CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Chuang Wang,Yiqi Liao,Hou-Yong Yu,Yanjuan Dong,Juming Yao
Fiber-based wearable electronic textiles have broad applications, but non-degradable substrates may contribute to electronic waste. The application of cellulose-based composite fibers as e-textiles is hindered by the lack of fast and effective preparation methods. Here, we fabricated polyaniline (PANI)/cellulose fibers (PC) with a unique skin-core structure through a wet-spinning homogeneous blended system. The conductive network formation was enabled at a mere 1 wt% PANI. Notably, PC15 (15 wt% PANI) shows higher electrical conductivity of 21.50 mS cm −1 . Further, PC15 exhibits excellent ammonia sensing performance with a sensitivity of 2.49 %/ppm and a low limit of detection (LOD) of 0.6 ppm. Cellulose-based composite fibers in this work demonstrate good gas sensing and anti-static properties as potential devices for smart e-textiles.
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Journal of Materials Chemistry A
·
2023
·Vol. 11
·期 32
·17112-17124
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IF 11.9
Kai Han,Dadong Zhang,Wenbo Zhuang,Yanfen Wan,Peng Yang
Wearable sweat biosensors, as the only noninvasive and measurable body-fluid sensors, serve as a very important means to monitor an individual’s health status and more dynamic molecular-level information. The pursuit of wearable sweat biosensors includes not only detecting sweat components, but also integrating multiple functions, such as sweat-based health monitoring, near-field transmission and being self-powered. In this paper, we firstly bring forth a new idea of integrating sweat monitoring and dual electrical generation (hydrovoltaic and moisture electricity generation) for a multifunctional flexible device as a sweat-based health monitoring electronic (E)-skin. Herein, besides sweat composition analysis, a hydrovoltaic electricity generator is employed to detect the amount of sweat for the first time, and a dual electricity generator is used for self-supply of energy and skin-surface temperature measurement. Synergistic tandem nanogenerators are constructed using biomass carbon materials, and the power generation voltage can reach about 500 mV and is relatively stable. Our sweat E-skin (SE-skin) has five main functional areas, realizing real-time monitoring of sweat volume, sweat composition analysis‚ skin-surface temperature measurement and power-supply functions. This new integrated design not only enables real-time monitoring of indicators of health in sweat, but also provides a new idea for future intelligent wearables for human beings.
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BIOSENSORS & BIOELECTRONICS
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2020
·
IF 10.257
Ziqi Zhou,Yangzi Zhang,Mingzhang Guo,Kunlun Huang,Wentao Xu
A relatively-simple and high-efficient fluorescent magnetic biosensor based on DNAzyme was established for the detection of E. coli O157:H7. In order to solve the problem of weak signal and low sensitivity in the detection of foodborne pathogenic bacteria , we ingeniously designed a fluorescent sensor based on triple signal amplification of magnetic beads, DNAzyme and photoluminescence . In the detection process, the E. coli -specific RNA-cleaving DNAzyme can specifically identify the target protein in crude intracellular mixture (CIM), which caused its conformation changes and induced rolling circle amplification (RCA) to the generation and luminescence of copper nanoclusters (CuNCs). This cascade amplification design can capture weak signals in the sample. The biosensor also indicated a good linear range from 10 CFU mL −1 to 1000 CFU mL −1 and obtained a limit of detection (LOD) of 1.57 CFU mL −1 , which showed a relatively high sensitivity compared with other studies. Furthermore, the biosensor displayed high-efficient detection capability in 1.5 h and good reproducibility (relative standard deviations < 2%). It has been proved that this sensor is feasible to the detection of E. coli O157:H7 in drinking water and apple juice. Moreover, we found that the final detection product can effectively wrap the magnetic beads and can be driven by the magnetic field. And this unexpected discovery will provide ideas for the development of biosensing robots.
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ANALYTICA CHIMICA ACTA
·
2020
·
IF 5.977
Zhi Li,Jiayue Hu,Yongguang Xiao,Qingbing Zha,Lixi Zeng,Mingshan Zhu
Due to their highly porous structures, metal organic framework materials are widely used in analytic areas. In this paper, Cr-metal organic framework (MIL-101(Cr)) modified electrode was prepared and then was used as electrochemical sensor for the detection of bisphenol A (BPA). By using one kind of surfactant of cetyltrimethylammonium bromide (CTAB), the analytic performances of MIL-101 (Cr) towards BPA detection were greatly improved. Compared with pure MIL-101 (Cr), the differential pulse voltammetry (DPV) behavior of CTAB/MIL-101 (Cr) was improved 3.0 times in the presence of BPA. The hydrophobic long chain alkanes of CTAB can improve the enrichment and electrochemical oxidation for BPA. The CTAB/MIL-101 (Cr) sensor exhibited a linear range from 20 to 350 nM and a low detection limit of 9.95 nM (LOD = 3 s b / S ) and showed good reproducibility, stability and selectivity . Finally, real samples of dusts from E-waste recycling area in South China were collected and the CTAB/MIL-101 (Cr) sensor demonstrated satisfactory results for BPA detection from these dust samples.
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EUROPEAN JOURNAL OF PHARMACOLOGY
·
2020
·
IF 3.263
Cui Zhai,Wei Feng,Wenhua Shi,Jian Wang,Qianqian Zhang,Xin Yan,Qingting Wang,Shaojun Li,Lu Liu,Yilin Pan,Yanting Zhu,Limin Chai,Cong Li,Pengtao Liu,Yuqian Chen,Manxiang Li
It has been shown that sphingosine-1-phosphate (S1P) is elevated in patients with pulmonary arterial hypertension (PAH) and promotes the proliferation of pulmonary artery smooth muscle cells (PASMCs). Meanwhile, S1P has been found to induce the activation of autophagy in several types of human diseases including cancers. However, it is still unclear whether activation of autophagy mediates S1P-induced PASMCs proliferation, and detailed mechanisms responsible for these processes are indefinite. The aims of this study are to address these issues. S1P dose- and time-dependently reduced the expression of E-cadherin/CDH1 and stimulated PASMCs proliferation; this was accompanied with the elevation of TNF receptor-associated factor 2 (TRAF2), up-regulation and ubiquitination of BECN1 and the activation of autophagy. Prior silencing TRAF2 or BECN1 using siRNA or pre-incubation of cells with autophagy inhibitor chloroquine phosphate (CQ) suppressed S1P-induced autophagy activation and subsequent CDH1 degradation and further PASMCs proliferation. Taken together, our study indicates that S1P promotes the activation of autophagy by accelerating TRAF2-mediated BECN1 up-regulation and ubiquitination, which in turn results in CDH1 reduction and contributes to PASMCs proliferation.
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JOURNAL OF HAZARDOUS MATERIALS
·
2021
·
IF 10.588
Qianqian Jin,Danyang Tao,Yichun Lu,Jiaji Sun,Chun Ho Lam,Guanyong Su,Yuhe He
Liquid crystal monomers (LCMs) have been proposed as a class of emerging organic pollutants , which were recently detected in indoor dust and sediment samples collected near electronic devices recycling facilities. However, there is a knowledge gap for analytical method, occurrence, and distribution of LCMs in aqueous sample. Herein, a robust method was developed to determine 38 target LCMs in landfill leachate . A combined ultrasonic enhanced liquid-liquid extraction, saponification and silica/florisil packed column purification method achieved recoveries of 76.9~127.1%, 84.5~114.6% and 81.3~104.6% at spiking levels of 2 ng, 10 ng and 50 ng in leachate, respectively. The developed method was validated through determination of target LCMs in leachate samples collected from municipal landfills in Hong Kong (HK) and Shenzhen (SZ), China. There were 23 and 20 LCMs detected in the HK (ΣLCMs=1120 ng/L) and SZ (ΣLCMs=409 ng/L) sample, respectively, with 6 LCMs newly detected in the environment. This study provided the first evidence suggesting that landfill leachate might be a potential sink of LCMs emitted from e-waste. Future study is urged to investigate the potential migration of LCMs from landfill leachate as a point source, and their occurrence, distribution, fate, and ecotoxicological risk in aquatic environments on regional and global scales.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Xinyu Hu,Juntao Wang,Jing Wang,Kehui Xue,Ting Yang,Yi Peng,Ying Yan,Hongbo Xiao,Wenlei Wang
Controlling the migration behavior of photogenerated carriers by designing the microstructure of materials remains a significant challenge. In this work, the solvothermal method was used to fabricate a SnO 2 /SnS 2 heterojunction anchored on biochar through −C Sn− bonds between biochar and SnS 2 , as demonstrated by X-ray photoelectron spectroscopy characterization. DFT calculations further confirmed −C Sn− bonds can shorten theoretical band gap of SnS 2 @biochar from 1.01 eV to 0.66 eV and provide a pathway for swift electron migration, which can effectively modulate the separation of photo-induced carriers and promote the generation of e − and h + . Additionally, the oxalate activated by −C Sn− bonds can effectively capture h + and produce abundant ∙CO 2 – free radicals. When the obtained composites were used as photocatalysts , Cr(VI) was thoroughly reduced by the SnO 2 /SnS 2 @biochar composite with a molar ratio of SnO 2 and SnS 2 of 2 within 20 min under visible light irradiation when oxalate was 1.0 mM (CSO-2/H 2 C 2 O 4 -1). Furthermore, CSO-2/H 2 C 2 O 4 -1 exhibited excellent reusability, and the degradation efficiency of Cr(VI) remained above 91.71% after five cycles. The remarkable photocatalytic properties can be ascribed to the synergistic effects of e − and ∙CO 2 – . This work proposes a new strategy for the preparation of an applied photocatalyst with a high separation rate of photoinduced carriers.
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JOURNAL OF ELECTROCERAMICS
·
2019
·Vol. 43
·期 1
·96-105
·
IF 1.966
Wang Ziyang,Chen Peng,Shi Wenjing,Li Yang,Li Dequan,Zhang Leiyang,Yan Yan,Wang Yifei,Peng He,Li Quan,Liu Gang
In the current investigation, the CuO modified BaTiO 3 ceramics were prepared through the conventional electroceramic processing. XRD, XPS, and SEM have been employed to characterize the phases, valences of ions and the microstructures. The sintering behaviors of the prepared samples were performed using a dilatometer, and ceramics could be fabricated at lower temperature. The electric field and temperature dependent energy storage performance have been studied. The introducing of CuO is very effective to improve the energy storage density and the efficiency due to the formed double P-E loops. 0.5 wt.% CuO modified ceramic exhibited an energy density of 0.52 J/cm 3 , which is nearly twice of pure BaTiO 3 ceramic. The J-E loops of CuO modified samples indicated double domain switches, consistent with the double P-E loops.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2019
·
IF 3.571
Weibin Ma,Luling Zhao,Wenhong Zhao,Yanli Xie
Fungal contamination imposes threats to agriculture and food production and human health. A method to safely and effectively restrict fungal contamination is still needed. Here, we report the effect and mode of action of (E)-2-hexenal, one of the green leaf volatiles (GLVs), on the spore germination of Aspergillus flavus, which can contaminate a variety of crops. The EC50 value, minimum inhibitory concentration (MIC), and minimum fungicidal concentration (MFC) of (E)-2-hexenal were 0.26, 1.0, and 4.0 μL/mL, respectively. As observed by scanning electron microscopy (SEM), the surface morphology of A. flavus spores did not change after treatment with the MIC of (E)-2-hexenal, but the spores were shrunken and depressed upon treatment with the MFC of (E)-2-hexenal. The MIC and MFC of (E)-2-hexenal induced evident phosphatidylserine (PS) externalization of A. flavus spores as detected by double staining with Annexin V-FITC and propidium iodide, indicating that early apoptosis was potentially induced. Furthermore, sublethal doses of (E)-2-hexenal disturbed pyruvate metabolism and reduced the intracellular soluble protein content of A. flavus spores during the early stage of germination, and MIC treatment decreased acetyl-CoA and ATP contents by 65.7 ± 3.7% and 53.9 ± 4.0% (P < 0.05), respectively. Additionally, the activity of mitochondrial dehydrogenases was dramatically inhibited by 23.8 ± 2.2% (P < 0.05) at the MIC of (E)-2-hexenal. Therefore, the disruption of mitochondrial energy metabolism and the induction of early apoptosis are involved in the mechanism of action of (E)-2-hexenal against A. flavus spore germination.
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CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Shulong Jiang,Mengying Li,Ying Hu,Zhenhai Zhang,Huixia Lv
A polymer of Galactosamine-hyaluronic acid-Vitamin E succinate (Gal-HA-VES) was designed to prepare multifunctional self-assembled micelles for delivery of Norcantharidin (NCTD) to Hepatic carcinoma. NCTD/Gal-HA-VES showed higher cytotoxicity toward CD44-overexpressing MCF-7 cells, MCF-7/Adr cells and ASGP-R overexpressing HepG2 cells, consistent with the enhanced cellular uptake in the selected cell models, indicating Gal-HA-VES micelles were taken up in MCF-7 and HepG2 cells by CD44 and ASGPR receptor mediated endocytosis, respectively. Moreover, the accumulation of Rhodamine 123 demonstrated that Gal-HA-VES has the same action of TPGS as a P -glycoprotein inhibitor blocked drug efflux-related MDR mechanism in resistant MCF-7/Adr cells. The Cell apoptosis assays indicated that NCTD/Gal-HA-VES were more effective in triggering apoptosis, compared with free NCTD or NCTD/HA-VES groups. In vivo study demonstrated that NCTD/Gal-HA-VES group exhibited enhanced tumor targeting and antitumor activity with lower systemic toxicity. Hence NCTD/Gal-HA-VES micelles system can achieve significant tumor targeting and effective treatment of hepatic carcinoma.
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Biomaterials Science
·
2018
·Vol. 6
·期 12
·3397-3409
·
IF 5.831
Jing-Bo Hu,Di Liu,Jing Qi,Kong-jun Lu,Fei-yang Jin,Xiao-Ying Ying,Jian You,Yong-Zhong Du
Based on the overproduction of matrix metalloproteinase-2 (MMP-2) in renal tissue during acute kidney injury (AKI) occurrence, we developed a MMP-2 enzyme-triggered polymeric prodrug with sialic acid (SA) as the targeting group to the inflamed vascular endothelial cells for enhanced therapeutic outcomes. An MMP-2-responsive peptide, PVGLIG, was used to endow the polymeric prodrug with the ability to rapidly release the anti-inflammatory drug, curcumin (CUR), after the targeted site is reached and to improve the drug concentration in the target tissue. The sialic acid–dextran–PVGLIG–curcumin (SA-DEX-PVGLIG-CUR) polymeric prodrug was successfully synthesized via multi-step chemical reactions and characterized by 1H NMR. The water solubility of CUR was significantly increased in the polymeric prodrug and was approximately 23-fold higher than that of free CUR. The in vitro drug release results showed that the release rate of SA-DEX-PVGLIG-CUR was significantly enhanced compared to that of SA-DEX-CUR in a dissolving medium containing the MMP-2 enzyme, suggesting that SA-DEX-PVGLIG-CUR had rapid drug release characteristics in an inflammatory environment. A cellular uptake test confirmed that SA-DEX-PVGLIG-CUR was effectively internalized by inflamed vascular endothelial cells in comparison with that by normal cells, and the mechanism was associated with the specific interaction between SA and E-selectin receptors specifically expressed on inflamed vascular endothelial cells. Bio-distribution results further demonstrated the rapid and increased renal accumulation of SA-DEX-PVGLIG-CUR in AKI mice. Benefiting from the rapid drug release in renal tissue, SA-DEX-PVGLIG-CUR effectively ameliorated the pathological progression of AKI compared with free CUR and SA-DEX-CUR, as reflected by the improved renal functions, histopathological changes, pro-inflammatory cytokine production, oxidative stress and expression of apoptosis related proteins. Altogether, this study provided a new therapeutic strategy for the treatment of AKI.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2015
·
IF 3.313
Huan-Na Lin,Bin-Bin Hu,Ming-Jun Zhu
Clostridium thermocellum can degrade lignocellulosic materials to produce hydrogen , acetate, lactate and ethanol, and surfactants have been proven to have the ability of increasing the enzymatic hydrolysis of cellulosic substrates. Here, the effects of surfactants on the fermentation of spent mushroom compost by C. thermocellum were investigated and their underlying mechanisms were preliminarily studied. PEG8000 and JFC-E had different effects on the fermentation performance of spent mushroom compost. Under optimum conditions, PEG8000 increased the hydrogen production by 59.78%, compared to the control without surfactant, while JFC-E improved the accumulation of glucose and xylose rather than hydrogen yield. PEG8000 also had different impacts on the bioconversion of non-lignin substrates (Avicel, carboxyl methyl cellulose and filter paper). With added PEG8000, the hydrogen production was improved when using Avicel as the substrate, and with PEG8000, the yields of products and sugar accumulation were different from those without PEG8000, indicating that PEG8000 may increase the hydrogen yield by shifting the microbial metabolism.
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