Current Nanoscience
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2025
·Vol. 21
·期 1
·92-98
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IF 1.5
Qiang Wan,Rong Li,Meiping Ren,Gang Ke
Background In the paper, Boletus Brucella was used as carbon source material to prepare carbon dots (CDs) by one-step hydrothermal method. The CDs had high quantum yield and high photostability. Methods A range of characterization studies were conducted on CDs, and the results showed that the average particle size of CDs was 5 nm, emitting blue fluorescence. The optimal excitation wavelength was 337 nm, and the emission wavelength was 440 nm. Results Based on the static quenching, the fluorescence of CDs could be effectively quenched by VB2. Therefore, a highly sensitive and selective fluorescent probe for detecting VB2 was constructed. The CDs were successfully used to detect tablets, human blood, and urine. Conclusion The recovery rate of VB2 was 97.55~99.45%, and the relative standard deviation was 1.29~3.76 (n=3).
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Materials Science & Engineering C-Materials for Biological Applications
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2018
·
IF 5.08
Dongjing Zhang,Cheng Zhou,Pin Lv,Yulin Zhao,Jing Liang,Xiali Liao,Bo Yang
The purpose of this study was to develop a novel folate-modified host-guest complex to enhance antitumor activity of the artesunate and improve the solubility and stability by encapsulated in β-cyclodextrin and linked with folate. In this work, we designed and prepared the inclusion complex of adamantanamine conjugated artesunate (AD-ATS) with folic acid-ethylenediamine-β-cyclodextrin (FA-EN-β-CD). This material was characterized by 1D and 2D NMR, XRD, TG and SEM. The results suggested that AD-ATS was encapsulated within the FA-EN-β-CD cavity to form host-guest inclusion complex, and the water solubility of AD-ATS was improved in the form of inclusion complex with FA-EN-β-CD. The assessment of antitumor activity showed that cytotoxicity of AD-ATS/FA-EN-β-CD complex was significantly enhanced in comparison to free AD-ATS, ATS/β-CD inclusion complex and ATS/FA-EN-β-CD inclusion complex.
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Small
·
2015
·Vol. 11
·期 42
·5675-5686
·
IF 8.368
Qiao An,Jing Liu,Meng Yu,Jiaxun Wan,Dian Li,Changchun Wang,Chunying Chen,Jia Guo
To overcome traditional barriers in optical imaging and microscopy, optoacoustic-imaging has been changed to combine the accuracy of spectroscopy with the depth resolution of ultrasound, achieving a novel modality with powerful in vivo imaging. However, magnetic resonance imaging provides better spatial and anatomical resolution. Thus, a single hybrid nanoprobe that allows for simultaneous multimodal imaging is significant not only for cutting edge research in imaging science, but also for accurate clinical diagnosis. A core-shell-structured coordination polymer composite microsphere has been designed for in vivo multimodality imaging. It consists of a Fe 3 O 4 nanocluster core, a carbon sandwiched layer, and a carbocyanine-Gd III (Cy-Gd III ) coordination polymer outer shell (Fe 3 O 4 @C@Cy-Gd III ). Folic acid-conjugated poly(ethylene glycol) chains are embedded within the coordination polymer shell to achieve extended circulation and targeted delivery of probe particles in vivo. Control of Fe 3 O 4 core grain sizes results in optimal r 2 relaxivity (224.5 × 10 –3 m −1 s -1 ) for T 2 -weighted magnetic resonance imaging. Cy-Gd III coordination polymers are also regulated to obtain a maximum 25.1% of Cy ligands and 5.2% of Gd III ions for near-infrared fluorescence and T 1 -weighted magnetic resonance imaging, respectively. The results demonstrate their impressive abilities for targeted, multimodal, and reliable imaging.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Fengjie Liu,Fansu Meng,Xiaoshan Hong,Anil K. Giri,Mulazim Hussain Asim,Zhong Chen,Yiqi Chen,Yixuan Lin,Lulu He,Qiaowen Bu,Yong Huang,Xiaoli Sun,Zhenjiang Yang,Yu Cai
Background Baicalin (BA), a natural flavonoid compound, exhibits potential anti-breast cancer (BC) activity. However, its therapeutic efficacy is limited by biological membrane and tumor barriers. Albumin nanoparticles demonstrate excellent biocompatibility and ease of modification, making them highly advantageous for antitumor drug delivery. Despite these advantages, current preparation methods for albumin-based NPs have significant limitations, including the use of organic or toxic reagents, large and uneven particle size products, complex processes, etc. Objective The purpose of this study was to develop a novel method for preparing albumin nanoparticles (BSA NPs). Subsequently, BSA NPs were modified with folic acid (FA) and polymers and loaded with BA to construct a novel nanodrug delivery system (BA@mPEG-FA-BSA NPs) to improve the anti-breast cancer efficacy of BA. Methods Compared with the desolvation method and the thermal gelation method, the advantages of the new preparation method of BSA NPs are: less organic solvent and preparation time, greater yield, smaller particle size and uniform product. The preparation method of BSA NPs was investigated by single factor experiment. The encapsulation efficiency (EE) and drug loading (DL) of BA in BA@mPEG-FA-BSA NPs were detected by HPLC. The structural composition and physicochemical properties of the nanoparticles were characterized using transmission electron microscopy (TEM), infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), and X-ray diffraction (XRD). The anti-breast cancer efficacy of BA@mPEG-FA-BSA NPs was evaluated through cellular uptake, cytotoxicity, apoptosis, cell cycle analysis, and in vivo tumor-bearing mouse studies. Results According to the setting of process parameters, the established method can control the acquisition of uniform BSA NPs with a particle size between 20 and 300 nm. BA@mPEG-FA-BSA NPs exhibited a particle size of approximately 59.26 nm, a polydispersity index (PDI) < 0.3, EE of about 46.7 %, and DL of approximately 2.6 %. Cellular uptake experiments demonstrated that mPEG-FA-BSA NPs enhanced the uptake of free coumarin 6 in BT20 cells, with free FA showing competitive inhibition effects. Efficacy evaluation revealed that BA@mPEG-FA-BSA NPs exhibited cytotoxicity against BT20 cells, induced cell cycle arrest and apoptosis, and inhibited tumor growth in 4 T1 tumor-bearing mice. In most cases, the effects of BA@mPEG-FA-BSA NPs were superior to those of free BA, with a concentration- or dose-dependent manner observed. Conclusion This study established a novel preparation method for albumin nanoparticles, providing a new methodology for the construction of nano-drug delivery systems based on albumin materials. The developed BA@mPEG-FA-BSA NPs, with their relatively small particle size, demonstrated enhanced cellular uptake and anti-breast cancer activity of BA, highlight the potential for further optimization and clinical translation.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yue Wang,Xiangyan He,Qi Zhang,Ling Luo,Tianping Lv,Xiuwu Wang,Junhua Zhang
Construction of highly efficient catalysts is crucial for the catalytic transfer hydrogenation (CTH) of bio-based carbonyls to valuable chemicals and fuels. Herein, we successfully synthesized a series of uniformly dispersed Zr(OH) 4 -Fe 3 O 4 nanoparticles with the regulation of sodium dodecyl benzene sulfonate (SDBS), which exhibited exceptional activity for the CTH of furfural (FAL) into furfuryl alcohol (FOL). Systematic characterizations revealed that SDBS effectively modified the interaction between Fe 3 O 4 and Zr(OH) 4 , thereby enhancing Lewis acidity by facilitating the construction of electron-deficient zirconium sites. Meanwhile, the presence of oxygen vacancies and surface hydroxyl groups in Zr(OH) 4 -Fe 3 O 4 -SDBS facilitated the adsorption and activation of both substrate and hydrogen donor. Thanks to these synergistic effects, a complete conversion of FAL with an impressive selectivity towards FOL was achieved, with a remarkable turn-over frequency value reaching as high as 42.5 h −1 . Encouragingly, Zr(OH) 4 -Fe 3 O 4 -SDBS also demonstrated its universality in the CTH of carbonyl compounds by exhibiting remarkable separation capability while maintaining its activity and structure after being reused for 11 cycles without significant changes.
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ACS Nano
·
2025
·
IF 16
Zifan Li,Zicheng Zhang,Yueyue Wu,Zhe Zhou,Zixi He,Bin Liu,Xingyue Ji,Fa Zhang,Chen Chen,Fei Xiu,Xuemei Dong,Yuhan Zhang,Qiye Wang,Xiujuan Li,Wei Huang,Juqing Liu
All-optical neuromorphics that can capture, process, and output photonic signals are in prospect to advance optical computing and imaging. Bidirectional neuroplasticity is essential for executing training and inference in optical neural networks, but most of the all-optical hardware only exhibits unidirectional weight modulation. Here, we explore bidirectional neuroplasticity in carbon dot phosphorescence (CDP) with potentiation and depression synaptic behaviors capable of neuroregulation for photonic intensity. This function enables the CDP as a neuroconverter to convert pulse light into excitatory and inhibitory light output for neuromorphic vision owing to the delayed release and superimposition dynamics of excitons in persistent phosphorescence, which allows for image digitization or direct observation. By integration with an optical neural network, the real-time motion tracking of light spots, including trajectory, direction, and speed, can be recorded and recognized, with a high accuracy of 96%. Such phosphor-based neuromorphics can be extended to other phosphorescent architectures for all-optical imaging and computing.
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Small
·
2025
·
IF 12.1
Xu Zhang,Zhichao Dou,Huayang Fan,Tu Huang,Zhuohao Zhang,Yaling Tang,Xin-hua Liang
Reactive oxygen species (ROS) can catalyze the palmitoylation of Gasdermin D (GSDMD), thereby promoting pyroptosis. However, tumor cells frequently exhibit elevated expression of heat shock proteins (HSPs), which attenuate pyroptosis through the inhibition of key pyroptotic mediators. To solve these problems, a folate-acid-modified polydopamine nanoparticle loaded with copper peroxide (PDCF nanoparticles) is developed to simultaneously trigger and amplify pyroptosis while suppressing HSPs-mediated defensive mechanisms. PDCF nanoparticles efficiently elevated intracellular ROS, thereby directly promoting the palmitoylation and subsequent cleavage of GSDMD to its active N-terminal GSDMD (GSDMD-N). This process created a positive feedback loop that enhanced pyroptosis, characterized by pore formation in the plasma membrane and the release of interleukin 1β (IL-1β) and interleukin 18 (IL-18). Concurrently, the elevated ROS significantly downregulated HSPs expression to achieve a mild photothermal therapy (MPTT). This combined strategy of pyroptosis amplification and HSPs inhibition potently suppressed tumor growth in oral squamous cell carcinoma (OSCC). The novel multifunctional therapeutic strategy provides a new view for the treatment of OSCC through ROS-mediated downregulation of HSPs and improving pyroptosis.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Shanguo Zhang,Tianyi Jiang,Haoxiu Sun,Depeng Yang,Liangyu Cao,Ming Li,Aitong Xu,Gu Qi,Wenlong Wu,Yu Li,Hongyuan Jiang
Psoriasis is a common chronic immune-mediated skin disease with recurrent scaly plaques that impair quality of life. Although drugs such as methotrexate have been developed for this disease, they often cause serious adverse effects, limiting long-term use. Here, we present a Dual-Lock Targeting (DLT) strategy at both the device and the cellular levels that integrates receptor-guided exosome homing with electric-field gating to localize therapy spatiotemporally. We engineer a folate-modified, methotrexate-loaded exosome (FPC@MtExo) and load it using a wearable, self-powered microneedle (SPMD) system. The microneedle patch provides site lock-in and time-gated release via an electric-field–gated interface, while simultaneously achieving receptor-locked targeting at the cellular level through immune-cell recognition of FPC@MtExo. In vitro, FPC@MtExo exhibits markedly increased uptake by macrophages compared with non-targeted exosomes; this effect is further enhanced under the SPMD system. In psoriatic mouse models, the DLT strategy significantly attenuates manifestations and improves histopathology while suppressing cutaneous inflammation. Importantly, the strategy reduces circulating free methotrexate, with AST/ALT approaching baseline, indicating mitigated hepatotoxicity and an improved therapeutic effect. By coupling receptor-mediated engineered exosome homing with electric-field gating in a wearable microneedle patch, the DLT strategy delivers spatiotemporally precise therapy that concentrates the drug at the lesion while minimizing systemic side effects. This approach provides a general path to safer, more effective treatment of psoriasis and other inflammatory skin diseases.
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POLYMER BULLETIN
·
2025
·Vol. 83
·期 1
·31
·
IF 4
Huang Ruoxi,Yi Yaxin,Zhang Shiyu,Wang Jiaxin,Yuan Haikuan,Lu Jie
A stimulus-responsive drug delivery system holds promise for reducing adverse effects and enhancing the bioavailability of chemotherapeutic agents. In this study, amino-terminated dextran was utilized as a macromolecular initiator to prepare a range of amphiphilic dextran-b-poly(ε-benzyloxycarbonyl- l -lysine) (Dex-b-PZLL) copolymers with varying hydrophobic segment lengths via ring-opening polymerization (ROP). Folic acid (FA) was further grafted onto the dextran side chains via esterification (FA-Dex-b-PZLL), offering the potential tumor-specific recognition. The resulting copolymers were able to self-assemble into stable spherical micelles via dialysis and efficiently encapsulated the hydrophobic drug letrozole (LTZ). A systematic assessment was conducted on the drug encapsulation efficiency/loading capacity, drug release performance in vitro, and biocompatibility of the copolymers under aqueous conditions, indicating that these properties of the FA-Dex-b-PZLL micelles mainly depended on the copolymer composition. The optimized micelles, with a balanced hydrophilic/hydrophobic ratio, achieved a drug loading capacity with approximately 8.49% and an encapsulation efficiency with about 46.39%. Moreover, LTZ/FA-Dex-b-PZLL micelles exhibited pH-responsive release, with cumulative release rates within 72 h of 20.74%, 27.14% and 62.96% in phosphate buffer at pH 7.4, 6.5 and 4.5, respectively, indicating the accelerated release under acidic conditions. In addition, the micelles showed good cytocompatibility according to the CCK-8 assay. Graphical abstract
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Qin Xu,Shuaiqi Li,Maohua Chen,Yijie Hou,Dongbo Guo
The development of water-dispersible red-emissive carbon dots (CDs) in biological applications is urgently need but has been constrained by fluorescence quenching in aqueous media and inadequate tumor accumulation resulting from ultrafine dimensions. Here, we report a straightforward one-step solvothermal synthesis of CDs demonstrating pure red emission (r-CDs). Surface engineering with polyethylene glycol (PEG) markedly augments their (r-CDs-PEG) red fluorescence in water, elevating the photoluminescence quantum yield from 4 % to 64 % while preserving a high photothermal conversion efficiency. This PEGylation strategy not only mitigates aqueous quenching effects and promotes higher cellular uptake but also prolongs blood circulation duration without altering their size, consequently enhancing tumor accumulation in mouse models and significantly improving the efficacy of photothermal therapy. Theoretical calculations revealed that the intense red-light emission of r-CDs originates from the conjugated domains constructed by graphitic nitrogen and the modulation of electron transitions by external C O functional groups. The r-CDs-PEG also exhibited excellent water solubility, photostability, and biocompatibility. Capitalizing on these attributes, we successfully applied the r-CDs-PEG for in vivo high-contrast tumor imaging with photothermal therapy, achieving remarkable efficacy. This study addresses the longstanding challenge of water-induced quenching in red-emitting CDs, providing a robust platform for advanced bioimaging and tumor theranostics.
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Biomaterials Research
·
2025
·
IF 9.6
Ningning He,Huimei Jiang,Tong Dai,Geun-soo Kim,Peng Liu,Yifan Zhao,Shangyong Li,Jie Cao,Zequn Li
Ulcerative colitis (UC), a chronic inflammatory bowel disease characterized by recurrent colonic mucosal inflammation, substantially impairs patient quality of life. While photodynamic therapy offers promise for UC treatment, conventional photosensitizers face limitations including poor solubility and inadequate targeting. Here, we developed an orally administered multifunctional nanosystem (CBF@LCP) to remodel dysbiotic gut microbiota and enable synergistic phototherapy. The core comprises reactive-oxygen-species-responsive liposomes, encapsulating our previously established iodinated cyanine photosensitizer CyI, and folic acid with bovine serum albumin via amide bonds (CBF@L). This outer layer is coated with a prebiotic chitosan/pectin shell via layer-by-layer assembly. Following oral administration, CBF@LCP withstands the gastrointestinal tract via pH-dependent contraction. Following gastrointestinal-enzyme-mediated decoating, the exposed CBF@L is internalized by folate-receptor-overexpressing M1 macrophages at colitis sites. Under near-infrared irradiation, CyI executes dual photodynamic therapy/photothermal therapy, ablating pro-inflammatory macrophages while exploiting the oxygen-augmented UC microenvironment to enhance reactive oxygen species generation without exogenous oxygen carriers. Concurrently, the prebiotic shell restores microbial eubiosis by suppressing pathogens and promoting beneficial bacteria. In vivo studies in dextran sulfate sodium-induced colitis models demonstrate that CBF@LCP achieves targeted drug release, mitigates inflammation, reprograms macrophage polarization, preserves intestinal barrier integrity, and activates the phosphatidylinositol 3-kinase/AKT signaling pathway. Gut microbiota and transcriptomic analyses confirm restoration of microbial balance and mucosal healing. This work presents a potent targeted strategy for UC management through microbiota remodeling and oxygen-enhanced phototherapy.
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Journal of Physical Chemistry Letters
·
2025
·
IF 4.6
Weidong Liang,Yong Zhang,Dongniu Wang,Jianzhao Peng,Jinshuo Zou,Huiqi Li,Zhongxin Song,Manlin Tan,Jun Yu,Lei Zhang
Optimizing the electronic structures of metal sites is desirable for high intrinsic activity. Incorporated metal atoms in a carbon substrate can establish strong electronic interaction with loaded metal oxides. However, this structure may be unstable in a harsh oxygen evolution reaction (OER) environment. Herein, we take the NiSAFe sample of Ni–N–C supported Fe2O3 nanoparticles (NPs) as an example. Both in situ and ex situ characterizations show that the OER activation process facilitates the transformation of Ni single atoms into atomically dispersed NiOOH active species while retaining Fe2O3 NPs. Accordingly, abundant structural defects are formed in the carbon support, enhancing electron transfer and upshifting the d-band center of the NiFe catalyst. As a result, the catalyst exhibits accelerated OER kinetics and optimized adsorption energies for reaction intermediates, delivering outstanding intrinsic activity. A low overpotential of 230 mV at 10 mA cm–2 and a turnover frequency (TOF) more than 9 times higher than that of commercial RuO2 are achieved.
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