CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Jichao Zhu,Xianli Dong,Kunhao Li,Siyu Tian,Yao Kong,Weitong Chen,Shuping Zhou
In the field of pharmaceutical research and development, the development of nano drug carriers based on intercalation structures has become one of the important development directions. Hydrotalcite (LDHs) and its derivatives have the advantages of low cost, simple synthesis, high drug loading efficiency, good biocompatibility, and easy degradation, and have received widespread attention in the field of biomedicine. Based on this, we synthesized 5-aminosalicylate (5-ASA) intercalated NO 3 based and CO 3 based ZnAl-LDHs drug delivery systems using ion-exchange and chemical co-precipitation methods, respectively. The crystalline structure, morphology, thermal stability, and host-guest interaction were characterized in detail by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Ultraviolet visible spectroscopy (UV), Scanning electron microscopy (SEM), Thermogravimetric analysis (TGA) and X-ray photoelectron spectroscopic (XPS). The drug loading, drug release behavior and release kinetic of 5-ASA intercalated ZnAl-LDHs were studied. The characterization results indicated that the intercalation mode of the drug and the strength of the host-guest interaction are related to the interlayer anion type and synthesis process of ZnAl-LDHs. The amount of 5-ASA loaded into LDHs from an ion-exchange process was 28.6 and 13.8 wt% for NO 3 − and CO 3 2− based LDHs, respectively, whereas it was 6.9 and 10.4 wt% for co-precipitation process. The modeling kinetics results indicated that the release process of 5-ASA by ZnAl-LDHs intercalated with 5-ASA conforms to the parabolic diffusion model. These results indicated that the drug delivery system was controlled by diffusion of 5-ASA ions into aqueous solution through exchange with phosphate anions.
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Haoxin Cheng,Guangqi Tian,Hongmei Liu,Danmeng Bai,Yue Zhang,Qingqing Wang,Mengzhen Zhao,Shuangyuan Cao,Dan Deng,Xiaolei Wang
Oral mucosal ulcer is the most prevalent oral mucosal lesion, affecting over 25 % of general population. The current treatment regimens lack efficacy in addressing challenges such as wound bleeding, bacterial infection and inflammation on a continuous basis. Hence, a multi-functional oral gel (termed MPCST) with a long-acting duration is designed. It is based on a tannic acid-thioctic acid (TATA) supramolecular hydrogel which absorbs tissue exudate while exhibiting robust tissue adhesion properties. To form MPCST, TATA is loaded with MPCS, which are composed of polydopamine (PDA)-coated molybdenum disulfide (MoS 2 ) nanoflakes (MoS 2 @PDA) with high photothermal conversion efficiency, nitric oxide (NO) precursor nitroprusside (SNP) and cerium oxide (CeO 2 ) with high reactive oxygen species (ROS) scavenging rate. Upon exposure to 808 nm near-infrared (NIR) irradiation, MPCS rapidly heats up and releases NO to promote angiogenesis, while exhibiting strong ROS scavenging, antibacterial (including oral common Streptococcus mutans ), and anti-inflammatory properties. Animal experiments show that the MPCST oral gel, composed of MPCS and TATA hydrogel, exhibits superior therapeutic efficacy compared to the commonly used dexamethasone patch.
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DOI
PubMed
高影响因子
Analytical Methods
·
2025
·
IF 2.6
Liyu Yang,Siyi Yang,Ting Zhang,Langyi Zhao,Huanbao Fa,Yongzhong Wang,Danqun Huo,Changjun Hou,Mei Yang
Methotrexate (MTX), a widely administered medication for treating an array of tumors and autoimmune disorders, necessitated stringent monitoring due to the potential for severe adverse effects associated with its high dosage. Nevertheless, the existing methods for monitoring MTX were often intricate, time-consuming endeavors that incurred significant costs. In this work, we had constructed a controlled release sensor, harnessing the versatility of a personal glucose meter (PGM), which had been devised for swift detection of the MTX. This innovative approach employed HP-UiO-66-NH2 as a nanoscale reservoir for glucose encapsulation, while aptamer-conjugated gold nanoparticles (AuNPs@Apt) served as molecular gates, sealing the pores of the nano-container. Upon introduction of MTX into the solution, a specific recognition event occurred between the aptamer and MTX, leading to the formation of a stable AuNPs@Apt-MTX complex. This interaction triggered the release of AuNPs@Apt from the surface of HP-UiO-66-NH2, allowing glucose to escape, which was then detected by the PGM. This method demonstrated a robust linear response to MTX concentrations spanning from 0.1 μM to 20 μM, with a remarkable detection limit of 0.1 μM. Extensive experiments underscored the platform's exceptional selectivity for MTX detection, coupled with excellent reproducibility and stability, with a detection time of only 30 minutes. Importantly, it had been successfully applied to the analysis of MTX in diluted human serum with satisfactory recoveries. Given its portability and cost-effectiveness, this platform pioneered a novel avenue for monitoring MTX in blood drug levels, offering significant potential for clinical applications and drug monitoring strategies.
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Zongde Wu,Chaonan Shang,Qu Zeng,Haifang Liu,Furui He,Yuhong Feng,Haibin Luo,Jiacheng Li
Hydrogel materials hold great potential in agriculture. In this study, a photo-electric controlled-release double-network hydrogel carrier was fabricated based on polyacrylamide (PAM) and sodium alginate (SA) with the montmorillonite (MMT). This double-network (DN) structure of Fe 3+ /SA-PAM-MMT (SPM Fe 3+ ) gel can efficiently improve stability of the carrier through radical polymerization and ion cross-linking reactions. The physicochemical properties of the composite hydrogels were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermal gravimetric analysis, differential scanning calorimeter, rheometer, electronic universal testing machine and scanning electron microscopy. The SPM Fe 3+ gel carriers exhibit excellent mechanical properties and photo-electric responsiveness, attributed to their double-network structure and incorporation of MMT. The pore size of the SPM - Fe 3+ gel expands under an electric field due to the Coulomb force of carboxyl group on the SA chain. Additionally, the structure of SPM Fe 3+ was broken under UV-irradiation due to the photochemical reaction of Fe 3+ -SA. The release of urea is regulated by this photoelectrochemical stimulus - responsive mechanism. Therefore, this work provides a promising approach to prepare dual-responsive controlled-release carriers and demonstrates that SPM-Fe 3+ -5 % double-network hydrogel has potential applications in controlled-release fertilizers.
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Bei Yang,Shujuan Yang,Yan Zhou,Weimin Xing,Zhuoyue Wang,Gaobo Yu,Yuhong Feng,Jiacheng Li
Engineering biomass-derived Pickering emulsions offers a sustainable pathway for precision agrochemical delivery. However, concurrent optimization of impact tolerance, interfacial adhesion, and pathological microenvironment-triggered release poses significant challenges, as existing systems frequently exhibit structural disintegration under operational stresses and insufficient responsiveness to biotic signals. Herein, we fabricate an intelligent Pickering emulsion via interfacial supramolecular assembly governed by dynamic B O bonds between alginate-anchored polydopamine and phenylboronic acid moieties. The engineered system exhibits two synergistic characteristics: first, the self-adaptive interfacial layer demonstrates outstanding mechanical energy dissipation, with recorded dissipation efficiencies of 75.6 % and 94.1 % during the maximal spreading and retraction phases, respectively, while maintaining substantial foliar adhesion (51.9 % retention). Second, the architecture enables pathogen-specific release, responding to acidic microenvironments at infection sites with 56.8 % simulated medicine release under acidic conditions, compared to 36.3 % under neutral conditions. The system additionally exhibits pronounced antifungal efficacy, showing 68.7 % suppression against Botrytis cinerea in laboratory assays. By merging ecological biomaterials with stimulus-responsive coordination chemistry, this work presents a versatile paradigm for next-generation delivery systems that offer enhanced mechanical endurance and precise biological targeting.
研究领域:
农业材料科学
·
智能递送系统
·
可持续生物材料
·
界面化学
·
植物保护技术
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产品关联
DOI
高影响因子
ACS Agricultural Science & Technology
·
2025
·
IF 2.9
Qianqi Zheng,Jingyu Zhao,Keai Fang,Bing Luo,Xinru Yi,Hui Li,Wancheng Hu,Hao Yi,Kailin Liu,Bei Yan
To combat fungal plant diseases and induce plant resistance, this study employed w/o/w double emulsion technology to fabricate composite microcapsules using poly(lactide-co-glycolide) and hydroxypropyl methylcellulose phthalate as wall materials, coencapsulating pyraclostrobin of the outer layer and plant hormone 24-epibrassinolide of the inner layer. The microcapsules exhibited an average particle size of 2.12 μm, pyraclostrobin encapsulation efficiency (EE) of 74.1%, and 24-epibrassinolide EE of 64.8%. Cumulative release profiles showed 62% pyraclostrobin release at 10 h, reaching a maximum of 82% by 72 h, while 24-epibrassinolide achieved 52% release at 10 h and 60% by 48 h. Compared with the technical pyraclostrobin, the microcapsules significantly enhanced the photostability of 24-epibrassinolide by 4.36-fold, thereby facilitating the long-term utilization of active ingredients. The microcapsule formulations exhibited superior control efficacy against rice leaf blast and significantly reduced acute toxicity to zebrafish (20-fold higher LC50 than technical).
研究领域:
农业化学
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植物保护
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药物递送系统
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环境毒理学
·
纳米技术
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产品关联
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2022
·
IF 11.504
Peng Wang,Yucheng Zou,Yang Li,Zeyu Qin,Xingquan Liu,Hui Zhang
In this study, chitosan-dialdehyde-β-cyclodextrin-curcumin (CS-DCD-CUR) and alginate dialdehyde (ADA) were alternately deposited on the surface of electrospun cellulose acetate (CA) nanofibers driven by Schiff base bonding and electrostatic attraction. With the increasing number of bilayers, the self-assembled nanofibers showed an increased average fiber diameter from 441 to 576 nm and had relatively rough surfaces. The improved thermal stability and tensile strength of self-assembled nanofibers were attributed to the interactions between CS-DCD-CUR and ADA. The self-assembled nanofibers exhibited pH-sensitive release characteristics under acidic conditions due to the weakening of the electrostatic interaction and the hydrolysis of Schiff-base. Moreover, the self-assembled nanofibers could be used for sustained and controlled release of the curcumin within 620 min and maintained the antioxidant activities . The highest radical scavenging activities against ABTS and DPPH radicals of the nanofibers were 24.75% and 83.56%, respectively. These results suggested that the layer-by-layer self-assembled nanofibers provided a pH-responsive sustained delivery system for bioactive substances with potential applications in functional foods.
研究领域:
材料科学
·
药物递送
·
食品科学
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DOI
高影响因子
DALTON TRANSACTIONS
·
2020
·Vol. 49
·期 8
·2645-2651
·
IF 4.174
Shihao Li,Lin Zhang
Photothermal therapy (PTT), which involves an increase in temperature triggered only by light signals at tumor sites to remove cancer cells, has been considered an attractive strategy in cancer therapy. Nevertheless, the in vivo applications of photosensitizer-based PTT are limited due to the poor biocompatibility of photothermal agents. Employing red blood cell (RBC) membranes to encapsulate photothermal agents can solve this issue, but the extra surface coating will suppress heat dissipation, which is unfavorable for the subsequent treatment. Herein, biomimetic nano-capsules have been fabricated for light signal-activated cancer therapy by encapsulating photocatalyst titanium dioxide colloid and photothermal agent gold nanorods (Au NRs) in erythrocyte membrane vesicles. The fabricated Au/TiO2@RBC nano-capsules can achieve the controlled release of Au NRs upon the photocatalytic degradation of their surface cell membrane coatings, and generate therapeutic signals after the released Au NRs are irradiated by an NIR laser. Meanwhile, the reactive oxygen species (ROS) produced by photocatalysis are helpful for killing tumor cells photodynamically. Thus, the biomimetic nano-capsules prepared herein will contribute to the research and development in cancer cell therapy.
研究领域:
生物医学工程
·
癌症治疗
·
纳米技术
·
光化学
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DOI
PubMed
高影响因子
Biofabrication
·
2017
·Vol. 9
·期 2
·025028
·
IF 5.24
Ruiying Chen,Xinjie Cai,Kena Ma,Yi Zhou,Yining Wang,Tao Jiang
Bone regeneration is a complicated process and includes a number of distinct and sequential stages of coordinated cellular actions under the regulation of multiple growth factors. Therefore, bone grafting materials in which growth factors can be incorporated and released in a programmed order in line with the bone tissue healing process may lead to desirable clinical outcomes. In the present study, a double-layered chitosan/gelatin/genipin (d-CSG/G) nanosphere coating is developed by using layer-by-layer electrophoretic deposition and genipin crosslinking. The surface morphology, physicochemical and mechanical properties of the coatings are explored. Cytochrome C is used as a therapeutic model protein and is successfully loaded on the inner and outer layers of the coating. The protein release can be controlled by the loading position, genipin concentration and thickness of the outer layer. Furthermore, the cell response to the coatings was evaluated. Real-time polymerase chain reactions, immunofluorescence staining and extracellular matrix mineralization assay confirmed that the functions of the loaded growth factor are fully preserved after fabrication. Overall, the d-CSG/G nanosphere coating could be a promising growth factor delivery system to promote bone tissue regeneration.
研究领域:
生物材料学
·
组织工程学
·
药物递送系统
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DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 8
·3478-3486
·
IF 3.288
Fan Gao,Fei Wang,Xuan Nie,Ze Zhang,Guang Chen,Lei Xia,Long-Hai Wang,Chang-Hui Wang,Zong-Yao Hao,Wen-Jian Zhang,Chun-Yan Hong,Ye-Zi You
Mitochondrial malfunction is considered to be a decisive signal of apoptosis. It would be a promising strategy to target mitochondria in cancer cells to generate reactive oxygen species (ROS), thus directly inducing mitochondrial damage. We herein reported a mitochondria-targeted, photo-responsive polymer (Mito-PNBE), which can self-assemble into nanoparticles (Fe–CO@Mito-PNBE) encapsulated with diphenylcyclopropenone (light-responsive CO prodrugs) and aminoferrocene-based prodrugs via hydrophobic interactions. Upon UV-irradiation, the rapid release of CO and aminoferrocene-based prodrugs caused by disassembly was observed. On one hand, the released carbon monoxide in mitochondria could enhance ROS generation and accelerate oxidative metabolism. On the other hand, the aminoferrocene-based prodrugs will release Fe3+/Fe2+ ions in the tumor microenvironment, thus triggering the Fenton reaction, which generates more ROS and damages the mitochondria. Thus, the synergistic effect of the two drugs produces enough amounts of ROS in the mitochondria, leading to mitochondrial collapse with an enhanced cancer therapeutic effect. This multifunctional platform has potential in precision cancer therapy.
研究领域:
生物化学
·
肿瘤学
·
药物递送系统
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DOI
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2013
·Vol. 14
·期 2
·280-288
·
IF 3.742
Feifei Li,Bin Chen,Zhaohua Ping,Xiangxiang Jia,Xin Guo,Longqiang Xiao,Lijian Liu
Lipophilic 6- O -poly ( ϵ -caprolactone)- L -ascorbic acid (AA-6-PCL) is synthesized through ROP of ϵ -caprolactone (CL). The number of repeating CL units in the polymer chain varies from 6 to 19. AA-6-PCL loaded supramolecular polymer micelles (SMPMs) are constructed with β-cyclodextrin (β-CD) and PCL as blocks. Transmission electron microscopy images show a nanospheric morphology of the micelles with a size range of 43.3 ± 5.0 nm. The drug loading contents are 22.53–39.23% for AA-6-PCL. AA-6-PCL exhibits high radical scavenging capacity (93.96–96.73%) and efficient scavenging potency, and a cytotoxicity study proves the excellent cytocompatibility of AA-6-PCL loaded β-CD/PCL SMPMs, which altogether herald their potential application in the study of the induced pluripotent stem cells.
研究领域:
材料科学
·
药学
·
生物医学工程
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DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 47
·22133-22140
·
IF 3.591
Huaming Feng,Yang Luo,Ming Liu,Qing Chen,Zhu Tao,Xin Xiao
Cucurbit[n]urils (Q[n]s) are essential members of the supramolecular organic framework family owing to their distinct structure. In this study, Q[8] was employed as a building block and a Q[8]-based porous supramolecular assembly (Q[8]–PSA) was prepared by simple crystallization in an aqueous HCl solution. This Q[8]–PSA was constructed through the outer surface interaction of Q[8] and hydrogen bonding between the lattice water molecules and portal carbonyl oxygens of Q[8]. Q[8]–PSA provides a uniform pore structure, large specific surface area, and uniform pore size, which was characterized by single crystal XRD, TEM, SEM, and FT-IR spectroscopy. Following this, the obtained Q[8]–PSA was employed to evaluate its adsorption property towards 8 drugs with varying shape and size. Moreover, the controlled release of drugs from Q[8]–PSA was also investigated at pH 4.5 and 6.8 using an orbital oscillator.
研究领域:
材料科学
·
药物递送
·
超分子化学
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DOI
高影响因子
危险品化学品经营许可证（带存储）