BIOMATERIALS
·
2018
·
IF 8.806
Xuzhu Wang,Jundong Shao,Mustafa Abd El Raouf,Hanhan Xie,Hao Huang,Huaiyu Wang,Paul K. Chu,Xue-Feng Yu,Yang Yang,AbdelBasit M. AbdEl-Aal,Nefissa H.M. Mekkawy,Richard J. Miron,Yufeng Zhang
A near-infrared (NIR) light-triggered drug delivery platform is produced by incorporating SrCl 2 and BP nanosheets (BPs) into poly(lactic- co -glycolic acid) (PLGA) for bone regeneration . The fabricated BP-SrCl 2 /PLGA microspheres show efficient NIR absorption and photothermal effects due to the BPs. The NIR-triggered release behavior of Sr 2+ by flawing the PLGA shells is investigated and the microspheres exhibit excellent cell viability and biodegradability . Implantation of the BP-SrCl 2 /PLGA microspheres into a rat femoral defect demonstrates good tissue compatibility and excellent bone regeneration capacity under NIR light irradiation. Our study indicates that local release of Sr 2+ at optimal time periods controlled by NIR irradiation improves bone regeneration significantly and this NIR-triggered drug delivery system composed of BPs is suitable for therapies requiring precise control at specific time.
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DOI
PubMed
高影响因子
Frontiers in Materials
·
2022
·
IF 3.985
Zhang Zhang,Sun Chunyang
The rational design of the nanocarriers with active tumor targeting and specific chemotherapy for heat shock protein 90 (Hsp90) inhibition is attractive for combined chemo-photothermal therapy (PTT). Herein, a smart gold nanorod (GNR)-cored micelle (T-GNRAAG) was developed to encapsulate 17-allylamino-17-demethoxygeldanamycin (17-AAG, Hsp90 inhibitor) through a facile preparation approach. The characteristics of T-GNRAAG were evaluated both in vitro and in vivo. The designed nanoplatform possessed sufficient 17-AAG loading content and lactobionic acid-mediated active targeting for hepatoma cells. More importantly, the 808 nm laser irradiation not only initiated PTT for cell killing but also remotely triggered 17-AAG liberation within cancer cells via inducing the phase transition of poly(ɛ-caprolactone). All these features forcefully supported the effectiveness of T-GNRAAG in tumor growth inhibition. This work represents a proof-of-concept combinatorial chemo-PTT treatment.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 23
·10973-10983
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IF 3.3
Bicheng Hu,Yuhui Zhang,Jincheng Zhang,Jiazan Liu,Meng Lei,Chenxi Zhao,Qiujun Lu,Haiyan Wang,Fuyou Du,Shiying Zhang
In this work, a novel flower-shaped NV-g-C3N5@VS2 heterojunction was prepared by hydrothermal in situ synthesis using NV-g-C3N5 as the matrix and thioacetamide as the precursor. The prepared heterojunction showed a flower-like and layered structure, which widened the visible light absorption range and facilitated the usage of visible light. Under visible light irradiation, the NV-g-C3N5@VS2 heterojunction exhibited excellent photoelectrocatalytic nitrogen reduction activity with an ammonia yield of 49.26 μg h−1 mg−1 in an electrolyte solution saturated with N2. Moreover, the NV-g-C3N5@VS2 heterojunction achieved outstanding photocatalytic degradation activity. The photocatalytic degradation rate of Rhodamine (RhB) reached 95% in 35 min under visible light irradiation. More importantly, the catalyst displayed good reusability and stability after four cycling runs for the photodegradation of MB. The prepared catalyst showed excellent photocatalytic universality and was also applied to efficiently degrade organic pollutants such as methyl orange (MO) and methylene blue (MB). Therefore, solar light-driven photocatalytic and photoelectrocatalytic applications based on the NV-g-C3N5@VS2 heterojunction are expected to pave a new way for fertilizers, energy utilization, and environmental remediation.
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高影响因子
Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
Qinqin Yu,Youzhi Dai,Yulin Ling,Qian Wu,Zhu Zhang,Bo Feng
Single-atom catalysts have drawn tremendous attention on account of their high activity, selectivity and stability. Z-scheme heterojunctions can effectively improve the utilization of optical energy due to the enhanced separation of photogenerated electrons and holes. In this work, several catalysts associated with single-atom Fe (FeSA) loaded on Z-scheme heterojunction WO 3 /BiOBr were prepared; their structure, morphology and photoelectric properties were analyzed; their photocatalytic degradation performance of Ciprofloxacin (CIP) was investigated; and the effects of initial pH, initial CIP concentration, catalyst dosage, light intensity , inorganic anions and humic acid on CIP removal rate were examined. Relevant results showed that the percentage of CIP removal by FeSA/WO 3 /BiOBr could reach 98.5% (120 min); the optimal conditions were pH= 9, [CIP] 0 = 10 mg/L, [FeSA] 0 = 0.8 g/L and I light = 500 W (100% degradation rate within 30 min);·O 2 - and h + were the key active species. Results of the cyclic experiments suggested good stability of the catalyst. Furthermore, the mechanism of CIP photocatalytic degradation was proposed to be a synergistic mechanism of Z-scheme heterojunction migration and valence cycling between single-atom Fe 2+ and Fe 3+ . Finally, the products and pathways of CIP degradation were analyzed.
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高影响因子
BIOELECTROCHEMISTRY
·
2021
·
IF 5.373
Jintao Liang,Xiaohang Shi,Huafu Feng,Min Chen,Wenzhan Li,Junxiang Lai,Weipeng Hu,Guiyin Li
In this paper, a novel silicon-based light-addressable potentiometric sensor (LAPS) has been designed for the detection of 1,5-anhydroglucitol (1,5-AG) in human serum. Reduced graphene oxide-chitosan-ferrocene (RGO-CS-Fc)/AuNPs nanohybrids and pyranose oxidase (PROD) enzyme is used to fabricate biological sensitive membrane unit by layer-by-layer assembly technology. When a bias voltage is provided to the LAPS system, the catalytic oxidation reaction between 1,5-AG and PROD to produce H 2 O 2 . The by-product H 2 O 2 can oxidize Fc(Fe 2+ ) ions in RGO-CS-Fc nanohybrids into Fc(Fe 3+ ) ions, which cause the potential of the sensitive membrane surface to change and the potential shift of I-V curve will generate a corresponding offset response. Under the optimal conditions, the potential shift of the LAPS is linearly related to the concentration of 1,5-AG at 10 µg·mL −1 –350 µg·mL −1 with the correlation coefficient of 0.97414. The sensitivity is 0.44273 mV/µg·mL −1 and the lowest detection limit is 10 µg·mL −1 . In addition, the biosensor showed good specificity, acceptable stability and satisfactory recovery rates (91.28%-107.66%), which would be a potential testing methods in actual clinical samples.
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DOI
PubMed
高影响因子
Small
·
2022
·Vol. 18
·期 40
·2200263
·
IF 15.153
Ping-Ping He,Xiaoxue Du,Yuan Cheng,Qi Gao,Chang Liu,Xiaowen Wang,Yonghua Wei,Qilin Yu,Weiwei Guo
Stimuli-responsive DNA hydrogels are promising candidates for cancer treatment, as they not only possess biocompatible and biodegradable 3D network structures as highly efficient carriers for therapeutic agents but also are capable of undergoing programmable gel-to-solution transition upon external stimuli to achieve controlled delivery. Herein, a promising platform for highly efficient photothermal-chemo synergistic cancer therapy is established by integrating DNA hydrogels with Ti 3 C 2 T X -based MXene as a photothermal agent and doxorubicin (DOX) as a loaded chemotherapeutic agent. Upon the irradiation of near-infrared light (NIR), temperature rise caused by photothermal MXene nanosheets triggers the reversible gel-to-solution transition of the DOX-loaded MXene-DNA hydrogel, during which the DNA duplex crosslinking structures unwind to release therapeutic agents for efficient localized cancer therapy. Removal of the NIR irradiation results in the re-formation of DNA duplex structures and the hydrogel matrix, and the recombination of free DOX and adaptive hydrogel transformations can also be achieved. As demonstrated by both in vitro and in vivo models, the MXene-DNA hydrogel system, with excellent biocompatibility and injectability, dynamically NIR-triggered drug delivery, and enhanced drug uptake under mild hyperthermia conditions, exhibits efficient localized cancer treatment with fewer side effects to the organisms.
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2021
·
IF 4.539
Haitao Lv,Hui Chi,Xu Yang,Jing Peng,Wei Wang,Dongyan Tang
Compared with the typical stimulus of heat, which is difficult to manipulate under some actual conditions, light-induced mode to shape memory polymers(SMPs) can act as more ideal ones benefiting from the characteristics such as remote control, focused accuracy and rapid switched responses. Herein, inspired by the strong adhesion and efficient photothermal conversion of polydopamine (PDA) coatings, light-induced tunable shape memory of poly(ε-caprolactone)(PCL)-based polyurethanes (SMPUs) with better cell adhesiveness were fabricated by a post-synthesis approach of PDA onto the surfaces of micro/nanofibers to substitute its original thermo-responsiveness. The characterizations of the adjustable thickness of the coatings were detected by fourier transform infrared spectroscopy(FTIR) and the morphology was characterized by scanning electron microscopy (SEM). Shape memory behaviors of the PDA/SMPU fibers were investigated in details by differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA) and shape fixation/recovery angles detection. Moreover, by selecting bone marrow stem cells (BMSCs) as model, the viability and proliferation with the cell seeded onto were systematically characterized. The tenability of light-induced shape memory effects, their excellent cytocompatibility, and the more favorable for BMSC’s survival with better adhesion of osteoblast cells onto all these PDA-coated SMPU (PDA/SMPU), make it promising candidates for potential bone repairing and healing.
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高影响因子
Journal of Materials Chemistry A
·
2021
·Vol. 9
·期 43
·24308-24314
·
IF 12.732
Mingyue Jiang,Yue Yuan,Yuchen Fang,Shouxin Liu,Jian Li,Zhijun Chen,Qiuying Pang,Shujun Li
Using light-harvesting materials to enhance natural photosynthesis is attracting much attention in both materials and plant research. The working efficiency of most light-harvesting materials is, however, compromised by a narrow light-harvesting range (either ultraviolet (UV) only, or near-infrared (NIR) only) and a short lifetime of the excited state. We have now developed a new light-harvesting material (UCNP@CDs) from upconverting nanoparticles (UCNPs) and carbon dots (CDs), which has good photon up- and down-converting properties, because of the UCNPs and CDs, respectively. UCNP@CDs efficiently absorbed and converted both UV and NIR light to visible light, with a long lifetime for the excited state. UCNP@CDs was incorporated into a carboxymethylcellulose (CMC) matrix to produce a light-harvesting film that enhances natural photosynthesis, both by isolated chloroplasts and by living plants. Our rationally designed UCNP@CDs/CMC composite light-harvesting film was able to enhance photosynthesis by Arabidopsis thaliana by ∼12%.
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高影响因子
CATALYSIS TODAY
·
2013
·
IF 2.98
Xuefeng Hu,Huanhuan Ji,Fei Chang,Yongming Luo
In this study, a rapid reduction of Cr(VI) and degradation of 2,4,6-trichlorophenol (2,4,6-TCP) in a simultaneous manner was reported through the catalysis of g-C 3 N 4 under visible light ( λ > 420 nm) irradiation. The effects of initial concentration of reactants, dissolved O 2 and pH value were investigated systematically. It indicated that, under the optimized concentration, the Cr(VI) reduction and 2,4,6-TCP oxidation could be accomplished in couple of hours in the presence of g-C 3 N 4 . And also, the O 2 involvement and low pH value were able to significantly improve the removal rate of Cr(VI) and 2,4,6-TCP. In addition, the reaction mechanism was investigated through monitoring the reduced states of Cr(VI) and active oxygen intermediates formed during photoreaction by ESR and XPS, as well as determining the degradation products of 2,4,6-TCP by HPLC–MS. The results supported that the redox reactions of Cr(VI) and 2,4,6-TCP can be performed simultaneously via a synergistic oxidation–reduction mechanism in the presence of g-C 3 N 4 under visible light irradiation.
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高影响因子
AQUATIC TOXICOLOGY
·
2022
·
IF 5.202
Chun Wang,Lijuan Jiang,Wenxi Huang,Changhai Wang,Meilin He
The vertical movement of large-size and high-density MPs in the water column is usually along with dynamic changes in light intensity. However, whether the change in light availability affects the bioeffects of MPs on surrounding microalgae is currently unknown. This study investigated the effects of micron-sized polyvinyl chloride (mPVC, 143.5 μm) microplastics, alone and in combination with light intensity (from 7.5 to 162.5 μmol·m −2 ·s −1 ) on the growth and physiology of Desmodesmus sp. Although mPVC did not impact microalgal growth under optimal light (40 and 93.8 μmol·m −2 ·s −1 ), it could induce a no-contact shading effect, thereby significantly affecting the physiology of Desmodesmus sp. The growth of Desmodesmus sp. exposed to mPVC was enhanced under a high light intensity of 162.5 μmol·m −2 ·s −1 which can induce growth inhibition but was retarded when under a light inadequacy condition (20 μmol·m −2 ·s −1 ), along with a dose-dependent effect. Significantly, the photosynthesis of Desmodesmus sp. was a highly sensitive metabolic pathway to mPVC stress and largely influenced by the plastic particles under different light conditions. Additionally, mPVC modulated the energy metabolism strategy of Desmodesmus sp., depending on exposure dose and external light availability. Our findings provided a critical basis for the risk assessment of MPs in fluctuating light conditions.
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Han Tang,Zan Dai,Xiande Xie,Zhipan Wen,Rong Chen
A novel Cu 0.84 Bi 2.08 O 4 /PDS/visible-light (VL) system has been developed for efficient ciprofloxacin (CIP) degradation, which displayed much higher degradation activity and total organic carbon (TOC) removal efficiency than those of many bismuth-based and copper-based materials under visible light irradiation. More than 90% CIP could be removed over Cu 0.84 Bi 2.08 O 4 /PDS/VL system within 400 min. More importantly, the CIP degradation products completely lost the antibacterial activity towards Staphylococcus aureus , lowering the risk for the emergence of the drug resistance. Electron paramagnetic resonance (EPR) and trapping experiments demonstrated that sulfate radicals were the dominated reactive species and responsible for CIP degradation. Moreover, the Cu 0.84 Bi 2.08 O 4 /PDS/VL system maintained its high degradation capability and original composition after several recycles and easily recovered to its original activity after regeneration. The pH value, anions and ion strength had slightly influence on the CIP degradation over this reaction system. Moreover, Cu 0.84 Bi 2.08 O 4 /PDS/VL system also exhibited high activity for CIP degradation in actual river water. The results provided a new insight into the PDS activation for degradation of organic pollutants, which indicated a huge potential in practical wastewater treatment.
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高影响因子
Journal of Energy Storage
·
2023
·
IF 9.4
Xiaoyin Cao,Lijuan Yang,Jia Zhang,Zhaoqi Zhu,Jiyan Li,Hanxue Sun,Weidong Liang,An Li
The fabrication of composite phase change materials (CPCMs) is significant for harvesting and converting solar energy. Hence, we first report novel CPCMs based on inorganic multi-shelled hollow spheres (MHS) via a facile hydrothermal method and calcination treatment. 1-Hexadecylamine (HDA) and Octadecylamine (ODA) were incorporated into MHS by a simple impregnation treatment to prepare CPCMs. Owing to its multi-shelled structure, the CPCMs have an outstanding ability of leakage resistance . In addition, the CPCMs themselves exhibit excellent solar absorption of up to 80 % without further surface modification. The thermal conductivity of the CPCMs containing HDA and ODA was increased by 1.03 times and 1.67 times by comparison with that of pure PCMs. The enthalpy of the as-resulted CPCMs is 207.6 J/g and 151.5 J/g, which is higher than most existing CPCMs, and the enthalpy of the CPCMs containing HDA and ODA after 100 times cycles can still attain 110.9 J/g and 104.7 J/g. Under 1sun irradiation, the light-to-thermal conversion efficiency of the CPCMs containing HDA and ODA was measured to be 90.0 % and 92.1 %, respectively. Taking advantage of its inherently physicochemical stability, superior light absorption and thermal conductivity and leakage resistance , scalable and cost-efficient fabrication process, such MHS-based CPCMs may have great potential for a wide variety of applications such as photothermal conversion, solar energy harvesting and storage, and so on.
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高影响因子
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