RSC Advances
·
2020
·Vol. 10
·期 50
·29668-29674
·
IF 3.119
Shuangxia Wu,Fengjie Geng,Suqin He,Wentao Liu,Hao Liu,Miaoming Huang,Chengshen Zhu
To increase the bioavailability and water solubility of hydrophobic medicine, an amphiphilic block copolymer, polycaprolactone-block-polyhydroxyethyl acrylamide (PCL-b-PHEAA), was synthesized. The copolymer can self-assemble into micelles by dialysis. The micelles were characterized by the Tyndall effect, static drop method, fluorescence spectrometry, dynamic light scattering, scanning electron microscopy and transmission electron microscopy. Ibuprofen was encapsulated inside the micelles by dialysis as a model medicine. The results show that the amphiphilic copolymer forms a uniform micelle system, with spherical micelles dispersed well in solution which have a low critical micelle concentration. In addition, the system shows good amphipathic behavior. Average particle size of a micelle is 104 nm, which increases a lot after drug loading and standing for half a month. In the first few hours, the cumulative release of the drug increases gradually; the rate of increase in the first ten hours is faster, then reaching a plateau which tends to be flat finally. It is similar under two different pH conditions. This biocompatible, biodegradable amphiphilic block copolymer has potential applications in the biomedical field.
研究领域:
生物材料
·
药剂学
·
高分子化学
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PubMed
高影响因子
JOURNAL OF APPLIED PHYSICS
·
2017
·Vol. 121
·期 2
·
IF 2.068
You Y.,Wang C.,Xu Y. L.,Wan J. X.,Ren W.,Fang X. H.,Chen X. Y.
Boron-doped graphene (B-doped graphene) films with large area, high quality, and good uniformity are successfully prepared by chemical vapor deposition using ethylboronic acid (C 2 H 7 BO 2 ) as the sole precursor. The pre-treatment of the copper foil and post-annealing are introduced to the growth process and proved to be greatly influential to the quality of B-doped graphene. The films prepared are mainly monolayer with the transmittance of about 97.1%, the B/C ratio of about 2.3%, the sheet resistance of 1.5–3 kΩ/◻, and the carrier density of 1.13 × 10 13 cm −2 at room temperature.
研究领域:
材料科学
·
纳米技术
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DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2026
·
IF 5.7
Zi-Kun Lin,Cheng Chen,Jia-Hui Hong,Ping Tan,Yao Yuan,Peng Wang,Xue-Sen Yang,Ya Liu,Hai-Gang Zhang
Heat stroke (HS) represents a severe public concern due to its high mortality rate, with cardiac injury recognized as a critical pathological process. Schisandra chinensis has been utilized in traditional Chinese prescription to prevent and treat heat stroke, but the underlying mechanism is unclear. The present study was designed to explore the cardioprotective effect of its main component, Schisandrin B (SchB). We analyzed cardiac RNA sequencing differentially expressed genes (DEGs) between HS and control mice to initially evaluate SchB's potential in attenuating HS-induced cardiac injury and its relation with ferroptosis. Using murine (core temperature reaching 42 °C) and cellular HS models (42 °C exposure for 5 h), we verified the cardiac preventive effects of SchB against HS-induced injury and its role in the modifying of ferroptosis. Bioinformatic analysis suggested SchB could modulate ferroptosis during HS. SchB pretreatment significantly prolonged time to reach HS in mice, alleviated cardiomyocyte injury, decreased Fe 2+ and malondialdehyde (MDA) levels while elevated glutathione (GSH) levels. Additionally, SchB downregulated acyl-CoA synthetase long chain family member 4 (ACSL4) expression and upregulated solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4) in both murine and H9c2 cells HS models. Concurrently, SchB upregulated sirtuin 1 (SIRT1) expression while inhibiting the nuclear translocation of high mobility group box 1 (HMGB1). These findings suggest that SchB pretreatment may attenuate HS-induced cardiac ferroptosis and the associated myocardial injury through modulation of the SIRT1/HMGB1/ACSL4 pathway.
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DOI
PubMed
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2026
·Vol. 109
·期 1
·e70521
·
IF 3.8
Yonghui Yu,Limeng Liu,Yinbo Zhao,Yongchao Jin,Jie Wei,Xianghui Yan,Jian Ye,Biao Zhang,Yujin Wang
Synthesis and optimization of tantalum monoboride (TaB) ceramics were investigated to address a gap in the literature where TaB-based bulk ceramics are underexplored despite their predicted excellent mechanical properties. The main focus was put on evaluating influence of extra boron (0.85–1.5 at%), silicon carbide (3–15 wt%), and silicon nitride (1–15 wt%) additions on densification, phase purity, microstructure, and mechanical performance of the TaB ceramics. In the study, a Ta+B powder mixture for stoichiometric TaB was consolidated via reaction reaction hot pressing (RHP) at 1800°C and 1900°C under 30 MPa for 1 h. Because it yielded poor densification (∼62% relative density) and undesirable impurity phases, various processing routes were tried to obtain the desired TaB ceramic, the methods including (i) using B additive and C (introduced as impurity by wear of milling ball coating) to eliminate the minor oxygen-related impurities TaC and Ta 2 O, (ii) using SiC/Si 3 N 4 to deoxidize the reaction system and reinforce the TaB composites, and (iii) using RHP versus spark plasma sintering (SPS) to compare effects of sintering temperatures and time. Thermodynamic analysis was done to facilitate understanding phases formation. The results showed that densification was improved by additions of 0.85–1.5 at% extra B in combination with SPS at 2100°C under 40 MPa for 10–30 min, but the minor impurity phase TaC or Ta 2 O remained. Additions of Si 3 N 4 at 3 wt% and above emerged as effective, achieving near-full density (>97% relative density) and good mechanical properties, with Vickers hardness, flexural strength, and fracture toughness reaching 26.1 ± 1.3 GPa, 705 ± 45 MPa, and 4.40 ± 0.19 MPa·m 1/2 , respectively. Residual oxygen seemed to have been collected in Si 3 N 4 -Si 2 N 2 O aggregates due to the formation of minor Si 2 N 2 O, a beneficial situation, leaving clean TaB grain boundaries for possible better mechanical performance of the TaB-Si 3 N 4 composites at high temperatures. In contrast, SiC addition cannot be recommended because it promoted impurity phases (e.g., TaC, TaSi 2 , Ta 5 B 6 , and Ta 3 B 4 ) and failed to enhance densification (RHP at 1800°C under 30 MPa for 1 h) at low content of SiC additions <5 wt%, while the aimed TaB was completely missed at 5–15 wt% SiC additions.
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高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2013
·
IF 3.365
Xue Jiang,Zhuang Zhuang,Feng Xin
Highly b-oriented Titanium Silicalite-1 (TS-1) zeolite films were synthesized on polyvinyl acetate (PVAc) modified glasses by hydrothermal crystallization. The prepared samples were characterized by X-ray diffraction (XRD), field-emission scanning electron microscope (FE-SEM), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FT-IR) and a contact-angle instrument. The results showed that the mass of PVAc on the glasses would influence the process of superficial nucleation and oriented growth of TS-1 films profoundly. A favorable amount of PVAc on smooth surface of glassy substrate was determined to form a highly b-oriented and fully covered TS-1 film by attracting appropriate precursor and template, then making TS-1 nucleate and grow orientedly. Based on the obtained results, a scheme of fabricating b-oriented TS-1 films was proposed.
研究领域:
材料科学
·
无机化学
·
薄膜制备
·
沸石化学
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DOI
高影响因子
MOLECULES
·
2026
·Vol. 31
·期 13
·2270
·
IF 5.1
Kexin Ge,Shuaiqi Chen,Boning Jiang,Xuhui Wang,Xiangyu Xu,Jiaqing Song
Rhodamine B (RhB) is a typical xanthene-based cationic dye. Its widespread application has brought serious safety and environmental risks. Heterogeneous Fenton systems based on zero-valent iron (Fe0) are promising for RhB degradation. However, bare Fe0suffers from severe agglomeration and surface passivation. In this study, alumina with a large pore volume and high specific surface area was employed as a support to enhance Fe0dispersion and stability. The catalyst was prepared via a glucose-assisted carbothermal reduction method, and the formation of Fe0was confirmed by X-ray diffraction and electron microscopy analyses. Under optimal conditions (pH = 3.58, catalyst dosage = 0.8 g·L−1, H2O2= 10 mM), 10 mg·L−1RhB was completely degraded within 25 min, with a pseudo-first-order rate constant of 0.432 min−1. This exhibits a faster degradation rate and efficiency advantage. Radical quenching experiments indicated that hydroxyl radicals (•OH) were the dominant reactive species, while singlet oxygen (1O2) also contributed to the degradation process. Two primary degradation pathways, including N-deethylation and hydroxylation, were identified. The catalyst showed moderate reusability with slight deactivation after repeated cycles. This study demonstrates that tailoring the pore structure of alumina supports is an effective strategy to enhance Fe0dispersion, mass transfer, and catalytic performance in heterogeneous Fenton systems.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Ming Niu,Zhenghua Zhang,Rourou Wang,Yaxin Zhou,Jing Zhou,Lumei Pu,Weibing Xu
Research into antimicrobials is crucial for the sustainable development of the livestock industry. Trimethoprim (TMP) is one of the most widely used antimicrobial agents in the world. However, its efficacy is often limited by poor water solubility and dose-limiting properties. In this work, amphiphilic block polymer carriers are prepared using the oxygen-induced reversible addition–fragmentation chain transfer polymerization reaction. TMP is linked to carriers in different ratios to form poly(mPEG-b-PCEA)–TPM conjugates. The conjugates are characterized using various methods including 1H NMR, FT-IR, XRD and SEM. The results of in vitro antimicrobial experiments show that poly(mPEG-b-PCEA)–TMP with different ratios has more prominent antimicrobial effects than the same dosage of pure TMP. poly(mPEG-b-PCEA)–TMP80 shows the most significant results, inhibiting E. coli by 87.19% and S. aureus by 97.02%, with a hemolysis rate of <5% and good biocompatibility. In vivo pharmacokinetics show an increase in Cmax from 4.81 μg mL−1 to 6.57 μg mL−1 and AUC0–48 from 78.55 h μg mL−1 to 89.11 h μg mL−1 for poly(mPEG-b-PCEA)–TMP80 compared to commercially available TMP tablets. This strategy can effectively improve the antibacterial activity and pharmacokinetics and increase the bioavailability of TMP.
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高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2025
·
IF 6.2
Xiumei Wu,Jianwei Teng,Yunping Li,Xiangming Chen,Shu Yu
Boron (B)-doped SiOC (SiBOC) ceramics were prepared by sol-gel method with triethyl borate (B(OCH 2 CH 3 ) 3 as modifier, and SiBOC ceramic bulks were prepared by spark plasma sintering (SPS). The structure evolutions of SiBOC ceramics with various B doping content and pyrolysis temperature were studied. Meanwhile, the oxidation behaviors of different SiBOC ceramic bulks at 1200 °C and 1500 °C were investigated. Results showed that B 2 O 3 and borosilicate formed during oxidation can reduce the viscosity of SiO 2 -based oxide layer and improve its self-healing ability. S0.05B-1600 ceramic showed the highest oxidation resistance, with the lowest oxidation rate of 6.82 × 10 −5 mg 2 /(cm 4 ·h) after oxidation 4 h at 1200 °C, for the dense and continuous oxide layer with high self-sealing ability and low oxygen diffusion coefficient.
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高影响因子
NANOTECHNOLOGY
·
2022
·Vol. 33
·期 45
·455401
·
IF 3.953
Hongjing Wang,Hongyong Chen,Shuli Yin,Qiqi Mao,Chunjie Li,You Xu,Xiaonian Li,Ziqiang Wang,Liang Wang
Nonmetal doping is a promising strategy to improve electrocatalytic performance of noble metal based catalysts for oxygen reduction reaction (ORR). Herein, we report a facile method to fabricate PdCuBP nanothorn assemblies (PdCuBP NTAs) by co-doping B and P into pre-synthesized PdCu NTAs using NaBH4 and NaH2PO2 as B source and P source, respectively. The metal-nonmetal structure and multi-branched morphology can optimize oxygen adsorption energy and avoid catalyst migration, agglomeration and Ostwald ripening. As such, the obtained PdCuBP NTAs exhibit efficient activity and excellent long-term stability for ORR. This research offers an excellent strategy for co-doping nonmetal elements into metal nanocrystals with controllable composition and structure to improve electrocatalytic ORR performance.
研究领域:
材料科学
·
电化学
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Na Lei,Pianpian Ma,Bo Yu,Shuhong Li,Jianming Dai,Guohua Jiang
The perovskite-type SrMn 0.875 Nb 0.125 O 3 (SMN) and SrCo 0.875 Nb 0.125 O 3 (SCN) materials are prepared through the solid-state reaction method as novel oxygen-intercalated electrode materials for supercapacitor . The crystal structure, powder morphology, and electrochemical performance have been characterized in detail. SMN exhibits a six-layer hexagonal (6 H ) structure with space group P 6 3 / mmc , while SCN shows the tetragonal structure of space group P 4/ mmm . Under the three-electrode system with 1 M Na 2 SO 4 neutral electrolyte solution, the specific capacitance ( C s ) of SCN can reach 894 mF cm −2 at 1 mA cm −2 , which is 4.7 times the value of SMN at the same condition. For SCN, the superiority of electrochemical performance is attributed to its porous surface morphology , perovskite structure with shorter B O bond length and large B-O-B bond angle, and a higher oxygen vacancy content. When combined with activated carbon (AC) electrode, the SCN//AC asymmetric supercapacitor with a working voltage of 2.0 V presents a specific energy density of 82.33 μWh cm −2 , while maintaining prominent cycling stability with a capacity retention of 88.88% after 10,000 cycles.
研究领域:
材料科学
·
电化学
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DOI
高影响因子
MATERIALS LETTERS
·
2018
·
IF 2.687
Leilei Li,Jie Xu,Shuyao Cao,Qian Chen,Junting Liu,Emilia Pawlikowska,Mikołaj Szafran,Feng Gao
B-site complex perovskite Ba(Zr 0.1 Ti 0.9 )O 3 microcrystals at micron size with a plate-like shape was successfully synthesized using topochemical microcrystal conversion and molten salt method. A plate-like Bi 4 (Zr 0.1 Ti 0.9 ) 3 O 12 precursor was first synthesized by Zr 4+ substitution of Ti 4+ using molten salt. Then plate-like 4–9 μm Ba(Zr 0.1 Ti 0.9 )O 3 microcrystals with an average thickness <500 nm were synthesized by mixing BaCO 3 , Bi 4 (Zr 0.1 Ti 0.9 ) 3 O 12 , and KCl molten salt at 800 °C. Finally, the topochemical microcrystal conversion reaction between BaCO 3 and Bi 4 (Zr 0.1 Ti 0.9 ) 3 O 12 precursor was carried out. The results pave the way for fabricating plate-like B-site complex perovskite microcrystals.
研究领域:
材料科学
·
无机化学
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DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2026
·
IF 4
Xuhua Qi,Zengbo Fang,Siqi Li,Shuyao Wang,Nan Tao,Huarong Xu,Yan Cui
Chiral HPLC-MS/MS developed for axial chiral Sch B in diverse complex matrices. • Coated Chiralcel OD-RH showed superior selectivity for rigid axial enantiomers. • Stereoselective BBB permeability of Sch B was identified using the new platform. • Neuroprotective effect and BBB permeability of Sch B enantiomers were first compared. Schisandrin B (Sch B), a major dibenzocyclooctadiene lignan from Schisandra chinensis , possesses a unique form of axial chirality and exhibits significant neuropharmacological properties. To address the formidable analytical challenge of resolving this rigid axial chiral scaffold in complex biological environments, a high-performance chiral HPLC platform was systematically developed. Superior resolution ( Rs = 2.93) was achieved on a Chiralcel OD-RH column using a methanol-water (90:10, v/v ) mobile phase. By coupling experimental optimization with molecular docking simulations, the separation mechanism was elucidated, revealing that specific hydrogen bonding and π-σ hydrophobic interactions between the cellulose-based chiral stationary phase (CSP) and the axial chiral framework are the primary driving forces for stereoselective recognition. To overcome the matrix-resolution trade-off, the method was optimized to ensure high sensitivity and minimal Ion Suppression in five distinct biological matrices, including lipid-rich brain tissue. Under multiple reaction monitoring (MRM) mode, the analytes were measured with high specificity ( m/z 401.2→285.2). This robust analytical platform was then applied to investigate the stereoselective blood-brain barrier permeability and neuroprotective efficacy of Sch B. While R -Sch B showed superior antioxidant efficacy in PC12 cells, S -Sch B exhibited significantly higher brain-to-plasma ratios (2.31 vs. 1.49) and preferential central nervous system accumulation. These findings, facilitated by enantiomer-specific interactions with efflux transporters such as P-glycoprotein, highlight the critical role of chirality in drug disposition and provide a reliable analytical framework for the development of enantiomer-specific neuroprotective agents.
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高影响因子
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