Cellular and Molecular Bioengineering
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2025
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IF 5
Liu Junyu,Wang Hua,Zhang Caihua
Background Skin wound healing is a complex biological process involving cellular, molecular, and physiological events. Traditional treatments often fail to provide optimal outcomes, particularly for chronic wounds. Objectives This study aimed to develop a self-healing hydrogel loaded with Acteoside, a bioactive compound with antioxidant and anti-inflammatory properties, to enhance skin wound healing. Methods Using transcriptomic analysis, Rab31 was identified as a key target of Acteoside in regulating hair follicle stem cells (HFSCs). In vitro assays demonstrated that Acteoside promotes HFSC proliferation, migration, and differentiation by upregulating Rab31 expression. The self-healing hydrogel was prepared using quaternized chitosan derivatives, which exhibited excellent mechanical properties, antibacterial, and antioxidant activities. Results In vivo studies in a mouse model showed that Acteoside-loaded hydrogel significantly accelerated wound healing, promoting skin regeneration and improving wound closure. Conclusions This research highlights the potential of Acteoside-loaded self-healing hydrogels as an innovative therapeutic strategy for enhancing skin wound healing. By modulating HFSC activity, this hydrogel offers a promising solution for improving healing outcomes in challenging wound environments. Graphical Schematic representation of an injectable self-healing hydrogel loaded with the phenylethanoid compound acteoside for regulating the proliferation and differentiation of HFSCs to mediate the healing of skin wounds.
研究领域:
生物材料学
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分子生物学
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皮肤修复
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DOI
PubMed
高影响因子
JOURNAL OF FOOD ENGINEERING
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2025
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IF 5.8
Yue Chen,Shengqi Li,Na Zhang,Ke Zhang,Xiaoqiang Chen
Oleogels have significant potential for delivering lipid-soluble bioactive compounds. We here prepared a tea polysaccharide conjugate (TPC)-Xanthan gum (XG) complex using the emulsion template method and investigated its curcumin (Cur) loading capacity and in vitro digestion mechanisms. Results unveiled that XG interacts non-covalently with TPC, primarily through electrostatic interactions and hydrogen bonding, enhancing emulsion template formation and stabilization. In addition, XG improved the oleogel’s oil-binding capacity, gel strength, hardness, apparent viscosity, and other gel properties. Meanwhile, the complex oleogel-loaded Cur exhibited a high Cur encapsulation efficiency (>80%), increased antioxidant activity, an augmented free fatty acid release rate, and improved Cur bioaccessibility (>50%) and digestive stability. These findings provide a novel approach to designing oleogels for the effective delivery of lipid-soluble bioactive compounds.
研究领域:
食品科学
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生物化学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Mengru Zhuo,Changhao Liu,Qianbu Wang,Ze Wang,Yue Wang,Fang Yu,Yue Zhang
Although the potential of chitosan (CS) -based biomass packaging materials for food preservation is encouraging, their use is severely constrained by the poor mechanical, UV, antioxidant, and solubility qualities. This study successfully combined silver nanoparticles made from Catharanthus roseus extracts with chitosan (CS- Ca -Ag) to enrich the functions of CS film. The films' Young's modulus values (45.489 MPa) were considerably raised after adding the extract-biosynthesized silver nanoparticles, in contrast to the chitosan film, and their water vapor permeability (2.386 × 10 −12 g·mm −1 ·Pa −1 ·h −1 ) was greatly reduced. Furthermore, the antibacterial, antioxidant, and UV adsorption capabilities of CS- Ca -Ag films were significantly improved. The prepared Cs- Ca -Ag film had high biocompatibility and safety, making it suitable for strawberry coatings and chicken packaging. The CS- Ca -Ag film effectively limited the weight loss of fresh food, reduced nutrient loss, prevented microbial growth, and significantly extended food's shelf life. CS-based reinforced films containing Catharanthus roseus extract and silver nanoparticles showed potential food coating and packaging material applications.
研究领域:
食品科学
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材料科学
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植物学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Teng Zhang,Jialiang He,Ming Xu,Wenqing Shi,Hao Jiang
The present study sought to examine the impact of cold plasma (CP) treatment on the functionality, structural integrity, and bioactive properties of biomolecules such as starch and phenolic compounds in Xinong Black Spike whole flour (XBS-WF). XBS-WF was exposed to CP at 40 V for various durations. X-ray Diffraction (XRD) and Rapid Viscosity Analysis (RVA) revealed that CP treatment induced aggregation and cross-linking of starch and other molecules, leading to enhanced intermolecular interactions and improved starch crystallinity. In addition, Differential Scanning Calorimetry (DSC) showed enhanced thermal stability and increased enthalpy. Furthermore, CP treatment promoted the oxidation and cleavage of phenolic macromolecules into smaller, biologically active compounds, resulting in a notable increase in antioxidant and anticancer activities. These findings suggest that CP treatment can effectively improve the functional and qualitative properties of XBS-WF, particularly by modifying starch and phenolic macromolecules. This study provides a foundation for exploring the multiscale applications of the CP process on starch and phenolic macromolecules.
研究领域:
食品科学
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生物化学
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功能食品研究
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DOI
PubMed
高影响因子
RSC Advances
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2025
·Vol. 15
·期 13
·9997
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IF 4.6
Zhendong Fu,Jiahe Qiu,Ping Gong,Danhong Zhang,Liping Wang
The precise and sensitive quantification of total antioxidant capacity (TAC) is indispensable for evaluating the quality of foods rich in antioxidants. In this investigation, a novel nanozyme exhibiting robust oxidase activity was synthesized via a sonochemical doping process utilizing copper ions and the modification of 2-propylimidazole onto nanoceria. Subsequently, a CeO2@Cu-PrIm/ox-TMB assay system was successfully formulated, furnishing a practical and highly sensitive analytical tool for TAC determination. The colorimetric sensor exhibited a linear response over a concentration range of 1 μM to 70 μM, accompanied by a limit of detection (LOD) of 1.26 μM under meticulously screened conditions. This assay displayed substantial practical utility for TAC analysis in fruits, attributed to its exceptional accuracy and selectivity. This research endeavor may offer a novel direction for the design of nanozymes and colorimetric biosensors possessing heightened oxidase activity, thereby advancing the field of analytical chemistry and food science. Schematic depicting the reaction system of CeO2@Cu-PrIm/ox-TMB assay for the determination of TAC.
研究领域:
分析化学
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食品科学
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Jiarun Li,Abudusaimi Maimaiti,Xiyuan Huang,Siwei Wang,Dongying Li,Qinmei Wang,Wei Teng
Tannic acid (TA), a naturally abundant plant-derived polyphenol, is known for its versatile properties, including antibacterial, antioxidant, adhesive and metal chelating properties. However, its high density of phenolic hydroxyl groups limits its applications in advanced material design. To address this, we introduce a green and efficient strategy to modify TA with cyclic carbonate to yield vinylated tannic acid (vTA) with precisely controlled vinyl substituent content. This modification preserves the beneficial properties of TA while imparting new functionalities, such as enhanced hydrophobicity, improved compatibility with hydrophilic macromolecules, and the ability to self-assemble into nanoparticles. The introduced aliphatic vinyl groups also enable vTA to serve as a versatile organic building block for the construction of functional materials through various chemical reactions, such as thiol-ene click chemistry, particularly as a bio-based aromatic resource. Given its unique dendritic structure and the presence of abundant phenolic hydroxyl groups, aliphatic hydroxyl groups, benzene rings, and alkenyl groups, vTA holds immense potential for applications in industrial and biomedical fields. This green synthesis method represents a significant advance in the sustainable modification of plant-derived polyphenols, offering a pathway for the development of next-generation functional materials with tailored properties using bio-based aromatic building blocks.
研究领域:
材料科学
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化学工程
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生物医学
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DOI
高影响因子
PLoS One
·
2025
·Vol. 20
·期 4
·e0320582
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IF 2.6
Wenqing Pei,Yuting Sun,Juan Li,Yupei Zhang,Chenkang Jian,Feng Lu,Ali Tao,Qizhao Li
Ultrasound-assisted extraction technology was utilized to extract total flavonoids from Chaenomeles speciosa (Sweet) Nakai, and response surface methodology was employed to optimize the extraction process. The anti-oxidant and lipoxygenase inhibitory activities were evaluated, along with an analysis of the type of inhibition. The results revealed that the optimal extraction conditions for total flavonoids from Chaenomeles speciosa (Sweet) Nakai were as follows: an ethanol concentration of 62%, a liquid-to-solid ratio of 15:1 mL/g, an ultrasonic temperature of 68°C, and an ultrasonic time of 40 min, resulting in a total flavonoid extraction rate of 10.18%. Antioxidant assays demonstrated that the Chaenomeles speciosa (Sweet) Nakai extract exhibited significant radical scavenging activities against 1,1-diphenyl-2-picrylhydrazyl radicals, 2,2’-azinobis (3-ethylbenzothiazoline-6-sulfonic acid ammonium salt) radicals, and hydroxyl radicals, with IC 50 values of 582 µg/mL, 538 µg/mL, and 1709 µg/mL, respectively. Furthermore, enzyme inhibition assays indicated that the Chaenomeles speciosa (Sweet) Nakai extract possesses notable inhibitory activity against lipoxygenase, with an IC 50 value of 2658 µg/mL. This inhibition is mediated through a mixed reversible inhibition mechanism.
研究领域:
植物化学
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药理学
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食品科学
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DOI
PubMed
高影响因子
Small
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2025
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IF 12.1
Chengkai He,Xiang Lin,Luoran Shang
The development of biomaterials capable of on-demand delivery holds significant promise for wound therapy. Current research is centered on refining design precision and enhancing structural functionality to achieve effective controlled release of active agents, thereby facilitating wound healing. In this study, a coaxial microfluidic electrospray technique is employed to fabricate microcapsules comprising a black phosphorus (BP)-laden alginate shell and a gelatin methacrylate (GelMA) core. Curcumin nanoparticles (CNPs) and vascular endothelial growth factor (VEGF) are respectively incorporated into the shell and core of the microcapsules. The photothermal performance of the microcapsules contributed to superior sterilization efficacy in the early stages of wound healing, while the growth factors in the core provided robust angiogenic effects during the later stages. These attributes enabled the microcapsules to significantly accelerate wound healing, enhance collagen deposition, and modulate inflammatory responses in a rat wound model, underscoring their potential for clinical application.
研究领域:
生物材料
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组织工程
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伤口愈合
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药物递送系统
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光热疗法
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产品关联
DOI
PubMed
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
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2025
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IF 5.1
Jingwei Gong,Yern Chee Ching,Shuangwu Huang,Q. Jason Niu,Anyu Li,Ching Kuan Yong,Thennakoon M. Sampath Udeni Gunathilake,Nguyen Dai Hai,Chuah Cheng Hock
Cellulose-based carbon dots (C-CDs) with fluorescence and non-toxicity properties have attracted wide attention in the field of biomedicine. However, constructing dual-stimuli hydrogels incorporated with C-CDs using biomass-based raw materials with biodegradable and antimicrobial characteristics for drug sustained-release remains a challenge. Herein, an interpenetrated-network method was proposed in which the N-isopropyl acrylamide (NIPAM) monomer, regarded as the second network, was polymerized via photo-initiation. Additionally, C-CDs derived from lychee waste were used as cross-linking agent, which was introduced into β-cyclodextrin (β-CD)/carboxymethyl cellulose (CMC)/polyvinyl alcohol (PVA) first-network system, to fabricate a dual-network fluorescence hydrogels called β-CD/CMC-(PVA-NIPAM). The design of dual-network hydrogel can effectively enhance swelling and water retention abilities within a certain time. To evaluate the biomedical application of the obtained hydrogel, ibuprofen, as a poorly water-soluble model drug, was loaded into the hydrogel utilizing advantages of possessing hydrophobic inner cavity of β-CD and the highly dense structure of double-network hydrogels, to complete release behavior under different pH and temperature, with the maximum release rate reaching up to 96 %. Furthermore, it is noted that the cellulose-based interpenetrated-network hydrogel has access to cells but exhibits no cytotoxicity in vitro. Herein, this dual-responsive fluorescent hydrogel is expected to play a potential role in drug delivery and drug tracking.
研究领域:
材料科学
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生物医学工程
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药剂学
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产品关联
DOI
高影响因子
Food Packaging and Shelf Life
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2025
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IF 10.6
Tao Yu,Tong Wang,Renguo Zhang,Chenglin Su,Shuang Cao,Yini Zhao,Hejing Wang,Jiaxing Li,Na Niu,Ligang Chen
Biodegradable cling film is an environmentally friendly alternative to traditional plastics which still requires the addition of preservatives to improve its ability to retain freshness. Lignin, which is a natural product with both safety and antioxidant effects, has become a potential preservative. In this study, lignin was extracted from pine and corn straw by deep eutectic solvent. The lignin yield was 40.54 % and 60.60 %, respectively. A series of CS/LNPs cling films were prepared by lignin nanoparticles as the main freshness preservation and chitosan (CS) as substrates. The film with 5 % lignin nanoparticles (CS/LNPs-5) demonstrated an 89.10 % DPPH radical scavenging rate, indicating superior antioxidant capacity. Moreover, the CS/LNPs-5 films showed good UV shielding ability, mechanical properties, and hydrophobicity. Remarkably, CS/LNPs-5 was applied to preserve perishable strawberries, which extended their freshness for up to 9 days. In this study, lignin nanoparticles were successfully used to prepare cling film with high antioxidant properties, which provides a new approach for lignin in food packaging.
研究领域:
食品科学
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材料科学
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环境科学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Hong Zhang,Xin Zhang,Bo Wang,Bo Ren,Xiaodong Yang
Food spoilage leads to plenty of food being wasted every year. Safe and multifunctional food preservation packaging is urgently required to prevent food from contamination. Chitosan/gallic acid/Fe 3+ (CSGA-Fe 3+ ) composite films were synthesized by incorporating gallic acid (GA) and Fe 3+ into a chitosan solution. The integration of GA forms covalent and hydrogen bonds with chitosan, whereas Fe 3+ addition establishes metal-ligand interactions with both chitosan and GA, resulting in a film characterized by a multi-crosslinked network structure. This multi-crosslinked system substantially enhanced the material's mechanical properties and increased resistance to oxidation and ultraviolet degradation. The data indicate that the mechanical strength of chitosan/gallic acid (CSGA) films, with an inclusion of 0.3 mmol of GA, improved by 37.5 % over pure chitosan (CS) films. Moreover, the mechanical strength of the CSGA-Fe 3+ films saw a significant increase of 124.2 %, escalating from 1.32 MPa to 17.72 MPa. Additionally, the free radical scavenging capacities of the CSGA and CSGA-Fe 3+ films rose by 279.4 % and 255.0 %, respectively, compared to the pure CS film. The UV-blocking efficacy of the CSGA-Fe 3+ films, evaluated at 365 nm, reached 84.9 %. The water contact angle of the CSGA-1.5Fe 3+ film increased by 18.08 % compared to the CS film. This study provides innovative ideas to promote the broader application of safe and multifunctional chitosan-based composite films in food preservation packaging.
研究领域:
食品科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
Open Veterinary Journal
·
2025
·Vol. 15
·期 4
·1836
·
IF 1
Jin-Kui Ma,Qian-Ru Lin,Zhi-Yao Liu,Jia-Min Wang,Xin Peng,Yu-Tong Lin,Li-Zhen Nie,Xiao-Chen Huang
Background: Food spoilage, particularly in meat products, presents a significant economic and health concern, necessitating the development of reliable and user-friendly monitoring methods. Aim: This study presents the development and evaluation of novel colorimetric films for real-time monitoring of meat freshness. Methods: Films were formulated using anthocyanin (AHO) and betacyanin (BTA) from purple cabbage and red dragon fruit, respectively, embedded within polyvinyl alcohol and carboxymethyl cellulose matrix. Two pigment ratios, AHO:BTA (1:3) and (3:1), were compared to evaluate mechanical properties, antioxidant activity, and ammonia sensitivity. Results: The AHO:BTA (1:3) film demonstrated higher tensile strength, whereas the (3:1) film exhibited greater antioxidant capacity and ammonia responsiveness. Colorimetric changes were assessed across the pH range, showing sensitivity to pH shifts. The films were then applied to beef, lamb, fish, and pork samples, and their color alterations during storage under ambient and refrigerated conditions were correlated with total volatile basic nitrogen and pH levels. Conclusion: The results show a strong correlation between film color changes and established meat spoilage indicators, demonstrating the potential of these natural pigment-based films for effective, nontoxic, and visual monitoring of meat freshness.
研究领域:
食品科学
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生物化学
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产品关联
DOI
PubMed
高影响因子
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