Journal of Materials Chemistry A
·
2022
·Vol. 10
·期 19
·10625-10637
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IF 14.511
Kun Wang,Xiaobing Huang,Tao Zhou,Dan Sun,Haiyan Wang,Zhi Zhang
The NASICON-type Na4MnV(PO4)3 (NMVP) possesses potential as a cathode material in SIBs, and is known for its stable 3D Na+ superconductive framework, high voltage platform, and relatively low cost and toxicity. Nevertheless, the intrinsic poor electronic conductivity and Jahn–Teller effect from Mn3+ during cycling limit its further application. Herein, to address such issues, a well-designed 3D porous spheroidal Ce3+-doped NMVP@CeO2/C cathode was constructed via a simple spraying drying-assisted route. As proved, the synergistic effect of Ce3+ doping in the crystal framework and CeO2 surface coating was achieved simultaneously, which greatly improved the electronic conductivity, facilitated the ion diffusion transfer and stabilized the crystalline structure. As a result, the as-prepared sample delivered superior discharge performance (50.3 mA h g−1 at 50C) and long circular life (91.0 mA h g−1 after 2000 cycles at 5C with 86.7% capacity retention). Furthermore, the reversible biphasic reaction for cathodes was confirmed by Galvanostatic intermittent titration technique (GITT) and ex situ XRD. The DFT calculation revealed the influence of Ce3+-doping on the crystalline framework and electrochemical properties. Finally, the optimized NMVP cathode also showed great potential for practical utilization through the successful assembly of full cells.
研究领域:
材料科学
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电化学
·
能源存储
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DOI
高影响因子
BIOORGANIC CHEMISTRY
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2020
·
IF 4.831
Shiyang Zhou,Gangliang Huang
In this study, a series of novel 7 H -benzo [ c ] [1,3] dioxolo [4, 5- f ] chromen-7-one derivatives were obtained by structural modification of the lead compounds with Fissitungfine B. A total 15 compounds were designed, synthesized and evaluated as inhibitors of tumor. These target compounds have the novel chemical structures that named three six-membered rings including one lactone six-membered ring. In vitro assay, the results showed that the target compounds have a broad spectrum and strong of anti-tumor activity. Such as the target compound 4n to MCF-7 was IC 50 = 0.35 ± 0.01 μM, to A-549 was IC 50 = 0.37 ± 0.01 μM, to Hela was IC 50 = 0.56 ± 0.02 μM, to MDC-803 was IC 50 = 0.53 ± 0.02 μM and COLO-205 was IC 50 = 0.50 ± 0.02 μM in vitro . At the same time, in vivo anti-tumor activity assay results showed that the target compounds had a good inhibitory effect on tumor growth. Among them, the target compound 4n had the best anti-tumor activity, it could inhibit tumor growth well at a low dose. The target compound 4n could be used as a candidate drug for further research and development, in order to be used as early as application in the clinical treatment of tumors.
研究领域:
药物化学
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肿瘤学
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有机合成
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DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2012
·
IF 1.693
Xiao-Ming Peng,Yu-Feng Hu,Jin-Zhu Zhang,Zhi-Xin Wang,Zhe-Yu Li,Chao Miao
Viscosities were measured for the ternary systems Y(NO3)3 + Ce(NO3)3 + H2O, Y(NO3)3 + Nd(NO3)3 + H2O, and Ce(NO3)3 + Nd(NO3)3 + H2O and their binary subsystems Y(NO3)3 + H2O, Ce(NO3)3 + H2O, and Nd(NO3)3 + H2O at (293.15, 298.15, and 308.15) K and atmospheric pressure. The results were used to test the applicability of simple equations for the viscosity of mixed solutions. The predictions agree well with measured values, implying that the viscosities of the examined electrolyte solutions can be related to those of their constituent binary solutions using these simple equations.
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产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2023
·
IF 6.7
Changjun Zhang,Yi Lu,Jingqi Zhang,Anjie Zang,Jinhui Ren,Zhiyuan Zheng,Miaoliang Fan,Yuanyuan Xie
Recent advances in understanding the role of iron and ROS in cell death suggest new therapeutic avenues to treat organ damage including acute kidney injury (AKI). Inhibiting ferroptosis was expected to have great potential for the treatment of this disease. Ferroptosis is characterized by iron-dependent lipid peroxidation and currently, a majority of reported ferroptosis inhibitors belong to either radical-trapping antioxidants or iron chelators . However, clinically used iron chelators such as deferoxamine and deferiprone have limited efficacy against ferroptosis (generally with EC 50 > 100 μM), despite their proven safety. Herein, we present the rational design of novel ferroptosis inhibitors by incorporating the naturally occurring cinnamic acid scaffold and the 3-hydroxypyridin-4(1 H )-one iron-chelating pharmacophore . Through ABTS ˙ + radical-scavenging assay, oxygen radical absorbance capacity (ORAC) measurement, Fe 3+ affinity evaluation, and anti-erastin-induced HT22 cell ferroptosis assays, we identified compound 9c as the most prospective ferroptosis inhibitor (ABTS ˙ + , IC 50 = 4.35 ± 0.05 μM; ORCA = 23.79 ± 0.56 TE; pFe 3+ = 18.59; EC 50 = 14.89 ± 0.08 μM, respectively). Notably, 9c dose-dependently alleviated cell death in cisplatin-induced AKI model. Our results provide insight into the development of new ferroptosis inhibitors through rational incorporation of pharmacophores from existing ferroptosis inhibitors, and compound 9c could be a promising lead compound worth further investigation.
研究领域:
药理学
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医学
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分子生物学
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2011
·
IF 3.37
Tao Liu,Haichao Su,Xiangjin Qu,Peng Ju,Lin Cui,Shiyun Ai
A novel amperometric biosensor based on immobilizing acetylcholinesterase on 3-carboxyphenylboronic/reduced graphene oxide–gold nanocomposites modified electrode was developed for the detection of organophosphorus and carbamate pesticides . Acetylcholinesterase was successfully immobilized on the electrode with relatively high activity by the specific binding between the boronic acid group of 3-carboxyphenylboronic and the glycosyl of acetylcholinesterase. The biosensor enjoyed good sensitivity owing to the excellent properties of gold nanoparticles and reduced graphene oxide , which promoted electron transfer reaction and enhanced the electrochemical response. Parameters affecting the biosensor response such as pH, applied potential, enzyme loading and inhibition time were optimized. Based on the inhibition of an organophosphorus insecticide on the enzymatic activity of AChE, organophosphorus and carbamate pesticides were determined with satisfactory results in the presence of acetylthiocholine chloride as a substrate. Moreover, the fabricated biosensor had good repeatability and high stability.
研究领域:
分析化学
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环境毒理学
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生物传感器
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农药残留检测
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纳米生物技术
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电化学传感
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食品安全
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DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2022
·
IF 4.598
Xiuxia Lu,Haohao Liu,Xiaoxiao Shi,Jianyin Zhang
At present, it is still challenging to fabricate anode materials for lithium-ion batteries with excellent electrochemical performances by simple process on a large scale. In this paper, by using a conventional solid state reaction technique along with a mechanical ball milling method, an unique Li 3 Fe(MoO 4 ) 3 @C composite was synthesized. The amorphous carbon introduction is helpful in mitigating the volume expansion and enhancing the structural stability and electrochemical performance of the composite materials. After 100 cycles at 200 mA g −1 , the Li 3 Fe(MoO 4 ) 3 @C composite electrode maintained a high reversible capacity of 739 mAh/g with an initial Coulombic efficiency of 82 %. In addition, the rate performances of the composite electrode is also remarkable, and the reversible capacity is up to 740 mAh/g at 1600 mA g −1 . This work can provide inspiration for the preparation of molybdenum based transition metal oxide composites with high electrochemical performances for other alkali metal secondary batteries.
研究领域:
材料科学
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电化学
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能源存储
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2023
·Vol. 34
·期 9
·794
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IF 2.8
Li Ji,Xiang Peng,Tan Xinyu,Li Bowen,Zhang Kai,Zhu Ying,Ren Yanqi,Chen Xiaobo
Organic–inorganic lead halide peroxides (OIHPs) have attracted much interest due to their excellent photovoltaic properties, but practical applications are limited by long-term stability and further performance enhancement. Two-dimensional/three-dimensional (2D/3D) heterojunction is a promising strategy to address these issues. Here, short-chain 3,5-dichlorobenzylamine (DBA) with halogen functional groups is introduced to react with excess PbI 2 to form the 2D perovskite layer in mixed perovskite films of Cs 0.05 (FA 0.85 MA 0.15 ) 0.95 Pb(I 0.85 Br 0.15 ) 3 , which passivates surface defects, favours energy band alignment of functional layers and suppresses non-radiative recombination of carriers. As a result, DBA-treated 2D/3D PSCs obtained a champion PCE of 21.54% with an improved open circuit voltage ( V oc ) of 1.171 V. More importantly, the 2D/3D heterojunction can effectively protect the underlying 3D perovskite from moisture ingress. The unencapsulated 2D/3D devices retain 90% of their initial efficiency even after aging at 40 ± 5% RH for 1000 h, while the 3D device retains only 40%.
研究领域:
材料科学
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光伏技术
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纳米结构材料
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表面化学
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能源材料
✓ 已验证
DOI
高影响因子
Journal of Energy Storage
·
2024
·
IF 8.9
Mengyue Liu,Kexin Wan,Xinmiao Zhang,Mingkun Wang,Dawei Yang,Jishi Wei,Kun Chang,Hongwei Tang
NASICON-type cathodes as promising candidates have attracted more and more attention, and Na 3 V 2 (PO 4 ) 3 is one of the outstanding representatives. In particular, it can tolerate complex interface reaction processes during the Zn 2+ insertion/desertion in the aqueous environment. However, existing three-dimensional channels in the intrinsic Na 3 V 2 (PO 4 ) 3 always hardly play to their advantages as narrow pathways and some other defects. This work has considered both the conductivity and capacity of this vanadium-based NASICON cathode at the same time, where a sodium-rich cathode material Na 3.2 V 1.8 Mn 0.15 Mg 0.05 (PO 4 ) 3 (NVMMP) with Mn 2+ and Mg 2+ dual-substituents has been designed considering the low cost and environmentally friendly characteristics. The synergistic effects introduced by Mn 2+ and Mg 2+ substitution led to a significant increase in the capacity and cycle life of the optimized NVMMP cathode material (with a capacity retention rate of 90.6 % after 2500 cycles at 2 A g −1 ). Furthermore, the reversible storage mechanism of Zn 2+ in NVMMP cathode materials and the theoretical study of such synergistic substitution on intrinsic electronic conductivity have been revealed by different in/ex-situ characterization techniques and theoretical calculations, where redox processes generated by Mn 3+ /Mn 4+ , enhanced ionic/electron pathway, and the pinning effect caused by injecting inert MgO 6 octahedra into the NASICON framework are key points to high capacity and long-life span.
研究领域:
材料科学
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电化学
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能源存储
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DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2023
·
IF 6.1
Xiang Ye,Wen Chen,Fu-Jie Yan,Xiao-Dong Zheng,Peng-Cheng Tu,Peng-Fei Shan
Berries and their functional components have been put forward as an alternative to pharmacological treatments of type 2 diabetes mellitus (T2DM), and more attention has been paid to the gut microbiome in the pathophysiology of T2DM. Thus, we tried to examine the metabolic impact of red bayberry-derived cyanidin-3-O-glucoside (C3G) and investigate whether the antidiabetic effects of C3G were associated with the gut microbiome. As a result, C3G administration was found to reduce blood glucose levels of diabetic db/db mice, accompanied by increased levels of glucagon-like peptide (GLP-1) and insulin. Moreover, 16S rRNA analysis showed that the dominant microbiota modulated by C3G were pivotal in the glucose metabolism. Furthermore, the modulation of C3G on metabolic activities of gut bacteria leads to an increase in intestinal levels of key metabolites, particularly short-chain fatty acids. This contribution helps in promoting the secretion of GLP-1, which in turn increases insulin release with the purpose of reducing blood glucose levels. Overall, these findings may offer new thoughts concerning C3G against metabolic disorders in T2DM.
研究领域:
药理学
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糖尿病研究
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微生物学
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营养保健品
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代谢紊乱
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DOI
PubMed
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2018
·
IF 2.559
Peng Zhang,Menghuan Tang,Qin Huang,Guanjian Zhao,Ning Huang,Xiang Zhang,Ying Tan,Yuan Cheng
Mesoporous silica nanoparticles (MSNPs) of a small diameter were loaded with the anticancer drug temozolomide (TMZ), coated with polydopamine (PDA), and conjugated with Asn-Gly-Arg (NGR) for use in the treatment of glioma. The accumulation of NGR-MSNPs in C6 cells was shown to be higher than that of unmodified MSNPs. Anticancer drugs can cause autophagy in tumor cells, whereas autophagy inhibitors can block this reaction and enhance the therapeutic effect of the drugs. In this study, we demonstrated that MSNP-TMZ-PDA-NGR had stronger autophagy- and apoptosis-inducing effects in C6 cells than TMZ alone, and its anticancer effect was further enhanced when combined with autophagy inhibition. These results demonstrate that the combination of targeting vehicles and autophagy inhibitors may have research value in the treatment of gliomas.
研究领域:
纳米技术
·
药学
·
肿瘤学
·
细胞生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2017
·Vol. 22
·期 2
·441-452
·
IF 2.316
Yang Kaiqi,Ma Xiaoyan,Sun Kun,Liu Yi,Chen Fang
Gel polymer electrolyte (GPE) based on octa(3-chloropropyl)-polyhedral oligomeric silsesquioxane (OCP-POSS)-modified polyvinylidene fluoride/poly(acrylonitrile) /poly(methylmethacrylate) (PVDF/PAN/PMMA) fibrous membrane was prepared by electrospinning method to improve the thermal stability of GPE and prevent the leakage of liquid electrolyte for lithium ion battery. The effect of OCP-POSS content on the morphology, porosity and electrolyte uptake, mechanical strength, thermal stability of spinning fibrous membrane and ionic conductivity, electrochemical stability window, and interface resistance of GPE was investigated. The cycle performance of cells assembled with GPE was also tested. The results show that the spinning fibrous membrane with 10 wt% OCP-POSS possesses high electrolyte uptake (660%) and excellent thermal stability. The ionic conductivity of corresponding GPE is 9.23 × 10 −3 S cm −1 at room temperature and the electrochemical stability window is up to 5.82 V; the interface resistance of 10 wt% OCP-POSS modified GPE decreases by 42% after 168 h compared with pure PVDF/PAN/PMMA GPE. Furthermore, cells assembled with 10 wt% OCP-POSS modified GPE show high discharge capacity (166.5 mA h g −1 at 0.1 C) and excellent cycle stability during 50 cycles. The results indicate that the GPE could improve the safety of lithium ion battery and show great potential in lithium ion battery applications.
研究领域:
材料科学
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电化学
·
能源存储
·
纳米技术
·
高分子化学
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DOI
高影响因子
MICROBIAL PATHOGENESIS
·
2022
·
IF 3.848
Bingxin Liu,Han Lu,Zong Li,Peihan Yan,Ruyin Liu,Xinchun Liu
Salmonella infection is a major public health concern. Several strategies for Salmonella infection prevention and control are currently available including vaccines and antibiotics. However, vaccines are expensive and inefficient, and the use of antibiotics can lead to antibiotic resistance. Thus, alternative strategies for the treatment of Salmonella remain warrant. In this study, recombinant holin HolST-3 and lysin LysST-3 from Salmonella phage ST-3 were expressed and purified, and their bactericidal properties were analyzed. HolST-3 and LysST-3 possessed a wider lysis spectrum and more efficient bactericidal effect than phage ST-3, and a synergistic bactericidal effect was observed when combined in vitro . In addition, we explored the bactericidal properties of HolST-3 and LysST-3 in vivo using zebrafish as a model organism, and found that the bactericidal effects of both HolST-3 and LysST-3 in vivo were comparable to those of cefotaxime , an antibiotic. This study provides a basis for the development of HolST-3 and LysST-3 as novel bactericidal agents for the prevention and treatment of infectious diseases caused by Salmonella spp.
研究领域:
微生物学
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传染病学
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药理学
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DOI
PubMed
高影响因子
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