DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
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2026
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IF 2.6
Yuxin Liu,Zhenlin Shang,Wenxin Hu,Dongxu Liu,Jun Zhu,Xiaojing Pei,Ze Zhang
Background Nanoemulsions (NEs) are promising delivery systems for lipophilic active ingredients. However, traditional preparation methods of NEs are energy-intensive, complex, and lead to poor stability and high costs.Objective This study aims to introduce a novel pre-nanoemulsions (PNEs) system to overcome the limitations of traditional NE preparation methods.Methods The PNEs, composed of an oil phase, surfactant, co-surfactant, and aqueous phase, form thermodynamically stable isotropic mixtures. The optimized PNEs were characterized in terms of particle size, zeta potential, and polydispersity index (PDI). Comprehensive stability tests, including centrifugation, dilution, and long-term storage, were conducted. Turbiscan analysis was also performed to further assess their stability. Additionally, the sustained release and transdermal absorption capabilities of the PNEs were evaluated.Results The optimized PNEs exhibited a particle size of 115.8 ± 2.6 nm, zeta potential of −40.4 ± 2.4 mV, and PDI of 0.15 ± 0.02, with high encapsulation efficiency for lipophilic substances. Comprehensive stability tests, including centrifugation, dilution, and long-term storage, demonstrated robust performance, which was further confirmed by Turbiscan analysis. The PNEs also showed enhanced sustained release and transdermal absorption capabilities.Conclusions This universal PNEs system provides a simple, low-cost, and efficient solution for delivering lipophilic active ingredients. It addresses the key challenges of traditional NEs and offers significant potential for practical applications across various industries.
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Journal of Inorganic and Organometallic Polymers and Materials
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2026
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IF 6
Wang Haixia,Sun Yilei,Liu Chuang,Meng Zeda D.,Oh Won-Chun
A series of graphene-modified copper–metal–organic framework composites (G-Cu-MOF-0.3, G-Cu-MOF-0.5, G-Cu-MOF-1) were fabricated via a solvothermal method. Structural characterizations verified that graphene was successfully composited without damaging the Cu-MOF crystalline framework, among the four materials, G-Cu-MOF-0.5 exhibits the largest specific surface area and pore size. Electrochemical results showed that G-Cu-MOF-0.5 displayed the best CO₂ electroreduction performance, with a current density of − 11 mA cm⁻², a double-layer capacitance (Cdl) of 4.97 mF cm⁻² and a Tafel slope value of 36.5 mV dec⁻¹. At − 1.5 V vs. RHE, the total Faradaic efficiency for CH₄ and CO reached 24% with stable operation over 12 h. Graphene modification significantly improves the conductivity, active site density, and structural stability of Cu-MOF, realizing efficient and controllable CO 2 conversion to C1 products. The hydrogen evolution reaction (HER) remains the dominant side reaction, and the Faradaic efficiency toward CH 4 is still moderate, leaving room for further selectivity optimization.This work provides a feasible strategy for designing MOF–carbon composites for electrocatalytic CO₂ reduction to methane.
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Tong Qi,Xiao Wang,Yijing Han,Chengqi He
The regeneration and functional rehabilitation of peripheral nerve defects remain major clinical challenges. Piezoelectric materials have the potential to restore both nerve morphology and function. Conventional grafts struggle to repair nerves with complex structures. To address this issue, band-aid–inspired tissue-adhesive membranes were designed to accommodate diverse nerve diameters and branching structures. Electrospinning was used to prepare a Janus membrane that served as a suture-free piezoelectric nerve repair membrane. The inner layer comprised oriented adhesive hydrogel fibers fabricated from gelatin methacryloyl and tannic acid, whereas the outer layer comprised piezoelectric silk fibroin fibers that provided barrier function and structural support. In vivo experiments demonstrated that this membrane streamlined surgery, enabled rapid and facile bridging of complex peripheral nerve defects, and significantly facilitated morphological and functional nerve recovery. This finding holds significant promise for advancing personalized, simplified, and more effective clinical management of peripheral nerve defects. Additionally, it is anticipated to treat defects in other tissues and organs, specifically those with irregular morphologies.
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Nano-Micro Letters
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2026
·Vol. 18
·期 1
·430
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IF 38.5
Guo Ping,Wang Kai,An Xuyang,Ren Xuanyu,He Xinxin,Hu Yinhua,Zhou Lijie,Cai Guohua,Wang Lifeng,Liu Tiezhu,Ge Wenyu,Zhang Jia
A novel Yb-doped Bi 2 S 3 H 2 S sensor was fabricated for periodontitis exhalation diagnosis, which enables room temperature detection with high response (3.31/100 ppb) and superior selectivity.
Mechanism analysis combined with density functional theory calculations confirms that Yb doping-induced lattice distortion in Bi 2 S 3 enhances O 2- formation and H 2 S adsorption.
The sensor quantifies H 2 S produced by Porphyromonas gingivalis to confirm the association among pathogens, H 2 S and periodontitis, and is integrated into a portable analyzer for rapid, real‑time diagnosis and severity assessment of periodontitis clinically.
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Baoyi Liu,Haibo Ning,Zhenghao Gong,Junsheng Chen,Bin Yang,Yuanyuan Feng,Huan Liu,Tianxin Bai,Qingkun Kong
Halide perovskites exhibit exceptional optoelectronic properties, including strong light absorption and efficient generation of photogenerated charge carriers. However, these advantages are extremely limited in electrocatalytic systems, and their full potential remains largely unexplored. In particular, the underlying mechanisms governing light-assisted electrocatalysis in perovskite materials remain poorly understood. Herein, a Pt-modified Cs2PdBr6 all-inorganic halide perovskite (Cs2PdBr6@Pt1.5) is designed, which achieves a low overpotential of 11 mV at 10 mA cm–2 with excellent water stability. Femtosecond transient absorption spectroscopy further demonstrates that the incorporation of Pt increases the population of transient species (<1 ps) and acts as an efficient charge separation channel, thereby promoting charge migration to catalytic active sites and enhancing hydrogen evolution reaction properties. Density functional theory (DFT) calculations reveal that electrons transfer from Cs2PdBr6 to Pt, and Pt-modified Cs2PdBr6 optimizes the adsorption energies of key reaction intermediates, thereby lowering the overpotential for water splitting. These findings highlight the potential of halide perovskites as a stable and efficient platform for light-assisted electrocatalytic water splitting and related energy conversion processes.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 7
·496
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IF 5.4
Yao Haixu,Wang Yan,Shi Jincheng,Gao Xinzhuo,Yang Xueqiong,Liu Mengyuan,Li Yuxin,Jin Yingyu,Zhou Qin,Cui Feiyun
Real-time, synchronous profiling of key inflammatory cytokines such as IFN-γ, IL-6 and TNF-α is critical for understanding and managing dysregulated immune responses, including cytokine storms associated with severe infections. However, conventional immunoassays are not readily compatible with the requirements of rapid, multiplexed analysis in point-of-care settings. Herein, we report a multiplexed electrochemical biosensing platform based on biomimetic interfacial encoding using Fe 3 O 4 @Au nanoplatforms (BIENs). The core sensing element consists of extracellular vesicle-mimetic nanocomposites functionalized with cell membranes overexpressing specific cytokine receptors, enabling native-like molecular recognition. This encoded biomimetic interface affords high-affinity and selective detection of IFN-γ, IL-6 and TNF-α with wide linear ranges (0.1 ~ 1000 pg/mL) and low detection limits (0.043 ~ 0.159 pg/mL). The sensor exhibits excellent selectivity, operational stability, and reproducibility, and maintains high accuracy in serum samples with minimal matrix interference. Beyond analytical performance, this work establishes a receptor-mimetic interfacial encoding strategy for multiplexed biosensing, offering a versatile and scalable paradigm for the development of next-generation intelligent biointerfaces and dynamic immune monitoring systems. Graphical
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Haijun Wu,Shenggui Ma,Dianhang Wei,Yaolin Wang,Quanwei Lv,Ziheng Jin,Xinrui Wang,Xin Tu,Xia Jiang
A strategy for plasma-coupled O v -rich catalytic hydrogen production is proposed. • The catalyst shows high activity and universality for hydrogen production. • Synergistic cascade from plasma dissociation to catalytic surface reforming. • The key mechanism of “hydrogen promotion and anti-coking” were revealed. Hydrogen production from plastics contributes to the circular economy by enabling both waste valorisation and green energy generation. Integrated pyrolysis-plasma catalytic technology offers notable advantages in improving hydrogen production, but it still faces challenges such as catalyst coking and limited understanding of the reaction mechanisms. This study proposes a water vapor plasma-coupled oxygen vacancy-rich (O v -rich) catalytic strategy to systematically investigate the improved hydrogen production from plastics over an anti-coking catalyst. The results show that the O v -rich catalyst exhibits outstanding hydrogen production activity, strong synergistic effect, and universality in the non-thermal plasma catalytic (NTP-C) reforming reaction of mixed model compounds in plastic pyrolysis oil. Crucially, its practical effectiveness was successfully validated in the NTP-C reforming of polyethylene (PE)/polypropylene (PP) pyrolysis oils. Moreover, the O v -rich catalysts significantly inhibited coking and maintained good stability for 1800 min in a multi-component mixed system. The mechanisms of hydrogen production and coking inhibition were revealed via Density Functional Theory (DFT) calculations, in situ plasma-coupled Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS), and Optical Emission Spectroscopy (OES). A synergistic reaction pathway, coupling plasma gas-phase dissociation with catalytic surface reforming, was identified as a key mechanism for enhancing hydrogen yield in plasma-catalytic systems. The study offers valuable insights for advancing plasma-assisted hydrogen production technologies. Download: Download high-res image (150KB) Download: Download full-size image
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BIOSENSORS & BIOELECTRONICS
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2026
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IF 11.8
Bo-Han Kou,Cheng Yuan,Zi-Mo Han,Ao Xiao,Yu-Ting Huang,Wei-Wei Zhao,Jing-Juan Xu
Photoelectrochemistry (PEC) presents an emerging paradigm for aqueous neurosynaptic emulation. Here, a bioinspired PEC synapse integrating optical perception and biosensing of real neurotransmitter glutamate (Glu) is devised for visuomorphic in-sensor computing. Short-term and spiking-dependent plasticity with Glu-tunable excitatory and inhibitory signals are realized, making possible Glu-tunable convolutional kernel for in-sensor preprocessing and convolutional neural network. This work achieves PEC in-sensor processing and real neurotransmitter-mediated visuomorphic computing for the first time.
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POLYMER
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2026
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IF 5.1
Fengyi Cao,Juan Hu,Yuhao Li,Yunan Li,Meng Song,Qi Qin
Proton exchange membrane (PEM) plays a critical role in conducting protons and mitigating methanol crossover in direct methanol fuel cells (DMFCs). In recent years, sulfonated poly(ether sulfone) (SPES) membrane has been extensively studied in DMFCs, while its methanol permeability is still unsatisfied. In this work, a methanol barrier layer was fabricated on the SPES membrane via interfacial polymerization to prevent methanol permeation. The interfacial polymerized polyamide layer has a dense structure that could prevent methanol permeation across the membrane, and the methanol permeability decreases with an increasing number of interfacial polymerization cycles. It is demonstrated that the optimized SPES-PA 5 membrane achieves a methanol permeability of 0.986 × 10 −7 cm 2 s −1 , which is much smaller than the SPES membrane (2.17 × 10 −7 cm 2 s −1 ). And it is noteworthy that the SPES-PA 5 membrane still exhibits a high proton conductivity of 0.12 S cm −1 at 20 °C. This work provides a feasible approach to reduce methanol permeability and preserve the high proton conductivity of PEMs.
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JOURNAL OF HAZARDOUS MATERIALS
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2026
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IF 10.6
Yanzeng Li,Tianyi Luo,Chong Chen,Zhou Chen,Shiyu Liu,Hong Wang,Yu Hua,Xiaohu Dai
Wastewater treatment plants (WWTPs) are pivotal in the dissemination of antibiotics, antibiotic resistance genes (ARGs), and human pathogenic bacteria (HPB); however, their fate across treatment units and the associated microbial metabolic responses remain poorly quantified, and current risk assessments based on relative abundance mask the true occurrence of contaminants due to biomass fluctuations. Here, we applied absolute quantification across the wastewater-sludge continuum of a large-scale WWTP (serving 9 million inhabitants) to unravel the divergent fates of 46 antibiotics, ARGs, and HPB, and to elucidate metabolic responses associated with biogeochemical cycling and xenobiotic biodegradation. The results revealed distinct phase-partitioning behaviors of antibiotics within the WWTP. Sulfonamides and macrolides predominated in the wastewater, whereas quinolones strongly partitioned into the sludge, enriching across gravity thickening, anaerobic digestion (AD), dewatering, and drying processes. The anoxic unit was a key hotspot for sulfonamides, quinolones, and associated ARG accumulation during wastewater treatment. Sludge AD effectively removed sulfonamides (44.42%–100%) and reduced the absolute abundances of sul 1 and sul 2 by 1.47 and 1.60 log copies/g, respectively. Microbial absolute quantification analysis indicated that, although most potential HPB were significantly reduced during biological wastewater treatment and AD, Legionella -like amoebal pathogen HT99 distinctly enriched. Functional prediction indicated that xenobiotics biodegradation and metabolism was most abundant in sludge AD, with enriched cytochrome P450 and monooxygenase encoding genes likely facilitated antibiotic co-metabolic pathways. Collectively, this study demonstrates that the anoxic zone and sludge processing are critical reservoirs requiring targeted optimization, and underscores the importance of absolute quantification for accurate antimicrobial resistance risk management.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Xiaoyong Xia,Jiaqing Huang,Qimeng Sun,Jinkai Qiu,Parada Weaoseng,Chanat Chokejaroenrat,Cheng Lian,Qingfeng Xu,Jianmei Lu
A cage-like multi-imidazolium sorbent is designed for 99 TcO 4 − /ReO 4 − capture. • Cooperative clamping in confined spaces enables ultrafast adsorption kinetics. • The sorbent exhibits a high ReO 4 − uptake capacity of 730 mg g −1 . • Excellent selectivity is achieved in highly competitive nuclear waste media. • Composite beads allow efficient fixed-bed removal with good regenerability. The efficient and selective removal of pertechnetate ( 99 TcO 4 − ) from water remains a significant challenge due to its high solubility, low charge density, and competition from coexisting anions. Herein, we report tetraphenylethene (TPE)-based, imidazolium-functionalized nanomicrospheres for pertechnetate ( 99 TcO 4 − )/perrhenate (ReO 4 − ) capture with high efficiency. The nonplanar, propeller-like TPE core stereospecifically arranges multiple imidazolium sites in a semi-encapsulating/polyhedral fashion, generating size-complementary pockets. Hierarchically confined nano-spaces enable cooperative multi-imidazolium clamping, where hydrophobic effects, electrostatic attraction, ion exchange, multipoint C–H···O hydrogen bonding, and geometric confinement act in concert to afford precise recognition and strong binding. Using ReO 4 − as a nonradioactive surrogate for 99 TcO 4 − , the sorbent delivers ultrafast kinetics (11.23 g mg −1 min −1 ), high capacity (730 mg g −1 ), and 86.5% removal from Hanford low-activity waste (LAW) stream. The powder is readily formed into mechanically robust granules and shows excellent regenerability in fixed-bed tests, retaining >95% efficiency after multiple cycles. This work demonstrates that cooperative multi-imidazolium clamping within confined nano-spaces amplifies multimechanism synergy, providing a general strategy for precise recognition and strong binding of weakly coordinating anions. Propeller-like TPE-based cage-like microspheres spatially organize multiple imidazolium sites into confined binding pockets, enabling cooperative multi-site clamping for rapid and selective ReO 4 − / 99 TcO 4 − capture through hydrogen bonding, electrostatic attraction, ion exchange, and hydrophobic confinement. Download: Download high-res image (184KB) Download: Download full-size image
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Cell Reports Medicine
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2026
·
IF 14
Yao Tang,Xin Cheng,Jing Zhou,Yuqi Shi,Jiaying Zhou,Zaiyang Chen,Yan Zhang,Liucun Zhu,Jian-Qun Chen,Jiang Gu,Qiang Wang,Qihan Chen
The escalating crisis of multidrug-resistant bacteria necessitates innovative antibiotic discovery platforms. Conventional antimicrobial peptide (AMP) mining often relies on complete biosynthetic gene clusters (BGCs), leaving fragmented genomic resources underexplored. Here, we present an evolution-inspired approach to reconstruct and predict AMPs from partial BGCs. Applying this strategy to 954 Paenibacillus genomes identifies five polymyxin-like peptides, NP001–NP005, with broad in vitro activity. Crucially, in murine models of polymyxin-resistant infection, NP001 reduced bacterial burdens by up to 1,000-fold in a thigh infection model and improved survival (50% vs. 0%) in a lethal peritonitis model. Structural simulations and biophysical assays revealed that NP001 maintains high affinity for bacterial membranes and effectively binds to MCR - 1 -modified lipid A, a key colistin-resistance mechanism. Moreover, Leu at position 10 of NP001 plays a key role in antibacterial activity against MCR -1-resistant bacteria. Our work establishes a generalizable framework for AMP discovery and introduces a promising therapeutic candidate, NP001, which effectively counteracts polymyxin-resistant pathogens.
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