₄/ZnTiO₃/BiOI composite with a mass ratio of 1:1:2 exhibited excellent photocatalytic activity toward Rhodamine B (RhB), achieving nearly complete degradation within 40 min at pH 11, with an apparent rate constant of 0.05114 min⁻¹ . The composite also showed photocatalytic degradation ability toward methylene blue (MB) and methyl orange (MO), as well as satisfactory performance in different real water matrices, demonstrating its broader applicability. Structural and surface analyses confirmed the successful formation of the ternary composite, while BET results indicated that the retained mesoporous structure facilitated reactant diffusion and interfacial mass transfer. UV–vis DRS revealed an extended light absorption range beyond 600 nm, and photoelectrochemical measurements demonstrated reduced charge-transfer resistance and enhanced separation and migration of photogenerated carriers. Radical trapping and EPR analyses identified ¹O₂ and •OH as the dominant reactive species. After five cycles, the RhB degradation efficiency remained above 90%, indicating good stability. Combined with Mott–Schottky measurements, XPS analysis, work-function calculations, Bader charge analysis, and differential charge density results, a ZnTiO₃-mediated dual S-scheme charge-transfer mechanism was proposed. This work provides a feasible strategy for designing efficient ternary heterojunction photocatalysts for dye-contaminated wastewater treatment.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2026
·Vol. 28
·期 5
·135
·
IF 3.5
Guo Hao,Zhang Baowen,Bai Ziwei,Miao Rusen,Zhang Kaiyue,Wang Meng,Tian Fei
A rapid, sensitive, and convenient surface-enhanced Raman spectroscopy (SERS) substrate was developed using Fe₃O₄/C as the magnetic core and SiO₂-SH as the shell for the detection of aflatoxin B1 (AFB1). Ultra-small Fe₃O₄/C nanoparticles (NPs) with an average size of 6.30 ± 0.68 nm and excellent magnetic responsiveness were synthesized via a one-pot hydrothermal method, followed by the deposition of a uniform SiO₂ shell, followed by thiol-group functionalization to yield Fe₃O₄/C/SiO₂-SH. The magnetic core enables instantaneous separation of the substrate from solution after AFB1 adsorption, eliminating the need for centrifugation or filtration. When employed as a SERS substrate, significant enhancement of the characteristic Raman peak at 1482 cm⁻ 1 was observed across AFB1 concentrations of 0.1–10 μg/mL. Notably, the peak intensity at 10 μg/mL exceeded that of solid AFB1 powder. Comprehensive characterization (TEM, XRD, FTIR, XPS, and vibrating sample magnetometry) confirmed the core–shell structure, high crystallinity, and strong magnetic properties. The prepared Fe₃O₄/C/SiO₂-SH nanocomposite offers a low-cost, easily recyclable, and noble-metal-free platform, demonstrating strong potential for trace AFB1 monitoring in herbal medicines and food products.
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Yizhe Wang,Siyue Li,Ye Yuan,Qixin Zhuang,Xiaoyun Liu,Peiyuan Zuo
The rational design of yolk–shell structured materials with integrated dielectric–magnetic synergy has emerged as a critical strategy for developing lightweight and high-performance electromagnetic wave (EMW) absorbers. Comparing to the conventional yolk–shell structures that typically rely on single cavity configuration, the air-induced dual-cavity yolk–shell structures offer both lightweight absorber design and substantial enhancements in interfacial polarization over wide frequency range. To this end, this study proposes a novel “coating-protected etching-high temperature carbonization” strategy to successfully construct an air-induced dual-cavity yolk–shell hollow Fe₃O₄@air@Co/C composite absorber. The unique nanostructure possesses two independent cavities: one within the inner hollow Fe₃O₄ core, and another between the inner Fe₃O₄ core and the Co/C shell. The dual cavities not only significantly reduce the material density but also optimize the impedance matching. Importantly, the synergistic effects of the air-induced dual-cavity interfaces (Fe₃O₄-air and Co/C-air) amplify multi-interfacial polarization and improve the absorption ability via combined magnetic and dielectric loss mechanisms. Experimental results demonstrate that the optimized absorber achieves a remarkable reflection loss of –67.21 dB and a maximum effective absorption bandwidth (EAB) of 5.12 GHz (12.08–17.20 GHz) at an ultra-thin thickness of 2.0 mm and a low filler loading of 20 wt%. Collectively, our findings provide a new design approach for constructing high-efficiency, lightweight EMW absorption materials.
✓ 已验证
产品关联
DOI
高影响因子
ORGANIC & BIOMOLECULAR CHEMISTRY
·
2026
·
IF 2.8
Lin Chen,Shuang Xu,Zhiming Chen
Direct α-C(sp3)−H arylation of 4-aminopyrazolones involving arynes, enabled by dual phase-transfer catalysis and ultraviolet irradiation, has been developed. The dual phase-transfer catalytic pathway powered by triaminocyclopropenium salts gave rise to the generation of structurally diverse 4-amino-4-arylpyrazolones in moderate to excellent yields, while the photochemical protocol furnished the products with moderate yields. Notably, these products are tentatively proposed as candidates for carbamate pesticides based on the preliminary structural analysis. The synthetic potentials of the methods were shown by gram-scale reactions, and the possibilities for greater structural diversity of the product were highlighted by derivatizations. The results of control experiments indicated that the timely capture of the transient arynes by the activated 4-aminopyrazolone nucleophiles is the key to the success of the reactions.
✓ 已验证
DOI
PubMed
高影响因子
Science Bulletin
·
2026
·
IF 20.7
Ying Feng,Zhiquan Hou,Peijie Ma,Xiaohui Yu,Xun Wang,Kun Zheng,Yuxi Liu,Zhihua Wang,Zhenxia Zhao,Jiguang Deng,Hongxing Dai
The activation of C–H bonds is a fundamental process in various chemical reactions, while faces significant challenge under mild conditions due to the high bond energy and low polarity. An ultrathin (∼3 nm) amorphous oxygen-containing carbon layer inserted into Pt/TiO 2 yields C–O–M (M = Pt and Ti) dual interfaces. The photothermocatalytic consumption rate of n -heptane over Pt/C/TiO 2 at 140 ℃ is 8.8 and 61.8 times higher than that over Pt/TiO 2 and Pt/C, respectively. Temperature-programmed desorption (TPD) and density functional theory (DFT) calculations reveal that the constructed C–O–M interfaces significantly enhance the adsorption of hydrocarbon reactant, and decrease the C–H bond scission energy barrier. The photothermal X-ray photoelectron spectroscopy (XPS), femtosecond transient absorption (fs-TA) and electron paramagnetic resonance (EPR) experiments demonstrate that the C–O–Ti interface accelerates the electron migration and transforms the adsorbed oxygen into the superoxide species, thus efficiently oxidizing the reactant. Furthermore, introduction of an amorphous carbon layer to Pt/Al 2 O 3 , Pt/CeO 2 , Ce/TiO 2 or Cu/TiO 2 remarkably enhances the photothermal catalytic performance for propane, pentane, octane, toluene or hexanal oxidation. The unique effect of C–O–M dual interfaces induced via the ultrathin amorphous carbon layer provides a guideline for designing catalysts with efficient C–H bond activation ability.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CATALYSIS TODAY
·
2026
·
IF 5.1
Xiaohan Liu,Youhe Wang,Zhengyang Liu,Zhehui Zhang,Long Wang,Guanqi Li,Yulin He,Qingyi Yuan,Zifeng Yan
Transition metal-carbon compounds derived from Ni-MOFs show promise as catalysts for the hydrogen evolution reaction (HER) water electrolysis but suffer from limited reactivity and stability. Elemental doping is a key strategy to enhance both catalytic activity and durability. Here, we present an effective approach to simultaneously improve catalyst performance and structural robustness by in-situ doping a Ni-MOF precursor with La. Using a La-doped nanoflower-structured NiLa-MOF precursor as a self-sacrificing template, we obtained a highly active and stable nanoflower-like NiLa-Ni 2 P/C electrocatalyst via pyrolysis and phosphidation.Uniform La doping into the MOF precursor not only promotes nanoflower-like morphology formation and enhances stability, but also tunes the electronic structure of Ni active centres, markedly improving catalytic reactivity. Consequently, the NiLa-Ni 2 P/C catalyst delivers exceptional HER performance: only 167 mV overpotential and 90 mV·dec −1 Tafel slope at 10 mA·cm −2 in 1.0 M KOH. It also shows superior long-term stability over undoped Ni-Ni 2 P/C at the same current density. This work provides new insights and practical strategies for rare-earth-element-based HER catalysts in alkaline water electrolysis.
✓ 已验证
产品关联
DOI
高影响因子
CRYSTAL GROWTH & DESIGN
·
2026
·
IF 3.6
Tao Niu,Wenju Gu,Youwen Wang,Bin Gao,Wingkei Ho,Dingze Lu
To address the high energy consumption and low efficiency associated with traditional ammonia synthesis, we developed a nickel-doped cobalt-based bimetallic catalyst (CoNi-NC) derived from ZIF-67 for the efficient electrocatalytic reduction of nitric oxide (NO) to ammonia (NORR). The CoNi-NC-x catalyst, which features cobalt nanoparticles measuring 5–10 nm on a carbon support, was synthesized by introducing Ni2+ ions into ZIF-67 followed by vacuum pyrolysis. The incorporation of nickel optimized the electronic configuration of cobalt, maintained a high specific surface area, and improved the distribution of active sites. Electrochemical tests indicated that CoNi-NC-2 achieved an ammonia production rate of 19.7 μmol cm–2 h–1 and a Faraday efficiency of 15.8% at −1.0 V vs. RHE, outperforming Co-NC. Additionally, the catalyst exhibited excellent stability. The Zn-NO battery utilizing this catalyst facilitated the synergistic removal of NO, ammonia synthesis, and power generation, achieving a peak power density of 1.34 mW cm–2 and an open-circuit voltage of 1.91 V. Density functional theory calculations revealed that nickel doping reduced the d-band center of cobalt, weakened NO adsorption, and activated the N–O bond, thereby enhancing NORR activity.
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Chen Qiu,Yisen Huang,Yanhang Li,Fenglin Wang,Liwei Yan,Yang Chen,Huawei Zou,Yinfu Luo,Mei Liang
Silicone-phenolic hybrids (SiPRs) exhibit intrinsic self-ceramization behavior and unparalleled thermal-oxidative resistance, which endow them with significant potential in thermal protection engineering. However, obvious phase separation limits their practical use by causing an interfacial failure. In this study, 2-allylphenol and vinyltriethoxysilane were introduced into carborane and polysiloxane, respectively, to construct an unsaturated bond-modified organic–inorganic hybrid structure. Through regulation of the allyl groups in the resin matrix and utilization of addition cross-linking reactions, the hybrid resin achieves controlled transformation from a sea-island phase separation to a homogeneous phase. Benefiting from the molecular-scale homogeneity and tailored composition, the hybrids exhibited significantly enhanced thermo-oxidative stability and ablation resistance. Compared to phenolic resin (PR), SiCBPR0.75 showed enhanced thermal stability in air atmosphere, with its initial decomposition temperature and 800 °C residual weight increasing by 147.7 °C and 42.33%, respectively. Its ablation resistance improved significantly, reducing linear (LAR) and mass ablation rates (MAR) by 17.46% and 33.33% versus PR. Importantly, the back temperature decreased significantly from 129.2 to 70.1 °C, further confirming the material’s improved thermal protection capability. This study provides an effective approach for synthesizing tailored homogeneous organic–inorganic hybrid materials, offering valuable insights for developing next-generation thermal protection systems with combined erosion and ablation resistance.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Magnesium and Alloys
·
2026
·
IF 15.8
Bogu Liu,Shuo Liang,Xingqing Duan,Yawei Li,Haixiang Huang,Tingting Xu,Bao Zhang,Jianguang Yuan,Xiaohong Chen,Ying Wu
High entropy alloys (HEAs) have garnered considerable interest in catalysis owing to their unique characteristics, while transition metal oxides remain widely studied as classical catalysts. Herein, a novel core-shell FeCoNiCrCu/Fe 2 O 3 @C catalyst coated by a micro- and nano-scale amorphous carbon layer was prepared via a relatively facile synthesis method involving complexing multiple metal cations in organic solvents followed by calcination. Compared with MgH 2 , the initial hydrogen desorption temperature of MgH 2 with the FeCoNiCrCu/Fe 2 O 3 @C catalyst decreases significantly from 290 °C to 172 °C, and the peak temperature is reduced to 268 °C. Furthermore, the catalyzed MgH 2 enables hydrogen absorption even at room temperature under 3 MPa. It also demonstrates excellent cyclability, maintaining over 90% of its initial capacity after 50 cycles, along with progressively enhanced dehydrogenation kinetics. The excellent hydrogen storage performance of the catalyzed MgH 2 is contributed to the synergistic interplay of catalytic components collectively, including the “hydrogen diffusion channel” effect of the in-situ generated Co 3 Fe 7 , the “hydrogen pump effect” exhibited by the reversible catalytic phase pair Mg 2 Ni(Cu)/Mg 2 Ni(Cu)H 4 , as well as the multiphase interface composed of HEAs FeCoNiCrCu, Co 3 Fe 7 and MgH 2 . The amorphous carbon prevents particle agglomeration. This study demonstrates that the HEAs can exhibit significant catalytic effects through rational design.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）