ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Lijing Zhu,Fu Liu,Xuemin Yu,Lixin Xue
Poly(lactic acid) (PLA) hemodialysis membranes with enhanced antifouling capability and hemocompatibility were developed using poly(lactic acid)-block-poly(2-hydroxyethyl methacrylate) (PLA–PHEMA) copolymers as the blending additive. PLA–PHEMA block copolymers were synthesized via reversible addition–fragmentation (RAFT) polymerization from aminolyzed PLA. Gel permeation chromatography (GPC) and 1H-nuclear magnetic resonance (1H NMR) were applied to characterize the synthesized products. By blending PLA with the amphiphilic block copolymer, PLA/PLA–PHEMA membranes were prepared by nonsolvent induced phase separation (NIPS) method. Their chemistry and structure were characterized with X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM) and atomic force microscopy (AFM). The results revealed that PLA/PLA–PHEMA membranes with high PLA–PHEMA contents exhibited enhanced hydrophilicity, water permeability, antifouling and hemocompatibility. Especially, when the PLA–PHEMA concentration was 15 wt %, the water flux of the modified membrane was about 236 L m–2 h–1. Its urea and creatinine clearance was more than 0.70 mL/min, lysozyme clearance was about 0.50 mL/min, BSA clearance was as less as 0.31 mL/min. All the results suggest that PLA–PHEMA copolymers had served as effective agents for optimizing the property of PLA-based membrane for hemodialysis applications.
研究领域:
生物材料
·
医学工程
·
高分子化学
✓ 已验证
DOI
高影响因子
CHEMISTRY OF NATURAL COMPOUNDS
·
2024
·Vol. 60
·期 1
·92-97
·
IF 0.8
Wang Yong,Wang Wei,Liu Cong-Jun,Gao Song,Xiong Yong-Ge,Gao Tian-Zeng,Li Wei-Shi,Li Jing-Jing
Eight new stigmasterol derivatives possessing 1,2,3-triazoles moiety were synthesized by a 1,3-dipolar cycloaddition reaction. All the compounds were characterized by IR, NMR, and HR-MS. In addition, human cervical cancer cells (HeLa), human gastric cancer cells (HGC-27), and human renal epithelial cells (HEK-293T) were selected to study the antitumor activity of the synthesized compounds. The results demonstrated that compounds 3c and 3d exhibited better inhibitory activity against the tested tumor cell lines. The IC 50 value of the inhibitory activity on HeLa was 52.3 μmol·L –1 and 31.4 μmol·L –1 , and 40.6 μmol·L –1 and 44.6 μmol·L –1 for HGC-27, respectively.
研究领域:
有机合成
·
药物化学
·
药理学
·
癌症研究
·
细胞生物学
✓ 已验证
DOI
高影响因子
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
·
2023
·Vol. 71
·期 1
·1-10
·
IF 3.2
Qiao Junying,Guo Shanshan,Huang Xianjie,Zhang Luodan,Li Fan,Fan Yazhen
This study aimed to observe the expression of angiopoietin-2 (Ang-2) in the lung tissue of juvenile SD rats with lipopolysaccharide (LPS)-induced acute lung injury (ALI) and to clarify the role of ulinastatin (UTI). Ninety 18–21-day-old juvenile SD male rats were randomly divided into five groups ( n = 18). ALI rat model was established by intraperitoneal injection of LPS (LPS 10 mg/kg), while the control group was given the same dose of normal saline. The UTI intervention group was given the injection of UTI (5000 U/mL) immediately after the injection of LPS, which was divided into UTI low-dose group (LPS + 5 ml/kg UTI), UTI medium-dose group (LPS + 10 ml/kg UTI), and UTI high-dose group (LPS + 20 ml/kg UTI).The respiratory status of each group of rats was observed, and six rats were randomly selected to be killed in each group at 6, 12, and 24 h, and the lung tissues were dissected and retained. The pathological changes of the lung tissues were observed by hematoxylin–eosin (HE) staining, the expression levels and locations of Ang-2 and vascular endothelial growth factor (VEGF) in lung tissue were observed by immunohistochemical staining, and the expressions of genes and proteins of Ang-2 and VEGF were detected by quantitative reverse transcription polymerase chain reaction (RT-PCR) and Western blot analysis. Three hours after intraperitoneal injection, rats in the model group developed shortness of breath and the developed respiratory distress progressed over time. The lung pathological changes in the model group were obvious compared with those in the control group, and gradually worsened with time, and the pathological changes of lung in the rats in the UTI intervention group were reduced compared with those in the model group. At different time points, the expressions of Ang-2 and VEGF in the lung tissue of rats in the model group were higher than those in the control group, and were lower in the UTI intervention group than those in the model group. The expressions of Ang-2 and VEGF protein were lower in the low-dose group of UTI group than those in the high-dose group of UTI group at different time points ( P < 0.05), and the expressions of Ang-2 and VEGF protein in the low-dose group of UTI were significantly lower than those in the medium-dose group at 12 h and 24 h ( P < 0.05). The expression of Ang-2 was increased in the lung tissue of juvenile SD rats with LPS-induced ALI, and was associated with the degree of lung injury. UTI might attenuate LPS-induced ALI by inhibiting the expression of Ang-2 in lung tissue, and the low dose was more obvious than the medium and high dose.
研究领域:
药理学
·
呼吸病学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
iScience
·
2023
·
IF 5.8
Chang-Yu Yan,Yue Ye,Han-Lu Mu,Tong Wu,Wen-Shan Huang,Yan-Ping Wu,Wan-Yang Sun,Lei Liang,Wen-Jun Duan,Shu-Hua Ouyang,Rui-Ting Huang,Rong Wang,Xin-Xin Sun,Hiroshi Kurihara,Yi-Fang Li,Rong-Rong He
Prenatal stress has been extensively documented as a contributing factor to adverse cardiac development and function in fetuses and infants. The release of glucocorticoids (GCs), identified as a significant stressor, may be a potential factor inducing cardiac hypertrophy. However, the underlying mechanism remains largely unknown. Herein, we discovered that corticosterone (CORT) overload induced cardiac hypertrophy in embryonic chicks and fetal mice in vivo , as well as enlarged cardiomyocytes in vitro . The impaired mitochondria dynamics were observed in CORT-exposed cardiomyocytes, accompanied by dysfunction in oxidative phosphorylation and ATP production. This phenomenon was found to be linked to decreased mitochondrial fusion protein mitofusin 2 (MFN2). Subsequently, we found that CORT facilitated the ubiquitin-proteasome-system-dependent degradation of MFN2 with an enhanced binding of appoptosin to MFN2, serving as the underlying cause. Collectively, our findings provide a comprehensive understanding of the mechanisms by which exposure to stress hormones induces cardiac hypertrophy in fetuses.
研究领域:
发育生物学
·
心脏病学
·
分子生物学
·
应激生理学
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2022
·Vol. 12
·期 38
·24596-24606
·
IF 4.036
Yong-Hong Cai,Jia-Li Zhao,Xin-Yu Guo,Xiao-Juan Zhang,Ran-Ran Zhang,Shao-Rong Ma,Ya-Min Cheng,Zhong-Yan Cao,Ying Xu
Polyaspartic acid (PASP), a well-known green scale inhibitor for industrial water treatment, might be decomposed with prolonged duration, and its anti-scaling performance against CaCO3 and CaSO4 is diminished at a low concentration (<10 mg L−1) and a high temperature. With semi-ethylenediaminetetraacetic acid (EDTA) tetrasodium salt as the mimicking model, novel phosphorus-free PASP-capped 2-aminoethylamino acid (PASP–ED2A) containing side chains bearing multi-functional groups is rationally designed and successfully prepared via the ring-opening reaction of cheap poly(succinimide) under mild reaction conditions with the assistance of readily available 2-aminoethyl amino acid. The static scale inhibition method is used to evaluate the scale inhibition performance of the as-synthesized PASP derivative. Scanning electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy are utilized to monitor the crystallization process of calcium carbonate and calcium sulfate scales, and density functional theory calculations are conducted to shed light on the relationship between the molecular structure and scale inhibition mechanism of PASP–ED2A. Results show that the as-prepared PASP–ED2A shows better scale inhibition performance for CaCO3 and CaSO4 than PASP with a low concentration, a high temperature, and an extended duration. Particularly, PASP–ED2A with a concentration of 10 mg L−1 exhibits the best scale inhibition performance for CaCO3; its scale inhibition capacity is about two times as much as that of PASP. The reason lies in that the coordination atoms in the molecular structure of PASP–ED2A can chelate with Ca2+ to inhibit the combination of Ca2+ with anions and prevent the generation of CaCO3 and CaSO4 scales. The PASP–ED2A derivative can more efficiently retard the formation and growth of CaCO3 and CaSO4 crystal nuclei and exerts better inhibition performance against CaCO3 and CaSO4 scales than PASP.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2019
·
IF 4.978
Atian Xie,Jiuyun Cui,Yangyang Chen,Jihui Lang,Chunxiang Li,Yongsheng Yan,Jiangdong Dai
Realization of fast, efficient and continuous oil–water separation is of great significance for solving the problem of oil pollution. We present here a facile hydrothermal strategy to synthesize a superhydrophilic platanus fruit-like Ni@Ni(OH) 2 hierarchical architecture (SI-PFHA). Additionally, superhydrophobic platanus fruit-like Ni@Ni(OH) 2 hierarchical architecture (SO-PFHA) is obtained through stearic acid modification of SI-PFHA. Dual-channel separation system is integrated based on two superwetting membranes. Such separation system is competent for continuous light/heavy oil–water separation with high flux and high separation efficiency. Importantly, outstanding durability and reusability make this separation system a promising strategy for practical application in remediation of oily wastewater.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry A
·
2017
·Vol. 5
·期 26
·13448-13456
·
IF 8.867
Mengna Sun,Fei Zhang,Hongli Liu,Xianggao Li,Yin Xiao,Shirong Wang
Here, we report a rapid and simple process to prepare perovskite solar cells in ambient air by adding 2-pyridylthiourea in the precursor solution. 2-Pyridylthiourea can not only promote the conversion of 2-D PbI2 to tetragonal CH3NH3PbI3 crystals, but also improve the quality of the perovskite absorber layer via enhancing the uniformity and the size of the crystal grains. The perovskite solar cells with the addition of 2-pyridylthiourea at a concentration of 0.5 mg mL−1 exhibited a remarkable overall power conversion efficiency (PCE) of 18.2%, which is among the highest PCE of CH3NH3PbI3-based devices fabricated in ambient air. It also showed an 18% increase and less hysteresis compared with the cells without additives. Importantly, the devices with 2-pyridylthiourea show relatively better stability compared to reference devices when aged under ambient air of 55 ± 5% relative humidity in the dark and under 65 °C after 30 days. The presented results clearly show that 2-pyridylthiourea can be an additive candidate for tuning the morphology of perovskite thin films, which may be a new direction for large-scale production of PSCs.
研究领域:
材料科学
·
能源技术
✓ 已验证
DOI
高影响因子
OPTICS AND LASER TECHNOLOGY
·
2016
·
IF 1.879
Rong Chen,Ying Tian,Bingpeng Li,Feifei Huang,Caizhi Wang,Xufeng Jing,Junjie Zhang,Shiqing Xu
Nd 3+ /Ho 3+ co-doped silicate-germanate glass has been synthesized by high temperature melt-quenching method. Near infrared emission centered at 2 µm has been successfully obtained by incorporating Nd 3+ and Ho 3+ in present glass. The Judd-Ofelt intensity parameters Ω t (t=2, 4, 6), and radiative properties of Ho 3+ were calculated and discussed by using the Judd-Ofelt theory. The energy transfer processes and luminescence properties of Nd 3+ /Ho 3+ co-doped glasses were analyzed pumped by a conventional 808 nm laser diode . Desirable spectroscopic characteristics indicates that Nd 3+ /Ho 3+ co-doped silicate-germanate glass might be a good alternative matrix for 2 µm band mid-infrared laser.
研究领域:
光学材料
·
无机非金属材料
·
光子学
·
激光技术
·
固体物理
✓ 已验证
DOI
高影响因子
Polymer Chemistry
·
2013
·Vol. 4
·期 12
·3545-3553
·
IF 5.231
Yuan-Jia Pan,Dian Li,Sha Jin,Chuan Wei,Ke-Yi Wu,Jia Guo,Chang-Chun Wang
Folate-conjugated poly(N-(2-hydroxypropyl)methacrylamide-co-methacrylic acid) nanohydrogels were facilely prepared via distillation–precipitation polymerization and subsequent folate modification. Due to the nanohydrogels being crosslinked with disulphide bonds, they could be easily degraded into short polymer chains in the presence of glutathione, which will be beneficial for easily discharging the nanohydrogels from the body. Doxorubicin (DOX), a clinical anti-cancer drug, was efficiently loaded in the nanohydrogels (up to 39.3 wt%) by the electrostatic interactions between the amine group in doxorubicin (DOX) and the carboxyl groups in the nanohydrogels at neutral conditions. The cumulative release profile of the DOX-loaded nanohydrogels showed a relatively low level of drug release (23 wt% in 48 h) at pH 7.4 and a quick release (over 95 wt% in 2 h) at pH 5.0 with reducing environment, exhibiting pH/redox dual-stimuli-responsive drug release. The dose-dependent cytotoxicity of the drug-loaded nanohydrogels was studied by the CCK-8 assay. The nanohydrogels possess many favourable merits of drug carriers, such as excellent biocompatibility, high drug loading capacity, minimal drug release under an extracellular condition, rapid drug release in response to the intracellular level of pH and reducing environment, and folate-mediated endocytosis, which endow them as great candidates for targeted delivery of anti-cancer drugs.
研究领域:
药剂学
·
生物材料学
·
肿瘤学
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2022
·
IF 3.428
Yuxiang Zhang,Chuan Yao,Zhiyu Ju,Shixing Zhang,Heng Wang,Wenyu Yin,Na Qin,Xueding Li,Yange Zhang
In this study, a 2-isopropyl-aminopyridine adduct of cobalt(II) chloride [Co(2- i PrNH-C 5 H 4 N) 2 Cl 2 ] was synthesized and used as a precursor for preparing cobalt-based films through chemical vapor deposition (CVD). This compound was synthesized through a simple coordination reaction and characterized through 1 H NMR, elemental analysis, and single-crystal diffraction. The thermal properties (including volatility, vapor pressure, and thermal stability) of the compound were investigated through thermogravimetric analysis (TGA) to determine its feasibility for use in CVD. Moreover, a film deposition experiment was conducted in a low-pressure CVD reactor system, and a Co 3 O 4 film was obtained. This result verified the reported compound’s applicability as a CVD precursor for fabricating cobalt-based films.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2017
·
IF 0.646
Da-Hua Shi,Zong-Ming Tang,Xiao-Dong Ma,Wei Min,Xiang-Jian Xu,Yu-Wei Liu,Xiao-Kai Song,Wei-Wei Liu,Meng-Qiu Song
Three novel 2-phenylthiazole derivatives were synthesised and characterised by spectroscopic techniques. The structure of the synthesised compounds was unambiguously confirmed by a single-crystal X-ray diffraction analysis of ethyl 2-(4-{[5-(4-benzylpiperidin-1-yl)pentyl]oxy}phenyl)thiazole-4-carboxylate. All of the compounds presented good cholinesterase-inhibition activities and ethyl 2-(4-{[5-(4-benzylpiperidin-1-yl)pentyl]oxy}phenyl)thiazole-4-carboxylate showed the best acetylcholinesterase-inhibition and butyrylcholinesterase-inhibition abilities with IC50 values of 5.19 μM and 5.83 μM. The docking study demonstrated that it could interact with both the catalytic active site (CAS) and the peripheral anionic site (PAS) of acetylcholinesterase and could chelate with metal ions like Cu2+ and Zn2+.
研究领域:
有机化学
·
药物化学
·
神经科学
✓ 已验证
DOI
高影响因子
Molecular Catalysis
·
2022
·
IF 5.089
Canshuo Gu,Lungang Chen,Yong Liu,Xinghua Zhang,Jianguo Liu,Qi Zhang,Chenguang Wang,Longlong Ma
The production of furanic biofuel 2-methyltetrahydrofuran (2-MTHF) has been studied by hydrodeoxygenation of biomass-derived levulinic acid (LA) over bimetallic NiCo/γ-Al 2 O 3 catalyst. The contents of Ni and Co in NiCo/γ-Al 2 O 3 were investigated. The Ni 5 Co 25 /γ-Al 2 O 3 catalyst gave high activity in hydrodeoxygenation of LA with a 73.4% yield of 2-MTHF under optimal conditions. The crystal phase, valence states, acidity and basicity of catalysts were measured by multiple characterizations to understand the relationships among 2-MTHF yields and catalyst properties. XPS characterization revealed that the number of metal oxides increased on bimetallic catalysts while the reduced metals occupied on monometallic catalysts. The bimetallic catalysts also presented increased acidity than that of monometallic catalysts. These distinct properties were also observed among bimetallic catalysts with different contents of Ni and Co, which were responsible for different performances. Besides, the solvent effect on the structure of 1,4-pentanediol, which was further converted to 2-methyltetrahydrofuran, was disclosed by molecular dynamics simulations.
研究领域:
化学工程
·
催化
·
生物燃料
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）