ADVANCED MATERIALS
·
2025
·
IF 26.8
Ruizeng Luo,Yijie Fan,Yilin Qi,Yuan Bai,Meng Xiao,Yujia Lv,Jinrui Liang,Mingcheng Tang,Jiaping Zhang,Zhou Li,Dan Luo
Endogenous electric field (EF) originating from differences in ionic gradients plays a decisive role in the wound healing process. Based on this understanding, a self-manipulating sodium ion gradient-based endogenic electrical stimulation dressing (smig-EESD) is developed to achieve passive, non-invasive, endogenic electrical stimulation of wounds, which avoids the side effects of electrode occupancy, electrochemical reactions, and thermal effects present in traditional exogenous electrical stimulation. smig-EESD reduced the potential at the center of the wound by specifically absorbing Na+ in the exudate, ultimately strengthening the wound endogenous EF. Importantly, smig-EESD converted the active transport dependent on Na + /K + -ATPase into passive diffusion by adsorbing extracellular matrix Na+, and the saved ATP consumption promoted tissue repair process. smig-EESD regulated innate and adaptive immune responses by upregulating the secretion of multiple cytokines, thereby suppressing injury-associated inflammatory responses and reducing scar formation. smig-EESD reveals an endogenic electrical stimulation strategy that is independent of electrodes and circuits, and provides new insights into the future development of electronic medicine.
研究领域:
生物医学工程
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伤口愈合
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组织工程
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电疗法
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免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2011
·
IF 3.068
Wenhui Xiong,Jian Peng,Yongfeng Hu
This paper presents a novel technique integrating bulk-sensitive and surface-sensitive XANES methods to distinguish between physisorption and chemisorption for phosphate adsorption onto ferrihydrite-modified diatomite (FHMD). XANES P K-edge, L-edge, and Fe M-edge spectra were obtained for reference samples (K 2 HPO 4 and FePO 4 ·2H 2 O) and test samples (phosphate adsorbed onto FHMD (FHMD-Ps) and Si-containing ferrihydrite (FHYD-Ps)). A resolvable pre-edge peak in the P K-edge spectra of FHMD-Ps and FHYD-Ps provided direct evidence for the formation of P–O–Fe(III) coordination and the occurrence of chemisorption. The resemblance between the P L-edge spectra of K 2 HPO 4 and FHMD-Ps and the marked difference between the spectra of FHMD-Ps and FePO 4 ·2H 2 O indicated the intact existence of the adsorbate and the adsorbent. The similarity between Fe M-edge spectra of FHMD and FHMD-Ps and the difference between the spectra of FHMD-Ps and FePO 4 ·2H 2 O confirmed the findings from P L-edge analyses. Therefore, chemisorption and physisorption coexisted during phosphate adsorption onto FHMD. Phosphate chemisorption occurred in the deeper zone of FHMD (from 50 nm to 5 μm); whereas physisorption occurred in the zone of FHMD shallower than 50 nm since the probing depth of XANES P K-edge method is 5 μm and that of P L-edge and Fe M-edge methods is 50 nm.
研究领域:
环境化学
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材料科学
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表面科学
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吸附
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光谱学
✓ 已验证
DOI
高影响因子
ADVANCED MATERIALS
·
2024
·
IF 27.4
Qiyue Wang,Sirui Cui,Dao Shi,Pan Tao,Chencheng Zhang,Fang Wang,Peihua Lin,Fangyuan Li,Daishun Ling
Surgery remains an essential treatment for managing drug-resistant focal epilepsy, but its accessibility and efficacy are limited in patients without distinct structural abnormalities on magnetic resonance imaging (MRI). Potassium ion (K + ), a critical marker for seizure-associated neuronal signaling, shows significant promise for designing sensors targeting hidden epileptic foci. However, existing sensors cannot cross the blood-brain barrier and lack the ability to specifically enrich and amplify K + signals in the brain with high temporal and spatial resolution. Here, an intravenously administered neuronal signal sorting and amplifying nanosensor (NSAN) is reported that combines real-time dynamic reversible K + fluorescence imaging with high-resolution structural MRI, enabling electroencephalogram-concordant imaging of MRI-negative epileptic foci. Guided by NSANs, minimally invasive surgery is successfully performed in both intrahippocampal kainic acid (KA) epilepsy model with foci confined to the ipsilateral hippocampus, and intraperitoneal KA model where foci are randomly distributed, resulting in sustained seizure control and cognitive improvement. These findings highlight the NSAN as a transformative tool for visualizing hidden epileptic foci, thereby broadening eligibility for minimally invasive and precision surgical intervention.
研究领域:
神经科学
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纳米技术
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医学影像
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外科干预
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
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2024
·
IF 4.8
Danilo de Souza Costa,Rayssa A. Cajas,Carla Monteiro Leal,Lara S. Aleixo de Carvalho,Lara Cruz de Souza,Lucas Fukui-Silva,Josué de Moraes,Ademar A. Da Silva Filho
Ethnopharmacological relevance Acmella oleracea (L.) R. K. Jansen, commonly referred to as “Jambu”, is a valuable medicinal plant native to the Amazon regions. Inflorescences of A. oleracea is utilized as local anesthetic properties and for its insecticidal, antiparasitic, and anthelmintic attributes. Aims of this study This study aimed to evaluate the in vitro and in vivo antiparasitic properties of A. oleracea extract and spilanthol (SPL) against Schistosoma mansoni . Materials and methods The ethanolic extract of A. oleracea inflorescences (AoE) was prepared, analyzed by HPLC-DAD, and characterized by UHPLC-HRMS/MS. SPL was isolated from AoE by chromatographic fractionation. The antischistosomal properties of AoE and SPL were evaluated in vitro against adult schistosomes and in preclinical assays using murine models of patent S. mansoni infection. Results Through UHPLC-HRMS/MS analysis, 14 alkamides were annotated in AoE. HPLC-DAD analysis of AoE revealed a peak with a substantial relative area of ∼85%, which was isolated and identified as SPL. AoE and SPL caused mortality of adult schistosomes ex vivo , showing EC 50 values of 32.6 μg/mL and 27.8 μM, respectively, without affected Vero cells or Caenorhabditis elegans . In preclinical studies, the oral administration (400 mg/kg) of AoE and SPL resulted in significant reductions in worm burden of 28% and ∼42%, respectively. Additionally, SPL exhibits remarkable effects on oogram, decreasing egg burden and the number of immature eggs by over 80%, while also promoting significant reductions in hepato- and splenomegaly. Conclusions The research underscores the antischistosomal activity of A. oleracea highlighting the potential of SPL as a lead for the development of new schistosomicidal drugs and encouraging further studies to validate the traditional anthelmintic use of A. oleracea inflorescences.
研究领域:
药理学
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寄生虫学
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药物开发
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Rui Zhu,Peng Sun,Guofeng Cui,Jie Zhao,Yaoguang Yu
Ion transportation via the mixed mechanisms of hydrogels underpins ultrafast biological signal transmission in nature, and its application to the rapid and sensitive sensing detection of human specific ions is of great interest for the field of medical science. However, current research efforts are still unable to achieve transmission results that are comparable to those of bioelectric signals. Herein, 3D interconnected nanochannels based on poly(pyrrole-co-dopamine)/poly(vinyl alcohol) (P(Py-co-DA)/PVA) supernetwork conductive hydrogels are designed and fabricated as stimuli-responsive structures for K+ ions. Distinct from conventional configurations, which exhibit rapid electron transfer and permeability to biosubstrates, interconnected nanofluidic nanochannels collaborated with the P(Py-co-DA) conductive polymer in the supernetwork conductive hydrogel significantly improve conductivity (88.3 mS/cm), ion transport time (0.1 s), and ion sensitivity (74.6 mV/dec). The faster ion response time is attributed to the synergism of excellent conductivity originating from the P(Py-co-DA) polymer and the electronic effect in the interconnected nanofluidic channels. Furthermore, the supernetwork conductive hydrogel demonstrates K+ ion selectivity relative to other cations in biofluids such as Na+, Mg2+, and Ca2+. The DFT calculation indicates that the small solvation energy and low chemical transfer resistance are the main reasons for the excellent K+ ion selectivity. Finite element analysis (FEA) simulations further support these experimental results. Consequently, the P(Py-co-DA)/PVA supernetwork conductive hydrogels enriched with the 3D interconnected nanofluidic channels developed in this work possess excellent sensing of K+ ions. This strategy provides great insight into efficient ion sensing in traditional biomedical sensing that has not been explored by previous researchers.
研究领域:
生物医学工程
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材料科学
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传感器技术
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产品关联
DOI
PubMed
高影响因子
NANOTECHNOLOGY
·
2021
·Vol. 32
·期 21
·215202
·
IF 3.874
Guandong Wang,Daiming Liu,Shuangqing Fan,Zhaoyang Li,Jie Su
In this work, high-dielectric-constant (high-k) erbium oxide（Er2O3）film is fabricated using the spin coating method, and annealed at a series of temperatures (from 400 °C to 700 °C). The effect of annealing temperature on the microstructural and electrical properties of Er2O3 nanofilm is investigated. To demonstrate the applicability of the Er2O3 film, the indium oxide (In2O3) thin film transistor (TFT)-based amorphous Er2O3 dielectric film is fabricated at different temperatures. The TFT-based EO-600 shows a low-operating voltage and good electrical properties. The inverter demonstrates that the Er2O3 nanofilm synthesized by the sol-gel method could be a promising candidate as the dielectric layer in a low-voltage electronic device.
研究领域:
材料科学
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电子工程
✓ 已验证
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
Liangmin Xiong,Shuang Liu,Yong Men,Lin Li,Xiaoda Niu,Kailiang Guo,Junzhe Xu,Wei An,Jinguo Wang,Yu Cong
CO 2 hydrogenation to liquid fuels is significant to reduce CO 2 emissions and replace fossil fuels . Herein, we reported that Fe catalysts promoted by combination of K and Pd showed a three-synergistic catalytic effect to high selectivity of C 5+ hydrocarbons in CO 2 hydrogenation reaction. The catalysts were prepared using an impregnation method and characterized with physical adsorption , XRD , XPS , HRTEM , H 2 -TPR, H 2 -TPD and CO 2 -TPD. The results indicated that K 0.016 Pd 0.12 Fe catalysts showed K-overlapped PdFe-like alloy structure which enhanced H 2 activation behaviors and moderately chemisorption of CO 2 . K addition promoted Fe to activate carbide species while active H originated from H 2 pool generated by PdFe alloy spilled to Fe species surface, consequently boosting not only conversion of CO 2 to 41.8% but also selectivity of C 5+ hydrocarbon to 70.6%. The maximum yield of long-chain C 5+ hydrocarbon reached up to 20.0% under high space velocity 6000 mL g cat −1 h −1 . These results provide a new insight to develop highly selective Fe based catalysts for long-chain hydrocarbons via CO 2 hydrogenation.
研究领域:
化学工程
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催化反应
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能源转化
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2024
·
IF 2
Shouxiang Jiang,Kai Fu,Xiangyu Sun,Xin Huang,Wenjun Xie,Chengfei Wang,Haoran Li,Xia Jiang,Yongjin Zou,Gengxiu Zheng,Guan Wang
The solubilities of glutathione in four binary solvent mixtures (water + acetone, water + 1,4-dioxane, water + acetonitrile, and water + tetrahydrofuran) were measured using a dynamic laser monitoring method at temperatures ranging from 278.15 to 318.15 K. The molar fraction solubility of glutathione in the binary solvent increased with increasing water content and temperature. The modified Apelblat, CNIBS/R-K, Van’t Hoff–Jouyban–Acree, Apelblat–Jouyban–Acree, and NRTL were applied to calculate the solubility of glutathione in these mixtures. The relative average deviation and root-mean-square deviation indicated a good correlation between the experimental and model solubility data. In addition, the KAT-LSER model was used to evaluate the solvent effect in the solvent–solvent and solvent–solute interactions. The results showed that the nonspecific dipolarity/polarizability interactions between the solvent and the solute were the main influencing factors, followed by the hydrogen bonding interactions between the solvent and the solute.
研究领域:
药物化学
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物理化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2024
·
IF 2
Cheng Yang,Haijun Yan,Qianhe Huang,Wenge Yang,Yonghong Hu
Esculetin is derived from the leaves of lemons of Rutaceae and the bark of bittersweet ash, belladonna, mandala, and Rehmannia plants. In this research, the solubility of esculetin in ten solvents such as ethyl acetate, isobutyl alcohol, water, methanol, acetonitrile, n-propyl alcohol, isopropyl alcohol, n-butanol, ethanol, and acetone was determined by utilizing static equilibrium-high performance liquid chromatography (HPLC) under standard atmospheric pressure conditions and temperatures in the range of 273.15 to 318.15 K. Among the above ten pure solvents, water displayed the least solubility, while methanol exhibited the highest solubility. At the same temperature (T = 273.15 ∼ 318.15 K), the solubility of esculetin increased with the increase of the molar ratio of soluble solvents. Similarly, when the temperature increases (T = 273.15 ∼ 318.15 K), the solubility of the three binary solvents increases under the condition of a constant molar ratio. The above results suggest that the main factor affecting the solubility of esculetin in the solvent may be the polarization/bipolarity of the solvent. The experimental data was fitted by five thermodynamic models (the Buchowski–Ksiazaczak λh model, the Modified Apelblat model, the Jouyban–Acree model, the SUN model, and the CNIBS/R-K model), and the relative average deviation and root-mean-square deviation of the data were calculated, which proved that the correlation of the solubility data and the five models was relatively good. XRD and DSC were used to detect the crystal form and stability of esculetin during the experiment.
研究领域:
药学
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物理化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2024
·
IF 2
Shouxiang Jiang,Guangbing Zheng,Xiangyu Sun,Junwei Wang,Haibo Mu,Wenjun Xie,Chengfei Wang,Haoran Li,Xia Jiang,Gengxiu Zheng,Guan Wang
The solubility of paliperidone in 15 pure solvents (methanol, ethanol, i-propanol, n-propanol, n-butanol, n-pentanol, n-hexanol, methyl acetate, ethyl acetate, propyl acetate, butyl acetate, acetone, acetonitrile, tetrahydrofuran, and 1,4-dioxane) was determined using a dynamic laser monitoring method at 0.1 MPa and temperatures ranging from 288.15 to 328.15 K. With increasing temperature, the molar fraction solubility of paliperidone in each solvent also increased. Acetonitrile exhibited the lowest solubility at 288.15 K, whereas 1,4-dioxane showed the highest at 328.15 K. Various models, including the modified Apelblat, Yaws, λh, Wilson, and NRTL models, were applied to correlate and analyze the experimental data. The relative average deviation and root-mean-square deviation indicated strong correlation between experimental and modeled solubility data. Additionally, based on the Wilson model, the thermodynamic analysis of paliperidone dissolution suggested an entropy-driven and spontaneous process, with entropy exerting a greater influence on Gibbs free energy than enthalpy.
研究领域:
药学
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物理化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2024
·
IF 2
Yueheng Wang,Ziyu Zhuang,Yanfei Fan,Dandan Gao,Dongdong Li
Ammonium ion is of the same charge as alkali ions and with similar ionic radius as potassium, rubidium, and cesium ions. Solid solutions are very common between ammonium and alkali salts, which is of great interest for understanding the geology, soil, and environment fate of these elements. In this study, the solid–aqueous equilibrium in the NH4Cl + RbCl + H2O and NH4Cl + CsCl + H2O systems was determined at 298.15 K. For each system, two incontinuous solid solutions, i.e. (NH4,Rb)Cl(α) and (Rb,NH4)Cl(β), or (Cs,NH4)Cl(α) and (NH4,Cs)Cl(β), presented, and their composition and structure were studied using Schreinemakers’ wet residues analysis, XRD, and Raman characterization. The equilibrium between these solid solutions and aqueous solutions were well modeled using an integrated solution equilibrium calculator program, in which a Pitzer-Simonson-Clegg model and a subregular model were implemented for describing the nonideality of aqueous phase and solid solution. According to the experimental and thermodynamic modeling results, NH4Cl can dissolve RbCl and CsCl in the solid state (NH4,Rb)Cl(α) or (NH4,Cs)Cl(β) with limited solid solubilities of 0.18 or 0.051 in mole fraction, respectively. RbCl or CsCl can also dissolve NH4Cl in the solid state (Rb,NH4)Cl(β) or (Cs,NH4)Cl(α) with limited solid solubilities of 0.37 and 0.095 in mole fraction, respectively.
研究领域:
化学
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环境科学
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地质学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2026
·
IF 2.4
Jia Xu,Xun Wang,Jiazheng Qin,Ziwei Hu,Ruyi Lin,Yong Ma,Dan Li,Lingzong Meng
The solid–liquid phase equilibria of the quaternary system Na+, Cs+//Cl–, CO32––H2O and its subsystem Na2CO3–Cs2CO3–H2O at 308.15 K were studied by the isothermal dissolution method. The phase diagram of the system Na2CO3–Cs2CO3–H2O is composed of two single-salt crystallization fields of Na2CO3·H2O and Cs2CO3·H2O, two solubility univariant curves, and one invariant point. The dry-salt phase diagram of the quaternary system consists of three invariant points, seven univariant curves, and five crystallization regions corresponding to Na2CO3·H2O, NaCl, solid solution [Cs1–x(Na·H2O)x]Cl, Cs2CO3·H2O, and double salt CsCl·2NaCl·2H2O. The areas of crystallization zones decrease according to the above order. The Jan̈ecke index of H2O, pH, and refractive index of the liquid phase in the quaternary system change regularly with the Jan̈ecke index of Cs+. These results on the phase diagram of the quaternary system can supply theoretical references for cesium salt separation from carbonate-type brine.
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DOI
高影响因子
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