SENSORS AND ACTUATORS B-CHEMICAL
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2025
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IF 7.7
Shuwen Zhu,Huiqing Fan,Lin Lei,Yongbo Fan,Weijia Wang
Developing triethylamine (TEA) sensors using metal oxide semiconductors (MOS) presents challenges such as achieving high sensitivity, low operating temperatures, and reliable detection of trace TEA. In this study, a novel two-step solvothermal synthesis strategy was developed for the sequential fabrication of δ-MnO 2 nanosheets and δ-MnO 2 /WO 3 (WMn) heterojunction composites. The resulting WMn heterostructure features a unique morphology, where δ-MnO 2 nanosheets are encapsulated within a WO 3 matrix, forming well-defined layered interfaces and abundant active sites. This tailored structure significantly enhances the TEA sensing performance. In particularly, WMn1 sensor achieves an ultrahigh response of 515.37 to 20 ppm TEA at 140 °C. The sensor also exhibits an exceptionally low detection limit of 15.91 ppb, along with rapid response/recovery kinetics and long-term stability. The superior performance is attributed to the formation of n–p heterojunction and the synergistic effects of electronic and chemical sensitization, which optimize charge carrier dynamics, reduce interfacial resistance, and enhance surface reactivity. By focusing on interface engineering in heterojunction-based gas sensors, this study contributes to the strategic design of high-performance sensing materials, with potential applications in environmental monitoring and industrial safety.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2025
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IF 5.6
Xue Wang,Lu Liu,Di Wu,Yuxin Hu,Hongzhuo Liu,Yizhou Sun,Guangqi Yan
Noninfectious uveitis (NIU) remains a significant cause of vision impairment, typically managed with glucocorticoids. However, current glucocorticoid implants present considerable side effects, including elevated intraocular pressure and cataracts. To overcome these limitations, we synthesized a novel prodrug, dexamethasone gallate (DG), which possesses the powerful anti-inflammatory ability of dexamethasone (DEX) and exhibits strong antioxidant activity of gallic acid (GA) that helps protect ocular tissues against oxidative stress. DG was formulated into cyclodextrin microparticle suspension eye drops, designed to progressively disintegrate and penetrate ocular tissues effectively. In experimental autoimmune uveitis (EAU) models, DG suspension eye drops demonstrated comparable therapeutic efficacy to conventional DEX eye drops at reduced dosages, significantly reducing anterior and posterior ocular inflammation. Notably, DG formulations substantially minimized intraocular pressure elevation and glucocorticoid-related adverse effects. These findings support the potential of DG suspension eye drops as a safer, efficient, and patient-friendly therapeutic alternative for treating NIU.
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Frontiers in Pharmacology
·
2025
·
IF 4.8
Hanbin Chen,Guanghong Li,Lin Deng,Nan Xu,Simon Ming-Yuen Lee,Xiaowei Nie,Jin-Song Bian
Introduction: Pain is a complex phenomenon involving physiological and psychological responses to noxious stimuli. Long-term opioid or NSAID use leads to reduced efficacy and tolerance. Initially a thermosensitive receptor, TRPV1 is increasingly recognized as a target for analgesic intervention.Methods: Our investigation is focused on the exploration of novel TRPV1 antagonists derived from natural sources through computational screening methodologies, aiming to assess their efficacy as analgesic agents.Results: Among the compounds screened, a promising TRPV1 antagonist named pinocembrin-7-o-3-o-galloyl-4-6-hexahydroxydiphenoyl-beta-d-glucoside (PINO) has exhibited superior stability in its interaction with TRPV1 through virtual screening and molecular dynamics simulation. A dosage of 20 mg/kg of PINO had been shown to reduce the writhing response in acetic acid-induced mice, elevate the thermal pain threshold in the hot water tail-flick and hot plate assays, and concurrently increase the mechanical pain threshold in CFA-induced inflammatory pain models in mice. Moreover, in a murine Lewis lung carcinoma cell line LL-induced bone cancer pain model, PINO also effectively raised the thermal and mechanical pain thresholds in mice. Furthermore, PINO had been found to attenuate the production and gene expression of pro-inflammatory cytokines. The underlying mechanism was attributed to the suppression of NF-κB and MAPK signaling cascades.Discussion: This innovative compound represents a prospective avenue for the management of acute, chronic, and bone cancer pain, providing a viable alternative analgesic option for individuals suffering from such conditions.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Mingxiao Feng,Qianyu Wang,Minzhen Lei,Dawei Zhang,Qian Yu,Chunyan Yan
Neuroinflammation is closely linked to Alzheimer's disease, where the deposition of amyloid-beta activates microglia, triggering multiple processes that lead to neuronal damage and cognitive decline. However, studies have shown that water extract of Pinellia ternata can improve cognitive function and reduce inflammatory response in the brain injury of mice. Herein, a water-soluble polysaccharide, PTTBP-2-2. with a molecular weight of 11.7 kDa, consisting of D-Glc, D-Gal, D-Xyl, and L-Ara, was isolated from P. ternata . Methylation analysis, partial acid hydrolysis, and nuclear magnetic resonance revealed that the of PTTBP-2-2 backbone consisted of →4)- α -D-Glc p -(1→, →4,6)- α -D-Glc p -(1→, and →6)- α -D-Gal p -(1 → residues, with side chains substituted at O -2, O -3, and O -6 positions of →4)- α -D-Glc p -(1→. In vitro experiments demonstrated that PTTBP-2-2 significantly reduced nitrous oxide levels in BV2 microglia cells and suppressed the expression of pro-inflammatory genes, including COX2 , iNOS , TNF-α , IL-1β , and IL-6 . These factors are key mediators of neuroinflammation. Mechanistic investigations revealed that the anti-neuroinflammatory activity of PTTBP-2-2 was mediated through the regulation of NF-κB and Nrf2/HO-1 signaling pathways. Overall, PTTBP-2-2 shows potential as a therapeutic agent for the treatment of neuroinflammation.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2025
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IF 4.6
Peng-cheng Zhao,Xiao-xing Wang,Lv-qi Xie,Zi-ting Li,Xue Li,Zi-qin Dai,Xi-yang Tang,Zhi-hong Yao,Xin-sheng Yao,Yi Dai
Oligosaccharides (OSs) are abundant in natural products (NPs), yet their rapid and effective characterization, especially for absorbed OSs, remains challenging. In this study, an enhanced data acquisition and analysis strategy using three derivative labels was proposed and successfully applied to characterize the in vitro and in vivo profiles of OSs in Mori Fructus fruit (MF). For data acquisition, Data Independent Acquisition (DIA) was performed to maximize the MS information of OSs, followed by Mass Defect Filtering (MDF) using Metabolynx XS™ to automatically exclude irrelevant ions and generate Precursor Ion List (PIL) of potential OSs. A PIL-based Data Dependent Acquisition (DDA) was subsequently implemented to obtain clear MS 2 spectra. For data analysis, fragmentation behaviors of OS reference standards were evaluated to obtain Characteristic Fragment Ions (CFIs) and Neutral Losses (NLs) that served as criteria for eliminating false-positives. Ultimately, 79 OSs (44 neutral-reducing OSs, 11 nitrogen-reducing OSs, 20 acid-reducing OSs, and 4 neutral non-reducing OSs) were characterized in MF extract. In addition, 68 OS prototypes were detected in intestinal contents and 15 OS prototypes were observed in plasma. In conclusion, this novel strategy enabled stepwise screening, classification and systematic characterization of OSs in NPs in vitro and in vivo .
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FOOD HYDROCOLLOIDS
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2025
·
IF 12.4
Pan Wang,Bangfeng Yin,Ping Zou,Zhenjia Zheng,Dan Wang,Peiyou Qin,Wenting Zhao,Yuanyuan Zhao,Ye Liu,Xiaoyan Zhao
To address the limitation of resveratrol (Res) related to its low bio-accessibility and poor stability, Res-pectin complexes with varying degrees of esterification were developed. The encapsulation efficiency of Res in these complexes was determined, revealing the following order: Res-L106 > Res-L13 > Res-H121 > Res-H115. Upon non-covalent interaction with pectins, Res exhibited enhanced stability, reduced crystallinity, and modified microstructure. The complexes exhibited stable particle sizes across a pH range of 4 to 8, with the Res-L106 complex showing minimal sensitivity to variations in ionic strength and temperature. All complexes exhibited improved antioxidant activities compared to pectins alone, with the Res-L106 complex displaying the highest activity. The complex enhancing the bio-accessibility of Res follows the order of Res-L106 > Res-L13 > Res-H121 > Res-H115. Additionally, all complexes promoted the production of short-chain fatty acids (SCFAs), with butyric acid being the predominant product. Notably, the Res-L106 complex exhibited the highest SCFAs-producing capacity. In conclusion, this study provides valuable insights into the design and optimization of strategies to enhance the bioavailability of Res, highlighting the potential of low-esterified pectin as an effective delivery carrier for bioactive compounds.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Weijie Zhang,Lintao Wang,Wei Pei,Jie Dang,Yewen Zhang,Xiang Liu,Abdullah Maqsood,QinQin He,Min Li
Introducing defects into Metal–organic frameworks (MOFs) is an effective measure to increase adsorption sites, which is of great significance for improving phosphorus (P) adsorption performance. In this study, various defect-containing cerium (Ce)-based MOFs (Ce-MOFs) were prepared by introducing different types and equivalents of monocarboxylates. Among them, butyric acid (BA)-regulated Ce-MOF (Ce-MOF(40BA)) exhibited excellent adsorption performance with a maximum phosphate adsorption capacity of 117.28 mg P/g. When the initial phosphate concentration was 3 mg P/L, the adsorption equilibrium could be reached within 10 min with a phosphate removal rate of 96.6%. Thermogravimetry analysis (TGA) showed that the average coordination number of Ce-MOF (40BA) was only 4.33 compared to six of the pristine Ce-MOF, indicating an abundant defect content. By increasing defects, mesopores were introduced, enriching the material’s pore structure and achieving a mesopore proportion up to 58.81%. X-ray photoelectron spectroscopy (XPS) analysis revealed that the introduction of defects created numerous unsaturated metal centers, leading to a significant increase in Ce(III) contents. Further density functional theory (DFT) calculations indicated that the defective Ce-MOF had a lower binding energy compared to the pristine Ce-MOF, making it more favorable for phosphate adsorption. This study provides a strategy for preparing efficient defect-containing MOF adsorbents. The excellent adsorption performance of Ce-MOF(40BA) in practical wastewater bodies makes it a promising material for solving water eutrophication.
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POLYMER COMPOSITES
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2025
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IF 4.7
Lei Li,Shumei Liu,Pengwei Duan,Xing Liu,Jianjun Li,Jianqing Zhao
Glass fiber reinforced nylon 66 (GF/PA66) composites have been widely used in a range of industrial applications, but it is still a challenge to design and manufacture GF/PA66 composites with simultaneously improved processability, thermal, and mechanical properties. Here, a novel imide oligomer (FPI) was synthesized and used as a multifunctional modifier. Thanks to trifluoromethyl ( CF 3 ) and anhydride groups, FPI was located at the interface between GF and the PA66 matrix, and enhanced the interfacial interactions via covalent interactions and hydrogen bonds (H bonds), leading to the homogeneous dispersion of GF in composites and the improved processability. In addition, the results were confirmed by molecular dynamics (MD) simulations. The equilibrium torque of GF30/PA-FPI3 (30 wt% GF and 3 wt% FPI) was decreased by 54.2% compared to that of GF30/PA, attributed to the rigid-flexible structure of FPI. Furthermore, unlike conventional flow modifiers that have a negative effect on the thermal, mechanical, and hydrophobic properties of GF/PA66 composites, the glass transition temperature ( T g ), heat deflection temperature (HDT), fracture energy, flexural modulus, and water contact angle of GF30/PA-FPI3 were increased by 10.6°C, 40.3°C, 67.8%, 20.1%, and 26.9° respectively, compared to those of GF30/PA. Therefore, this study demonstrated the potential application of FPI for GF/PA66 composites and provided a promising avenue for preparing high performance GFRP composites as advanced engineering composites.
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JOURNAL OF FOOD SCIENCE
·
2025
·Vol. 90
·期 6
·e70310
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IF 3.4
Arooj Rehman Sheikh,Miral Javed,Hao Zhang,Qiaojun Jia,Zisheng Luo
Camellia oleifera shells, waste material obtained after oil extraction, contain a significant number of terpenes. This study introduces a novel, eco-friendly, and sustainable method to combine N 2 -NBs with limonene and ultrasound to enhance terpene extraction from food waste. N 2 -NBs suspension stabilized by Tween 80, resulting in 255 nm size with reduced surface tension. Raman spectroscopy indicates strong hydrogen bonding at 1646 cm⁻¹, suggesting that the enhanced release of compounds and micelle formation improved the solubility of terpenes. Meanwhile, SEM demonstrated that the collapse of N 2 -NBs effectively disrupted cell walls. Together, these mechanisms significantly enhanced terpene compounds' release, solubility, and overall yield. Combining Tween 80 and N 2 -NBs with ultrasound achieved a terpene yield of 42.88 ± 1.87 mg/g DW, significantly higher than the 10.96 ± 2.87 mg/g DW from ethanol extraction. These findings highlight the novel eco-friendly approach to effectively extract terpenes, which can be useful for industrial applications. Practical applications The novel, eco-friendly extraction method can be used to reuse food waste. High-yielding extraction method can be used to extract pharmaceutical compounds. Extracted terpenes can be used for various food industry applications.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Shujing Yu,Qiaoqi Guo,Xinyan Feng,Ruya Chen,Huajun Feng,Yingfeng Xu
Conventional photocatalysts face limitations in solar energy absorption and photocatalytic efficiency, hindering their practical applications in energy conversion and environmental remediation. Given that heat is a general promoter of catalytic reaction activity, we here developed hydrogenated hollow mesoporous WO3 spheres (WO3–x) as dual-functional photocatalysts. They can utilize ultraviolet–visible light for direct photocatalysis, while simultaneously harnessing the remaining near-infrared portion of the solar spectrum to achieve photothermal enhancement. Due to the photothermally improved activation of reactants and accelerated reaction kinetics, the developed WO3–x exhibited a 3-fold increase in CH4 production with 96% selectivity in CO2 photoreduction and a 10-fold enhancement in toluene degradation under full-spectrum irradiation, compared to pristine WO3. Moreover, even after 100 days of storage in air, WO3–x retained its excellent near-infrared photothermal conversion ability and sustained enhancement of reaction activity. These findings highlight the significant potential of photothermal catalysis for efficient solar energy utilization, further driving the development of near-infrared photothermal conversion materials and their application in sustainable energy conversion and environmental remediation.
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ACS Applied Materials & Interfaces
·
2025
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IF 8.2
Kun Lu,He Ding,Mengmeng Long,Xiaoyang Zhu,Xiaoyi Lou,Yan Li,Ning Gu
Given that reactive oxygen species (ROS) accumulation and inflammatory microenvironments are key issues hindering wound repair, nanozyme-functionalized hydrogels have been widely used in different types of wound healing modes to regulate ROS. Since wound healing is a long-term process, the long-term effectiveness or even enhancement of enzyme-like activities of hydrogels is critical. Based on the electron transfer catalytic mechanism and enzyme-like activity enhancement effect of Prussian blue nanozymes (PBNZs), this study used classic hydrogel materials as carriers and PBNZs as functionalized nanozymes to construct a wound dressing with enhanced enzyme-like activity. In the system, the effect of self-enhanced enzyme activity as a wound dressing and the good promotion effect on the healing of skin defect models were successfully verified. Moreover, PBNZs can be stably fixed in the hydrogel system and will not be released during the application process, which is a necessary condition for achieving enzyme-like activity self-enhancement. It is precisely due to the self-enhanced effect of its enzyme-like activity that PBNZs can express excellent ROS regulation ability in the effective contact area. This article explores the intrinsic properties of PBNZs-based hydrogels for wound healing, focusing on their catalytic mechanisms. The developed PBNZs-functionalized hydrogel shows significant potential as an advanced dressing to accelerate wound healing. Notably, the self-enhanced wound dressing with enzyme-like activity proposed in this study offers valuable insights for material design in this field.
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ChemNanoMat
·
2025
·
IF 2.6
Zhixin Gao,Meng Yan,Zhen Sun,Teng Wang,Yaoming Zhang,Sen Lin,Yong Yang
Porous layered hydroxides has garnered significant attention for ion adsorption applications due to their unique combination of layered and porous structures. Herein, porous layered lanthanum hydroxide nanowires (NWs) is synthesized to efficiently adsorb Br − , utilizing the modulation of interlayer ions to optimize their performance. These NWs exhibit a porous surface structure and a positively charged surface, which increases the number of active sites and enhances their affinity for Br − . The layered hydroxide lanthanum acetate (LHL-acetate) NWs possess an adsorption capacity of 221 mg g −1 , a wide range of pH suitability (from 3.0 to 10.0) and remarkable stability, surpassing many previously reported adsorbents. The superior Br − adsorption performance of LHL-acetate NWs can be attributed to the synergistic effect between ion-exchange properties of interlayer anions and surface adsorption facilitated by the porous structure, which strengthens electrostatic interactions at the adsorbent-solution interface. Impressively, these NWs achieved 100% Br − removal from simulated wastewater with varying initial concentrations and flow rates in a fixed-bed adsorption system, highlighting the effectiveness of LHL-acetate NWs for advanced Br − removal in practical applications. This study reveals the structure-reactivity relationship of porous layered lanthanum hydroxide adsorbents and offers insights for the application of such materials in the adsorption domain.
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